Source: Journal of Clinical Investigation
Date: January 17, 2011
Summary:
In new research, Noriyuki Tsumaki and his team at the Osaka University Graduate School of Medicine, used fibroblasts isolated from adult mouse skin, and expressed proteins used to induce pluripotency along with a factor that promotes a chondrocyte fate. The resulting cells resembled chondrocytes and produced cartilage when injected into mice. This may be an important step toward a therapy that will allow the repair of cartilage injury using a patient's own skin cells.
In the study, researchers used fibroblasts isolated from adult mouse skin, and expressed proteins that have previously been used to induce pluripotency along with a factor that promotes a chondrocyte fate. This produced cells with traits that resembled chondrocytes and produced cartilage when injected into mice. The researchers believe this may be an important step toward a therapy that will allow th e repair of cartilage injury using a patient's own skin cells. The research is published in the Journal of Clinical Investigation.
Showing posts with label cartilage. Show all posts
Showing posts with label cartilage. Show all posts
Monday, January 17, 2011
Sunday, November 21, 2010
Study of genetic disease reveals new path to cell reprogramming
Source: Harvard University
Date: November 21, 2010
Summary:
As debilitating as disease can be, sometimes it acts as a teacher. Researchers at Harvard Medical School and the Harvard School of Dental Medicine have found that by mimicking a rare genetic disorder in a dish they can rewind the internal clock of a mature cell and drive it back into an adult stem-cell stage. This new “stem cell” can then branch out into a variety of differentiated cell types, both in culture and in animal models. These findings appear online in Nature Medicine on Nov. 21.
Date: November 21, 2010
Summary:
As debilitating as disease can be, sometimes it acts as a teacher. Researchers at Harvard Medical School and the Harvard School of Dental Medicine have found that by mimicking a rare genetic disorder in a dish they can rewind the internal clock of a mature cell and drive it back into an adult stem-cell stage. This new “stem cell” can then branch out into a variety of differentiated cell types, both in culture and in animal models. These findings appear online in Nature Medicine on Nov. 21.
Tuesday, November 16, 2010
Bioengineers Provide Adult Stem Cells with Friendly Environment: Simultaneous Chemical, Electrical and Mechanical Cues
Source: University of California - San Diego
Date: November 16, 2010
Summary:
Bioengineers from the University of California, San Diego have achieved the “Triple Crown” of stem cell culture – they created an artificial environment for stem cells that simultaneously provides the chemical, mechanical and electrical cues necessary for stem cell growth and differentiation. Building better microenvironments for nurturing stem cells is critical for realizing the promises of stem-cell-based regenerative medicine, including cartilage for joint repair, cardiac cells for damaged hearts, and healthy skeletal myoblasts for muscular dystrophy patients. The advance could also lead to better model systems for fundamental stem cell research. This work appears in a paper published online in Advanced Functional Materials on November 13.
Date: November 16, 2010
Summary:
Bioengineers from the University of California, San Diego have achieved the “Triple Crown” of stem cell culture – they created an artificial environment for stem cells that simultaneously provides the chemical, mechanical and electrical cues necessary for stem cell growth and differentiation. Building better microenvironments for nurturing stem cells is critical for realizing the promises of stem-cell-based regenerative medicine, including cartilage for joint repair, cardiac cells for damaged hearts, and healthy skeletal myoblasts for muscular dystrophy patients. The advance could also lead to better model systems for fundamental stem cell research. This work appears in a paper published online in Advanced Functional Materials on November 13.
Monday, October 18, 2010
Scientists turn stem cells into cells for cartilage repair
Source: University of Manchester
Date: 18 October 2010
Summary:
Scientists have turned embryonic stem cells into the cells that produce cartilage, which could be used to repair damaged and diseased joints. The team, based at The University of Manchester and Central Manchester NHS Foundation Trust, hope this work will lead the way to the use of human embryonic stem cells to provide cheaper and more readily available treatments for joint diseases and that the principles can be developed for other chronic human conditions.
Date: 18 October 2010
Summary:
Scientists have turned embryonic stem cells into the cells that produce cartilage, which could be used to repair damaged and diseased joints. The team, based at The University of Manchester and Central Manchester NHS Foundation Trust, hope this work will lead the way to the use of human embryonic stem cells to provide cheaper and more readily available treatments for joint diseases and that the principles can be developed for other chronic human conditions.
