Source: University of Texas Southwestern Medical Center
Date: August 1, 2012
Summary:
A study by UT Southwestern Medical Center researchers published August 1 in Nature reveals new insight into why the most common, deadly kind of brain tumor in adults recurs and identifies a potential target for future therapies.
Glioblastoma multiforme (GBM) currently is considered incurable. Despite responding to initial therapy, the cancer almost always returns. GBM is a fast-growing, malignant brain tumor that occurred in 15 percent of the estimated 22,000 Americans diagnosed with brain and nervous system tumors in 2010. The median survival rate is about 15 months, according to the National Cancer Institute. Using a genetically engineered mouse model of GBM, the researchers found that the resting tumor cells act more like stem cells -- the non-cancerous cells the body uses to repair and replenish itself,
Showing posts with label tumor. Show all posts
Showing posts with label tumor. Show all posts
Wednesday, August 01, 2012
Monday, April 25, 2011
Scientists create stable, self-renewing neural stem cells
Source: University of California - San Diego
Date: April 25, 2011
Summary:
In a paper published in the April 25 early online edition of the Proceedings of the National Academy of Sciences, researchers at the University of California, San Diego School of Medicine, the Gladstone Institutes in San Francisco and colleagues report a game-changing advance in stem cell science: the creation of long-term, self-renewing, primitive neural precursor cells from human embryonic stem cells (hESCs) that can be directed to become many types of neuron without increased risk of tumor formation.
Date: April 25, 2011
Summary:
In a paper published in the April 25 early online edition of the Proceedings of the National Academy of Sciences, researchers at the University of California, San Diego School of Medicine, the Gladstone Institutes in San Francisco and colleagues report a game-changing advance in stem cell science: the creation of long-term, self-renewing, primitive neural precursor cells from human embryonic stem cells (hESCs) that can be directed to become many types of neuron without increased risk of tumor formation.
Thursday, March 10, 2011
Cerebral Spinal Fluid Guides Stem Cell Development in the Brain
Source: Howard Hughes Medical Institute
Date: March 10, 2011
Summary:
Cerebrospinal fluid—the clear and watery substance that bathes the brain and spinal cord—is much more important to brain development than previously realized. Howard Hughes Medical Institute investigator Christopher Walsh, his postdoctoral fellow Maria Lehtinen, former student Mauro Zappaterra, and their colleagues have discovered that cerebrospinal fluid (CSF) contains a complex mix of proteins that changes dramatically with age. In the lab, CSF by itself is enough to support the growth of neural stem cells, and this effect is particularly robust in young brains.
What's more, the protein make-up of CSF in people with malignant brain cancer is different from that of healthy people, the researchers found. "This suggests that the CSF can make a more supportive or less supportive environment for tumor growth," notes Walsh, Chief of Genetics at Children's Hospital Boston. The work is published in the March 10, 2011, issue of the journal Neuron.
Date: March 10, 2011
Summary:
Cerebrospinal fluid—the clear and watery substance that bathes the brain and spinal cord—is much more important to brain development than previously realized. Howard Hughes Medical Institute investigator Christopher Walsh, his postdoctoral fellow Maria Lehtinen, former student Mauro Zappaterra, and their colleagues have discovered that cerebrospinal fluid (CSF) contains a complex mix of proteins that changes dramatically with age. In the lab, CSF by itself is enough to support the growth of neural stem cells, and this effect is particularly robust in young brains.
What's more, the protein make-up of CSF in people with malignant brain cancer is different from that of healthy people, the researchers found. "This suggests that the CSF can make a more supportive or less supportive environment for tumor growth," notes Walsh, Chief of Genetics at Children's Hospital Boston. The work is published in the March 10, 2011, issue of the journal Neuron.
Monday, February 28, 2011
Discoveries offer first new hope in three decades for lethal pediatric brain tumor
Source: Stanford University Medical Center
Date: February 28, 2011
Summary:
A pediatric brain tumor that causes gruesome suffering is finally yielding its secrets. For the first time, scientists at the Stanford University School of Medicine have cultured human cells from this cancer, Diffuse Intrinsic Pontine Glioma, and used those cells to create an animal model of the disease. Their discoveries will facilitate research on new treatments for DIPG, a tumor of school-aged children that is now almost universally fatal. The study is published online Feb. 28 in the Proceedings of the National Academy of Sciences.
