Source: University of Sheffield
Date: 12 September 2012
Summary:
In research funded by the Medical Research Council and leading UK research charity, Action on Hearing Loss, experts from the University of Sheffield’s Department of Biomedical Sciences developed a method to turn human embryonic stem cells into ear cells. They then transplanted them into deaf gerbils, obtaining a functional recovery that, on average, was of around 46 per cent. The improvement was evident about four weeks after administering the cells. As well as proving that stem cells can be used to repair damaged hearing, it is hoped the breakthrough – published in the journal Nature – will lead to new treatments and therapies in the future.
Showing posts with label hearing. Show all posts
Showing posts with label hearing. Show all posts
Wednesday, September 12, 2012
Friday, February 11, 2011
HOW NASAL STEM CELLS MIGHT PREVENT CHILDHOOD DEAFNESS
Source: Garvan Institute of Medical Research
Date: 11 February 2011
Summary:
Australian scientists have shown for the first time in mice that nasal stem cells injected into the inner ear have the potential to reverse or restore hearing during early onset sensorineural hearing loss. Sensorineural hearing loss occurs when hearing cells in the cochlea lose their function. Frequently inherited, and usually starting during infancy and early childhood, the condition can slow a child’s development and lead to speech and language problems.
Drs Jeremy Sullivan, Sonali Pandit and Sharon Oleskevich from Sydney’s Garvan Institute of Medical Research, found that stem cells appear to release ‘factors’, or chemical substances, that help preserve the function of cochlear hearing cells, without the stem cells becoming part of the tissue of the inner ear. Their findings are published in STEM CELLS, now online.
Date: 11 February 2011
Summary:
Australian scientists have shown for the first time in mice that nasal stem cells injected into the inner ear have the potential to reverse or restore hearing during early onset sensorineural hearing loss. Sensorineural hearing loss occurs when hearing cells in the cochlea lose their function. Frequently inherited, and usually starting during infancy and early childhood, the condition can slow a child’s development and lead to speech and language problems.
Drs Jeremy Sullivan, Sonali Pandit and Sharon Oleskevich from Sydney’s Garvan Institute of Medical Research, found that stem cells appear to release ‘factors’, or chemical substances, that help preserve the function of cochlear hearing cells, without the stem cells becoming part of the tissue of the inner ear. Their findings are published in STEM CELLS, now online.
Thursday, May 13, 2010
Aiming to cure deafness, scientists first to create functional inner-ear cells
Source: Stanford University Medical Center
Date: May 13, 2010
Summary:
Deep inside the ear, specialized cells called hair cells detect vibrations in the air and translate them into sound. Ten years ago, Stefan Heller, PhD, professor of otolaryngology at the Stanford University School of Medicine, came up with the idea that if you could create these cells in the laboratory from stem cells, it would go a long way toward helping scientists understand the molecular basis of hearing in order to develop better treatments for deafness.
After years of lab work, researchers in Heller’s lab report in the May 14 issue of Cell that they have found a way to develop mouse cells that look and act just like the animal’s inner-ear hair cells — the linchpin to our sense of hearing and balance — in a petri dish. If they can further perfect the recipe to generate hair cells in the millions, it could lead to significant scientific and clinical advances along the path to curing deafness in the future, they said.
Date: May 13, 2010
Summary:
Deep inside the ear, specialized cells called hair cells detect vibrations in the air and translate them into sound. Ten years ago, Stefan Heller, PhD, professor of otolaryngology at the Stanford University School of Medicine, came up with the idea that if you could create these cells in the laboratory from stem cells, it would go a long way toward helping scientists understand the molecular basis of hearing in order to develop better treatments for deafness.
After years of lab work, researchers in Heller’s lab report in the May 14 issue of Cell that they have found a way to develop mouse cells that look and act just like the animal’s inner-ear hair cells — the linchpin to our sense of hearing and balance — in a petri dish. If they can further perfect the recipe to generate hair cells in the millions, it could lead to significant scientific and clinical advances along the path to curing deafness in the future, they said.
Wednesday, April 22, 2009
Cell transplants may cure deafness
Source: Uppsala University
Date: April 22, 2009
Summary:
When Uppsala researchers found immature stem cells in the inner ear of humans a few years ago, it caused a global sensation. They have also managed to grow hearing nerves from stem cells and human tissue from donated cochleae. Moving images of how nerve cells, like social, swimming beings, seek out each other are now suggesting entirely new and breathtaking perspectives to researchers. The next step will be to study how this growth is affected by electric fields. The researchers want to see, on the one hand, whether electric stimulation can get remaining nerve fibers to grow in hearing impaired individuals and, on the other hand, whether nerves can be made to grow out again after having been damaged or exposed to alcohol and other toxins.
