Tuesday, October 31, 2006

Scientists grow liver from stem cells

Source: United Press International
Posted: October 31, 2006

Summary:

British scientists have grown a liver from stem cells in the first step toward creating fully viable livers, perhaps within 10 years.

Parts Of Liver Created Using Umbilical Cord Stem Cells

Source: Medical News Today
Posted: October 31, 2006 - 11:00am (PST)

Summary:

Scientists from Newcastle University, UK, reported that small sections of human liver have been created from umbilical cord stem cells. The researchers say this technology could eventually be used to grow small livers that could be used for drug tests - doing away with the need for human volunteers to take risks. The scientists cautioned that it the ability to produce whole new livers for transplants is still far off. However, within the next 15 years, tiny livers could be produced and used for treating patients.

This finding seems as if it might be able to yield safer drug trials and replace damaged or diseased livers humans in the future.

Artificial liver for transplant ‘in ten years’

Source: The Times
Date: October 31, 2006

Summary:

BRITISH scientists have grown the first artificial liver in a breakthrough that could eventually allow livers to be grown for human transplants.

Liver cells grown from cord blood

Source: BBC News
Posted: 31 October 2006, 15:06 GMT

Summary:

British Scientists say they have grown tiny sections of human liver using stem cells from umbilical cords. It is hoped the "mini-livers" will be used to test drugs. However, the scientists believe it will be decades before a grown liver can be used in a human transplant operation. Some scientists are calling this a significant ethical advance because embryos were not required to grow the sections of the liver.

Commentary: Maybe this will eventually lead to regeneration and replacement of livers and other organs in humans. It may also end the ethical controversy surrounding embryonic stem cells if scientists can create replacement organs using alternatives to embryonic stem cells, such as the umbilical cord blood stem cells that were used to grow the sections of the human liver in this experiment.

Scientists grow artificial liver

Source: Daily Telegraph
Posted: October 31, 2006

Summary:

British scientists have grown a miniature liver from stem cells in a world breakthrough. The tiny organ, about the size of a 1p coin, will be used for drug testing and reduce the need for animal experiments. Scientists said it was the first stage to creating sections which can be used to repair damaged livers and even a full-size functioning version. The creation of the mini-liver by scientists at Newcastle University involved taking stem cells - blank cells capable of developing into different types of tissue - from the umbilical cords of newborn babies.

Commentary: Maybe this finding will have successful clinical applications for repairing damaged and diseased livers in humans.

STEM CELL SCIENTISTS GROW LIVER: New hope to end medical testing

Source: Daily Record
Posted: October 31, 2006

Summary:

UK scientists have grown the first artificial human liver using stem cells from umbilical cords to produce a tiny version of the body's largest internal organ. Researchers believe the mini-liver could be used to test new drugs, ending the need for animal testing and clinical trials using human volunteers.

Commentary: Maybe this advancement will lead to safe and effective treatments for patients with liver diseases.

First liver grown from stem cells offers hope for transplant patients

Source: The Scotsman
Posted: October 31, 2006

Summary:

British scientists announced an artificial liver has been grown for the first time using stem cells taken from umbilical cords. The breakthrough is considered the vital first step towards creating a fully artificial liver that could be used to tackle ever-growing waiting lists for transplants.

Commentary: Hopefully this finding will eventually lead to the creation of a liver from stem cells that functions effectively in human liver transplant patients.

Monday, October 30, 2006

Fat Stem Cells Being Studied As Option For Breast Reconstruction

Source: University of Pittsburgh Medical Center via Medical News Today
Posted: October 30, 2006 - 17:00pm (PST)

Summary:

Breast cancer survivors might one day avoid the prospect of invasive breast reconstruction surgery by using stem cells derived from their own fat according to University of Pittsburgh researchers who are studying the potential these cells may have for regenerating new breast tissue.

British scientists grow human liver in a laboratory

Source: Evening Standard
Posted: October 30, 2006

Summary:

British scientists have grown the world's first artificial liver from stem cells in a breakthrough that could pave the way to the development of entire human organs for transplant. The technique that created the 'mini-liver', currently the size of a one pence piece, will be developed to create a full-size functioning liver. Lab-grown liver tissue could be used to test new drugs, and may also reduce the number of animal experiments

Commentary: Hopefully this new breakthrough will eventually lead to organ transplants that are both safe and effective in humans.

Cause Of Nerve Fiber Damage In Multiple Sclerosis Identified

Source: University of California - Irvine
Date: October 30, 2006

Summary:

Researchers have identified how the body's own immune system contributes to the nerve fiber damage caused by multiple sclerosis, a finding that can potentially aid earlier diagnosis and improved treatment for this chronic disease.

Commentary: This finding could provide researchers with new understanding of the neurodgenerative functions of multiple sclerosis in order to develop effective treatments for it.

Researchers Identify Cell Line That Is Resistant To Retroviruses, Including HIV

Source: University of Minnesota
Date: October 30, 2006

Summary:

Researchers at the University of Minnesota have identified a protein that enables viruses such as HIV to infect cells and spread through the body. This discovery gives drug developers a target to discover new types of drugs to stop the virus from spreading.

