Source: The Hospital for Sick Children (SickKids)
Date: August 26, 2012
Summary:
New stem cell research paves the way towards individualized medicine for patients with cystic fibrosis and other lung diseases. The study, led by The Hospital for Sick Children (SickKids), is the first to successfully use stem cells to produce mature lung cells that could potentially be used to study the disease and test drugs. The study is published in the August 26 advance online edition of Nature Biotechnology.
Researchers were able to induce human embryonic stem cells to become mature lung cells, that contained a gene, called CFTR that when mutated is responsible for cystic fibrosis (CFTR gene was discovered at SickKids in 1989). They then took the experiment a step further, by using induced pluripotent stem cells derived from the skin of patients with cystic fibrosis. They prompted these stem cells to become lung cells, which contain mutations specific to the patients involved. (Induced pluripotent stem cells are adult cells genetically induced to function like embryonic stem cells.)
Once researchers found that they could create lung cells derived from individual patients they then used a compound that resembles an investigational drug that is currently being tested for cystic fibrosis to see if it would rescue the CFTR gene mutation.
The Winnipeg Free Press published a news story today on this development.
Showing posts with label lung. Show all posts
Showing posts with label lung. Show all posts
Sunday, August 26, 2012
Thursday, April 05, 2012
Big Advance Against Cystic Fibrosis: Stem Cell Researchers Create Lung Surface Tissue in a Dish
Source: Massachusetts General Hospital
Date: April 5, 2012
Summary:
Harvard stem cell researchers at Massachusetts General Hospital (MGH) have taken a critical step in making possible the discovery in the relatively near future of a drug to control cystic fibrosis (CF), a fatal lung disease that claims about 500 lives each year, with 1,000 new cases diagnosed annually.
Beginning with the skin cells of patients with CF, Jayaraj Rajagopal, MD, and colleagues first created induced pluripotent stem (iPS) cells, and then used those cells to create human disease-specific functioning lung epithelium, the tissue that lines the airways and is the site of the most lethal aspect of CF, where the genes cause irreversible lung disease and inexorable respiratory failure.
That tissue, which researchers now can grow in unlimited quantities in the laboratory, contains the delta-508 mutation, the gene responsible for about 70 percent of all CF cases and 90 percent of the ones in the United States. The tissue also contains the G551D mutation, a gene that is involved in about 2 percent of CF cases and the one cause of the disease for which there is now a drug.
The work is featured on the cover of this month's Cell Stem Cell journal. Postdoctoral fellow Hongmei Mou, PhD, is first author on the paper, and Rajagopal is the senior author.
Date: April 5, 2012
Summary:
Harvard stem cell researchers at Massachusetts General Hospital (MGH) have taken a critical step in making possible the discovery in the relatively near future of a drug to control cystic fibrosis (CF), a fatal lung disease that claims about 500 lives each year, with 1,000 new cases diagnosed annually.
Beginning with the skin cells of patients with CF, Jayaraj Rajagopal, MD, and colleagues first created induced pluripotent stem (iPS) cells, and then used those cells to create human disease-specific functioning lung epithelium, the tissue that lines the airways and is the site of the most lethal aspect of CF, where the genes cause irreversible lung disease and inexorable respiratory failure.
That tissue, which researchers now can grow in unlimited quantities in the laboratory, contains the delta-508 mutation, the gene responsible for about 70 percent of all CF cases and 90 percent of the ones in the United States. The tissue also contains the G551D mutation, a gene that is involved in about 2 percent of CF cases and the one cause of the disease for which there is now a drug.
The work is featured on the cover of this month's Cell Stem Cell journal. Postdoctoral fellow Hongmei Mou, PhD, is first author on the paper, and Rajagopal is the senior author.
Researchers Derive Purified Lung and Thyroid Progenitors from Embryonic Stem Cells
Source: Boston University Medical Center
Date: April 5, 2012
Summary:
Researchers at Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) have derived a population of pure lung and thyroid progenitor cells in vitro that successfully mimic the developmental milestones of lung and thyroid tissue formation. The research, which will be published in the April 6 edition of the journal Cell Stem Cell, identifies factors necessary for embryonic stem cells to differentiate into lung progenitor cells and provides key information about how the tissue engineering technology can be used to develop new gene and cell-based therapies to treat lung diseases.
