Source: University of Maryland Medical Center
Date: July 3, 2012
Summary:
Baltimore, MD – Researchers from the University of Maryland School of Medicine report promising results from using adult stem cells from bone marrow in mice to help create tissue cells of other organs, such as the heart, brain and pancreas -- a scientific step they hope may lead to potential new ways to replace cells lost in diseases such as diabetes, Parkinson's or Alzheimer's. The research in collaboration with the University of Paris Descartes is published online in the June 29, 2012 edition of Comptes Rendus Biologies, a publication of the French Academy of Sciences.
Showing posts with label connective tissue. Show all posts
Showing posts with label connective tissue. Show all posts
Tuesday, July 03, 2012
Monday, November 14, 2011
Self-Organized Pituitary-Like Tissue from Mouse ES Cells
Source: RIKEN
Date: 14 November 2011
Summary:
The possibility that functional, three-dimensional tissues and organs may be derived from pluripotent cells, such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), represents one of the grand challenges of stem cell research, but is also one of the fundamental goals of the emerging field of regenerative medicine. New research has shown that when ES cells are cultured under the appropriate conditions, they can be driven to self-organize into complex, three-dimensional tissue-like structures that closely resemble their physiological counterparts, a remarkable advance for the field.
New work by Hidetaka Suga of the Division of Human Stem Cell Technology, Yoshiki Sasai, Group Director of the Laboratory for Organogenesis and Neurogenesis, and others has unlocked the most recent achievement in self-organized tissue differentiation, steering mouse ESCs to give rise to tissue closely resembling the hormone-secreting component of the pituitary, known as the adenohypophysis, in vitro. Conducted in collaboration with Yutaka Oiso at the Nagoya University Graduate School of Medicine, this work was published in Nature.
Date: 14 November 2011
Summary:
The possibility that functional, three-dimensional tissues and organs may be derived from pluripotent cells, such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), represents one of the grand challenges of stem cell research, but is also one of the fundamental goals of the emerging field of regenerative medicine. New research has shown that when ES cells are cultured under the appropriate conditions, they can be driven to self-organize into complex, three-dimensional tissue-like structures that closely resemble their physiological counterparts, a remarkable advance for the field.
New work by Hidetaka Suga of the Division of Human Stem Cell Technology, Yoshiki Sasai, Group Director of the Laboratory for Organogenesis and Neurogenesis, and others has unlocked the most recent achievement in self-organized tissue differentiation, steering mouse ESCs to give rise to tissue closely resembling the hormone-secreting component of the pituitary, known as the adenohypophysis, in vitro. Conducted in collaboration with Yutaka Oiso at the Nagoya University Graduate School of Medicine, this work was published in Nature.
Thursday, May 12, 2011
Pluripotent adult stem cells power planarian regeneration
Source: Whitehead Institute for Biomedical Research
Date: May 12, 2011
Summary:
Researchers at the Whitehead Institute for Biomedical Research have determined that the planarian flatworm regenerates missing tissues by using pluripotent adult stem cells. Until now, scientists could not determine whether the dividing cells in planarians, called neoblasts, are a mixture of specialized stem cells that each regenerates specific tissues, or if individual neoblasts are pluripotent and able to regenerate all tissues. Using complementary methods, the researchers demonstrated that adult planarians not only possess pluripotent stem cells -- known as clonogenic neoblasts (cNeoblasts) -- but that a single such cell is capable of regenerating an entire animal. Their results are published in the May 13 issue of Science.
Date: May 12, 2011
Summary:
Researchers at the Whitehead Institute for Biomedical Research have determined that the planarian flatworm regenerates missing tissues by using pluripotent adult stem cells. Until now, scientists could not determine whether the dividing cells in planarians, called neoblasts, are a mixture of specialized stem cells that each regenerates specific tissues, or if individual neoblasts are pluripotent and able to regenerate all tissues. Using complementary methods, the researchers demonstrated that adult planarians not only possess pluripotent stem cells -- known as clonogenic neoblasts (cNeoblasts) -- but that a single such cell is capable of regenerating an entire animal. Their results are published in the May 13 issue of Science.