Date: April 22, 2009
Summary:
When Uppsala researchers found immature stem cells in the inner ear of humans a few years ago, it caused a global sensation. They have also managed to grow hearing nerves from stem cells and human tissue from donated cochleae. Moving images of how nerve cells, like social, swimming beings, seek out each other are now suggesting entirely new and breathtaking perspectives to researchers. The next step will be to study how this growth is affected by electric fields. The researchers want to see, on the one hand, whether electric stimulation can get remaining nerve fibers to grow in hearing impaired individuals and, on the other hand, whether nerves can be made to grow out again after having been damaged or exposed to alcohol and other toxins.
Thursday, April 02, 2009
Cure for hearing loss one step closer
Source: University of Sheffield
Date: 02 April 2009
Summary:
Researchers at the University of Sheffield successfully isolated human stem cells and discovered how to turn these into either cells that behave like sensory hair cells or auditory neurons. The cells could be used to restore hearing. The research has been published in the May edition ofStem Cells. The results show there is now a system based on human cells for testing new therapies in the laboratory.
Date: 02 April 2009
Summary:
Researchers at the University of Sheffield successfully isolated human stem cells and discovered how to turn these into either cells that behave like sensory hair cells or auditory neurons. The cells could be used to restore hearing. The research has been published in the May edition ofStem Cells. The results show there is now a system based on human cells for testing new therapies in the laboratory.
Monday, March 23, 2009
New stem cell therapy may lead to treatment for deafness
Source: Wiley - Blackwel
Date: March 23, 2009
Summary:
A new study led by Dr. Marcelo N. Rivolta of the University of Sheffield has successfully isolated human auditory stem cells from fetal cochleae (the auditory portion of the inner ear) and found they had the capacity to differentiate into sensory hair cells and neurons. The study is published in the April issue of Stem Cells. The researchers painstakingly dissected and cultured cochlear cells from 9-11 week-old human fetuses. The cells were expanded and maintained in vitro for up to one year, with continued division for the first 7 to 8 months and up to 30 population doublings, which is similar to other non-embryonic stem cell populations, such as bone marrow. Gene expression analysis showed that all cell lines expressed otic markers that lead to the development of the inner ear as well as markers expressed by pluripotent embryonic stem cells, from which all tissues and organs develop.
Date: March 23, 2009
Summary:
A new study led by Dr. Marcelo N. Rivolta of the University of Sheffield has successfully isolated human auditory stem cells from fetal cochleae (the auditory portion of the inner ear) and found they had the capacity to differentiate into sensory hair cells and neurons. The study is published in the April issue of Stem Cells. The researchers painstakingly dissected and cultured cochlear cells from 9-11 week-old human fetuses. The cells were expanded and maintained in vitro for up to one year, with continued division for the first 7 to 8 months and up to 30 population doublings, which is similar to other non-embryonic stem cell populations, such as bone marrow. Gene expression analysis showed that all cell lines expressed otic markers that lead to the development of the inner ear as well as markers expressed by pluripotent embryonic stem cells, from which all tissues and organs develop.
Wednesday, November 19, 2008
Stem cells restore hearing, vision in animals
Source: Reuters
Posted: November 19, 2008 6:59am EST
Summary:
Reuters reports researchers have found that adult stem cells can restore hearing and vision in animals:
"Stem cells from tiny embryos can be used to restore lost hearing and vision in animals, researchers said Tuesday in what they believe is a first step toward helping people. One team repaired hearing in guinea pigs using human bone marrow stem cells, while another grew functioning eyes in tadpoles using frog cells. While there are no immediate uses for humans, they said their findings help describe some of the most basic biological processes underlying the development of hearing and sight, and may help in the development of the new field of regenerative medicine."
Posted: November 19, 2008 6:59am EST
Summary:
Reuters reports researchers have found that adult stem cells can restore hearing and vision in animals:
"Stem cells from tiny embryos can be used to restore lost hearing and vision in animals, researchers said Tuesday in what they believe is a first step toward helping people. One team repaired hearing in guinea pigs using human bone marrow stem cells, while another grew functioning eyes in tadpoles using frog cells. While there are no immediate uses for humans, they said their findings help describe some of the most basic biological processes underlying the development of hearing and sight, and may help in the development of the new field of regenerative medicine."
Wednesday, September 03, 2008
Hearing Restoration May Be Possible With Cochlear Repair After Transplant Of Human Cord Blood Cells
Source: Cell Transplantation Center
Date: September 3, 2008
Summary:
Hearing loss due to cochlear damage may be repaired by transplanting human umbilical cord hematopoietic stem cells. This study, using animal models of chemical and auditory cochlear damage, found that when transplanted stem cells migrated to the damaged area, "surprisingly few" transplanted cells were necessary to help repair sensory hair cells and neurons. Researchers say transplanting umbilical cord stem cells provides hope for the repair of human hearing impairments rising from cochlear damage.
Date: September 3, 2008
Summary:
Hearing loss due to cochlear damage may be repaired by transplanting human umbilical cord hematopoietic stem cells. This study, using animal models of chemical and auditory cochlear damage, found that when transplanted stem cells migrated to the damaged area, "surprisingly few" transplanted cells were necessary to help repair sensory hair cells and neurons. Researchers say transplanting umbilical cord stem cells provides hope for the repair of human hearing impairments rising from cochlear damage.