Date: April 5, 2012
Summary:
Researchers at Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) have derived a population of pure lung and thyroid progenitor cells in vitro that successfully mimic the developmental milestones of lung and thyroid tissue formation. The research, which will be published in the April 6 edition of the journal Cell Stem Cell, identifies factors necessary for embryonic stem cells to differentiate into lung progenitor cells and provides key information about how the tissue engineering technology can be used to develop new gene and cell-based therapies to treat lung diseases.
Thursday, October 27, 2011
Lung Stem Cells Offer Therapeutic Clues
Source: Harvard Medical School
Date: October 27, 2011
Summary:
Guided by insights into how mice recover after H1N1 flu, researchers at Harvard Medical School and Brigham and Women's Hospital, together with researchers at A*STAR of Singapore, have cloned three distinct stem cells from the human airways and demonstrated that one of these cells can form into the lung's alveoli air sac tissue. What's more, the researchers showed that these same lung stem cells are rapidly deployed in a dynamic process of lung regeneration to combat damage from infection or chronic disease. The findings will be reported in the Oct. 28 issue of Cell.
Date: October 27, 2011
Summary:
Guided by insights into how mice recover after H1N1 flu, researchers at Harvard Medical School and Brigham and Women's Hospital, together with researchers at A*STAR of Singapore, have cloned three distinct stem cells from the human airways and demonstrated that one of these cells can form into the lung's alveoli air sac tissue. What's more, the researchers showed that these same lung stem cells are rapidly deployed in a dynamic process of lung regeneration to combat damage from infection or chronic disease. The findings will be reported in the Oct. 28 issue of Cell.
Monday, July 25, 2011
Cystic fibrosis-associated changes in lung stem cells may contribute to disease progression
Source: University of Iowa
Date: July 25, 2011
Summary:
Researchers at the University of Iowa's Roy J. and Lucille A. Carver College of Medicine have discovered that in cystic fibrosis (CF) patients, the airway glands are depleted of a specific population of airway stem cells that participate in airway repair following injury. Their results are published in the July 18 issue of Journal of Clinical Investigation.
Date: July 25, 2011
Summary:
Researchers at the University of Iowa's Roy J. and Lucille A. Carver College of Medicine have discovered that in cystic fibrosis (CF) patients, the airway glands are depleted of a specific population of airway stem cells that participate in airway repair following injury. Their results are published in the July 18 issue of Journal of Clinical Investigation.
Thursday, June 16, 2011
Signaling Pathway Is “Executive Software” of Airway Stem Cells
Source: Duke University
Date: June 16, 2011
Summary:
Researchers at Duke University Medical Center have found out how mouse basal cells that line airways “decide” to become one of two types of cells that assist in airway-clearing duties. The findings could help provide new therapies for either blocked or thinned airways.
“Our work has identified the Notch signaling pathway as a central regulatory ‘switch’ that controls the differentiation of airway basal stem cells,” said Jason Rock, PhD, lead author and postdoctoral researcher in Brigid Hogan's cell biology laboratory.
“Studies like ours will enhance efforts to develop effective genetic, cellular, and molecular therapies for airway diseases -- a leading cause of death worldwide.”
The work was published in Cell Stem Cell on June 3.
Together with the current findings, recent studies suggest that the Notch signaling pathway represents a potential therapeutic target for airway remodeling and lung disease, he said.
Date: June 16, 2011
Summary:
Researchers at Duke University Medical Center have found out how mouse basal cells that line airways “decide” to become one of two types of cells that assist in airway-clearing duties. The findings could help provide new therapies for either blocked or thinned airways.
“Our work has identified the Notch signaling pathway as a central regulatory ‘switch’ that controls the differentiation of airway basal stem cells,” said Jason Rock, PhD, lead author and postdoctoral researcher in Brigid Hogan's cell biology laboratory.
“Studies like ours will enhance efforts to develop effective genetic, cellular, and molecular therapies for airway diseases -- a leading cause of death worldwide.”
The work was published in Cell Stem Cell on June 3.
Together with the current findings, recent studies suggest that the Notch signaling pathway represents a potential therapeutic target for airway remodeling and lung disease, he said.
