Source: Children's Hospital Boston
Date: February 17, 2010
Summary:
Boston, Mass. -- In a study that ties stem cell research together with research on aging and cancer, investigators at Children's Hospital Boston have used genetic reprogramming to create cells from patients with a rare premature-aging disorder that are able to rebuild their telomeres--the tips of chromosomes that must be maintained to prevent a cell from "aging" and enabling it to divide and make copies of itself.
Publishing in Nature (Advance Online) on February 17, researchers in the laboratory of George Q. Daley, MD, PhD, Director of the Stem Cell Transplantation Program at Children's, report successfully reactivating the cellular enzyme telomerase, which maintains the telomeres, in patients with dyskeratosis congenita. In this rare genetic disorder, genetic mutations cause telomerase to be defective, leaving the chromosomes without protection from damage and unable to compensate for the natural shortening of telomeres that occurs when a cell divides. As a result, a patient's cells "age" more quickly, leading to bone-marrow failure (an inability to make enough blood cells), degradation of multiple tissues, premature aging-like symptoms and a much-shortened lifespan.
USA Today and Technology Review carried news stories on this news release today.
Wednesday, February 17, 2010
Tuesday, February 16, 2010
UWM engineer creates unique software that predicts stem cell fate
Source: University of Wisconsin - Milwaukee
Date: February 16, 2010
Summary:
A software program created by an engineer at the University of Wisconsin–Milwaukee (UWM) can not only predict the types of specialized cells a stem cell will produce, but also foresee the outcome before the stem cell even divides.
The software, developed by Andrew Cohen, an assistant professor of electrical engineering, analyzes time-lapse images capturing live stem cell behaviors. It will allow scientists to search for mechanisms that control stem cell specialization, the main obstacle in advancing the use of stem cell therapy for treatment of disease. It could also lead to new research into causes of cancer, which involves cells that continuously self-renew.
The research is published Feb. 7 in the journal Nature Methods. Co-authors are Michel Cayouette and Francisco Gomez neurobiologists at the Institut de recherches cliniques de Montreal, and Badri Roysam, a computer engineering professor at Rensselaer Polytechnic Institute.
The software is 87 percent accurate in determining the specific "offspring" a stem cell will ultimately produce, and 99 percent accurate in predicting when self-renewal of these stem cells will end in specialization.
Date: February 16, 2010
Summary:
A software program created by an engineer at the University of Wisconsin–Milwaukee (UWM) can not only predict the types of specialized cells a stem cell will produce, but also foresee the outcome before the stem cell even divides.
The software, developed by Andrew Cohen, an assistant professor of electrical engineering, analyzes time-lapse images capturing live stem cell behaviors. It will allow scientists to search for mechanisms that control stem cell specialization, the main obstacle in advancing the use of stem cell therapy for treatment of disease. It could also lead to new research into causes of cancer, which involves cells that continuously self-renew.
The research is published Feb. 7 in the journal Nature Methods. Co-authors are Michel Cayouette and Francisco Gomez neurobiologists at the Institut de recherches cliniques de Montreal, and Badri Roysam, a computer engineering professor at Rensselaer Polytechnic Institute.
The software is 87 percent accurate in determining the specific "offspring" a stem cell will ultimately produce, and 99 percent accurate in predicting when self-renewal of these stem cells will end in specialization.
Monday, February 15, 2010
New study suggests stem cells sabotage their own DNA to produce new tissues
Source: Ottawa Hospital Research Institute
Date: February 15, 2010
Summary:
A new study from the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa suggests that stem cells intentionally break their own DNA as a way of regulating tissue development. The study, published in Proceedings of the National Academy of Sciences (PNAS), could dramatically change how researchers think about tissue development, stem cells and cancer.
The discovery has important implications for a number of areas. It could help researchers develop better ways to activate stem cells, so that they can produce new tissues for therapeutic purposes. It also suggests that DNA mutations, which can contribute to a variety of diseases, may initially occur as a result of a normal cellular process. And it has implications for researchers developing therapies that inhibit programmed cell death, suggesting that such therapies may also inhibit normal tissue development.