Commentary: Figuring out how to disable or eliminate this protein will be a critical component of the development any new drugs that effectively stop viruses from spreading.

Sunday, October 29, 2006

Stem cell insulin offers hope to type 1 diabetics

Source: New Scientist
Date: 28 October 2006

Summary:

For the first time, Insulin-secreting cells have been created from human embryonic stem cells by using a cocktail of chemicals to coax the stem cells to form pancreatic cells, raising hopes of a limitless supply of cells that could be transplanted into people with type 1 diabetes.

Commentary; Hopefully this new finding can be successfully replicated in humans and proven an effective treatment for type 1 diabetes.

Friday, October 27, 2006

Embryonic Stem Cells: Hope Vs. Controversy: What Exactly Are Embryonic Stem Cells, And Where Do They Come From?

Source: CBS News
Posted: October 27, 2006

This news story is a feature that examines the scientific and ethical debate surrounding embryonic stem cell research.

Fat Stem Cells Being Studied As Option For Breast Reconstruction

Source: University of Pittsburgh Medical Center
Date: October 27, 2006

Summary:

Breast cancer survivors might one day avoid the prospect of invasive breast reconstruction surgery by using stem cells derived from their own fat according to University of Pittsburgh researchers who are studying the potential these cells may have for regenerating new breast tissue.

Wednesday, October 25, 2006

Older embryos can survive stem-cell extraction: Mouse study suggests stem-cell work could be made more efficient.

Source: Nature
Posted: 25 October 2006

Summary:

US researchers say they have improved the technique by which stem cells can be coaxed from an embryo without harming it. The technique has been used only on mouse embryos and is still being refined. But it might improve attempts to make embryonic stem (ES) cell lines without destroying human embryos.

Adult Stem Cells Help Weakened Hearts: Even patients who suffered an episode decades ago can benefit, researchers say.

Source: Los Angeles Times
Date: September 21, 2006

Summary:

Using stem cells harvested from patients' own bone marrow, researchers reported improved cardiac function in heart attack patients months, years — and even decades — after the attacks.

Commentary: Maybe this advancement will lead to new stem cell treatments for cariovascular disease in humans.

Tuesday, October 24, 2006

Stem Cell Treatment Proven to Reduce Parkinson's Symptoms

Source: Tiantan Puhua Neurosurgical Hospital
Posted: October 24, 2006 9:54 am ET

Summary:

Doctors at Tiantan Puhua Neurosurgical Hospital announced the first known successful stem cell therapy treatment in China, and one of the first in the world, of an American citizen inflicted with the debilitating Parkinson's disease. The new treatment introduces 'Human Retinal Pigment Epithelial cells' (hRPE) to patients' bodies causing them to naturally produce Dopamine, enhancing Dopamine levels in the brain. The doctors are hopeful this treatment could applied to other neurological conditions and other central nervous system disorders.

Commentary: It will be important for these results to be replicated in a large and diverse patient population over a long period of time to ensure that the results are valid and the treatment can truly be considered effective.

Stem cell treatments called 'well-tolerated': 18 cardiac patients had no major side effects, study says

Source: Bloomberg News
Posted: October 24, 2006

Summary:

Treatment with adult stem cells, which may have the potential to help millions of people battling severe coronary artery disease, is "well tolerated" by patients, an initial study found. Patients said they had less chest pain and more ability to exercise after the injection. The research expands on animal studies that have shown that injecting stem cells into the heart may regenerate or repair damaged tissue in the cardiac muscle However, researchers cautioned that the initial study wasn't sufficient to prove that the treatment works.

Commentary: Hopefully this treatment can be successfully replicated and eventually proven effective in treating coronary artery disease in humans.

Injecting Patient's Own Stem Cells Treat´s Severe Coronary Artery Disease

Source: Caritas St. Elizabeth's Medical Center
Posted: October 24, 2006

Summary:

Encouraging 12-month results from a Phase I trial investigating the injection of adult bone marrow stem cells into the hearts of patients with severe coronary artery disease will be presented for the first time. The therapy involves injecting patients with a protein that helps to release stem cells from the patient's bone marrow into the blood stream. The stem cells are gathered, selected and then injected into areas of the heart that have been damaged due to an insufficient supply of oxygen-rich blood. The data provide evidence that this therapy is well tolerated at this stage and that larger, Phase II clinical trials can continue in humans.

Commentary: Hopefully Phase II clinical trials to this new stem cell treatment will also be successful and become a widespread, standard treatment for patients with severe coronary artery disease.

Monday, October 23, 2006

Stem cells might cause brain tumors, study finds

Source: Reuters
Posted: Ocober 22, 2006

Summary:

Researchers at the University of Rochester Medical Center in New York reported that injecting human embryonic stem cells into the brains of Parkinson's disease patients may cause tumors to form. The researchers said human stem cells injected into rat brains turned into cells that looked like early tumors. The idea behind brain cell transplants is to replace the dead cells.

Commentary: Hopefully researchers will figure out how to eliminate the tumors that formed from this treatment and be able to eventually test it in humans with Parkinson's Disease and treat them successfully.