Date: February 28, 2011
Summary:
A pediatric brain tumor that causes gruesome suffering is finally yielding its secrets. For the first time, scientists at the Stanford University School of Medicine have cultured human cells from this cancer, Diffuse Intrinsic Pontine Glioma, and used those cells to create an animal model of the disease. Their discoveries will facilitate research on new treatments for DIPG, a tumor of school-aged children that is now almost universally fatal. The study is published online Feb. 28 in the Proceedings of the National Academy of Sciences.
Friday, January 07, 2011
Researchers pinpoint origin of deadly brain tumor
Source: University of Rochester Medical Center
Date: January 7, 2011
Summary:
Scientists at University of Rochester Medical Center have identified the type of cell that is at the origin of brain tumors known as oligodendrogliomas, which are a type of glioma – a category that defines the most common type of malignant brain tumor. In a paper published in the December 2010 issue of the journal Cancer Cell, investigators found that the tumor originates in and spreads through cells known as glial progenitor cells – cells that are often referred to as "daughter" cells of stem cells. The work comes at a time when many researchers are actively investigating the role that stem cells which have gone awry play in causing cancer. For scientists trying to create new ways to treat brain tumors, knowing whether stem cells or progenitor cells are part of the process is crucial.
In a paper published in the December 2010 issue of the journal Cancer Cell, investigators found that the tumor originates in and spreads through cells known as glial progenitor cells – cells that are often referred to as "daughter" cells of stem cells. The work comes at a time when many researchers are actively investigating the role that stem cells which have gone awry play in causing cancer. For scientists trying to create new ways to treat brain tumors, knowing whether stem cells or progenitor cells are part of the process is crucial.
Date: January 7, 2011
Summary:
Scientists at University of Rochester Medical Center have identified the type of cell that is at the origin of brain tumors known as oligodendrogliomas, which are a type of glioma – a category that defines the most common type of malignant brain tumor. In a paper published in the December 2010 issue of the journal Cancer Cell, investigators found that the tumor originates in and spreads through cells known as glial progenitor cells – cells that are often referred to as "daughter" cells of stem cells. The work comes at a time when many researchers are actively investigating the role that stem cells which have gone awry play in causing cancer. For scientists trying to create new ways to treat brain tumors, knowing whether stem cells or progenitor cells are part of the process is crucial.
In a paper published in the December 2010 issue of the journal Cancer Cell, investigators found that the tumor originates in and spreads through cells known as glial progenitor cells – cells that are often referred to as "daughter" cells of stem cells. The work comes at a time when many researchers are actively investigating the role that stem cells which have gone awry play in causing cancer. For scientists trying to create new ways to treat brain tumors, knowing whether stem cells or progenitor cells are part of the process is crucial.
Tuesday, November 09, 2010
Rogue Gene Hijacks Stem Cells to Jumpstart Human Cancer
Source: Queen Mary, University of London
Date: 9 November 2010
Summary:
A gene thought to be responsible for initiating human cancer has been identified by researchers at Barts and The London School of Medicine and Dentistry. The study - published online today (9 November) in the journal Cancer Research - paves the way for developing early cancer diagnostic tests, and finding new treatments that prevent or stop the spread of cancer cells at an early stage.
Researchers have shown that a gene called FOXM1 exploits the inherent self-renewal property of stem cells causing excessive cell proliferation. Using adult human stem cells isolated from mouth tissues the team demonstrated that normal stem cells engineered in the lab to express abnormal levels of FOXM1 gene, triggered excessive cell growth within a 3D tissue culture model system set up to mimic human tissue regeneration in the laboratory.
Date: 9 November 2010
Summary:
A gene thought to be responsible for initiating human cancer has been identified by researchers at Barts and The London School of Medicine and Dentistry. The study - published online today (9 November) in the journal Cancer Research - paves the way for developing early cancer diagnostic tests, and finding new treatments that prevent or stop the spread of cancer cells at an early stage.
Researchers have shown that a gene called FOXM1 exploits the inherent self-renewal property of stem cells causing excessive cell proliferation. Using adult human stem cells isolated from mouth tissues the team demonstrated that normal stem cells engineered in the lab to express abnormal levels of FOXM1 gene, triggered excessive cell growth within a 3D tissue culture model system set up to mimic human tissue regeneration in the laboratory.