Date: February 15, 2010
Summary:
A new study from the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa suggests that stem cells intentionally break their own DNA as a way of regulating tissue development. The study, published in Proceedings of the National Academy of Sciences (PNAS), could dramatically change how researchers think about tissue development, stem cells and cancer.
The discovery has important implications for a number of areas. It could help researchers develop better ways to activate stem cells, so that they can produce new tissues for therapeutic purposes. It also suggests that DNA mutations, which can contribute to a variety of diseases, may initially occur as a result of a normal cellular process. And it has implications for researchers developing therapies that inhibit programmed cell death, suggesting that such therapies may also inhibit normal tissue development.
Thursday, February 11, 2010
Cord blood stem cells show promise treating cerebral palsy
Source: KOLD-TV - Tucson, Arizona
Posted: Feb 11, 2010 3:56 PM
Updated: Feb 12, 2010 11:58 AM
Summary:
In a TV new segment, KOLD-TV News reports scientists at the Medical College of Georgia will begin the first FDA-approved trial to see if stem cells from umbilical cord blood can improve function in children with cerebral palsy:
Posted: Feb 11, 2010 3:56 PM
Updated: Feb 12, 2010 11:58 AM
Summary:
In a TV new segment, KOLD-TV News reports scientists at the Medical College of Georgia will begin the first FDA-approved trial to see if stem cells from umbilical cord blood can improve function in children with cerebral palsy:
The Medical College of Georgia will use cord blood stem cells, the building blocks of the body, to treat 40 children who have cerebral palsy, a type of brain injury. The stem cells come from each child's own cord blood stored here in Tucson when they were born. This is the first Food and Drug Administration-approved clinical trial. The study will include 40 children age 2-12 whose parents have stored cord blood at the Cord Blood Registry in Tucson, Ariz.
MCG to conduct first FDA-approved stem cell trial in pediatric cerebral palsy
Source: Medical College of Georgia
Date: February 11, 2010
Summary:
Medical College of Georgia researchers are conducting the first FDA-approved clinical trial to determine whether an infusion of stem cells from umbilical cord blood can improve the quality of life for children with cerebral palsy. The study will include 40 children age 2-12 whose parents have stored cord blood at the Cord Blood Registry in Tucson, Ariz. Umbilical cord blood is rich in stem cells, which can divide and morph into different types of cells throughout the body, said Dr. James Carroll, professor and chief of pediatric neurology in MCG School of Medicine and principal investigator on the study.
Date: February 11, 2010
Summary:
Medical College of Georgia researchers are conducting the first FDA-approved clinical trial to determine whether an infusion of stem cells from umbilical cord blood can improve the quality of life for children with cerebral palsy. The study will include 40 children age 2-12 whose parents have stored cord blood at the Cord Blood Registry in Tucson, Ariz. Umbilical cord blood is rich in stem cells, which can divide and morph into different types of cells throughout the body, said Dr. James Carroll, professor and chief of pediatric neurology in MCG School of Medicine and principal investigator on the study.
Wednesday, February 10, 2010
StemCells, Inc. Announces First Human Neural Stem Cell Transplant in Landmark Myelination Disorder Trial
Source: StemCells, Inc.
Date: February 10, 2010
Summary:
In an official company news release, Stem Cells, Inc., a biotechnology company in the field of stem cell research, announced that human neural stem cells have been used to treat Pelizaeus-Merzbacher Disease ( PMD), a pediatric neurological disorder:
Date: February 10, 2010
Summary:
In an official company news release, Stem Cells, Inc., a biotechnology company in the field of stem cell research, announced that human neural stem cells have been used to treat Pelizaeus-Merzbacher Disease ( PMD), a pediatric neurological disorder:
StemCells, Inc. announced today that its proprietary HuCNS-SC(R) human neural stem cells have been used to treat the first patient enrolled in its Phase I clinical trial in Pelizaeus-Merzbacher Disease (PMD), a myelination disorder that afflicts male children. ...Myelin is the substance that surrounds and insulates nerve cells' communications fibers (also known as axons). Without sufficient myelination, these fibers are unable to properly transmit nerve impulses, leading to a progressive loss of neurological function. Multiple sclerosis, transverse myelitis and certain types of cerebral palsy are more commonly known myelination disorders that also affect the central nervous system.