Tuesday, March 22, 2011
Stem cells in heart form scar after heart attack
Source: Baylor College of Medicine
Date: March 22, 2011
Summary:
HOUSTON -- A fibroblast is not always just a fibroblast – particularly in the heart. In a heart attack, fibroblasts – special repair cells that form a scar after injury – come from a population of stem cells that reside within the heart, said researchers from Baylor College of Medicine and the Methodist Hospital in a report that appears in the journal Cardiovascular Research. By contrast, earlier work showed that the fibroblasts responsible for fibrosis – excess fibrous connective tissue – found in cardiomyopathy or heart failure came from a special kind of white blood cell called a monocyte, which originates in the bone marrow. The finding has implications for the treatment of heart failure, said Dr. Mark Entman, chief of the division of cardiovascular sciences in the department of medicine at BCM and the paper's corresponding author.
Date: March 22, 2011
Summary:
HOUSTON -- A fibroblast is not always just a fibroblast – particularly in the heart. In a heart attack, fibroblasts – special repair cells that form a scar after injury – come from a population of stem cells that reside within the heart, said researchers from Baylor College of Medicine and the Methodist Hospital in a report that appears in the journal Cardiovascular Research. By contrast, earlier work showed that the fibroblasts responsible for fibrosis – excess fibrous connective tissue – found in cardiomyopathy or heart failure came from a special kind of white blood cell called a monocyte, which originates in the bone marrow. The finding has implications for the treatment of heart failure, said Dr. Mark Entman, chief of the division of cardiovascular sciences in the department of medicine at BCM and the paper's corresponding author.
Wednesday, January 12, 2011
Biomedical breakthrough: blood vessels for lab-grown tissues
Source: Rice University
Date: January 12, 2011
Summary:
Researchers from Rice University and Baylor College of Medicine (BCM) have broken one of the major roadblocks on the path to growing transplantable tissue in the lab: They've found a way to grow the blood vessels and capillaries needed to keep tissues alive. The new research is available online and due to appear in the January issue of the journal Acta Biomaterialia. To test these new vascular networks, the team implanted the hydrogels into the corneas of mice, where no natural vasculature exists. After injecting a dye into the mice's bloodstream, the researchers confirmed normal blood flow in the newly grown capillaries.
Date: January 12, 2011
Summary:
Researchers from Rice University and Baylor College of Medicine (BCM) have broken one of the major roadblocks on the path to growing transplantable tissue in the lab: They've found a way to grow the blood vessels and capillaries needed to keep tissues alive. The new research is available online and due to appear in the January issue of the journal Acta Biomaterialia. To test these new vascular networks, the team implanted the hydrogels into the corneas of mice, where no natural vasculature exists. After injecting a dye into the mice's bloodstream, the researchers confirmed normal blood flow in the newly grown capillaries.
Monday, November 29, 2010
Scientists report partial reversal of age-related degeneration in aged mice
Source: Dana-Farber Cancer Institute
Date: November 29, 2010
Summary:
Scientists at Dana-Farber Cancer Institute say they have for the first time partially reversed age-related degeneration in mice, resulting in new growth of the brain and testes, improved fertility, and the return of a lost cognitive function. In a report posted online by the journal Nature in advance of print publication, researchers led by Ronald A. DePinho, MD, said they achieved the milestone in aging science by engineering mice with a controllable telomerase gene. The telomerase enzyme maintains the protective caps called telomeres that shield the ends of chromosomes.
As humans age, low levels of telomerase are associated with progressive erosion of telomeres, which may then contribute to tissue degeneration and functional decline in the elderly. By creating mice with a telomerase switch, the researchers were able to generate prematurely aged mice. The switch allowed the scientists to find out whether reactivating telomerase in the animals would restore telomeres and mitigate the signs and symptoms of aging. The work showed a dramatic reversal of many aspects of aging, including reversal of brain disease and infertility.