Sunday, June 24, 2007
Can you hear me now? Stem cells enhance hearing recovery
Source: American Journal of Pathology
Date: June 25, 2007
Summary:
Tokyo, Japan -- Researchers have shown that bone marrow stem cells injected into a damaged inner ear can speed hearing recovery after partial hearing loss. The related report by Kamiya et al, “Mesenchymal stem cell transplantation accelerates hearing recovery through the repair of injured cochlear fibrocytes,” appears in the July issue of The American Journal of Pathology.
Date: June 25, 2007
Summary:
Tokyo, Japan -- Researchers have shown that bone marrow stem cells injected into a damaged inner ear can speed hearing recovery after partial hearing loss. The related report by Kamiya et al, “Mesenchymal stem cell transplantation accelerates hearing recovery through the repair of injured cochlear fibrocytes,” appears in the July issue of The American Journal of Pathology.
Thursday, April 05, 2007
Isolation Of Stem Cells May Lead To A Treatment For Hearing Loss
Source: Case Western Reserve University
Date: April 5, 2007
Summary:
Members of the National Center for Regenerative Medicine research team, Dr. Robert Miller and Dr. Kumar Alagramam, both of Case Western Reserve University School of Medicine, recently published research findings in Developmental Neuroscience which suggest new ways of treating hearing loss. These researchers have isolated "cochlear stem cells" located in the inner ear and already primed for development into ear-related tissue due to their proximity to the ear and expression of certain genes necessary for the development of hearing.
Date: April 5, 2007
Summary:
Members of the National Center for Regenerative Medicine research team, Dr. Robert Miller and Dr. Kumar Alagramam, both of Case Western Reserve University School of Medicine, recently published research findings in Developmental Neuroscience which suggest new ways of treating hearing loss. These researchers have isolated "cochlear stem cells" located in the inner ear and already primed for development into ear-related tissue due to their proximity to the ear and expression of certain genes necessary for the development of hearing.
Tuesday, February 20, 2007
Tech Could End Deafness
Source: Wired News
Posted: February 20, 2007 10:30 AM PST
Summary:
The science of hearing is advancing to a point where new techniques, such as combining stem-cell transplants with the "recharging" of cells that power an amplifier in the ear, may enable patients to regain their hearing through manipulation of their own biology. A Stanford University professor who discovered stem cells in the inner ear, believes they can be used to cure deafness in mice within five years.
Posted: February 20, 2007 10:30 AM PST
Summary:
The science of hearing is advancing to a point where new techniques, such as combining stem-cell transplants with the "recharging" of cells that power an amplifier in the ear, may enable patients to regain their hearing through manipulation of their own biology. A Stanford University professor who discovered stem cells in the inner ear, believes they can be used to cure deafness in mice within five years.
Sunday, February 18, 2007
Loud music and noisy world take toll on hearing
Source: Associated Press
Date: February 18, 2007
Summary:
Damage to the inner cells cannot be repaired and causes deafness. Now researchers at Stanford University have isolated ear stem cells in a laboratory and coaxed them to grow into cells that resembled hair cells that have potential to restore lost hearing.
Date: February 18, 2007
Summary:
Damage to the inner cells cannot be repaired and causes deafness. Now researchers at Stanford University have isolated ear stem cells in a laboratory and coaxed them to grow into cells that resembled hair cells that have potential to restore lost hearing.
Stem cell transplants explored at Stanford as a possible treatment for hearing loss
Source: Stanford University Medical Center
Date: February 17, 2007
Summary:
Researchers at Stanford University are working to develop a variety of possible cures for deafness, focusing on two paths: drug therapy -- which could be as simple as an application of ear drops - and stem cell transplantation into the inner ear to remedy hearing loss.
Date: February 17, 2007
Summary:
Researchers at Stanford University are working to develop a variety of possible cures for deafness, focusing on two paths: drug therapy -- which could be as simple as an application of ear drops - and stem cell transplantation into the inner ear to remedy hearing loss.
Monday, March 28, 2005
Researchers Closer To Helping Hearing-Impaired Using Stem Cells
Source: Indiana University School Of Medicine
Posted: March 28, 2005
Summary:
Researchers at Indiana University School of Medicine are several steps closer to the day when a profoundly deaf patient's own bone marrow cells could be used to let him or her hear the world. They were able able to transform, in the laboratory, stem cells taken from adult bone marrow into cells with many of the characteristics of sensory nerve cells -- neurons -- found in the ear. The results suggest that these adult stem cells could be used to treat deaf patients in the future.
Posted: March 28, 2005
Summary:
Researchers at Indiana University School of Medicine are several steps closer to the day when a profoundly deaf patient's own bone marrow cells could be used to let him or her hear the world. They were able able to transform, in the laboratory, stem cells taken from adult bone marrow into cells with many of the characteristics of sensory nerve cells -- neurons -- found in the ear. The results suggest that these adult stem cells could be used to treat deaf patients in the future.
Subscribe to:
Posts (Atom)