Monday, February 08, 2010
Scientists discover gene that improves the quality of reprogrammed stem cells
Source: Agency for Science, Technology and Research (A*STAR), Singapore
Date: February 8, 2010
Summary:
Scientists from the Genome Institute of Singapore (GIS), a biomedical research institute of the Agency for Science, Technology and Research (A*STAR), have discovered a genetic molecule, called Tbx3, which greatly improves the quality of stem cells that have been reprogrammed from differentiated cells (stem cells reprogrammed from differentiated cells are known as induced pluripotent stem cells or iPS cells). The study was published on 7 February 2010 in the prestigious journal Nature.
Date: February 8, 2010
Summary:
Scientists from the Genome Institute of Singapore (GIS), a biomedical research institute of the Agency for Science, Technology and Research (A*STAR), have discovered a genetic molecule, called Tbx3, which greatly improves the quality of stem cells that have been reprogrammed from differentiated cells (stem cells reprogrammed from differentiated cells are known as induced pluripotent stem cells or iPS cells). The study was published on 7 February 2010 in the prestigious journal Nature.
Sunday, February 07, 2010
Virus-free technique enables scientists to easily make stem cells pluripotent
Source: Stanford University Medical Center
Date: February 7, 2010
Summary:
Tiny circles of DNA are the key to a new and easier way to transform stem cells from human fat into induced pluripotent stem cells for use in regenerative medicine, say scientists at the Stanford University School of Medicine. Unlike other commonly used techniques, the method, which is based on standard molecular biology practices, does not use viruses to introduce genes into the cells or permanently alter a cell's genome.
It is the first example of reprogramming adult cells to pluripotency in this manner, and is hailed by the researchers as a major step toward the use of such cells in humans. They hope that the ease of the technique and its relative safety will smooth its way through the necessary FDA approval process.
The Stanford researchers used the so-called minicircles - rings of DNA about one-half the size of those usually used to reprogram cell - to induce pluripotency in stem cells from human fat. Pluripotent cells can then be induced to become many different specialized cell types. Although the researchers plan to first use these cells to better understand - and perhaps one day treat-human heart disease, induced pluripotent stem cells, or iPS cells, are a starting point for research on many human diseases. The research will be published online Feb. 7 in Nature Methods. Research assistant Fangjun Jia, PhD is the lead author of the work.
Date: February 7, 2010
Summary:
Tiny circles of DNA are the key to a new and easier way to transform stem cells from human fat into induced pluripotent stem cells for use in regenerative medicine, say scientists at the Stanford University School of Medicine. Unlike other commonly used techniques, the method, which is based on standard molecular biology practices, does not use viruses to introduce genes into the cells or permanently alter a cell's genome.
It is the first example of reprogramming adult cells to pluripotency in this manner, and is hailed by the researchers as a major step toward the use of such cells in humans. They hope that the ease of the technique and its relative safety will smooth its way through the necessary FDA approval process.
The Stanford researchers used the so-called minicircles - rings of DNA about one-half the size of those usually used to reprogram cell - to induce pluripotency in stem cells from human fat. Pluripotent cells can then be induced to become many different specialized cell types. Although the researchers plan to first use these cells to better understand - and perhaps one day treat-human heart disease, induced pluripotent stem cells, or iPS cells, are a starting point for research on many human diseases. The research will be published online Feb. 7 in Nature Methods. Research assistant Fangjun Jia, PhD is the lead author of the work.