Researchers said these results may provide new avenues for regenerative medicine, because they suggest that quiescent adult stem cells in severely aged tissues remain viable and can be reactivated to repair tissue damage. In addition, researchers said, these results may provide new avenues for regenerative medicine, because they suggest that quiescent adult stem cells in severely aged tissues remain viable and can be reactivated to repair tissue damage.
Date: November 29, 2010
Summary:
Scientists at Dana-Farber Cancer Institute say they have for the first time partially reversed age-related degeneration in mice, resulting in new growth of the brain and testes, improved fertility, and the return of a lost cognitive function. In a report posted online by the journal Nature in advance of print publication, researchers led by Ronald A. DePinho, MD, said they achieved the milestone in aging science by engineering mice with a controllable telomerase gene. The telomerase enzyme maintains the protective caps called telomeres that shield the ends of chromosomes.
As humans age, low levels of telomerase are associated with progressive erosion of telomeres, which may then contribute to tissue degeneration and functional decline in the elderly. By creating mice with a telomerase switch, the researchers were able to generate prematurely aged mice. The switch allowed the scientists to find out whether reactivating telomerase in the animals would restore telomeres and mitigate the signs and symptoms of aging. The work showed a dramatic reversal of many aspects of aging, including reversal of brain disease and infertility.
Researchers said these results may provide new avenues for regenerative medicine, because they suggest that quiescent adult stem cells in severely aged tissues remain viable and can be reactivated to repair tissue damage. In addition, researchers said, these results may provide new avenues for regenerative medicine, because they suggest that quiescent adult stem cells in severely aged tissues remain viable and can be reactivated to repair tissue damage.
Wednesday, August 25, 2010
Biosynthetic corneas restore vision in humans
Source: Ottawa Hospital Research Institute
Date: August 25, 2010
Summary:
A new study from researchers at Ottawa Hospital Research Institute in Canada and Linköping University in Sweden has shown that biosynthetic corneas can help regenerate and repair damaged eye tissue and improve vision in humans. The results, from an early phase clinical trial with 10 patients, are published in the August 25th, 2010 issue of Science Translational Medicine.
Date: August 25, 2010
Summary:
A new study from researchers at Ottawa Hospital Research Institute in Canada and Linköping University in Sweden has shown that biosynthetic corneas can help regenerate and repair damaged eye tissue and improve vision in humans. The results, from an early phase clinical trial with 10 patients, are published in the August 25th, 2010 issue of Science Translational Medicine.
Friday, July 30, 2010
Researchers Build New Joint with Stem Cells
Source: Columbia University
Date: July 30, 2010
Summary:
A pioneering study published "Online First" in The Lancet this week shows that failing joints can be replaced with a joint grown "naturally," using the host's own stem cells. The work paves the way for future joints that would last longer than today's artificial joints. The work was carried out in the Tissue Engineering and Regenerative Medicine Laboratory of Dr. Jeremy Mao, the Edward V. Zegarelli Professor at Columbia University, along with his team at Columbia University Medical Center, and colleagues from the University of Missouri and Clemson University.
Date: July 30, 2010
Summary:
A pioneering study published "Online First" in The Lancet this week shows that failing joints can be replaced with a joint grown "naturally," using the host's own stem cells. The work paves the way for future joints that would last longer than today's artificial joints. The work was carried out in the Tissue Engineering and Regenerative Medicine Laboratory of Dr. Jeremy Mao, the Edward V. Zegarelli Professor at Columbia University, along with his team at Columbia University Medical Center, and colleagues from the University of Missouri and Clemson University.
Thursday, July 29, 2010
Researchers Make Progress Toward Regenerating Tissue to Replace Joints
Source: National Institute of Biomedical Imaging and Bioengineering
Date: July 29, 2010
Summary:
A team of NIH-funded researchers has successfully regenerated rabbit joints using a cutting edge process to form the joint inside the body, or in vivo. Regenerative in vivo procedures are performed by stimulating previously irreparable organs or tissues to heal themselves. In this study, bioscaffolds, or three-dimensional structures made of biocompatible and biodegradable materials in the shape of the tissue, were infused with a protein to promote growth of the rabbit joint. The experiment demonstrated the feasibility of an approach to growing dissimilar tissues, such as cartilage and bone, derived entirely from the host’s own cells. Results of the study are in the July 29 issue of The Lancet.
