Source: Yale University
Date: September 1, 2011
Summary:
New Haven, Conn. — Yale researchers have discovered the source of signals that trigger hair growth, an insight that may lead to new treatments for baldness. The researchers identified stem cells within the skin's fatty layer and showed that molecular signals from these cells were necessary to spur hair growth in mice, according to research published in the Sept. 2 issue of the journal Cell.
Showing posts with label hair. Show all posts
Showing posts with label hair. Show all posts
Thursday, September 01, 2011
Tuesday, June 14, 2011
New Research Provides Clues on Why Hair Turns Gray Communication Between Hair Follicles and Melanocyte Stem Cells Key to Mystery
Source: NYU Langone Medical Center / New York University School of Medicine
Date: June 14, 2011
Summary:
A new study by researchers at NYU Langone Medical Center has shown that, for the first time, Wnt signaling, already known to control many biological processes, between hair follicles and melanocyte stem cells can dictate hair pigmentation. The study was published in the June 11, 2011 issue of the journal Cell. Using genetic mouse models, researchers were able to examine how Wnt signaling pathways enabled both hair follicle stem cells and melanocyte stem cells to work together to generate hair growth and produce hair color. Research also showed the depletion (or inhibition or abnormal) Wnt signaling in hair follicle stem cells not only inhibits hair re-growth but also prevents melanocytes stem cell activation required for producing hair color. The lack of Wnt activation in melanocyte stem cells leads to depigmented or gray hair.
Date: June 14, 2011
Summary:
A new study by researchers at NYU Langone Medical Center has shown that, for the first time, Wnt signaling, already known to control many biological processes, between hair follicles and melanocyte stem cells can dictate hair pigmentation. The study was published in the June 11, 2011 issue of the journal Cell. Using genetic mouse models, researchers were able to examine how Wnt signaling pathways enabled both hair follicle stem cells and melanocyte stem cells to work together to generate hair growth and produce hair color. Research also showed the depletion (or inhibition or abnormal) Wnt signaling in hair follicle stem cells not only inhibits hair re-growth but also prevents melanocytes stem cell activation required for producing hair color. The lack of Wnt activation in melanocyte stem cells leads to depigmented or gray hair.
Wednesday, August 18, 2010
Stem cell versatility could help tissue regeneration
Source: University of Edinburgh
Date: August 18, 2010
Summary:
Scientists from the Ecole Polytechnique Federale de Lausanne in Switzerland and the University of Edinburgh
have reprogrammed stem cells from a key organ in the immune system in a development that could have implications for tissue regeneration. Their research shows that it is possible to convert one stem type to another without the need for genetic modification.
The researchers used rat models to grow stem cells from the thymus - an organ important for our immune systems - in the laboratory using conditions for growing hair follicle skin stem cells. When the cells were transplanted into developing skin, they were able to maintain skin and hair for more than a year. The transplanted follicles outperformed naturally-produced hair follicle stem cells, which are only able to heal and repair skin for three weeks. Once they were transplanted, the genetic markers of the cells changed to be more similar to those of hair follicle stem cells. The research, published in the journal Nature, shows that triggers from the surrounding environment - in this case from the skin - can reprogramme stem cells to become tissues they are not normally able to generate.
Date: August 18, 2010
Summary:
Scientists from the Ecole Polytechnique Federale de Lausanne in Switzerland and the University of Edinburgh
have reprogrammed stem cells from a key organ in the immune system in a development that could have implications for tissue regeneration. Their research shows that it is possible to convert one stem type to another without the need for genetic modification.
The researchers used rat models to grow stem cells from the thymus - an organ important for our immune systems - in the laboratory using conditions for growing hair follicle skin stem cells. When the cells were transplanted into developing skin, they were able to maintain skin and hair for more than a year. The transplanted follicles outperformed naturally-produced hair follicle stem cells, which are only able to heal and repair skin for three weeks. Once they were transplanted, the genetic markers of the cells changed to be more similar to those of hair follicle stem cells. The research, published in the journal Nature, shows that triggers from the surrounding environment - in this case from the skin - can reprogramme stem cells to become tissues they are not normally able to generate.
Thursday, May 13, 2010
Aiming to cure deafness, scientists first to create functional inner-ear cells
Source: Stanford University Medical Center
Date: May 13, 2010
Summary:
Deep inside the ear, specialized cells called hair cells detect vibrations in the air and translate them into sound. Ten years ago, Stefan Heller, PhD, professor of otolaryngology at the Stanford University School of Medicine, came up with the idea that if you could create these cells in the laboratory from stem cells, it would go a long way toward helping scientists understand the molecular basis of hearing in order to develop better treatments for deafness.