Thursday, February 04, 2010
Scientists Map Epigenome of Human Stem Cells During Development
Source: Agency for Science, Technology and Research (ASTAR) and The Scripps Research Institute (TSRI)
Date: February 4, 2010
Summary:
Scientists at the Genome Institute of Singapore (GIS) and the Scripps Research Institute (TSRI) led an international effort to build a map that shows in detail how the human genome is modified during embryonic development. This detailed mapping is a significant move towards the success of targeted differentiation of stem cells into specific organs, which is a crucial consideration for stem cell therapy. The study was published in the genomics journal Genome Research on February 4, 2010.
Date: February 4, 2010
Summary:
Scientists at the Genome Institute of Singapore (GIS) and the Scripps Research Institute (TSRI) led an international effort to build a map that shows in detail how the human genome is modified during embryonic development. This detailed mapping is a significant move towards the success of targeted differentiation of stem cells into specific organs, which is a crucial consideration for stem cell therapy. The study was published in the genomics journal Genome Research on February 4, 2010.
Tuesday, February 02, 2010
3-D scaffold provides clean, biodegradable structure for stem cell growth
Source:University of Washington
Date: February 2, 2010
Summary:
Medical researchers were shocked to discover that virtually all human embryonic stem cell lines being used in 2005 were contaminated. Animal byproducts used to line Petri dishes had left traces on the human cells. If those cells had been implanted in a human body they likely would have been rejected by the patient's immune system. Even today, with new stem cell lines approved for use in medical research, there remains a risk that these cells will be contaminated in the same way. Most research labs still use animal-based "feeder layers" because it remains the cheapest and most reliable way to get stem cells to multiply.
Materials scientists at the University of Washington have now created an alternative. They built a three-dimensional scaffold out of a natural material that mimics the binding sites for stem cells, allowing the cells to reproduce on a clean, biodegradable structure. Results published in the journal Biomaterials show that human embryonic stem cells grow and multiply readily on the structure.
Date: February 2, 2010
Summary:
Medical researchers were shocked to discover that virtually all human embryonic stem cell lines being used in 2005 were contaminated. Animal byproducts used to line Petri dishes had left traces on the human cells. If those cells had been implanted in a human body they likely would have been rejected by the patient's immune system. Even today, with new stem cell lines approved for use in medical research, there remains a risk that these cells will be contaminated in the same way. Most research labs still use animal-based "feeder layers" because it remains the cheapest and most reliable way to get stem cells to multiply.
Materials scientists at the University of Washington have now created an alternative. They built a three-dimensional scaffold out of a natural material that mimics the binding sites for stem cells, allowing the cells to reproduce on a clean, biodegradable structure. Results published in the journal Biomaterials show that human embryonic stem cells grow and multiply readily on the structure.
Monday, February 01, 2010
New Form of Stem Cell Communication Rescues Diseased Neurons
Source: Sanford-Burnham Medical Research Institute
Date: February 1, 2010
Summary:
LA JOLLA, Calif., -- Investigators at Sanford-Burnham Medical Research Institute (Sanford-Burnham, formerly Burnham Institute for Medical Research), the Karolinska Institutet, Beth Israel Deaconess Medical Center (BIDMC), Harvard Medical School and Université Libre de Bruxelles have demonstrated in mouse models that transplanted stems cells, when in direct contact with diseased neurons, send signals through specialized channels that rescue the neurons from death. These direct cell-to-cell connections may also play a role in normal development by laying down the blueprint for more mature electrical connections between neurons and other cells. The research was published in the journal Proceedings of the National Academy of Sciences on February 1.
Date: February 1, 2010
Summary:
LA JOLLA, Calif., -- Investigators at Sanford-Burnham Medical Research Institute (Sanford-Burnham, formerly Burnham Institute for Medical Research), the Karolinska Institutet, Beth Israel Deaconess Medical Center (BIDMC), Harvard Medical School and Université Libre de Bruxelles have demonstrated in mouse models that transplanted stems cells, when in direct contact with diseased neurons, send signals through specialized channels that rescue the neurons from death. These direct cell-to-cell connections may also play a role in normal development by laying down the blueprint for more mature electrical connections between neurons and other cells. The research was published in the journal Proceedings of the National Academy of Sciences on February 1.