Date: July 29, 2010
Summary:
A team of NIH-funded researchers has successfully regenerated rabbit joints using a cutting edge process to form the joint inside the body, or in vivo. Regenerative in vivo procedures are performed by stimulating previously irreparable organs or tissues to heal themselves. In this study, bioscaffolds, or three-dimensional structures made of biocompatible and biodegradable materials in the shape of the tissue, were infused with a protein to promote growth of the rabbit joint. The experiment demonstrated the feasibility of an approach to growing dissimilar tissues, such as cartilage and bone, derived entirely from the host’s own cells. Results of the study are in the July 29 issue of The Lancet.
Monday, April 26, 2010
NIH Study Confirms Location of Stem Cells Near Cartilage-Rich Regions in Bones
Source: NIH / National Institute of Child Health and Human Development
Date: April 26, 2010
Summary:
Working with mice, a team of researchers has pinpointed the location of bone generating stem cells in the spine, at the ends of shins, and in other bones. The team also has identified factors that control the stem cells' growth. The research was conducted at the National Institutes of Health and other institutions.
Researchers have long known that stem cells from bone marrow give rise to bone cells and to red and white blood cells. The current study is the first to identify the location of bone stem cells in the adult mouse skeleton. The researchers refer to the newly identified cells as bone stromal cells. "Stroma" is a term used to describe a supportive or connective structure in biological tissue. The term distinguishes the cells from hematopoietic stem cells, which give rise to blood cells, and which are found in bone marrow. The findings appear online in the Proceedings of the National Academy of Sciences.
Date: April 26, 2010
Summary:
Working with mice, a team of researchers has pinpointed the location of bone generating stem cells in the spine, at the ends of shins, and in other bones. The team also has identified factors that control the stem cells' growth. The research was conducted at the National Institutes of Health and other institutions.
Researchers have long known that stem cells from bone marrow give rise to bone cells and to red and white blood cells. The current study is the first to identify the location of bone stem cells in the adult mouse skeleton. The researchers refer to the newly identified cells as bone stromal cells. "Stroma" is a term used to describe a supportive or connective structure in biological tissue. The term distinguishes the cells from hematopoietic stem cells, which give rise to blood cells, and which are found in bone marrow. The findings appear online in the Proceedings of the National Academy of Sciences.
Thursday, March 18, 2010
Using stem cells to mend damaged hips
Source: University of Southampton
Date: March 18, 2010
Summary:
Bone stem cells could in future be used instead of bone from donors as part of an innovative new hip replacement treatment, according to scientists at the University of Southampton. A team from the University’s School of Medicine believe that introducing a patient’s own skeletal stem cells into the hip joint during bone grafting would encourage more successful regrowth and repair. The grafting technique is used to repair the thigh bone and joint during replacement (known as 'revision') hip replacement therapy, a procedure in which surgeons introduce donor bone to the damaged area to provide support for the new hip stem. In this collaborative study between the University of Southampton and The University of Nottingham, researchers will use adult stem cells from bone marrow in combination with an innovative impaction process and polymer scaffolds.
Date: March 18, 2010
Summary:
Bone stem cells could in future be used instead of bone from donors as part of an innovative new hip replacement treatment, according to scientists at the University of Southampton. A team from the University’s School of Medicine believe that introducing a patient’s own skeletal stem cells into the hip joint during bone grafting would encourage more successful regrowth and repair. The grafting technique is used to repair the thigh bone and joint during replacement (known as 'revision') hip replacement therapy, a procedure in which surgeons introduce donor bone to the damaged area to provide support for the new hip stem. In this collaborative study between the University of Southampton and The University of Nottingham, researchers will use adult stem cells from bone marrow in combination with an innovative impaction process and polymer scaffolds.
