Source: University of Illinois at Chicago
Date: September 29, 2010
Summary:
A new approach to anchor teeth back in the jaw using stem cells has been developed and successfully tested in the laboratory for the first time by researchers at the University of Illinois at Chicago. The new strategy represents a potential major advance in the battle against gum disease, a serious infection that eventually leads to tooth loss. About 80 percent of U.S. adults suffer from gum disease, according to the National Institute of Dental and Craniofacial Research.
Researchers in UIC's Brodie Laboratory for Craniofacial Genetics used stem cells obtained from the periodontal ligament of molars extracted from mice, expanded them in an incubator, and then seeded them on barren rat molars. The stem cell-treated molars were reinserted into the tooth sockets of rats. After two and four months, the stem cells aligned and formed new fibrous attachments between the tooth and bone, firmly attaching the replanted tooth into the animal's mouth, said Smit Dangaria, a bioengineering doctoral candidate who conducted the research. Tissue sections showed that the replanted tooth was surrounded by newly formed, functional periodontal ligament fibers and new cementum, the essential ingredients of a healthy tooth attachment.
In contrast, tooth molars that were replanted without new stem/progenitor cells were either lost or loosely attached and were resorbed, Dangaria said. The study, published in an online issue of the journal Tissue Engineering, was funded through a grant by the National Institutes of Health.
Showing posts with label teeth. Show all posts
Showing posts with label teeth. Show all posts
Wednesday, September 29, 2010
Wednesday, May 19, 2010
Body’s Own Stem Cells Can Lead to Tooth Regeneration
Source: Columbia University Medical Center
Date: May 19, 2010
Summary:
NEW YORK - A technique pioneered in the Tissue Engineering and Regenerative Medicine Laboratory of Dr. Jeremy Mao, the Edward V. Zegarelli Professor of Dental Medicine at Columbia University Medical Center, can orchestrate stem cells to migrate to a three-dimensional scaffold infused with growth factor, holding the translational potential to yield an anatomically correct tooth in as soon as nine weeks once implanted.
An animal-model study has shown that by homing stem cells to a scaffold made of natural materials and integrated in surrounding tissue, there is no need to use harvested stem cell lines, or create an environment outside of the body (e.g., a Petri dish) where the tooth is grown and then implanted once it has matured. The tooth instead can be grown “orthotopically,” or in the socket where the tooth will integrate with surrounding tissue in ways that are impossible with hard metals or other materials.
This study is published in the most recent Journal of Dental Research, the top-rated, peer-reviewed scientific journal dedicated to the dissemination of new knowledge and information on all sciences relevant to dentistry, the oral cavity and associated structures in health and disease.
Date: May 19, 2010
Summary:
NEW YORK - A technique pioneered in the Tissue Engineering and Regenerative Medicine Laboratory of Dr. Jeremy Mao, the Edward V. Zegarelli Professor of Dental Medicine at Columbia University Medical Center, can orchestrate stem cells to migrate to a three-dimensional scaffold infused with growth factor, holding the translational potential to yield an anatomically correct tooth in as soon as nine weeks once implanted.
An animal-model study has shown that by homing stem cells to a scaffold made of natural materials and integrated in surrounding tissue, there is no need to use harvested stem cell lines, or create an environment outside of the body (e.g., a Petri dish) where the tooth is grown and then implanted once it has matured. The tooth instead can be grown “orthotopically,” or in the socket where the tooth will integrate with surrounding tissue in ways that are impossible with hard metals or other materials.
This study is published in the most recent Journal of Dental Research, the top-rated, peer-reviewed scientific journal dedicated to the dissemination of new knowledge and information on all sciences relevant to dentistry, the oral cavity and associated structures in health and disease.
Tuesday, November 11, 2008
Researchers find stem cells from monkey teeth can stimulate growth and generation of brain cells
Source: Emory University
Date: November 11, 2008
Summary:
Researchers at the Yerkes National Primate Research Center, Emory University, have discovered dental pulp stem cells can stimulate growth and generation of several types of neural cells. Findings from this study, available in the October issue of the journal Stem Cells, suggest dental pulp stem cells show promise for use in cell therapy and regenerative medicine, particularly therapies associated with the central nervous system.
Date: November 11, 2008
Summary:
Researchers at the Yerkes National Primate Research Center, Emory University, have discovered dental pulp stem cells can stimulate growth and generation of several types of neural cells. Findings from this study, available in the October issue of the journal Stem Cells, suggest dental pulp stem cells show promise for use in cell therapy and regenerative medicine, particularly therapies associated with the central nervous system.
Monday, June 11, 2007
Making new teeth
Source: Public Library of Science
Date: June 11, 2007
Summary:
Although mammals have a limited capacity to regenerate teeth, mouse incisors contain stem cells and grow continuously throughout life. Using a combination of mouse mutant analyses, organ culture experiments, and gene expression studies, Xiu-Ping Wang and colleagues identify the key signaling molecules that regulate epithelial stem cell proliferation in the stem cell niche. Their work is published online this week in the open-access journal PLoS Biology.