Wednesday, May 11, 2011
Human Lung Stem Cell Discovered
Source: Brigham and Women's Hospital
Date: May 11, 2011
Summary:
For the first time, researchers at Brigham and Women's Hospital (BWH) have identified a human lung stem cell that is self-renewing and capable of forming and integrating multiple biological structures of the lung including bronchioles, alveoli and pulmonary vessels. This research is published in the May 12, 2011 issue of the New England Journal of Medicine.
Using lung tissue from surgical samples, researchers identified and isolated the human lung stem cell and tested the functionality of the stem cell both in vitro and in vivo. Once the stem cell was isolated, researchers demonstrated in vitro that the cell was capable of dividing both into new stem cells and also into cells that would grow into various types of lung tissue. Next, researchers injected the stem cell into mice with damaged lungs. The injected stem cells differentiated into new bronchioles, alveoli and pulmonary vessel cells which not only formed new lung tissue, but also integrated structurally to the existing lung tissue in the mice.
Date: May 11, 2011
Summary:
For the first time, researchers at Brigham and Women's Hospital (BWH) have identified a human lung stem cell that is self-renewing and capable of forming and integrating multiple biological structures of the lung including bronchioles, alveoli and pulmonary vessels. This research is published in the May 12, 2011 issue of the New England Journal of Medicine.
Using lung tissue from surgical samples, researchers identified and isolated the human lung stem cell and tested the functionality of the stem cell both in vitro and in vivo. Once the stem cell was isolated, researchers demonstrated in vitro that the cell was capable of dividing both into new stem cells and also into cells that would grow into various types of lung tissue. Next, researchers injected the stem cell into mice with damaged lungs. The injected stem cells differentiated into new bronchioles, alveoli and pulmonary vessel cells which not only formed new lung tissue, but also integrated structurally to the existing lung tissue in the mice.
Human Lung Stem Cell Discovered: Crucial Role in Tissue Regeneration
Source: Brigham and Women's Hospital
Date: May 11, 2011
Summary:
For the first time, researchers at Brigham and Women's Hospital (BWH) have identified a human lung stem cell that is self-renewing and capable of forming and integrating multiple biological structures of the lung including bronchioles, alveoli and pulmonary vessels. This research is published in the May 12, 2011 issue of the New England Journal of Medicine.
Using lung tissue from surgical samples, researchers identified and isolated the human lung stem cell and tested the functionality of the stem cell both in vitro and in vivo. Once the stem cell was isolated, researchers demonstrated in vitro that the cell was capable of dividing both into new stem cells and also into cells that would grow into various types of lung tissue. Next, researchers injected the stem cell into mice with damaged lungs. The injected stem cells differentiated into new bronchioles, alveoli and pulmonary vessel cells which not only formed new lung tissue, but also integrated structurally to the existing lung tissue in the mice.
Date: May 11, 2011
Summary:
For the first time, researchers at Brigham and Women's Hospital (BWH) have identified a human lung stem cell that is self-renewing and capable of forming and integrating multiple biological structures of the lung including bronchioles, alveoli and pulmonary vessels. This research is published in the May 12, 2011 issue of the New England Journal of Medicine.
Using lung tissue from surgical samples, researchers identified and isolated the human lung stem cell and tested the functionality of the stem cell both in vitro and in vivo. Once the stem cell was isolated, researchers demonstrated in vitro that the cell was capable of dividing both into new stem cells and also into cells that would grow into various types of lung tissue. Next, researchers injected the stem cell into mice with damaged lungs. The injected stem cells differentiated into new bronchioles, alveoli and pulmonary vessel cells which not only formed new lung tissue, but also integrated structurally to the existing lung tissue in the mice.
Tuesday, March 29, 2011
Enzyme Essential for Healthy Lung Development Discovered
Source: Children's Hospital Los Angeles
Date: March 29, 2011
Summary:
LOS ANGELES – Investigators at The Saban Research Institute of Children’s Hospital Los Angeles have provided the first evidence that Eya1 protein phosphatase is a crucial regulator of the development of embryonic lung epithelial stem cells.
The correct functioning of lung epithelium is essential to life. Cellular polarity of lung epithelial cells, meaning that they have an asymmetrical orientation or a front and back, is crucial. Dysregulation of cell polarity has been associated with developmental disorders as well as cancer. Until now, little has been known about the mechanism that controls cell polarity, cell fate and self-renewal of embryonic lung epithelial stem cells. David Warburton, MD, director of Developmental Biology and Regenerative Medicine at The Saban Research Institute, and Ahmed El-Hashash, PhD, senior research scientist carrying out this study, will release their findings in the upcoming issue of Development.
