Source: University of Sheffield
Date: 12 September 2012
Summary:
In research funded by the Medical Research Council and leading UK research charity, Action on Hearing Loss, experts from the University of Sheffield’s Department of Biomedical Sciences developed a method to turn human embryonic stem cells into ear cells. They then transplanted them into deaf gerbils, obtaining a functional recovery that, on average, was of around 46 per cent. The improvement was evident about four weeks after administering the cells. As well as proving that stem cells can be used to repair damaged hearing, it is hoped the breakthrough – published in the journal Nature – will lead to new treatments and therapies in the future.
Showing posts with label sensory restoration. Show all posts
Showing posts with label sensory restoration. Show all posts
Wednesday, September 12, 2012
Wednesday, December 07, 2011
Research could help people with declining sense of smell
Source: University of California - Berkeley
Date: December 7, 2011
Summary:
University of California, Berkeley, neuroscientists have discovered a genetic trigger that makes the nose renew its smell sensors, providing hope for new therapies for people who have lost their sense of smell due to trauma or old age. The gene tells olfactory stem cells ‑ the adult tissue stem cells in the nose ‑ to mature into the sensory neurons that detect odors and relay that information to the brain. The discovery may also help scientists harness olfactory stem cells and stem cells found in other sensory systems more generally, to recover sensory function following injury or degenerative disease, scientists said. The findings are published in the Dec. 8 issue of the journal Neuron.
Date: December 7, 2011
Summary:
University of California, Berkeley, neuroscientists have discovered a genetic trigger that makes the nose renew its smell sensors, providing hope for new therapies for people who have lost their sense of smell due to trauma or old age. The gene tells olfactory stem cells ‑ the adult tissue stem cells in the nose ‑ to mature into the sensory neurons that detect odors and relay that information to the brain. The discovery may also help scientists harness olfactory stem cells and stem cells found in other sensory systems more generally, to recover sensory function following injury or degenerative disease, scientists said. The findings are published in the Dec. 8 issue of the journal Neuron.
Tuesday, June 14, 2011
Sniffing out a New Source of Stem Cells
Source: Journal of Clinical Investigation
Date: June 14, 2011
Summary:
New research in mice published in the Journal of Clinical Investigation suggests that adult stem cells from immune system tissue in the smell-sensing region of the human nose (human olfactory ecto--mesenchymal stem cells [OE-MSCs]) could provide a source of cells to treat brain disorders in which nerve cells are lost or irreparably damaged.
A team of researchers, led by Emmanuel Nivet, now at the Salk Institute for Biological Studies, La Jolla, has generated data in mice that suggest that adult stem cells from immune system tissue in the smell-sensing region of the human nose (human olfactory ecto-mesenchymal stem cells [OE-MSCs]) could provide a source of cells to treat brain disorders in which nerve cells are lost or irreparably damaged.
Date: June 14, 2011
Summary:
New research in mice published in the Journal of Clinical Investigation suggests that adult stem cells from immune system tissue in the smell-sensing region of the human nose (human olfactory ecto--mesenchymal stem cells [OE-MSCs]) could provide a source of cells to treat brain disorders in which nerve cells are lost or irreparably damaged.
A team of researchers, led by Emmanuel Nivet, now at the Salk Institute for Biological Studies, La Jolla, has generated data in mice that suggest that adult stem cells from immune system tissue in the smell-sensing region of the human nose (human olfactory ecto-mesenchymal stem cells [OE-MSCs]) could provide a source of cells to treat brain disorders in which nerve cells are lost or irreparably damaged.
Wednesday, April 06, 2011
Human Taste Cells Regenerate in a Dish
Source: Monell Chemical Senses Center
Date: April 6, 2011
Summary:
PHILADELPHIA – Following years of futile attempts, new research from the Monell Center demonstrates that living human taste cells can be maintained in culture for at least seven months. The findings provide scientists with a valuable tool to learn about the human sense of taste and how it functions in health and disease. This advance ultimately will assist efforts to prevent and treat taste loss or impairment due to infection, radiation, chemotherapy and chemical exposures.