Tuesday, July 06, 2010
Neural stem cells attack glioblastoma cells
Source: Helmholtz Association of German Research Centres
Date: July 6, 2010
Summary:
In their latest research, scientists of the Max Delbruck Center for Molecular Medicine (MDC) Berlin-Buch, Germany, have demonstrated how the brain's own stem cells and precursor cells control the growth of glioblastomas. Of all brain tumors, glioblastomas are among the most common and most aggressive. Dr. Sridhar Reddy Chirasani, Professor Helmut Kettenmann and Dr. Rainer Glass have now shown in cell culture and mouse model experiments just how the body's own protective mechanism they identified in an earlier study, actually works (Brain, July 6, 2010).
Glioblastomas are brain tumors that are most common in adults in their mid-fifties or early sixties. The causes for developing the disease are not yet known. Researchers assume that misdirected neural stem cells / precursor cells mutate into cancer cells and can form glioblastomas.
Date: July 6, 2010
Summary:
In their latest research, scientists of the Max Delbruck Center for Molecular Medicine (MDC) Berlin-Buch, Germany, have demonstrated how the brain's own stem cells and precursor cells control the growth of glioblastomas. Of all brain tumors, glioblastomas are among the most common and most aggressive. Dr. Sridhar Reddy Chirasani, Professor Helmut Kettenmann and Dr. Rainer Glass have now shown in cell culture and mouse model experiments just how the body's own protective mechanism they identified in an earlier study, actually works (Brain, July 6, 2010).
Glioblastomas are brain tumors that are most common in adults in their mid-fifties or early sixties. The causes for developing the disease are not yet known. Researchers assume that misdirected neural stem cells / precursor cells mutate into cancer cells and can form glioblastomas.
Thursday, September 10, 2009
Adult stem cell prostate cancer coverage summary
Below is a summary of news coverage of the recent announcement by researchers at Columbia University Medical Center that a new type of stem cell discovered in the prostate of adult mice can be a source of prostate cancer:
Agence France Presse (AFP), September 9, 2009: "Newly found stem cell causes prostate cancer: mouse study":
PARIS — Scientists in the United States, working with mice, have found a new type of stem cell in the prostate gland and shown that mutations in it can cause cancer, a study released Wednesday says. The discovery boosts evidence that cancers can be caused by modifications in stem cells, the dynamic precursor cells that develop into and replenish the body's specific tissues, it says. It also appears to resolve a mystery about the origin of prostate cancer, and could open new pathways for treatment of the deadly disease.
Reuters, September 9, 2009 5:29pm EDT: "Researchers find prostate cancer stem cell":
WASHINGTON (Reuters) - Researchers have found a stem cell, a kind of master cell, that may cause at least some types of prostate cancer. Their findings are only experimental -- the stem cells were found in mice -- but could explain at least some types of prostate cancer and eventually offer new ways to treat it, they reported on Wednesday in the journal Nature.
HealthDay News, September 9, 2009: "Getting Closer to the Origins of Prostate Cancer: Newly discovered stem cell, common STD could help spur tumors, studies find":
"Two studies take significant steps toward solving major mysteries about prostate cancer -- the exact spot in the gland where tumors can originate, and how to distinguish fast-growing malignancies that are life-threatening from the slower-growing kind that can safely be left alone."
"One study, reported in the Sept. 9 online edition of Nature, describes a previously unknown form of prostate stem cell that can become cancerous if genetic controls go haywire. The prostate consists of several layers of cells, with the lowest, the basal layer, playing a supporting role and the luminal layer, just above it, doing the actual work of the gland."
"The second report, published online Sept. 9 in the Journal of the National Cancer Institute, uncovered an association between infection with a sexually transmitted parasite, Trichomonas vaginalis, and an increased risk of prostate cancer, especially the virulent form of the disease."
BBC News, 10 September 2009: "Stem cell link to prostate cancer":
A newly identified type of stem cell may cause some cases of prostate cancer, research on mice suggests.
The cells, found among those which line the inner cavity of the prostate gland, can produce copies of themselves, and other, more mature cell types. But researchers showed that when the cells were deliberately mutated by switching off a tumour suppressor gene they rapidly formed tumours. The Columbia University study appears in the journal Nature.
Agence France Presse (AFP), September 9, 2009: "Newly found stem cell causes prostate cancer: mouse study":
PARIS — Scientists in the United States, working with mice, have found a new type of stem cell in the prostate gland and shown that mutations in it can cause cancer, a study released Wednesday says. The discovery boosts evidence that cancers can be caused by modifications in stem cells, the dynamic precursor cells that develop into and replenish the body's specific tissues, it says. It also appears to resolve a mystery about the origin of prostate cancer, and could open new pathways for treatment of the deadly disease.