Friday, January 29, 2010
Novel Theory for Mammalian Stem Cell Regulation
Source: Stowers Institute for Medical Research
Date: January 29, 2010
Summary:
Linheng Li, Ph.D., a Stowers Institute Investigator, together with Hans Clevers, M.D., Ph.D., Director of the Hubrecht Institute in Utrecht, Netherlands, co-authored a prospective review published today by the journal Science that proposes a model of mammalian adult stem cell regulation that may explain how the coexistence of two disparate stem cell states regulates both stem cell maintenance and simultaneously supports rapid tissue regeneration.
Adult stem cells are crucial for physiological tissue renewal and regeneration following injury. Current models assume the existence of a single quiescent (resting) population of stem cells residing in a single niche of a given tissue. The Linheng Li Lab and others have previously reported that primitive blood-forming stem cells can be further separated into quiescent (reserved) and active (primed) sub-populations. Emerging evidence indicates that quiescent and active stem cell sub-populations also co-exist in several tissues — including hair follicle, intestine, bone marrow, and potentially in the neural system — in separate yet adjacent microenvironments. In the review, Dr. Li proposes that quiescent and active stem cell populations have separate but cooperative functional roles.
Date: January 29, 2010
Summary:
Linheng Li, Ph.D., a Stowers Institute Investigator, together with Hans Clevers, M.D., Ph.D., Director of the Hubrecht Institute in Utrecht, Netherlands, co-authored a prospective review published today by the journal Science that proposes a model of mammalian adult stem cell regulation that may explain how the coexistence of two disparate stem cell states regulates both stem cell maintenance and simultaneously supports rapid tissue regeneration.
Adult stem cells are crucial for physiological tissue renewal and regeneration following injury. Current models assume the existence of a single quiescent (resting) population of stem cells residing in a single niche of a given tissue. The Linheng Li Lab and others have previously reported that primitive blood-forming stem cells can be further separated into quiescent (reserved) and active (primed) sub-populations. Emerging evidence indicates that quiescent and active stem cell sub-populations also co-exist in several tissues — including hair follicle, intestine, bone marrow, and potentially in the neural system — in separate yet adjacent microenvironments. In the review, Dr. Li proposes that quiescent and active stem cell populations have separate but cooperative functional roles.
Thursday, January 28, 2010
Making Old Stem Cells Act Young Again
Source: Howard Hughes Medical Institute
Date: January 28, 2010
Summary:
In virtually every part of the body, stem cells stand ready to replenish mature cells lost to wounds, disease, and everyday wear and tear. But like other cells, stem cells eventually lose their normal functions as they age, leaving the body less able to repair itself. Surprisingly, this age-related decline in stem cell potency may be somewhat reversible. A team of Howard Hughes Medical Institute (HHMI) researchers has found that in old mice, a several-week exposure to the blood of young mice causes their bone marrow stem cells to act “young” again.
The researchers have not yet isolated the blood-borne factors that can switch old stem cells back to a more youthful state, but their results are consistent with other recent studies that show stem-cell aging may be reversible. Together those results suggest that it might one day be possible to boost the practical lifespan of stem cells, and thereby increase the body’s resistance to disease and age-related degeneration. The new findings are reported in an advanced online publication in Nature on January 28, 2010.
Date: January 28, 2010
Summary:
In virtually every part of the body, stem cells stand ready to replenish mature cells lost to wounds, disease, and everyday wear and tear. But like other cells, stem cells eventually lose their normal functions as they age, leaving the body less able to repair itself. Surprisingly, this age-related decline in stem cell potency may be somewhat reversible. A team of Howard Hughes Medical Institute (HHMI) researchers has found that in old mice, a several-week exposure to the blood of young mice causes their bone marrow stem cells to act “young” again.