Monell scientists first demonstrated in 2006 that taste cells from rats could successfully be maintained in culture. In the current study, published online in the journal Chemical Senses, they then applied that methodology to a more clinically relevant population -- humans.
Taking tiny samples of tongue tissue from human volunteers, the researchers first adapted existing techniques to demonstrate that the human taste cells indeed can regenerate in culture. They went on to show that the new taste cells were functional, maintaining key molecular and physiological properties characteristic of the parent cells. For example, the new cells also were activated by sweet and bitter taste molecules.
Date: April 6, 2011
Summary:
PHILADELPHIA – Following years of futile attempts, new research from the Monell Center demonstrates that living human taste cells can be maintained in culture for at least seven months. The findings provide scientists with a valuable tool to learn about the human sense of taste and how it functions in health and disease. This advance ultimately will assist efforts to prevent and treat taste loss or impairment due to infection, radiation, chemotherapy and chemical exposures.
Monell scientists first demonstrated in 2006 that taste cells from rats could successfully be maintained in culture. In the current study, published online in the journal Chemical Senses, they then applied that methodology to a more clinically relevant population -- humans.
Taking tiny samples of tongue tissue from human volunteers, the researchers first adapted existing techniques to demonstrate that the human taste cells indeed can regenerate in culture. They went on to show that the new taste cells were functional, maintaining key molecular and physiological properties characteristic of the parent cells. For example, the new cells also were activated by sweet and bitter taste molecules.
Human Taste Cells Regenerate in a Dish
Source: Monell Chemical Senses Center
Date: April 6, 2011
Summary:
Following years of futile attempts, new research from the Monell Center demonstrates that living human taste cells can be maintained in culture for at least seven months. The findings provide scientists with a valuable tool to learn about the human sense of taste and how it functions in health and disease. This advance ultimately will assist efforts to prevent and treat taste loss or impairment due to infection, radiation, chemotherapy and chemical exposures.
To dispel the long-held belief, the Monell scientists first demonstrated in 2006 that taste cells from rats could successfully be maintained in culture. In the current study, published online in the journal Chemical Senses, they then applied that methodology to a more clinically relevant population -- humans. Taking tiny samples of tongue tissue from human volunteers, the researchers first adapted existing techniques to demonstrate that the human taste cells indeed can regenerate in culture. They went on to show that the new taste cells were functional, maintaining key molecular and physiological properties characteristic of the parent cells. For example, the new cells also were activated by sweet and bitter taste molecules.
Date: April 6, 2011
Summary:
Following years of futile attempts, new research from the Monell Center demonstrates that living human taste cells can be maintained in culture for at least seven months. The findings provide scientists with a valuable tool to learn about the human sense of taste and how it functions in health and disease. This advance ultimately will assist efforts to prevent and treat taste loss or impairment due to infection, radiation, chemotherapy and chemical exposures.
To dispel the long-held belief, the Monell scientists first demonstrated in 2006 that taste cells from rats could successfully be maintained in culture. In the current study, published online in the journal Chemical Senses, they then applied that methodology to a more clinically relevant population -- humans. Taking tiny samples of tongue tissue from human volunteers, the researchers first adapted existing techniques to demonstrate that the human taste cells indeed can regenerate in culture. They went on to show that the new taste cells were functional, maintaining key molecular and physiological properties characteristic of the parent cells. For example, the new cells also were activated by sweet and bitter taste molecules.
Friday, February 11, 2011
HOW NASAL STEM CELLS MIGHT PREVENT CHILDHOOD DEAFNESS
Source: Garvan Institute of Medical Research
Date: 11 February 2011
Summary:
Australian scientists have shown for the first time in mice that nasal stem cells injected into the inner ear have the potential to reverse or restore hearing during early onset sensorineural hearing loss. Sensorineural hearing loss occurs when hearing cells in the cochlea lose their function. Frequently inherited, and usually starting during infancy and early childhood, the condition can slow a child’s development and lead to speech and language problems.