Date: March 29, 2011
Summary:
LOS ANGELES – Investigators at The Saban Research Institute of Children’s Hospital Los Angeles have provided the first evidence that Eya1 protein phosphatase is a crucial regulator of the development of embryonic lung epithelial stem cells.
The correct functioning of lung epithelium is essential to life. Cellular polarity of lung epithelial cells, meaning that they have an asymmetrical orientation or a front and back, is crucial. Dysregulation of cell polarity has been associated with developmental disorders as well as cancer. Until now, little has been known about the mechanism that controls cell polarity, cell fate and self-renewal of embryonic lung epithelial stem cells. David Warburton, MD, director of Developmental Biology and Regenerative Medicine at The Saban Research Institute, and Ahmed El-Hashash, PhD, senior research scientist carrying out this study, will release their findings in the upcoming issue of Development.
Thursday, October 28, 2010
Human Induced Pluripotent Stem Cells Generated to Further Treatments for Lung Disease
Source: Boston University
Date: October 28, 2010
Summary:
(Boston) A team of researchers from Boston University’s Center for Regenerative Medicine and the Pulmonary Center have generated 100 new lines of human induced pluripotent stem cells (iPSC) from individuals with lung diseases, including cystic fibrosis and emphysema. The new stem cell lines could possibly lead to new treatments for these debilitating diseases. The findings, which appear in the current issue of Stem Cells, demonstrate the first time lung disease-specific iPSC have been created in a lab.
iPSCs are derived by reprogramming adult cells into a primitive stem cell state. This process results in the creation of cells that are similar to embryonic stem cells in terms of their capability to differentiate into different types of cells, including endoderm cells that can give rise to liver and lung tissue.
The study involved patients with different forms of lung disease – cystic fibrosis, alpha-1 antitrypsin deficiency-related emphysema, scleroderma (SSc) and sickle cell disease. The patients underwent skin biopsies and donated tissue samples, which the research team used to cultivate adult stem cells. Using a Boston University-patented vector in the form of a virus, named the Stem Cell Cassette (STEMCCA), the researchers were able to reprogram the skin cells into the primitive pluripotent stem cells known as iPSCs.
Date: October 28, 2010
Summary:
(Boston) A team of researchers from Boston University’s Center for Regenerative Medicine and the Pulmonary Center have generated 100 new lines of human induced pluripotent stem cells (iPSC) from individuals with lung diseases, including cystic fibrosis and emphysema. The new stem cell lines could possibly lead to new treatments for these debilitating diseases. The findings, which appear in the current issue of Stem Cells, demonstrate the first time lung disease-specific iPSC have been created in a lab.
iPSCs are derived by reprogramming adult cells into a primitive stem cell state. This process results in the creation of cells that are similar to embryonic stem cells in terms of their capability to differentiate into different types of cells, including endoderm cells that can give rise to liver and lung tissue.
The study involved patients with different forms of lung disease – cystic fibrosis, alpha-1 antitrypsin deficiency-related emphysema, scleroderma (SSc) and sickle cell disease. The patients underwent skin biopsies and donated tissue samples, which the research team used to cultivate adult stem cells. Using a Boston University-patented vector in the form of a virus, named the Stem Cell Cassette (STEMCCA), the researchers were able to reprogram the skin cells into the primitive pluripotent stem cells known as iPSCs.
Thursday, August 19, 2010
Natural Lung Material Is Promising Scaffold for Engineering Lung Tissue Using Embryonic Stem Cells
Source: Mary Ann Liebert, Inc.
Date: August 19, 2010
Summary:
The first successful report of using cell-depleted lung as a natural growth matrix for generating new rat lung from embryonic stem cells is presented in a breakthrough article in Tissue Engineering, Part A, a peer-reviewed journal published by Mary Ann Liebert, Inc. Researchers describe the first attempt to make acellular rat lung and use it as a biological matrix for differentiating ESCs into lung tissue. The authors present evidence of improved cell retention, repopulation of the matrix, and differentiation into the cell types present in healthy lung. They also report signs that the cells are organizing into the 3-D structures characteristic of complex tissues and are producing the chemical signals and growth factors that guide lung tissue function and development.
