Source: BioMed Central
Date: November 15, 2010
Summary:
Umbilical cord stem cells may be useful in the treatment of rheumatoid arthritis (RA). Animal and in vitro experiments, described in BioMed Central's open access journal Arthritis Research and Therapy, have shown that mesenchymal stem cells (MSCs) taken from umbilical cord blood can suppress inflammation and attenuate collagen-induced arthritis. The researchers took immune cells from RA patients and showed that the umbilical MSCs were able to suppress the cells' proliferation, invasive behavior and inflammatory responses. Systemic infusion of the umbilical MSCs into mice was shown to significantly reduce the severity of collagen-induced arthritis.
Showing posts with label joint. Show all posts
Showing posts with label joint. Show all posts
Wednesday, November 17, 2010
Monday, October 18, 2010
Scientists turn stem cells into cells for cartilage repair
Source: University of Manchester
Date: 18 October 2010
Summary:
Scientists have turned embryonic stem cells into the cells that produce cartilage, which could be used to repair damaged and diseased joints. The team, based at The University of Manchester and Central Manchester NHS Foundation Trust, hope this work will lead the way to the use of human embryonic stem cells to provide cheaper and more readily available treatments for joint diseases and that the principles can be developed for other chronic human conditions.
Date: 18 October 2010
Summary:
Scientists have turned embryonic stem cells into the cells that produce cartilage, which could be used to repair damaged and diseased joints. The team, based at The University of Manchester and Central Manchester NHS Foundation Trust, hope this work will lead the way to the use of human embryonic stem cells to provide cheaper and more readily available treatments for joint diseases and that the principles can be developed for other chronic human conditions.
Friday, July 30, 2010
Researchers Build New Joint with Stem Cells
Source: Columbia University
Date: July 30, 2010
Summary:
A pioneering study published "Online First" in The Lancet this week shows that failing joints can be replaced with a joint grown "naturally," using the host's own stem cells. The work paves the way for future joints that would last longer than today's artificial joints. The work was carried out in the Tissue Engineering and Regenerative Medicine Laboratory of Dr. Jeremy Mao, the Edward V. Zegarelli Professor at Columbia University, along with his team at Columbia University Medical Center, and colleagues from the University of Missouri and Clemson University.
Date: July 30, 2010
Summary:
A pioneering study published "Online First" in The Lancet this week shows that failing joints can be replaced with a joint grown "naturally," using the host's own stem cells. The work paves the way for future joints that would last longer than today's artificial joints. The work was carried out in the Tissue Engineering and Regenerative Medicine Laboratory of Dr. Jeremy Mao, the Edward V. Zegarelli Professor at Columbia University, along with his team at Columbia University Medical Center, and colleagues from the University of Missouri and Clemson University.
Thursday, July 29, 2010
Researchers Make Progress Toward Regenerating Tissue to Replace Joints
Source: National Institute of Biomedical Imaging and Bioengineering
Date: July 29, 2010
Summary:
A team of NIH-funded researchers has successfully regenerated rabbit joints using a cutting edge process to form the joint inside the body, or in vivo. Regenerative in vivo procedures are performed by stimulating previously irreparable organs or tissues to heal themselves. In this study, bioscaffolds, or three-dimensional structures made of biocompatible and biodegradable materials in the shape of the tissue, were infused with a protein to promote growth of the rabbit joint. The experiment demonstrated the feasibility of an approach to growing dissimilar tissues, such as cartilage and bone, derived entirely from the host’s own cells. Results of the study are in the July 29 issue of The Lancet.
Date: July 29, 2010
Summary:
A team of NIH-funded researchers has successfully regenerated rabbit joints using a cutting edge process to form the joint inside the body, or in vivo. Regenerative in vivo procedures are performed by stimulating previously irreparable organs or tissues to heal themselves. In this study, bioscaffolds, or three-dimensional structures made of biocompatible and biodegradable materials in the shape of the tissue, were infused with a protein to promote growth of the rabbit joint. The experiment demonstrated the feasibility of an approach to growing dissimilar tissues, such as cartilage and bone, derived entirely from the host’s own cells. Results of the study are in the July 29 issue of The Lancet.