Thursday, July 29, 2010
Researchers Make Progress Toward Regenerating Tissue to Replace Joints
Source: National Institute of Biomedical Imaging and Bioengineering
Date: July 29, 2010
Summary:
A team of NIH-funded researchers has successfully regenerated rabbit joints using a cutting edge process to form the joint inside the body, or in vivo. Regenerative in vivo procedures are performed by stimulating previously irreparable organs or tissues to heal themselves. In this study, bioscaffolds, or three-dimensional structures made of biocompatible and biodegradable materials in the shape of the tissue, were infused with a protein to promote growth of the rabbit joint. The experiment demonstrated the feasibility of an approach to growing dissimilar tissues, such as cartilage and bone, derived entirely from the host’s own cells. Results of the study are in the July 29 issue of The Lancet.
Date: July 29, 2010
Summary:
A team of NIH-funded researchers has successfully regenerated rabbit joints using a cutting edge process to form the joint inside the body, or in vivo. Regenerative in vivo procedures are performed by stimulating previously irreparable organs or tissues to heal themselves. In this study, bioscaffolds, or three-dimensional structures made of biocompatible and biodegradable materials in the shape of the tissue, were infused with a protein to promote growth of the rabbit joint. The experiment demonstrated the feasibility of an approach to growing dissimilar tissues, such as cartilage and bone, derived entirely from the host’s own cells. Results of the study are in the July 29 issue of The Lancet.
Tuesday, June 08, 2010
Researchers Convert Stem Cells into Cartilage
Source: University of Connecticut
Date: June 8, 2010
Summary:
For the millions of aging Americans who suffer from joint pain, stem cells may be riding to the rescue. Scientists at the University of Connecticut Health Center have recently developed a technique that reliably converts stem cells into cartilage cells. Someday, that might allow doctors to grow replacement cartilage in a laboratory for the surgical repair of joints lost to injury or impaired by degenerative diseases such as arthritis.
Stem cells have an unlimited capacity for self-renewal, as well as the ability to become any type of cell in the human body, so they are ideal for generating replacement cartilage tissue to repair damaged cartilage. Developmental biologists, like Dr. Caroline Dealy, an associate professor at UConn’s Center for Regenerative Medicine and Skeletal Development, are attempting to understand the signals and conditions that regulate how stem cells differentiate into articular chondrocytes – which make up the unique type of cartilage present at the surface of joints.
Research published in the Journal of Cellular Physiology in April details how Dealy and her colleague, Dr. Robert Kosher, a former professor at the Health Center, successfully developed a methodology to direct “substantially uniform and progressive in vitro differentiation of human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) into the chondrogenic lineage.”
Date: June 8, 2010
Summary:
For the millions of aging Americans who suffer from joint pain, stem cells may be riding to the rescue. Scientists at the University of Connecticut Health Center have recently developed a technique that reliably converts stem cells into cartilage cells. Someday, that might allow doctors to grow replacement cartilage in a laboratory for the surgical repair of joints lost to injury or impaired by degenerative diseases such as arthritis.
Stem cells have an unlimited capacity for self-renewal, as well as the ability to become any type of cell in the human body, so they are ideal for generating replacement cartilage tissue to repair damaged cartilage. Developmental biologists, like Dr. Caroline Dealy, an associate professor at UConn’s Center for Regenerative Medicine and Skeletal Development, are attempting to understand the signals and conditions that regulate how stem cells differentiate into articular chondrocytes – which make up the unique type of cartilage present at the surface of joints.
Research published in the Journal of Cellular Physiology in April details how Dealy and her colleague, Dr. Robert Kosher, a former professor at the Health Center, successfully developed a methodology to direct “substantially uniform and progressive in vitro differentiation of human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) into the chondrogenic lineage.”
Monday, April 26, 2010
NIH Study Confirms Location of Stem Cells Near Cartilage-Rich Regions in Bones
Source: NIH / National Institute of Child Health and Human Development
Date: April 26, 2010
Summary:
Working with mice, a team of researchers has pinpointed the location of bone generating stem cells in the spine, at the ends of shins, and in other bones. The team also has identified factors that control the stem cells' growth. The research was conducted at the National Institutes of Health and other institutions.