Reuters, September 9, 2009 5:29pm EDT: "Researchers find prostate cancer stem cell":
WASHINGTON (Reuters) - Researchers have found a stem cell, a kind of master cell, that may cause at least some types of prostate cancer. Their findings are only experimental -- the stem cells were found in mice -- but could explain at least some types of prostate cancer and eventually offer new ways to treat it, they reported on Wednesday in the journal Nature.
HealthDay News, September 9, 2009: "Getting Closer to the Origins of Prostate Cancer: Newly discovered stem cell, common STD could help spur tumors, studies find":
"Two studies take significant steps toward solving major mysteries about prostate cancer -- the exact spot in the gland where tumors can originate, and how to distinguish fast-growing malignancies that are life-threatening from the slower-growing kind that can safely be left alone."
"One study, reported in the Sept. 9 online edition of Nature, describes a previously unknown form of prostate stem cell that can become cancerous if genetic controls go haywire. The prostate consists of several layers of cells, with the lowest, the basal layer, playing a supporting role and the luminal layer, just above it, doing the actual work of the gland."
"The second report, published online Sept. 9 in the Journal of the National Cancer Institute, uncovered an association between infection with a sexually transmitted parasite, Trichomonas vaginalis, and an increased risk of prostate cancer, especially the virulent form of the disease."
BBC News, 10 September 2009: "Stem cell link to prostate cancer":
A newly identified type of stem cell may cause some cases of prostate cancer, research on mice suggests.
The cells, found among those which line the inner cavity of the prostate gland, can produce copies of themselves, and other, more mature cell types. But researchers showed that when the cells were deliberately mutated by switching off a tumour suppressor gene they rapidly formed tumours. The Columbia University study appears in the journal Nature.
Wednesday, September 09, 2009
New Type Of Adult Stem Cells Found In Prostate May Be Involved In Cancer Development
Source: Columbia University Medical Center
Date: September 9, 2009
Summary:
A new type of stem cell discovered in the prostate of adult mice can be a source of prostate cancer, according to a new study by researchers at the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center and NewYork-Presbyterian Hospital. The researchers found the rare stem cells, called CARNs (which stands for “castration-resistant Nkx3.1-expressing cells”), within the ducts inside the mouse prostate. The stem cells are involved in regenerating prostate tissue, but the researchers also found that CARNs can give rise to cancer if certain tumor suppressor genes in the cells are inactivated. The findings will be published in an advance online edition of Nature on September 9, 2009.
Date: September 9, 2009
Summary:
A new type of stem cell discovered in the prostate of adult mice can be a source of prostate cancer, according to a new study by researchers at the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center and NewYork-Presbyterian Hospital. The researchers found the rare stem cells, called CARNs (which stands for “castration-resistant Nkx3.1-expressing cells”), within the ducts inside the mouse prostate. The stem cells are involved in regenerating prostate tissue, but the researchers also found that CARNs can give rise to cancer if certain tumor suppressor genes in the cells are inactivated. The findings will be published in an advance online edition of Nature on September 9, 2009.
Thursday, August 13, 2009
New method takes aim at aggressive cancer cells
Source: Whitehead Institute for Biomedical Research
Date: August 13, 2009
Summary:
A multi-institutional team of Boston-area researchers has discovered a chemical that works in mice to kill the rare but aggressive cells within breast cancers that have the ability to seed new tumors. These cells, known as cancer stem cells, are thought to enable cancers to spread — and to reemerge after seemingly successful treatment. Although further work is needed to determine whether this specific chemical holds therapeutic promise for humans, the study shows that it is possible to find chemicals that selectively kill cancer stem cells. The scientists’ findings appear in the August 13 advance online issue of Cell.
Date: August 13, 2009
Summary:
A multi-institutional team of Boston-area researchers has discovered a chemical that works in mice to kill the rare but aggressive cells within breast cancers that have the ability to seed new tumors. These cells, known as cancer stem cells, are thought to enable cancers to spread — and to reemerge after seemingly successful treatment. Although further work is needed to determine whether this specific chemical holds therapeutic promise for humans, the study shows that it is possible to find chemicals that selectively kill cancer stem cells. The scientists’ findings appear in the August 13 advance online issue of Cell.
Monday, August 10, 2009
STAT3 Gene Regulates Cancer Stem Cells in Brain Cancer
Source: Tufts University
Date: August 10, 2009
Summary:
In a study published online in advance of print in Stem Cells, Tufts researchers report that the STAT3 gene regulates cancer stem cells in brain cancer. Cancer stem cells have many characteristics of stem cells and are thought to be the cells that drive tumor formation. The researchers report that STAT3 could become a target for cancer therapy, specifically in Glioblastoma multiforme (GBM), a type of malignant and aggressive brain tumor.