Wednesday, July 28, 2010
Rabbits grow their own joint replacements in study
Source: Reuters
Posted: July 28, 2010 6:32pm EDT
Summary:
Reuters reports rabbits implanted with artificial bones re-grew their own joints:
Posted: July 28, 2010 6:32pm EDT
Summary:
Reuters reports rabbits implanted with artificial bones re-grew their own joints:
Rabbits implanted with artificial bones re-grew their own joints, complete with cartilage, researchers reported on Thursday. Only a single compound called a growth factor was needed to induce the rabbits' bodies to remodel the joint tissue, said the team at Columbia University in New York, Clemson University in South Carolina and the University of Missouri.
Tuesday, June 08, 2010
Researchers Convert Stem Cells into Cartilage
Source: University of Connecticut
Date: June 8, 2010
Summary:
For the millions of aging Americans who suffer from joint pain, stem cells may be riding to the rescue. Scientists at the University of Connecticut Health Center have recently developed a technique that reliably converts stem cells into cartilage cells. Someday, that might allow doctors to grow replacement cartilage in a laboratory for the surgical repair of joints lost to injury or impaired by degenerative diseases such as arthritis.
Stem cells have an unlimited capacity for self-renewal, as well as the ability to become any type of cell in the human body, so they are ideal for generating replacement cartilage tissue to repair damaged cartilage. Developmental biologists, like Dr. Caroline Dealy, an associate professor at UConn’s Center for Regenerative Medicine and Skeletal Development, are attempting to understand the signals and conditions that regulate how stem cells differentiate into articular chondrocytes – which make up the unique type of cartilage present at the surface of joints.
Research published in the Journal of Cellular Physiology in April details how Dealy and her colleague, Dr. Robert Kosher, a former professor at the Health Center, successfully developed a methodology to direct “substantially uniform and progressive in vitro differentiation of human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) into the chondrogenic lineage.”
Date: June 8, 2010
Summary:
For the millions of aging Americans who suffer from joint pain, stem cells may be riding to the rescue. Scientists at the University of Connecticut Health Center have recently developed a technique that reliably converts stem cells into cartilage cells. Someday, that might allow doctors to grow replacement cartilage in a laboratory for the surgical repair of joints lost to injury or impaired by degenerative diseases such as arthritis.
Stem cells have an unlimited capacity for self-renewal, as well as the ability to become any type of cell in the human body, so they are ideal for generating replacement cartilage tissue to repair damaged cartilage. Developmental biologists, like Dr. Caroline Dealy, an associate professor at UConn’s Center for Regenerative Medicine and Skeletal Development, are attempting to understand the signals and conditions that regulate how stem cells differentiate into articular chondrocytes – which make up the unique type of cartilage present at the surface of joints.
Research published in the Journal of Cellular Physiology in April details how Dealy and her colleague, Dr. Robert Kosher, a former professor at the Health Center, successfully developed a methodology to direct “substantially uniform and progressive in vitro differentiation of human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) into the chondrogenic lineage.”
Thursday, March 18, 2010
Using stem cells to mend damaged hips
Source: University of Southampton
Date: March 18, 2010
Summary:
Bone stem cells could in future be used instead of bone from donors as part of an innovative new hip replacement treatment, according to scientists at the University of Southampton. A team from the University’s School of Medicine believe that introducing a patient’s own skeletal stem cells into the hip joint during bone grafting would encourage more successful regrowth and repair. The grafting technique is used to repair the thigh bone and joint during replacement (known as 'revision') hip replacement therapy, a procedure in which surgeons introduce donor bone to the damaged area to provide support for the new hip stem. In this collaborative study between the University of Southampton and The University of Nottingham, researchers will use adult stem cells from bone marrow in combination with an innovative impaction process and polymer scaffolds.
Date: March 18, 2010
Summary:
Bone stem cells could in future be used instead of bone from donors as part of an innovative new hip replacement treatment, according to scientists at the University of Southampton. A team from the University’s School of Medicine believe that introducing a patient’s own skeletal stem cells into the hip joint during bone grafting would encourage more successful regrowth and repair. The grafting technique is used to repair the thigh bone and joint during replacement (known as 'revision') hip replacement therapy, a procedure in which surgeons introduce donor bone to the damaged area to provide support for the new hip stem. In this collaborative study between the University of Southampton and The University of Nottingham, researchers will use adult stem cells from bone marrow in combination with an innovative impaction process and polymer scaffolds.