Date: August 19, 2010
Summary:
The first successful report of using cell-depleted lung as a natural growth matrix for generating new rat lung from embryonic stem cells is presented in a breakthrough article in Tissue Engineering, Part A, a peer-reviewed journal published by Mary Ann Liebert, Inc. Researchers describe the first attempt to make acellular rat lung and use it as a biological matrix for differentiating ESCs into lung tissue. The authors present evidence of improved cell retention, repopulation of the matrix, and differentiation into the cell types present in healthy lung. They also report signs that the cells are organizing into the 3-D structures characteristic of complex tissues and are producing the chemical signals and growth factors that guide lung tissue function and development.
Tuesday, August 17, 2010
Adult lung stem cells, vital to injury repair, associated with poor cancer prognosis
Source: University of California - Los Angeles
Date: August 17, 2010
Summary:
Adult stem cells that are vital for airway repair in the lung but that persist in areas where pre-cancerous lesions are found are associated with a poor prognosis in patients who develop cancer, even those with early-stage disease, researchers at UCLA's Jonsson Comprehensive Cancer Center have found.
These adult stem cells are found in areas repairing after injury and also are found in pre-cancerous areas, suggesting that they may mutate and become cancer-causing stem cells, making them a potential cell of origin for lung cancer and a possible target for prevention strategies and new targeted therapies.
The study found that when these adult stem cells are found in excised tumors, they are associated with a poor prognosis, and they could be used as markers to dictate the need for more aggressive treatment, said Jonsson Cancer Center researcher Brigitte Gomperts, an assistant professor of hematology–oncology and co-senior author of the study. The presence of the adult stem cells in the tumors also was found to be associated with a higher likelihood that the cancer had spread to other organs.
The study appeared Aug. 15 in the peer-reviewed journal Cancer Research.
Date: August 17, 2010
Summary:
Adult stem cells that are vital for airway repair in the lung but that persist in areas where pre-cancerous lesions are found are associated with a poor prognosis in patients who develop cancer, even those with early-stage disease, researchers at UCLA's Jonsson Comprehensive Cancer Center have found.
These adult stem cells are found in areas repairing after injury and also are found in pre-cancerous areas, suggesting that they may mutate and become cancer-causing stem cells, making them a potential cell of origin for lung cancer and a possible target for prevention strategies and new targeted therapies.
The study found that when these adult stem cells are found in excised tumors, they are associated with a poor prognosis, and they could be used as markers to dictate the need for more aggressive treatment, said Jonsson Cancer Center researcher Brigitte Gomperts, an assistant professor of hematology–oncology and co-senior author of the study. The presence of the adult stem cells in the tumors also was found to be associated with a higher likelihood that the cancer had spread to other organs.
The study appeared Aug. 15 in the peer-reviewed journal Cancer Research.
Friday, June 25, 2010
Researchers create breathing lungs in lab
Source: University of Minnesota
Date: June 25, 2010
Summary:
Scientists with the University of Minnesota’s Masonic Cancer Center and Medical School have achieved another research first – creating breathing lungs in the laboratory. This innovation comes two years after another group of University of Minnesota researchers used a similar technique to create a beating heart in the laboratory. Lead scientist Angela Panoskaltsis-Mortari, Ph.D., and assistant scientist Andrew Price used a process called whole organ decellularization to remove cells from the lungs of dead adult mice and implant healthy stem cells derived from unborn mice into the decellularized matrix, the natural framework of the lungs. After about seven days in an incubator, the infused cells attached themselves to the matrix while breathing with the aid of a tiny, make-shift ventilator. The scientists’ work is in the online version of the journal Tissue Engineering (hard copy to be released August 6, 2010).
Date: June 25, 2010
Summary:
Scientists with the University of Minnesota’s Masonic Cancer Center and Medical School have achieved another research first – creating breathing lungs in the laboratory. This innovation comes two years after another group of University of Minnesota researchers used a similar technique to create a beating heart in the laboratory. Lead scientist Angela Panoskaltsis-Mortari, Ph.D., and assistant scientist Andrew Price used a process called whole organ decellularization to remove cells from the lungs of dead adult mice and implant healthy stem cells derived from unborn mice into the decellularized matrix, the natural framework of the lungs. After about seven days in an incubator, the infused cells attached themselves to the matrix while breathing with the aid of a tiny, make-shift ventilator. The scientists’ work is in the online version of the journal Tissue Engineering (hard copy to be released August 6, 2010).