After years of lab work, researchers in Heller’s lab report in the May 14 issue of Cell that they have found a way to develop mouse cells that look and act just like the animal’s inner-ear hair cells — the linchpin to our sense of hearing and balance — in a petri dish. If they can further perfect the recipe to generate hair cells in the millions, it could lead to significant scientific and clinical advances along the path to curing deafness in the future, they said.
Date: May 13, 2010
Summary:
Deep inside the ear, specialized cells called hair cells detect vibrations in the air and translate them into sound. Ten years ago, Stefan Heller, PhD, professor of otolaryngology at the Stanford University School of Medicine, came up with the idea that if you could create these cells in the laboratory from stem cells, it would go a long way toward helping scientists understand the molecular basis of hearing in order to develop better treatments for deafness.
After years of lab work, researchers in Heller’s lab report in the May 14 issue of Cell that they have found a way to develop mouse cells that look and act just like the animal’s inner-ear hair cells — the linchpin to our sense of hearing and balance — in a petri dish. If they can further perfect the recipe to generate hair cells in the millions, it could lead to significant scientific and clinical advances along the path to curing deafness in the future, they said.
Tuesday, December 08, 2009
New Skin Stem Cells Surprisingly Similar to Those Found in Embryos
Source: Howard Hughes Medical Institute
Date: December 8, 2009
Summary:
Scientists have discovered a new type of stem cell in the skin that acts surprisingly like certain stem cells found in embryos: both can generate fat, bone, cartilage, and even nerve cells. These newly-described dermal stem cells may one day prove useful for treating neurological disorders and persistent wounds, such as diabetic ulcers, says Freda Miller, a Howard Hughes Medical Institute international research scholar.
Miller and her colleagues first saw the cells several years ago in both rodents and people, but only now confirmed that the cells are stem cells. Like other stem cells, these cell scan self-renew and, under the right conditions, they can grow into the cell types that constitute the skin’s dermal layer, which lies under the surface epidermal layer. “We showed that these cells are, in fact, the real thing,” says Miller, a professor at the University of Toronto and a senior scientist in the department of developmental biology at the Hospital for Sick Children in Toronto. The dermal stem cells also appear tohelp form the basis for hair growth.The new work was published December 4, 2009, in the journal Cell Stem Cell.
Date: December 8, 2009
Summary:
Scientists have discovered a new type of stem cell in the skin that acts surprisingly like certain stem cells found in embryos: both can generate fat, bone, cartilage, and even nerve cells. These newly-described dermal stem cells may one day prove useful for treating neurological disorders and persistent wounds, such as diabetic ulcers, says Freda Miller, a Howard Hughes Medical Institute international research scholar.
Miller and her colleagues first saw the cells several years ago in both rodents and people, but only now confirmed that the cells are stem cells. Like other stem cells, these cell scan self-renew and, under the right conditions, they can grow into the cell types that constitute the skin’s dermal layer, which lies under the surface epidermal layer. “We showed that these cells are, in fact, the real thing,” says Miller, a professor at the University of Toronto and a senior scientist in the department of developmental biology at the Hospital for Sick Children in Toronto. The dermal stem cells also appear tohelp form the basis for hair growth.The new work was published December 4, 2009, in the journal Cell Stem Cell.
Monday, October 13, 2008
New Properties Of Skin Stem Cells
Source: Karolinska Institutet
Date: 13 October 2008
Summary:
Recent research from the Swedish medical university Karolinska Institutet reveals completely new properties of the skin's stem cells - discoveries that contradict previous findings. The studies, which are published in Nature Genetics, show amongst other things, that hair follicle stem cells can divide actively and transport themselves through the skin tissue.
Date: 13 October 2008
Summary:
Recent research from the Swedish medical university Karolinska Institutet reveals completely new properties of the skin's stem cells - discoveries that contradict previous findings. The studies, which are published in Nature Genetics, show amongst other things, that hair follicle stem cells can divide actively and transport themselves through the skin tissue.