Tuesday, October 20, 2009
Growing Cartilage from Stem Cells
Source: University of California - Davis
Date: October 20, 2009
Summary:
Damaged knee joints might one day be repaired with cartilage grown from stem cells in a laboratory, based on research by Professor Kyriacos Athanasiou, chair of the UC Davis Department of Biomedical Engineering and his colleagues. Using adult stem cells from bone marrow and skin as well as human embryonic stem cells, Athanasiou and his group have already grown cartilage tissue in the lab. Now they are experimenting with various chemical and mechanical stimuli to improve its properties.
Date: October 20, 2009
Summary:
Damaged knee joints might one day be repaired with cartilage grown from stem cells in a laboratory, based on research by Professor Kyriacos Athanasiou, chair of the UC Davis Department of Biomedical Engineering and his colleagues. Using adult stem cells from bone marrow and skin as well as human embryonic stem cells, Athanasiou and his group have already grown cartilage tissue in the lab. Now they are experimenting with various chemical and mechanical stimuli to improve its properties.
Monday, July 20, 2009
Students Embed Stem Cells in Sutures to Enhance Healing
Source: Johns Hopkins University
Date: July 20, 2009
Summary:
Johns Hopkins biomedical engineering students have demonstrated a practical way to embed a patient’s own adult stem cells in the surgical thread that doctors use to repair serious orthopedic injuries such as ruptured tendons. The goal, the students said, is to enhance healing and reduce the likelihood of re-injury without changing the surgical procedure itself.
Date: July 20, 2009
Summary:
Johns Hopkins biomedical engineering students have demonstrated a practical way to embed a patient’s own adult stem cells in the surgical thread that doctors use to repair serious orthopedic injuries such as ruptured tendons. The goal, the students said, is to enhance healing and reduce the likelihood of re-injury without changing the surgical procedure itself.
Friday, April 11, 2008
Stem Cells Offer Cartilage Repair Hope For Arthritis Sufferers
Source: Biotechnology and Biological Sciences Research Council
Date: April 11, 2008
Summary:
Research being presented today at the UK National Stem Cell Network Annual Science Meeting in Edinburgh could offer hope that bone stem cells may be harnessed to repair the damaged cartilage that is one of the main symptoms of osteoarthritis. Scientists at Cardiff University have successfully identified stem cells within articular cartilage of adults, which although it cannot become any cell in the body like full stem cells, has the ability to derive into chondrocytes - the cells that make up the body’s cartilage – in high enough numbers to make treatment a realistic possibility. The team have even been able to identify the cells in people over 75 years of age.
Date: April 11, 2008
Summary:
Research being presented today at the UK National Stem Cell Network Annual Science Meeting in Edinburgh could offer hope that bone stem cells may be harnessed to repair the damaged cartilage that is one of the main symptoms of osteoarthritis. Scientists at Cardiff University have successfully identified stem cells within articular cartilage of adults, which although it cannot become any cell in the body like full stem cells, has the ability to derive into chondrocytes - the cells that make up the body’s cartilage – in high enough numbers to make treatment a realistic possibility. The team have even been able to identify the cells in people over 75 years of age.
Tuesday, March 04, 2008
Watery Pools in Bone Marrow Key to Psoriatic Arthritic Damage
Source: University of Rochester Medical Center
Date: March 4, 2008
Summary:
Researchers have learned more about how a leading drug prevents certain types of arthritis from eating away at bone. Precursors to bone-eating cells are a likely target of next-generation arthritis treatments. The findings may soon enable physicians to tell patients quickly whether or not they will respond to current therapies. In addition, the findings may help with the design of new drugs that prevent arthritis-related bone loss, but with fewer side effects.
Date: March 4, 2008
Summary:
Researchers have learned more about how a leading drug prevents certain types of arthritis from eating away at bone. Precursors to bone-eating cells are a likely target of next-generation arthritis treatments. The findings may soon enable physicians to tell patients quickly whether or not they will respond to current therapies. In addition, the findings may help with the design of new drugs that prevent arthritis-related bone loss, but with fewer side effects.