Drs Jeremy Sullivan, Sonali Pandit and Sharon Oleskevich from Sydney’s Garvan Institute of Medical Research, found that stem cells appear to release ‘factors’, or chemical substances, that help preserve the function of cochlear hearing cells, without the stem cells becoming part of the tissue of the inner ear. Their findings are published in STEM CELLS, now online.
Date: 11 February 2011
Summary:
Australian scientists have shown for the first time in mice that nasal stem cells injected into the inner ear have the potential to reverse or restore hearing during early onset sensorineural hearing loss. Sensorineural hearing loss occurs when hearing cells in the cochlea lose their function. Frequently inherited, and usually starting during infancy and early childhood, the condition can slow a child’s development and lead to speech and language problems.
Drs Jeremy Sullivan, Sonali Pandit and Sharon Oleskevich from Sydney’s Garvan Institute of Medical Research, found that stem cells appear to release ‘factors’, or chemical substances, that help preserve the function of cochlear hearing cells, without the stem cells becoming part of the tissue of the inner ear. Their findings are published in STEM CELLS, now online.
Wednesday, September 08, 2010
INVESTIGATORS DISCOVER A NEW HOT SPOT FOR THE GENESIS OF SIGNALING NEURONS IN THE ADULT BRAIN
Source: University of California - Davis
Date: September 8, 2010
Summary:
In an unanticipated finding, researchers at the UC Davis School of Medicine have discovered that, during early adulthood, the brain produces new excitatory neurons, and that these neurons arise from non-neuronal support cells in an area of the brain that processes smell. The study, conducted in mice, is the first to demonstrate that pyramidal neurons in the mature brain stem are generated by precursors of glial cells — non-neuronal support cells — and that these new neurons likely are capable of transmitting information to widespread regions of the brain, said David Pleasure, a professor of neurology and pediatrics at the UC Davis School of Medicine and the study's author. "Pyramidal Neurons are Generated from Oligodendroglial Progenitor Cells in Adult Piriform Cortex," is published online this week in the Journal of Neuroscience.
Date: September 8, 2010
Summary:
In an unanticipated finding, researchers at the UC Davis School of Medicine have discovered that, during early adulthood, the brain produces new excitatory neurons, and that these neurons arise from non-neuronal support cells in an area of the brain that processes smell. The study, conducted in mice, is the first to demonstrate that pyramidal neurons in the mature brain stem are generated by precursors of glial cells — non-neuronal support cells — and that these new neurons likely are capable of transmitting information to widespread regions of the brain, said David Pleasure, a professor of neurology and pediatrics at the UC Davis School of Medicine and the study's author. "Pyramidal Neurons are Generated from Oligodendroglial Progenitor Cells in Adult Piriform Cortex," is published online this week in the Journal of Neuroscience.
Thursday, May 13, 2010
Aiming to cure deafness, scientists first to create functional inner-ear cells
Source: Stanford University Medical Center
Date: May 13, 2010
Summary:
Deep inside the ear, specialized cells called hair cells detect vibrations in the air and translate them into sound. Ten years ago, Stefan Heller, PhD, professor of otolaryngology at the Stanford University School of Medicine, came up with the idea that if you could create these cells in the laboratory from stem cells, it would go a long way toward helping scientists understand the molecular basis of hearing in order to develop better treatments for deafness.
After years of lab work, researchers in Heller’s lab report in the May 14 issue of Cell that they have found a way to develop mouse cells that look and act just like the animal’s inner-ear hair cells — the linchpin to our sense of hearing and balance — in a petri dish. If they can further perfect the recipe to generate hair cells in the millions, it could lead to significant scientific and clinical advances along the path to curing deafness in the future, they said.
Date: May 13, 2010
Summary:
Deep inside the ear, specialized cells called hair cells detect vibrations in the air and translate them into sound. Ten years ago, Stefan Heller, PhD, professor of otolaryngology at the Stanford University School of Medicine, came up with the idea that if you could create these cells in the laboratory from stem cells, it would go a long way toward helping scientists understand the molecular basis of hearing in order to develop better treatments for deafness.