Date: August 10, 2009
Summary:
In a study published online in advance of print in Stem Cells, Tufts researchers report that the STAT3 gene regulates cancer stem cells in brain cancer. Cancer stem cells have many characteristics of stem cells and are thought to be the cells that drive tumor formation. The researchers report that STAT3 could become a target for cancer therapy, specifically in Glioblastoma multiforme (GBM), a type of malignant and aggressive brain tumor.
Tuesday, August 04, 2009
Gene signature for cancer stem cells may provide drug targets
Source: Baylor College of Medicine
Date: August 4, 2009
Summary:
A subset of tumor cells that remain after a woman with breast cancer undergoes treatment with either anti-cancer or anti-hormone therapy shows a "gene signature" that could be used to define targets for developing new drugs against the disease, said a consortium of researchers led by Baylor College of Medicine. The report appears in the current issue of the Proceedings of the National Academy of Sciences.
Date: August 4, 2009
Summary:
A subset of tumor cells that remain after a woman with breast cancer undergoes treatment with either anti-cancer or anti-hormone therapy shows a "gene signature" that could be used to define targets for developing new drugs against the disease, said a consortium of researchers led by Baylor College of Medicine. The report appears in the current issue of the Proceedings of the National Academy of Sciences.
Thursday, October 16, 2008
Researchers uncover new links between stem cells, aging and cancer
Source: University of Michigan
Date: October 16, 2008
Summary:
Four genes previously implicated in the control of cancer have been shown by University of Michigan scientists to play key roles in the aging process and stem-cell regulation. It's a case of genetic multiple personalities: Four genes that suppress tumor formation also regulate the ability of adult stem cells to replace worn-out tissues, as well as the shut-down of stem cells during aging. The genes switch on and off in a coordinated fashion as cells age to reduce the risk of cancer. In the process, they also shut down stem-cell function in aging tissues, reducing their capacity to regenerate. The findings, reported in the Oct. 17 edition of the journal Cell, clarify and highlight the links between cancer, aging and stem-cell function by revealing some of their shared genetic pathways.
Date: October 16, 2008
Summary:
Four genes previously implicated in the control of cancer have been shown by University of Michigan scientists to play key roles in the aging process and stem-cell regulation. It's a case of genetic multiple personalities: Four genes that suppress tumor formation also regulate the ability of adult stem cells to replace worn-out tissues, as well as the shut-down of stem cells during aging. The genes switch on and off in a coordinated fashion as cells age to reduce the risk of cancer. In the process, they also shut down stem-cell function in aging tissues, reducing their capacity to regenerate. The findings, reported in the Oct. 17 edition of the journal Cell, clarify and highlight the links between cancer, aging and stem-cell function by revealing some of their shared genetic pathways.
Monday, October 13, 2008
Stem Cell Sentry Sounds The Alarm To Maintain Balance Between Cancer And Aging
Source: University of Michigan
Date: October 13, 2008
Summary:
Four genes previously implicated in the control of cancer have been shown by University of Michigan scientists to play key roles in the aging process and stem-cell regulation. It’s a case of genetic multiple personalities: Four genes that suppress tumor formation also regulate the ability of adult stem cells to replace worn-out tissues, as well as the shut-down of stem cells during aging. The genes switch on and off in a coordinated fashion as cells age to reduce the risk of cancer. In the process, they also shut down stem-cell function in aging tissues, reducing their capacity to regenerate. The findings, reported in the Oct. 17 edition of the journal Cell, clarify and highlight the links between cancer, aging and stem-cell function by revealing some of their shared genetic pathways.
Date: October 13, 2008
Summary:
Four genes previously implicated in the control of cancer have been shown by University of Michigan scientists to play key roles in the aging process and stem-cell regulation. It’s a case of genetic multiple personalities: Four genes that suppress tumor formation also regulate the ability of adult stem cells to replace worn-out tissues, as well as the shut-down of stem cells during aging. The genes switch on and off in a coordinated fashion as cells age to reduce the risk of cancer. In the process, they also shut down stem-cell function in aging tissues, reducing their capacity to regenerate. The findings, reported in the Oct. 17 edition of the journal Cell, clarify and highlight the links between cancer, aging and stem-cell function by revealing some of their shared genetic pathways.
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