Friday, March 28, 2008
Stem Cells from Hair Follicles May Help "Grow" New Blood Vessels
Source: University of Buffalo
Date: March 28, 2008
Summary:
For a rich source of stem cells to be engineered into new blood vessels or skin tissue, clinicians may one day look no further than the hair on their patients' heads, according to new research published earlier this month by University at Buffalo engineers. In the study, the UB researchers demonstrate that stem cells isolated from sheep hair follicles contain the smooth muscle cells that grow new vasculature. The group recently produced data showing that stem cells from human hair follicles also differentiate into contractile smooth muscle cells. In addition to growing new skin for burn victims, cells from hair follicles could potentially be used to engineer vascular grafts and possibly regenerate cardiac tissues for patients with heart problems.
Date: March 28, 2008
Summary:
For a rich source of stem cells to be engineered into new blood vessels or skin tissue, clinicians may one day look no further than the hair on their patients' heads, according to new research published earlier this month by University at Buffalo engineers. In the study, the UB researchers demonstrate that stem cells isolated from sheep hair follicles contain the smooth muscle cells that grow new vasculature. The group recently produced data showing that stem cells from human hair follicles also differentiate into contractile smooth muscle cells. In addition to growing new skin for burn victims, cells from hair follicles could potentially be used to engineer vascular grafts and possibly regenerate cardiac tissues for patients with heart problems.
Thursday, February 14, 2008
Protein maintains cross talk between cells that control hair growth
Source: Rockefeller University
Date: February 14, 2008
Summary:
Genes, it turns out, are only as active as the signals that turn them on and off. Now scientists from Rockefeller University and the Howard Hughes Institute have identified the signaling molecule that ratchets up and clamps down the activity of key genes in dermal papilla, a type of skin cell whose unique collection of proteins ultimately instruct epithelial stem cells to make hair. The research, which will be published in the February 15 issue of Genes & Development, highlights the cross talk between these two cell types and how this signaling molecule, a protein called BMP, is crucial for this exchange.
Date: February 14, 2008
Summary:
Genes, it turns out, are only as active as the signals that turn them on and off. Now scientists from Rockefeller University and the Howard Hughes Institute have identified the signaling molecule that ratchets up and clamps down the activity of key genes in dermal papilla, a type of skin cell whose unique collection of proteins ultimately instruct epithelial stem cells to make hair. The research, which will be published in the February 15 issue of Genes & Development, highlights the cross talk between these two cell types and how this signaling molecule, a protein called BMP, is crucial for this exchange.
Thursday, January 24, 2008
Protein that controls hair growth also keeps stem cells slumbering
Source: Rockefeller University
Date: January 24, 2008
Summary:
Like fine china and crystal, which tend to be used sparingly, stem cells divide infrequently. It was thought they did so to protect themselves from unnecessary wear and tear. But now new research has unveiled the protein that puts the brakes on stem cell division and shows that stem cells may not need such guarded protection to maintain their potency. A protein involved in hair growth also keeps the skin's stem cells from proliferating. This research raises questions about what stem cells need in order to maintain their ability to regenerate tissues -- questions that may be key in developing treatments for patients with thinning hair.
Date: January 24, 2008
Summary:
Like fine china and crystal, which tend to be used sparingly, stem cells divide infrequently. It was thought they did so to protect themselves from unnecessary wear and tear. But now new research has unveiled the protein that puts the brakes on stem cell division and shows that stem cells may not need such guarded protection to maintain their potency. A protein involved in hair growth also keeps the skin's stem cells from proliferating. This research raises questions about what stem cells need in order to maintain their ability to regenerate tissues -- questions that may be key in developing treatments for patients with thinning hair.
Wednesday, January 16, 2008
Researchers identify mechanism that controls activation of stem cells during hair regeneration
Source: University of Southern California
Date: January 16, 2008
Summary:
Researchers at the University of Southern California have identified a novel cyclic signaling in the dermis that coordinates stem cell activity and regulates regeneration in large populations of hairs in animal models. The signaling switch involves bone morphogenetic protein (Bmp) pathway, according to the study that will be published in the Jan. 17 issue of the journal Nature.
Date: January 16, 2008
Summary:
Researchers at the University of Southern California have identified a novel cyclic signaling in the dermis that coordinates stem cell activity and regulates regeneration in large populations of hairs in animal models. The signaling switch involves bone morphogenetic protein (Bmp) pathway, according to the study that will be published in the Jan. 17 issue of the journal Nature.