Thursday, June 24, 2010
Scientists Implant Regenerated Lung Tissue in Rats
Source: Yale University
Date: June 24, 2010
Summary:
A Yale University-led team of scientists reports that it has achieved an important first step in regenerating fully functional lung tissue that can exchange gas, which is the key role of the lungs. Their paper appears in the June 24 issue of Science Express.
The Yale team's goal was to see if it was possible to successfully implant tissue-engineered lungs, cultured in vitro, that could serve the lung's primary function of exchanging oxygen and carbon dioxide. They took adult rat lungs and first removed their existing cellular components, preserving the extracellular matrix and hierarchical branching structures of the airways and vascular system to use later as scaffolds for the growth of new lung cells.
They then cultured a combination of lung-specific cells on the extracellular matrix, using a novel bioreactor designed to mimic some aspects of the fetal lung environment. Under the fetal-like conditions of the bioreactor, the cells repopulated the decellularized matrix with functional lung cells. When implanted into rats for short intervals of time (45-120 minutes), the engineered lungs exchanged oxygen and carbon dioxide similarly to natural lungs.
The team found that the mechanical characteristics of the engineered lungs were similar to those of native tissues and, when implanted, were capable of participating in gas exchange.
Date: June 24, 2010
Summary:
A Yale University-led team of scientists reports that it has achieved an important first step in regenerating fully functional lung tissue that can exchange gas, which is the key role of the lungs. Their paper appears in the June 24 issue of Science Express.
The Yale team's goal was to see if it was possible to successfully implant tissue-engineered lungs, cultured in vitro, that could serve the lung's primary function of exchanging oxygen and carbon dioxide. They took adult rat lungs and first removed their existing cellular components, preserving the extracellular matrix and hierarchical branching structures of the airways and vascular system to use later as scaffolds for the growth of new lung cells.
They then cultured a combination of lung-specific cells on the extracellular matrix, using a novel bioreactor designed to mimic some aspects of the fetal lung environment. Under the fetal-like conditions of the bioreactor, the cells repopulated the decellularized matrix with functional lung cells. When implanted into rats for short intervals of time (45-120 minutes), the engineered lungs exchanged oxygen and carbon dioxide similarly to natural lungs.
The team found that the mechanical characteristics of the engineered lungs were similar to those of native tissues and, when implanted, were capable of participating in gas exchange.
Scientists grow new lungs using 'skeletons' of old ones
Source: University of Texas Medical Branch at Galveston
Date: June 24, 2010
Summary:
Tissue engineers' progress toward growing new lungs for transplantation or research has long been frustrated by the problem of coaxing stem cells to develop into the varied cell types that populate different locations in the lung Now, researchers from the University of Texas Medical Branch at Galveston have demonstrated a potentially revolutionary solution to this problem. As they describe in an article published electronically ahead of print by the journal Tissue Engineering Part A, they seeded mouse embryonic stem cells into "acellular" rat lungs — organs whose original cells had been destroyed by repeated cycles of freezing and thawing and exposure to detergent. The result: empty lung-shaped scaffolds of structural proteins on which the mouse stem cells thrived and differentiated into new cells appropriate to their specific locations.
Date: June 24, 2010
Summary:
Tissue engineers' progress toward growing new lungs for transplantation or research has long been frustrated by the problem of coaxing stem cells to develop into the varied cell types that populate different locations in the lung Now, researchers from the University of Texas Medical Branch at Galveston have demonstrated a potentially revolutionary solution to this problem. As they describe in an article published electronically ahead of print by the journal Tissue Engineering Part A, they seeded mouse embryonic stem cells into "acellular" rat lungs — organs whose original cells had been destroyed by repeated cycles of freezing and thawing and exposure to detergent. The result: empty lung-shaped scaffolds of structural proteins on which the mouse stem cells thrived and differentiated into new cells appropriate to their specific locations.
Friday, March 19, 2010
Surgeons perform revolutionary transplant operation
Source: University College London
Date: 19 March 2010
Summary:
University College London scientists and surgeons have led a revolutionary operation to transplant a new trachea into a child and use the child's own stem cells to rebuild the airway in the body. The operation - a world first - involved laboratory-based scientists and hospital-based clinicians working in partnership with colleagues in Europe to treat a 10-year-old British boy.