Monday, February 15, 2010
New study suggests stem cells sabotage their own DNA to produce new tissues
Source: Ottawa Hospital Research Institute
Date: February 15, 2010
Summary:
A new study from the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa suggests that stem cells intentionally break their own DNA as a way of regulating tissue development. The study, published in Proceedings of the National Academy of Sciences (PNAS), could dramatically change how researchers think about tissue development, stem cells and cancer.
The discovery has important implications for a number of areas. It could help researchers develop better ways to activate stem cells, so that they can produce new tissues for therapeutic purposes. It also suggests that DNA mutations, which can contribute to a variety of diseases, may initially occur as a result of a normal cellular process. And it has implications for researchers developing therapies that inhibit programmed cell death, suggesting that such therapies may also inhibit normal tissue development.
Date: February 15, 2010
Summary:
A new study from the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa suggests that stem cells intentionally break their own DNA as a way of regulating tissue development. The study, published in Proceedings of the National Academy of Sciences (PNAS), could dramatically change how researchers think about tissue development, stem cells and cancer.
The discovery has important implications for a number of areas. It could help researchers develop better ways to activate stem cells, so that they can produce new tissues for therapeutic purposes. It also suggests that DNA mutations, which can contribute to a variety of diseases, may initially occur as a result of a normal cellular process. And it has implications for researchers developing therapies that inhibit programmed cell death, suggesting that such therapies may also inhibit normal tissue development.
Thursday, June 25, 2009
Stem Cells Created From Pigs' Connective Tissue Cells
Source: University of Missouri - Columbia
Date: June 25, 2009
Summary:
Scientists at the University of Missouri have developed the ability to take regular cells from a pig's connective tissues, known as fibroblasts, and transform them into stem cells, eliminating several of the hurdles associated with stem cell research. The new study appeared in a recent issue of the Proceedings of the National Academy of Science (PNAS).
Date: June 25, 2009
Summary:
Scientists at the University of Missouri have developed the ability to take regular cells from a pig's connective tissues, known as fibroblasts, and transform them into stem cells, eliminating several of the hurdles associated with stem cell research. The new study appeared in a recent issue of the Proceedings of the National Academy of Science (PNAS).
Thursday, August 28, 2008
Army researchers try to regrow fingers from 'pixie dust'
Source: United States Army
Date: August 28, 2008
Summary:
A powder that regrows limbs sounds like the stuff of fairy tales, but medical experts here are hoping they can use it to make magic happen for wounded warriors. Doctors from the U.S. Army Institute of Surgical Research are trying a regenerative medicine powder in hopes of stimulating tissue growth in Soldiers with missing extremities.
Date: August 28, 2008
Summary:
A powder that regrows limbs sounds like the stuff of fairy tales, but medical experts here are hoping they can use it to make magic happen for wounded warriors. Doctors from the U.S. Army Institute of Surgical Research are trying a regenerative medicine powder in hopes of stimulating tissue growth in Soldiers with missing extremities.
Tuesday, June 17, 2008
Researchers find key developmental pathway activates lung stem cells
Source: University of Pennsylvania
Date: June 17, 2008
Summary:
Researchers from the University of Pennsylvania School of Medicine found that the activation of a molecular pathway important in stem cell and developmental biology leads to an increase in lung stem cells. Harnessing this knowledge could help develop therapies for lung-tissue repair after injury or disease. The investigators published their findings online last week in advance of print publication in Nature Genetics.
Date: June 17, 2008
Summary:
Researchers from the University of Pennsylvania School of Medicine found that the activation of a molecular pathway important in stem cell and developmental biology leads to an increase in lung stem cells. Harnessing this knowledge could help develop therapies for lung-tissue repair after injury or disease. The investigators published their findings online last week in advance of print publication in Nature Genetics.
Wednesday, February 06, 2008
Grow Your Own Replacement Parts
Source:CBS News
Date: February 6, 2008
CBS News reports researchers at Wake Forest University are working on using stem cells to grow organs for transplants. A streaming CBS News video accompanies this story.