Thursday, January 10, 2008
Protein In Human Hair Shows Promise For Regenerating Nerves
Source: Wake Forest University Baptist Medical Center
Date: January 10, 2008
Summary:
A protein found in human hair shows promise for promoting the regeneration of nerve tissue and could lead to a new treatment option when nerves are cut or crushed from trauma. In the journal Biomaterials, scientists from Wake Forest University School of Medicine reported that in animal studies the protein keratin was able to speed up nerve regeneration and improve nerve function compared to current treatment options.
Date: January 10, 2008
Summary:
A protein found in human hair shows promise for promoting the regeneration of nerve tissue and could lead to a new treatment option when nerves are cut or crushed from trauma. In the journal Biomaterials, scientists from Wake Forest University School of Medicine reported that in animal studies the protein keratin was able to speed up nerve regeneration and improve nerve function compared to current treatment options.
Thursday, May 17, 2007
Studies Hint at a Way to Regrow Lost Hair
Source: National Public Radio (NPR) - All Things Considered
Date: May 17, 2007
Summary:
NPR covers the new finding reported in the journal Nature using Adult skin stem cells to re-grow hair:
"Researchers have found a way to encourage new hair growth in mice, and they're hoping something similar can be done with humans." An NPR streaming radio broadcast accompanies this story.
Date: May 17, 2007
Summary:
NPR covers the new finding reported in the journal Nature using Adult skin stem cells to re-grow hair:
"Researchers have found a way to encourage new hair growth in mice, and they're hoping something similar can be done with humans." An NPR streaming radio broadcast accompanies this story.
New Hope For Baldness Treatment: Hair Follicles Created For First Time In Mouse Study
Source: University of Pennsylvania School of Medicine
Date: May 17, 2007
Summary:
Researchers at the University of Pennsylvania School of Medicine have found that hair follicles in adult mice regenerate by re-awakening genes once active only in developing embryos. These findings provide unequivocal evidence for the first time that, like other animals such as newts and salamanders, mammals have the power to regenerate. A better understanding of this process could lead to novel treatments for hair loss, other skin and hair disorders, and wounds.
Date: May 17, 2007
Summary:
Researchers at the University of Pennsylvania School of Medicine have found that hair follicles in adult mice regenerate by re-awakening genes once active only in developing embryos. These findings provide unequivocal evidence for the first time that, like other animals such as newts and salamanders, mammals have the power to regenerate. A better understanding of this process could lead to novel treatments for hair loss, other skin and hair disorders, and wounds.
Scientists Make Skin Grow New Hair Follicles By Itself
Source: Medical News Today
Article Date: 17 May 2007 - 0:00 PDT
Summary:
Medical News Today reports on a new study in which researchers used adult skin stem cells to grow new hair follicles:
"US scientists have found a way to make the skin of laboratory mice gives rise to new fully working hair follicles complete with new hair by using a protein that stimulates follicle generating genes in skin cells when skin is wounded." The scientists discovered that the cells of the epidermis take on the properties of stem cells and generate new hair follicles that are capable of growing new shafts of hair. So far the results have only been achieved in mice, but the hope is the same is true of human skin and that the discovery may one day lead to treatments for baldness and abnormal hair growth. The study is published in the journal Nature.
Article Date: 17 May 2007 - 0:00 PDT
Summary:
Medical News Today reports on a new study in which researchers used adult skin stem cells to grow new hair follicles:
"US scientists have found a way to make the skin of laboratory mice gives rise to new fully working hair follicles complete with new hair by using a protein that stimulates follicle generating genes in skin cells when skin is wounded." The scientists discovered that the cells of the epidermis take on the properties of stem cells and generate new hair follicles that are capable of growing new shafts of hair. So far the results have only been achieved in mice, but the hope is the same is true of human skin and that the discovery may one day lead to treatments for baldness and abnormal hair growth. The study is published in the journal Nature.
Wednesday, May 16, 2007
Baldness breakthrough: Stem cells coaxed into growing hair
Source: Daily Mail
Date: 17 May 2007
Summary:
Scientists have coaxed stem cells into growing hair for the first time. Writing in the journal Nature, the scientists described how they had shown that adult mammals are able to grow new hair follicles. The breakthrough could also lead to new treatments for other conditions, such as alopecia, in which hair is lost in patches. Within a decade, advances in stem cell science could help them to regrow their own hair where it has been lost.
Date: 17 May 2007
Summary:
Scientists have coaxed stem cells into growing hair for the first time. Writing in the journal Nature, the scientists described how they had shown that adult mammals are able to grow new hair follicles. The breakthrough could also lead to new treatments for other conditions, such as alopecia, in which hair is lost in patches. Within a decade, advances in stem cell science could help them to regrow their own hair where it has been lost.