After years of lab work, researchers in Heller’s lab report in the May 14 issue of Cell that they have found a way to develop mouse cells that look and act just like the animal’s inner-ear hair cells — the linchpin to our sense of hearing and balance — in a petri dish. If they can further perfect the recipe to generate hair cells in the millions, it could lead to significant scientific and clinical advances along the path to curing deafness in the future, they said.
Monday, August 24, 2009
Wisconsin team grows retina cells from skin-derived stem cells
Source: University of Wisconsin-Madison
August 24, 2009
Summary:
MADISON — A team of scientists from the University of Wisconsin-Madison School of Medicine and Public Health has successfully grown multiple types of retina cells from two types of stem cells — suggesting a future in which damaged retinas could be repaired by cells grown from the patient's own skin.
Even sooner, the discovery will lead to laboratory models for studying genetically linked eye conditions, screening new drugs to treat those conditions and understanding the development of the human eye. A Waisman Center research team led by David Gamm, an assistant professor of ophthalmology and visual sciences, and Jason Meyer, a research scientist, announced their discovery in the Aug. 24 edition of the Proceedings of the National Academy of Sciences.
August 24, 2009
Summary:
MADISON — A team of scientists from the University of Wisconsin-Madison School of Medicine and Public Health has successfully grown multiple types of retina cells from two types of stem cells — suggesting a future in which damaged retinas could be repaired by cells grown from the patient's own skin.
Even sooner, the discovery will lead to laboratory models for studying genetically linked eye conditions, screening new drugs to treat those conditions and understanding the development of the human eye. A Waisman Center research team led by David Gamm, an assistant professor of ophthalmology and visual sciences, and Jason Meyer, a research scientist, announced their discovery in the Aug. 24 edition of the Proceedings of the National Academy of Sciences.
Tuesday, June 16, 2009
Human Embryonic Stem Cells Could Safely Treat Eye Diseases, Research Suggests
Source: Advanced Cell Technology, Inc.
Date: June 15, 2009
Summary:
Advanced Cell Technology and its collaborators at OHSU report the long-term safety and efficacy of human embryonic stem cell (hESC)-derived retinal pigment epithelium produced under manufacturing conditions suitable for human clinical trials. The research shows long-term functional rescue using hESC-derived cells in both the RCS rat and Elov14 mouse, animal models of retinal degeneration and Stargardt disease, respectively.
The research, which appears online ahead of print in the journal Stem Cells, shows long-term functional rescue using hESC-derived cells in both the RCS rat and Elov14 mouse, animal models of retinal degeneration and Stargardt, respectively. The cells survived transplantation for prolonged periods (>220 days) and sustained visual function without tumor formation or untoward pathological reactions. Near-normal functional rescue was also achieved in the 'Stargardt' mouse. To further address safety concerns, a study was carried out in the NIH III immune deficient mouse model. Long-term data (spanning the life of the animals) revealed no evidence of tumor formation after transplantation.
Date: June 15, 2009
Summary:
Advanced Cell Technology and its collaborators at OHSU report the long-term safety and efficacy of human embryonic stem cell (hESC)-derived retinal pigment epithelium produced under manufacturing conditions suitable for human clinical trials. The research shows long-term functional rescue using hESC-derived cells in both the RCS rat and Elov14 mouse, animal models of retinal degeneration and Stargardt disease, respectively.
The research, which appears online ahead of print in the journal Stem Cells, shows long-term functional rescue using hESC-derived cells in both the RCS rat and Elov14 mouse, animal models of retinal degeneration and Stargardt, respectively. The cells survived transplantation for prolonged periods (>220 days) and sustained visual function without tumor formation or untoward pathological reactions. Near-normal functional rescue was also achieved in the 'Stargardt' mouse. To further address safety concerns, a study was carried out in the NIH III immune deficient mouse model. Long-term data (spanning the life of the animals) revealed no evidence of tumor formation after transplantation.