Date: June 11, 2007
Summary:
Although mammals have a limited capacity to regenerate teeth, mouse incisors contain stem cells and grow continuously throughout life. Using a combination of mouse mutant analyses, organ culture experiments, and gene expression studies, Xiu-Ping Wang and colleagues identify the key signaling molecules that regulate epithelial stem cell proliferation in the stem cell niche. Their work is published online this week in the open-access journal PLoS Biology.
Wednesday, March 28, 2007
Dental Enamel Re-Grown From Cultured Cells
Source: International & American Association for Dental Research
Posted: March 27, 2007 - 23:00 PDT
Summary:
A team of researchers from the Institute of Medical Science, the University of Tokyo (Japan), have discovered a new technique for culturing cells that have the capacity to produce enamel. This group has recently shown that epithelial cells extracted from the developing teeth of 6-month-old pigs continue to proliferate when they are cultured on top of a special feeder layer of cells. This crucial step boosts the number of dental epithelial cells available for enamel production.
Posted: March 27, 2007 - 23:00 PDT
Summary:
A team of researchers from the Institute of Medical Science, the University of Tokyo (Japan), have discovered a new technique for culturing cells that have the capacity to produce enamel. This group has recently shown that epithelial cells extracted from the developing teeth of 6-month-old pigs continue to proliferate when they are cultured on top of a special feeder layer of cells. This crucial step boosts the number of dental epithelial cells available for enamel production.
Thursday, February 22, 2007
Regrowing Teeth
Source: Technology Review
Date: February 22, 2007
Summary:
Japanese researchers recently reported in Nature Methods they had successfully regrown a tooth from cells extracted from mouse embryos. The researchers were able to transplant the tooth into an adult mouse, and the tooth bud continued to grow to full size. However, researchers caution in that it is unclear whether the technique will be effective for re-growing teeth in humans, as the embryonic stem cells used by the researchers are difficult to obtain in large amounts and could be rejected as a foreign substance by a patient's immune system when they are transplanted in to the patient.
Date: February 22, 2007
Summary:
Japanese researchers recently reported in Nature Methods they had successfully regrown a tooth from cells extracted from mouse embryos. The researchers were able to transplant the tooth into an adult mouse, and the tooth bud continued to grow to full size. However, researchers caution in that it is unclear whether the technique will be effective for re-growing teeth in humans, as the embryonic stem cells used by the researchers are difficult to obtain in large amounts and could be rejected as a foreign substance by a patient's immune system when they are transplanted in to the patient.
Sunday, February 18, 2007
Japanese scientists grow teeth from single cells
Source: Reuters
Posted: February 18, 2007 9:10PM EST
Summary:
Japanese researchers reported they had grown normal-looking teeth from single cells in lab dishes, and transplanted them into mice. After growing them, they found their structures had developed into compounds that make teeth, including dentin, enamel, dental pulp, blood vessels, and periodontal ligaments.
Posted: February 18, 2007 9:10PM EST
Summary:
Japanese researchers reported they had grown normal-looking teeth from single cells in lab dishes, and transplanted them into mice. After growing them, they found their structures had developed into compounds that make teeth, including dentin, enamel, dental pulp, blood vessels, and periodontal ligaments.
Bioengineering helps toothless mice smile again
Source: Agence France Presse
Posted: February 18, 2007 2:08 PM ET
Summary:
In a world first, Japanese researchers reported Sunday they had successfully replaced natural teeth in mice with teeth that were created in a lab dish from single blood and skin cells.
Posted: February 18, 2007 2:08 PM ET
Summary:
In a world first, Japanese researchers reported Sunday they had successfully replaced natural teeth in mice with teeth that were created in a lab dish from single blood and skin cells.
Monday, April 04, 2005
Growing Your Own Replacement Teeth? Not Science Fiction!
Source: International & American Association For Dental Research
Posted: April 4, 2005
Summary:
Researchers from the Forsyth Institute (Boston, MA) and the University of Texas Health Science Center at San Antonio will describe successful experiments in bioengineering mineralized tissues, including periodontal tissues and replacement tooth phenotypes. This research is supported by the National Institute of Dental and Craniofacial Research, one of the National Institutes of Health (Bethesda, MD).
Posted: April 4, 2005
Summary:
Researchers from the Forsyth Institute (Boston, MA) and the University of Texas Health Science Center at San Antonio will describe successful experiments in bioengineering mineralized tissues, including periodontal tissues and replacement tooth phenotypes. This research is supported by the National Institute of Dental and Craniofacial Research, one of the National Institutes of Health (Bethesda, MD).
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