Experiment offers hope of remedy for baldness
Source: Reuters
Posted: May 16, 2007 3:24PM EDT
Summary:
Mice with deep skin wounds can grow new hair, a finding that offers hope for a baldness remedy for humans scientists said. The mice regenerated hair at the site of the wound via molecular processes similar to those used in embryonic development, according to the research, published in the journal Nature. The findings show mammals possess greater regenerative abilities than commonly believed. While some amphibians can regenerate limbs and some reptiles can regenerate tails, regeneration in mammals is far more limited.
Posted: May 16, 2007 3:24PM EDT
Summary:
Mice with deep skin wounds can grow new hair, a finding that offers hope for a baldness remedy for humans scientists said. The mice regenerated hair at the site of the wound via molecular processes similar to those used in embryonic development, according to the research, published in the journal Nature. The findings show mammals possess greater regenerative abilities than commonly believed. While some amphibians can regenerate limbs and some reptiles can regenerate tails, regeneration in mammals is far more limited.
Gene find triggers baldness hope
Source: BBC News
Posted: 16 May 2007, 17:01 GMT 18:01 UK
Summary:
BBC News reports on the discovery of a gene that, in combination with stem cells, could lead to new treatments for baldness and healing of wounds:
"Hair loss in humans might be reversible, suggest scientists who have helped create new hair cells on the skin of mice. It was thought hair follicles, once damaged, could never be replaced. But a University of Pennsylvania team, writing in the journal Nature, says hair growth can actually be encouraged using a single gene. A UK expert said the study could prove more important in aiding development of better wound-healing techniques."
Posted: 16 May 2007, 17:01 GMT 18:01 UK
Summary:
BBC News reports on the discovery of a gene that, in combination with stem cells, could lead to new treatments for baldness and healing of wounds:
"Hair loss in humans might be reversible, suggest scientists who have helped create new hair cells on the skin of mice. It was thought hair follicles, once damaged, could never be replaced. But a University of Pennsylvania team, writing in the journal Nature, says hair growth can actually be encouraged using a single gene. A UK expert said the study could prove more important in aiding development of better wound-healing techniques."
Skin's own cells could beat baldness
Source: Nature
Date: 16 May 2007
Summary:
The journal Nature reports on a new study which has revealed that adult skin stem cells may be able to grow hair:
"Skin may have the capacity to regenerate lost hair follicles from within, according to a new discovery that could yield better treatments for baldness or abnormal hair growth. Researchers have found that, when skin is wounded, skin cells can assume the properties of stem cells that generate hair follicles and growing new hair."
Date: 16 May 2007
Summary:
The journal Nature reports on a new study which has revealed that adult skin stem cells may be able to grow hair:
"Skin may have the capacity to regenerate lost hair follicles from within, according to a new discovery that could yield better treatments for baldness or abnormal hair growth. Researchers have found that, when skin is wounded, skin cells can assume the properties of stem cells that generate hair follicles and growing new hair."
Monday, February 12, 2007
Scientists Clone Mice From Hair Follicle Stem Cell
Source: HealthDay News
Date: February 12, 2007
Summary:
A team of researchers from Rockefeller University reported they successfully cloned mice using stem cells from the rodents' hair follicle region. The stem cells come from adult mice, are relatively easy to obtain and inject, and may become a source of stem cells for animal cloning, the team said.
Date: February 12, 2007
Summary:
A team of researchers from Rockefeller University reported they successfully cloned mice using stem cells from the rodents' hair follicle region. The stem cells come from adult mice, are relatively easy to obtain and inject, and may become a source of stem cells for animal cloning, the team said.
Tuesday, December 05, 2006
Stem cells found in adult hair follicles may provide alternative to embryonic stem cells
Source: Medical College of Wisconsin
Date: December 5, 2006
Summary:
Having recently identified the molecular signature of these epidermal neural crest stem cells in the mouse, their research resolves conflicting scientific opinions by showing that these cells are distinctly different from other types of skin-resident stem cells/progenitors. Their work provides a valuable resource for future mouse neural crest stem cell research.
Date: December 5, 2006
Summary:
Having recently identified the molecular signature of these epidermal neural crest stem cells in the mouse, their research resolves conflicting scientific opinions by showing that these cells are distinctly different from other types of skin-resident stem cells/progenitors. Their work provides a valuable resource for future mouse neural crest stem cell research.
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