Thursday, May 21, 2009
Stem cells hold promise in treating retinal degeneration
Source: University of Louisville
Date: May 21, 2009
Summary:
A team of University of Louisville scientists have discovered that stem cells taken from bone marrow can restore damaged retinal tissue by generating new cells. This is the first known study where stem cells derived from bone marrow have been used to restore the pigmented cell layer just outside the retina or the retinal pigment epithelium (RPE). During their experiments, UofL researchers found that bone-marrow derived stem cells (BMSCs) were attracted to damaged RPE, and were able to differentiate or move from less specialized cells into components of RPE. The study, published recently in the Archives of Ophthalmology. The research moves science a step closer to helping those who suffer from vision loss and blindness due to age-related macular degeneration and hereditary retinal degenerations.
Date: May 21, 2009
Summary:
A team of University of Louisville scientists have discovered that stem cells taken from bone marrow can restore damaged retinal tissue by generating new cells. This is the first known study where stem cells derived from bone marrow have been used to restore the pigmented cell layer just outside the retina or the retinal pigment epithelium (RPE). During their experiments, UofL researchers found that bone-marrow derived stem cells (BMSCs) were attracted to damaged RPE, and were able to differentiate or move from less specialized cells into components of RPE. The study, published recently in the Archives of Ophthalmology. The research moves science a step closer to helping those who suffer from vision loss and blindness due to age-related macular degeneration and hereditary retinal degenerations.
Wednesday, April 22, 2009
Cell transplants may cure deafness
Source: Uppsala University
Date: April 22, 2009
Summary:
When Uppsala researchers found immature stem cells in the inner ear of humans a few years ago, it caused a global sensation. They have also managed to grow hearing nerves from stem cells and human tissue from donated cochleae. Moving images of how nerve cells, like social, swimming beings, seek out each other are now suggesting entirely new and breathtaking perspectives to researchers. The next step will be to study how this growth is affected by electric fields. The researchers want to see, on the one hand, whether electric stimulation can get remaining nerve fibers to grow in hearing impaired individuals and, on the other hand, whether nerves can be made to grow out again after having been damaged or exposed to alcohol and other toxins.
Date: April 22, 2009
Summary:
When Uppsala researchers found immature stem cells in the inner ear of humans a few years ago, it caused a global sensation. They have also managed to grow hearing nerves from stem cells and human tissue from donated cochleae. Moving images of how nerve cells, like social, swimming beings, seek out each other are now suggesting entirely new and breathtaking perspectives to researchers. The next step will be to study how this growth is affected by electric fields. The researchers want to see, on the one hand, whether electric stimulation can get remaining nerve fibers to grow in hearing impaired individuals and, on the other hand, whether nerves can be made to grow out again after having been damaged or exposed to alcohol and other toxins.
Thursday, April 09, 2009
Stem Cell Therapy Makes Cloudy Corneas Clear
Source: University of Pittsburgh Schools of the Health Sciences
Date: April 9, 2009
Summary:
Stem cells collected from human corneas restore transparency and don’t trigger a rejection response when injected into eyes that are scarred and hazy, according to experiments conducted in mice by researchers at the University of Pittsburgh School of Medicine. Their study will be published in the journal Stem Cells and appears online today. The findings suggest that cell-based therapies might be an effective way to treat human corneal blindness and vision impairment due to the scarring that occurs after infection, trauma and other common eye problems, said senior investigator James L. Funderburgh, Ph.D., associate professor, Department of Ophthalmology. The Pitt corneal stem cells were able to remodel scar-like tissue back to normal.
Date: April 9, 2009
Summary:
Stem cells collected from human corneas restore transparency and don’t trigger a rejection response when injected into eyes that are scarred and hazy, according to experiments conducted in mice by researchers at the University of Pittsburgh School of Medicine. Their study will be published in the journal Stem Cells and appears online today. The findings suggest that cell-based therapies might be an effective way to treat human corneal blindness and vision impairment due to the scarring that occurs after infection, trauma and other common eye problems, said senior investigator James L. Funderburgh, Ph.D., associate professor, Department of Ophthalmology. The Pitt corneal stem cells were able to remodel scar-like tissue back to normal.