Date: February 6, 2008
CBS News reports researchers at Wake Forest University are working on using stem cells to grow organs for transplants. A streaming CBS News video accompanies this story.
Thursday, September 13, 2007
Scientists discover how to isolate stem cells in womb tissue
Source: European Society for Human Reproduction and Embryology
Date: September 13, 2007
Summary:
Scientists in Australia have found a way of identifying probable stem cells in the lining of women’s wombs. The finding opens up the possibility of using the stem cells for tissue engineering applications such as building up natural tissue to repair prolapsed pelvic floors. Pelvic floor prolapse is a common condition, affecting over 50% of women after childbirth; around one in ten women have surgery and a third of these women require repeated operations to correct the problem.
Date: September 13, 2007
Summary:
Scientists in Australia have found a way of identifying probable stem cells in the lining of women’s wombs. The finding opens up the possibility of using the stem cells for tissue engineering applications such as building up natural tissue to repair prolapsed pelvic floors. Pelvic floor prolapse is a common condition, affecting over 50% of women after childbirth; around one in ten women have surgery and a third of these women require repeated operations to correct the problem.
Monday, September 10, 2007
Scientists identify stem cells in tendons
Source: United Press International
Posted: Published: September 10, 2007 at 10:28 AM ET
Summary:
U.S. scientists have discovered stem cells in adult tendons can regenerate tissue -- a finding that promises new treatments for tendon injury and disease.
Posted: Published: September 10, 2007 at 10:28 AM ET
Summary:
U.S. scientists have discovered stem cells in adult tendons can regenerate tissue -- a finding that promises new treatments for tendon injury and disease.
USC researcher identifies stem cells in tendons that regenerate tissue in animal model
Source: University of Southern California
Date: September 10, 2007
Summary:
Athletes know that damage to a tendon can signal an end to their professional careers. But a consortium of scientists, led in part by University of Southern California (USC) School of Dentistry researcher Songtao Shi, has identified unique cells within the adult tendon that have stem-cell characteristics—including the ability to proliferate and self-renew. The research team was able to isolate these cells and regenerate tendon-like tissue in the animal model. Their findings hold tremendous promise for the treatment of tendon injuries caused by overuse and trauma.
Date: September 10, 2007
Summary:
Athletes know that damage to a tendon can signal an end to their professional careers. But a consortium of scientists, led in part by University of Southern California (USC) School of Dentistry researcher Songtao Shi, has identified unique cells within the adult tendon that have stem-cell characteristics—including the ability to proliferate and self-renew. The research team was able to isolate these cells and regenerate tendon-like tissue in the animal model. Their findings hold tremendous promise for the treatment of tendon injuries caused by overuse and trauma.
Sunday, September 09, 2007
Researchers Isolate Adult Stem Cells for First Time in Tendon
Source: NIH/National Institute of Dental and Craniofacial Research (NIDCR)
Posted: September 9, 2007 1:00 pm EDT
Summary:
Tendon, the cord-like tissue that connects muscle to bone, contains a small subset of previously unknown adult stem cells, scientists at the National Institute of Dental and Craniofacial Research (NIDCR) part of the National Institutes of Health, and their colleagues have discovered. The finding, published online today in the journal Nature Medicine, points to a natural source of tendon-producing cells in adults and raises the possibility that, with further research, these cells one day could help to mend torn or degenerating tendons that are slow to heal.
Posted: September 9, 2007 1:00 pm EDT
Summary:
Tendon, the cord-like tissue that connects muscle to bone, contains a small subset of previously unknown adult stem cells, scientists at the National Institute of Dental and Craniofacial Research (NIDCR) part of the National Institutes of Health, and their colleagues have discovered. The finding, published online today in the journal Nature Medicine, points to a natural source of tendon-producing cells in adults and raises the possibility that, with further research, these cells one day could help to mend torn or degenerating tendons that are slow to heal.
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