Tuesday, October 16, 2007
Stem cell growth 'may help hip replacements'
Source: Daily Telegraph
Posted: 16/10/2007 12:01am BST
Summary:
The Daily Telegraph reports scientists are researching a new way to use bone marrow stem cell to improve outcomes of hip replacements:
"British scientists are developing a promising way to harvest a patient's stem cells in the hope it can boost the success rate of 'revision hip replacements'."
The article continues to explain how the procedure would be performed and what outcome is expected if a potential treatment is created:
"The cells would be removed from bone marrow and extracted from the patient's hip under anaesthetic. Stem cells from the marrow are isolated, then grown in the laboratory in sterile conditions and used to seed new growth in the bone chips. It is hoped this will create a more effective way to fix bone damage and inflammation caused by debris from the old artificial joint."
Posted: 16/10/2007 12:01am BST
Summary:
The Daily Telegraph reports scientists are researching a new way to use bone marrow stem cell to improve outcomes of hip replacements:
"British scientists are developing a promising way to harvest a patient's stem cells in the hope it can boost the success rate of 'revision hip replacements'."
The article continues to explain how the procedure would be performed and what outcome is expected if a potential treatment is created:
"The cells would be removed from bone marrow and extracted from the patient's hip under anaesthetic. Stem cells from the marrow are isolated, then grown in the laboratory in sterile conditions and used to seed new growth in the bone chips. It is hoped this will create a more effective way to fix bone damage and inflammation caused by debris from the old artificial joint."
Monday, September 10, 2007
Scientists identify stem cells in tendons
Source: United Press International
Posted: Published: September 10, 2007 at 10:28 AM ET
Summary:
U.S. scientists have discovered stem cells in adult tendons can regenerate tissue -- a finding that promises new treatments for tendon injury and disease.
Posted: Published: September 10, 2007 at 10:28 AM ET
Summary:
U.S. scientists have discovered stem cells in adult tendons can regenerate tissue -- a finding that promises new treatments for tendon injury and disease.
USC researcher identifies stem cells in tendons that regenerate tissue in animal model
Source: University of Southern California
Date: September 10, 2007
Summary:
Athletes know that damage to a tendon can signal an end to their professional careers. But a consortium of scientists, led in part by University of Southern California (USC) School of Dentistry researcher Songtao Shi, has identified unique cells within the adult tendon that have stem-cell characteristics—including the ability to proliferate and self-renew. The research team was able to isolate these cells and regenerate tendon-like tissue in the animal model. Their findings hold tremendous promise for the treatment of tendon injuries caused by overuse and trauma.
Date: September 10, 2007
Summary:
Athletes know that damage to a tendon can signal an end to their professional careers. But a consortium of scientists, led in part by University of Southern California (USC) School of Dentistry researcher Songtao Shi, has identified unique cells within the adult tendon that have stem-cell characteristics—including the ability to proliferate and self-renew. The research team was able to isolate these cells and regenerate tendon-like tissue in the animal model. Their findings hold tremendous promise for the treatment of tendon injuries caused by overuse and trauma.
Sunday, September 09, 2007
Researchers Isolate Adult Stem Cells for First Time in Tendon
Source: NIH/National Institute of Dental and Craniofacial Research (NIDCR)
Posted: September 9, 2007 1:00 pm EDT
Summary:
Tendon, the cord-like tissue that connects muscle to bone, contains a small subset of previously unknown adult stem cells, scientists at the National Institute of Dental and Craniofacial Research (NIDCR) part of the National Institutes of Health, and their colleagues have discovered. The finding, published online today in the journal Nature Medicine, points to a natural source of tendon-producing cells in adults and raises the possibility that, with further research, these cells one day could help to mend torn or degenerating tendons that are slow to heal.
Posted: September 9, 2007 1:00 pm EDT
Summary:
Tendon, the cord-like tissue that connects muscle to bone, contains a small subset of previously unknown adult stem cells, scientists at the National Institute of Dental and Craniofacial Research (NIDCR) part of the National Institutes of Health, and their colleagues have discovered. The finding, published online today in the journal Nature Medicine, points to a natural source of tendon-producing cells in adults and raises the possibility that, with further research, these cells one day could help to mend torn or degenerating tendons that are slow to heal.