The researchers have not yet isolated the blood-borne factors that can switch old stem cells back to a more youthful state, but their results are consistent with other recent studies that show stem-cell aging may be reversible. Together those results suggest that it might one day be possible to boost the practical lifespan of stem cells, and thereby increase the body’s resistance to disease and age-related degeneration. The new findings are reported in an advanced online publication in Nature on January 28, 2010.
Stem Cell Breakthrough: Bone Marrow Cells Are the Answer
Source: Federation of American Societies for Experimental Biology
Date: January 28, 2010
Summary:
Using cells from mice, scientists discovered a new strategy for making embryonic stem cell transplants less likely to be rejected by a recipient's immune system. This strategy involves fusing bone marrow cells to embryonic stem cells. Once fused, hybrid cells have DNA from both donor and recipient, raising hopes that immune rejection of embryonic stem cell therapies can be avoided without drugs. This strategy, described in a new research report appearing in the February 2010 print issue of The FASEB Journal, involves fusing bone marrow cells to embryonic stem cells.
Date: January 28, 2010
Summary:
Using cells from mice, scientists discovered a new strategy for making embryonic stem cell transplants less likely to be rejected by a recipient's immune system. This strategy involves fusing bone marrow cells to embryonic stem cells. Once fused, hybrid cells have DNA from both donor and recipient, raising hopes that immune rejection of embryonic stem cell therapies can be avoided without drugs. This strategy, described in a new research report appearing in the February 2010 print issue of The FASEB Journal, involves fusing bone marrow cells to embryonic stem cells.
Wednesday, January 27, 2010
Research provides insight into the reprogramming of cell fate
Source: The Babraham Institute
Date: 27 January 2010
Summary:
A discovery by Babraham scientists brings new insight into how cells are reprogrammed and a greater understanding of how the environment, or factors like nutritional signals, can interact with our genes to affect health. As an embryo develops, cells acquire a particular fate, for example becoming a nerve or skin cell. The findings, reported online in the journal Nature, pinpoint a protein called AID as being important for complete cellular reprogramming in mammals. In addition, these findings may advance the field of regenerative medicine, by potentially enhancing our ability to guide the reversal of cell fate, and pave the way for novel therapeutics.
Date: 27 January 2010
Summary:
A discovery by Babraham scientists brings new insight into how cells are reprogrammed and a greater understanding of how the environment, or factors like nutritional signals, can interact with our genes to affect health. As an embryo develops, cells acquire a particular fate, for example becoming a nerve or skin cell. The findings, reported online in the journal Nature, pinpoint a protein called AID as being important for complete cellular reprogramming in mammals. In addition, these findings may advance the field of regenerative medicine, by potentially enhancing our ability to guide the reversal of cell fate, and pave the way for novel therapeutics.
Researchers directly turn mouse skin cells into neurons, skipping IPS stage
Source: Stanford University
Date: January 27, 2010
Summary:
Even Superman needed to retire to a phone booth for a quick change. But now scientists at the Stanford University School of Medicine have succeeded in the ultimate switch: transforming mouse skin cells in a laboratory dish directly into functional nerve cells with the application of just three genes. The cells make the change without first becoming a pluripotent type of stem cell — a step long thought to be required for cells to acquire new identities. The finding, published online Jan. 27 in Nature, could revolutionize the future of human stem cell therapy and recast our understanding of how cells choose and maintain their specialties in the body.
Date: January 27, 2010
Summary:
Even Superman needed to retire to a phone booth for a quick change. But now scientists at the Stanford University School of Medicine have succeeded in the ultimate switch: transforming mouse skin cells in a laboratory dish directly into functional nerve cells with the application of just three genes. The cells make the change without first becoming a pluripotent type of stem cell — a step long thought to be required for cells to acquire new identities. The finding, published online Jan. 27 in Nature, could revolutionize the future of human stem cell therapy and recast our understanding of how cells choose and maintain their specialties in the body.