Thursday, April 02, 2009
Cure for hearing loss one step closer
Source: University of Sheffield
Date: 02 April 2009
Summary:
Researchers at the University of Sheffield successfully isolated human stem cells and discovered how to turn these into either cells that behave like sensory hair cells or auditory neurons. The cells could be used to restore hearing. The research has been published in the May edition ofStem Cells. The results show there is now a system based on human cells for testing new therapies in the laboratory.
Date: 02 April 2009
Summary:
Researchers at the University of Sheffield successfully isolated human stem cells and discovered how to turn these into either cells that behave like sensory hair cells or auditory neurons. The cells could be used to restore hearing. The research has been published in the May edition ofStem Cells. The results show there is now a system based on human cells for testing new therapies in the laboratory.
Monday, March 23, 2009
New stem cell therapy may lead to treatment for deafness
Source: Wiley - Blackwel
Date: March 23, 2009
Summary:
A new study led by Dr. Marcelo N. Rivolta of the University of Sheffield has successfully isolated human auditory stem cells from fetal cochleae (the auditory portion of the inner ear) and found they had the capacity to differentiate into sensory hair cells and neurons. The study is published in the April issue of Stem Cells. The researchers painstakingly dissected and cultured cochlear cells from 9-11 week-old human fetuses. The cells were expanded and maintained in vitro for up to one year, with continued division for the first 7 to 8 months and up to 30 population doublings, which is similar to other non-embryonic stem cell populations, such as bone marrow. Gene expression analysis showed that all cell lines expressed otic markers that lead to the development of the inner ear as well as markers expressed by pluripotent embryonic stem cells, from which all tissues and organs develop.
Date: March 23, 2009
Summary:
A new study led by Dr. Marcelo N. Rivolta of the University of Sheffield has successfully isolated human auditory stem cells from fetal cochleae (the auditory portion of the inner ear) and found they had the capacity to differentiate into sensory hair cells and neurons. The study is published in the April issue of Stem Cells. The researchers painstakingly dissected and cultured cochlear cells from 9-11 week-old human fetuses. The cells were expanded and maintained in vitro for up to one year, with continued division for the first 7 to 8 months and up to 30 population doublings, which is similar to other non-embryonic stem cell populations, such as bone marrow. Gene expression analysis showed that all cell lines expressed otic markers that lead to the development of the inner ear as well as markers expressed by pluripotent embryonic stem cells, from which all tissues and organs develop.
Wednesday, November 19, 2008
Stem cells restore hearing, vision in animals
Source: Reuters
Posted: November 19, 2008 6:59am EST
Summary:
Reuters reports researchers have found that adult stem cells can restore hearing and vision in animals:
"Stem cells from tiny embryos can be used to restore lost hearing and vision in animals, researchers said Tuesday in what they believe is a first step toward helping people. One team repaired hearing in guinea pigs using human bone marrow stem cells, while another grew functioning eyes in tadpoles using frog cells. While there are no immediate uses for humans, they said their findings help describe some of the most basic biological processes underlying the development of hearing and sight, and may help in the development of the new field of regenerative medicine."
Posted: November 19, 2008 6:59am EST
Summary:
Reuters reports researchers have found that adult stem cells can restore hearing and vision in animals:
"Stem cells from tiny embryos can be used to restore lost hearing and vision in animals, researchers said Tuesday in what they believe is a first step toward helping people. One team repaired hearing in guinea pigs using human bone marrow stem cells, while another grew functioning eyes in tadpoles using frog cells. While there are no immediate uses for humans, they said their findings help describe some of the most basic biological processes underlying the development of hearing and sight, and may help in the development of the new field of regenerative medicine."