Thursday, September 06, 2007
Embryonic stem cells used to grow cartilage
Source: Rice University
Date: September 6, 2007
Summary:
Rice University biomedical engineers have developed a new technique for growing cartilage from human embryonic stem cells, a method that could be used to grow replacement cartilage for the surgical repair of knee, jaw, hip, and other joints.
Date: September 6, 2007
Summary:
Rice University biomedical engineers have developed a new technique for growing cartilage from human embryonic stem cells, a method that could be used to grow replacement cartilage for the surgical repair of knee, jaw, hip, and other joints.
Monday, August 20, 2007
Mesoblast's Stem Cells Protect Knee Cartilage in Osteoarthritis
Source: Mesoblast Limited
Date: August 20, 2007
Summary:
Australian Adult stem cell company Mesoblast Limited announced that preclinical trials using adult stem cells significantly protected knee cartilage against damage in osteoarthritis.
Date: August 20, 2007
Summary:
Australian Adult stem cell company Mesoblast Limited announced that preclinical trials using adult stem cells significantly protected knee cartilage against damage in osteoarthritis.
Tuesday, February 06, 2007
Stem Cells May Help Heal Joint Injuries
Source: University of Guelph
Date: February 6, 2007
Summary:
As anyone who’s ever injured a knee or elbow will tell you, recovery can be a long and painful process. Cartilage is an exceptionally slow-healing tissue, and, until now, the missing or damaged tissue is often irreplaceable. Researchers at the University of Guelph are hoping stem cells might provide the needed tissue replacements and improve cartilage healing after joint injuries.
Date: February 6, 2007
Summary:
As anyone who’s ever injured a knee or elbow will tell you, recovery can be a long and painful process. Cartilage is an exceptionally slow-healing tissue, and, until now, the missing or damaged tissue is often irreplaceable. Researchers at the University of Guelph are hoping stem cells might provide the needed tissue replacements and improve cartilage healing after joint injuries.
Tuesday, April 04, 2006
Factor Stimulates Cartilage Growth From Stem Cells
Source: Duke University Medical Center
Date: April 4, 2006
Summary:
A novel growth factor significantly improves the ability of specialized stem cells derived from human fat to be transformed into cartilage cells, according to Duke University Medical Center and Pratt School of Engineering researchers.
Date: April 4, 2006
Summary:
A novel growth factor significantly improves the ability of specialized stem cells derived from human fat to be transformed into cartilage cells, according to Duke University Medical Center and Pratt School of Engineering researchers.
Sunday, December 18, 2005
New hope for arthritis sufferers
Source: BBC NEWS:
Published: 2005/12/18 19:56:44 GMT
Summary:
BBC News reports on an advancement in growing cartilage from adult bone marrow stem cells to attempt to treat arthritis:
"Scientists say they have made a significant step towards finding a new treatment for osteoarthritis. Researchers at Bristol University successfully grew new cartilage from a patient's own stem cells. Experts from Bristol University grew a piece of cartilage using stem cells from the bone marrow of people undergoing hip replacement operations because of the disease. The new technique is expected to overcome problems of transplant rejection because the patient's own cells are used to create the cartilage. Ethical concerns over using human embryos in stem cell research can also be avoided. They hope the technique will allow them to carry out transplants in the future."
Published: 2005/12/18 19:56:44 GMT
Summary:
BBC News reports on an advancement in growing cartilage from adult bone marrow stem cells to attempt to treat arthritis:
"Scientists say they have made a significant step towards finding a new treatment for osteoarthritis. Researchers at Bristol University successfully grew new cartilage from a patient's own stem cells. Experts from Bristol University grew a piece of cartilage using stem cells from the bone marrow of people undergoing hip replacement operations because of the disease. The new technique is expected to overcome problems of transplant rejection because the patient's own cells are used to create the cartilage. Ethical concerns over using human embryos in stem cell research can also be avoided. They hope the technique will allow them to carry out transplants in the future."
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