Tuesday, January 26, 2010
Targeting cancer stem cells in the lab
Source: Oxford University
Date: 26 January 2010
Summary:
Understanding of the particular cancer cells within a tumour that drive its growth could now advance more rapidly, thanks to Oxford University scientists. They show in the journal PNAS how a crucial class of cancer cell, called cancer stem cells, can be investigated in the lab in ways that should greatly speed their study, and allow the development of drugs targeted against them.
Date: 26 January 2010
Summary:
Understanding of the particular cancer cells within a tumour that drive its growth could now advance more rapidly, thanks to Oxford University scientists. They show in the journal PNAS how a crucial class of cancer cell, called cancer stem cells, can be investigated in the lab in ways that should greatly speed their study, and allow the development of drugs targeted against them.
Scientists find survival factor for keeping nerve cells healthy
Source: Babraham Institute
Date: 26 January 2010
Summary:
Scientists at the Babraham Institute have discovered a novel survival factor whose rapid transport along nerve cells is crucial for keeping them alive. The same factor seems likely to be needed to keep our nerves healthy as we age. These findings, published today in the online, open-access journal PLoS Biology, show that a molecule known as Nmnat2 provides a protective function; in its absence healthy, uninjured nerve cells start to degenerate and boosting levels of Nmnat2 can delay degeneration when the cells are injured. This suggests an exciting new therapeutic avenue for protecting nerves from disease and injury-induced degeneration.
Date: 26 January 2010
Summary:
Scientists at the Babraham Institute have discovered a novel survival factor whose rapid transport along nerve cells is crucial for keeping them alive. The same factor seems likely to be needed to keep our nerves healthy as we age. These findings, published today in the online, open-access journal PLoS Biology, show that a molecule known as Nmnat2 provides a protective function; in its absence healthy, uninjured nerve cells start to degenerate and boosting levels of Nmnat2 can delay degeneration when the cells are injured. This suggests an exciting new therapeutic avenue for protecting nerves from disease and injury-induced degeneration.
Monday, January 25, 2010
Experimental Stem Cell Treatment Arrests Acute Lung Injury in Mice, Study Shows
Source: University of Texas Health Science Center at Houston
Date: January 25, 2010
Summary:
HOUSTON -- Stem cell researchers exploring a new approach for the care of respiratory diseases report that an experimental treatment involving transplantable lung cells was associated with improved outcomes in tests on mice with acute lung injury. The lung cells were derived from human embryonic stem cells (hESCs). Findings by investigators at The University of Texas Health Science Center at Houston are scheduled to appear in the March issue of Molecular Therapy.
Date: January 25, 2010
Summary:
HOUSTON -- Stem cell researchers exploring a new approach for the care of respiratory diseases report that an experimental treatment involving transplantable lung cells was associated with improved outcomes in tests on mice with acute lung injury. The lung cells were derived from human embryonic stem cells (hESCs). Findings by investigators at The University of Texas Health Science Center at Houston are scheduled to appear in the March issue of Molecular Therapy.
Friday, January 22, 2010
Scientists shed new light on walking
Source: Karolinska Institutet
Date: 22 January 2010
Summary:
Researchers at the medical university Karolinska Institutet have created a genetically modified mouse in which certain neurons can be activated by blue light. Shining blue light on brainstems or spinal cords isolated from these mice produces walking-like motor activity. The findings, which are published in the scientific journal Nature Neuroscience, are of potential significance to the recovery of walking after spinal cord injury.
Date: 22 January 2010
Summary:
Researchers at the medical university Karolinska Institutet have created a genetically modified mouse in which certain neurons can be activated by blue light. Shining blue light on brainstems or spinal cords isolated from these mice produces walking-like motor activity. The findings, which are published in the scientific journal Nature Neuroscience, are of potential significance to the recovery of walking after spinal cord injury.
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