Date: 19 March 2010
Summary:
University College London scientists and surgeons have led a revolutionary operation to transplant a new trachea into a child and use the child's own stem cells to rebuild the airway in the body. The operation - a world first - involved laboratory-based scientists and hospital-based clinicians working in partnership with colleagues in Europe to treat a 10-year-old British boy.
Monday, January 25, 2010
Experimental Stem Cell Treatment Arrests Acute Lung Injury in Mice, Study Shows
Source: University of Texas Health Science Center at Houston
Date: January 25, 2010
Summary:
HOUSTON -- Stem cell researchers exploring a new approach for the care of respiratory diseases report that an experimental treatment involving transplantable lung cells was associated with improved outcomes in tests on mice with acute lung injury. The lung cells were derived from human embryonic stem cells (hESCs). Findings by investigators at The University of Texas Health Science Center at Houston are scheduled to appear in the March issue of Molecular Therapy.
Date: January 25, 2010
Summary:
HOUSTON -- Stem cell researchers exploring a new approach for the care of respiratory diseases report that an experimental treatment involving transplantable lung cells was associated with improved outcomes in tests on mice with acute lung injury. The lung cells were derived from human embryonic stem cells (hESCs). Findings by investigators at The University of Texas Health Science Center at Houston are scheduled to appear in the March issue of Molecular Therapy.
Tuesday, December 01, 2009
Bone Marrow Stem Cells May Prevent Chronic Lung Disease
Source: Children's Hospital Boston
Date: December 1, 2009
Summary:
Researchers at Children's Hospital Boston have discovered a possible way to protect the fragile lungs of premature babies by using stem cells harvested from bone marrow. In experiments on laboratory mice, they found that bone marrow stromal cells (BMSCs), a type of stem cell with the potential to form lung cells, were able to reduce inflammation in lung tissue. Inflammation is the key factor that leads to chronic lung disease in premature babies. Surprisingly, even the fluid in which the cells were grown was able to protect the lungs - in fact, better than the stem cells themselves. Findings were published in the December 1 issue of American Journal of Respiratory and Critical Care Medicine.
Date: December 1, 2009
Summary:
Researchers at Children's Hospital Boston have discovered a possible way to protect the fragile lungs of premature babies by using stem cells harvested from bone marrow. In experiments on laboratory mice, they found that bone marrow stromal cells (BMSCs), a type of stem cell with the potential to form lung cells, were able to reduce inflammation in lung tissue. Inflammation is the key factor that leads to chronic lung disease in premature babies. Surprisingly, even the fluid in which the cells were grown was able to protect the lungs - in fact, better than the stem cells themselves. Findings were published in the December 1 issue of American Journal of Respiratory and Critical Care Medicine.
Wednesday, November 04, 2009
Lung tissue generated from human embryonic stem cells
Source: BioMed Central
November 4, 2009
Summary:
Scientists in Belgium have successfully differentiated human embryonic stem cells (hESC) into major cell types of lung epithelial tissue using a convenient air-liquid interface. The technique, published in BioMed Central's open access journal Respiratory Research, could provide an alternative to lung transplants for patients with lung injury due to chronic pulmonary disease and inherited genetic diseases such as cystic fibrosis.
November 4, 2009
Summary:
Scientists in Belgium have successfully differentiated human embryonic stem cells (hESC) into major cell types of lung epithelial tissue using a convenient air-liquid interface. The technique, published in BioMed Central's open access journal Respiratory Research, could provide an alternative to lung transplants for patients with lung injury due to chronic pulmonary disease and inherited genetic diseases such as cystic fibrosis.
Wednesday, October 28, 2009
Stem Cell Therapy May Offer Hope for Acute Lung Injury
Source: University of Illinois at Chicago
Date: October 28, 2009
Summary:
Researchers at the University of Illinois at Chicago College of Medicine have shown that adult stem cells from bone marrow can prevent acute lung injury in a mouse model of the disease. Their results are reported online in the October issue of the journal Stem Cells.
Date: October 28, 2009
Summary:
Researchers at the University of Illinois at Chicago College of Medicine have shown that adult stem cells from bone marrow can prevent acute lung injury in a mouse model of the disease. Their results are reported online in the October issue of the journal Stem Cells.
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