Wednesday, September 03, 2008
Hearing Restoration May Be Possible With Cochlear Repair After Transplant Of Human Cord Blood Cells
Source: Cell Transplantation Center
Date: September 3, 2008
Summary:
Hearing loss due to cochlear damage may be repaired by transplanting human umbilical cord hematopoietic stem cells. This study, using animal models of chemical and auditory cochlear damage, found that when transplanted stem cells migrated to the damaged area, "surprisingly few" transplanted cells were necessary to help repair sensory hair cells and neurons. Researchers say transplanting umbilical cord stem cells provides hope for the repair of human hearing impairments rising from cochlear damage.
Date: September 3, 2008
Summary:
Hearing loss due to cochlear damage may be repaired by transplanting human umbilical cord hematopoietic stem cells. This study, using animal models of chemical and auditory cochlear damage, found that when transplanted stem cells migrated to the damaged area, "surprisingly few" transplanted cells were necessary to help repair sensory hair cells and neurons. Researchers say transplanting umbilical cord stem cells provides hope for the repair of human hearing impairments rising from cochlear damage.
Wednesday, March 26, 2008
Growth hormone found to have new role in development of brain's smell center
Source: University of California - Berkeley
Date: March 26, 2008
Summary:
A human hormone known to stimulate the growth of cells throughout the body has a new role - helping to set up the proper nerve connections in the odor center of the brain, according to University of California, Berkeley scientists. Now, neuroscientists have shown that IGF also controls the direction of axon growth as axons stretch from the nose's odor detectors to the brain's olfactory bulb. Axon guidance represents a new role for IGF in development.
Date: March 26, 2008
Summary:
A human hormone known to stimulate the growth of cells throughout the body has a new role - helping to set up the proper nerve connections in the odor center of the brain, according to University of California, Berkeley scientists. Now, neuroscientists have shown that IGF also controls the direction of axon growth as axons stretch from the nose's odor detectors to the brain's olfactory bulb. Axon guidance represents a new role for IGF in development.
Wednesday, August 01, 2007
New Treatment For Glaucoma Shows Promise In Laboratory, Say Researchers
Source: Iowa State University
Date: August 1, 2007
Summary:
Iowa State University researchers have developed a new technique that successfully treated rats for blindness caused by glaucoma. Their experimental treatment will be used on canine patients in the next year. If successful, it is expected to move to human trials. The researchers previously determined that animals with glaucoma increase production of proteins with neuron-protective capabilities (neurotrophins) in an attempt to shield against blindness. So, they imitated that process in the laboratory, modifying bone marrow-derived stem cells. Then they transplanted the cells into the eyes.
Date: August 1, 2007
Summary:
Iowa State University researchers have developed a new technique that successfully treated rats for blindness caused by glaucoma. Their experimental treatment will be used on canine patients in the next year. If successful, it is expected to move to human trials. The researchers previously determined that animals with glaucoma increase production of proteins with neuron-protective capabilities (neurotrophins) in an attempt to shield against blindness. So, they imitated that process in the laboratory, modifying bone marrow-derived stem cells. Then they transplanted the cells into the eyes.
Sunday, June 24, 2007
Can you hear me now? Stem cells enhance hearing recovery
Source: American Journal of Pathology
Date: June 25, 2007
Summary:
Tokyo, Japan -- Researchers have shown that bone marrow stem cells injected into a damaged inner ear can speed hearing recovery after partial hearing loss. The related report by Kamiya et al, “Mesenchymal stem cell transplantation accelerates hearing recovery through the repair of injured cochlear fibrocytes,” appears in the July issue of The American Journal of Pathology.
Date: June 25, 2007
Summary:
Tokyo, Japan -- Researchers have shown that bone marrow stem cells injected into a damaged inner ear can speed hearing recovery after partial hearing loss. The related report by Kamiya et al, “Mesenchymal stem cell transplantation accelerates hearing recovery through the repair of injured cochlear fibrocytes,” appears in the July issue of The American Journal of Pathology.
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