Researchers have long known that stem cells from bone marrow give rise to bone cells and to red and white blood cells. The current study is the first to identify the location of bone stem cells in the adult mouse skeleton. The researchers refer to the newly identified cells as bone stromal cells. "Stroma" is a term used to describe a supportive or connective structure in biological tissue. The term distinguishes the cells from hematopoietic stem cells, which give rise to blood cells, and which are found in bone marrow. The findings appear online in the Proceedings of the National Academy of Sciences.
Date: April 26, 2010
Summary:
Working with mice, a team of researchers has pinpointed the location of bone generating stem cells in the spine, at the ends of shins, and in other bones. The team also has identified factors that control the stem cells' growth. The research was conducted at the National Institutes of Health and other institutions.
Researchers have long known that stem cells from bone marrow give rise to bone cells and to red and white blood cells. The current study is the first to identify the location of bone stem cells in the adult mouse skeleton. The researchers refer to the newly identified cells as bone stromal cells. "Stroma" is a term used to describe a supportive or connective structure in biological tissue. The term distinguishes the cells from hematopoietic stem cells, which give rise to blood cells, and which are found in bone marrow. The findings appear online in the Proceedings of the National Academy of Sciences.
Tuesday, October 20, 2009
Growing Cartilage from Stem Cells
Source: University of California - Davis
Date: October 20, 2009
Summary:
Damaged knee joints might one day be repaired with cartilage grown from stem cells in a laboratory, based on research by Professor Kyriacos Athanasiou, chair of the UC Davis Department of Biomedical Engineering and his colleagues. Using adult stem cells from bone marrow and skin as well as human embryonic stem cells, Athanasiou and his group have already grown cartilage tissue in the lab. Now they are experimenting with various chemical and mechanical stimuli to improve its properties.
Date: October 20, 2009
Summary:
Damaged knee joints might one day be repaired with cartilage grown from stem cells in a laboratory, based on research by Professor Kyriacos Athanasiou, chair of the UC Davis Department of Biomedical Engineering and his colleagues. Using adult stem cells from bone marrow and skin as well as human embryonic stem cells, Athanasiou and his group have already grown cartilage tissue in the lab. Now they are experimenting with various chemical and mechanical stimuli to improve its properties.
Wednesday, May 14, 2008
Pioneering induction of bone formation using embryonic stem cells
Source: University of Twente
Date: May 14, 2008
Summary:
Researchers at the University of Twente break new ground by successfully creating bone tissue “in vivo”, using embryonic stem cells. They imitated bone formation in embryos and children, which uses cartilage as a template. This new approach appears to be a promising way of repairing bone defects. This week, the researchers’ findings are presented in the Proceedings of the National Academy of Sciences (PNAS).
Date: May 14, 2008
Summary:
Researchers at the University of Twente break new ground by successfully creating bone tissue “in vivo”, using embryonic stem cells. They imitated bone formation in embryos and children, which uses cartilage as a template. This new approach appears to be a promising way of repairing bone defects. This week, the researchers’ findings are presented in the Proceedings of the National Academy of Sciences (PNAS).
Thursday, September 06, 2007
Embryonic stem cells used to grow cartilage
Source: Rice University
Date: September 6, 2007
Summary:
Rice University biomedical engineers have developed a new technique for growing cartilage from human embryonic stem cells, a method that could be used to grow replacement cartilage for the surgical repair of knee, jaw, hip, and other joints.
Date: September 6, 2007
Summary:
Rice University biomedical engineers have developed a new technique for growing cartilage from human embryonic stem cells, a method that could be used to grow replacement cartilage for the surgical repair of knee, jaw, hip, and other joints.
Thursday, April 19, 2007
System For Expanding Stem Cells To Form Cartilage Tissue Under Development
Source: Centre for Synthesis and Chemical Biology
Date: April 19, 2007
Summary:
The Centre for Synthesis and Chemical Biology is studying and developing new techniques using adult stem cells to restore damaged knee cartilage tissue:
"Professor Mohamed Al-Rubeai, currently a UCD Professor of Biochemical Engineering and principal investigator with the Centre for Synthesis and Chemical Biology and UCD Conway Institute has developed an economical tissue engineering approach which could offer new possibilities for restoring damaged or lost knee cartilage tissue."
Date: April 19, 2007
Summary:
The Centre for Synthesis and Chemical Biology is studying and developing new techniques using adult stem cells to restore damaged knee cartilage tissue:
"Professor Mohamed Al-Rubeai, currently a UCD Professor of Biochemical Engineering and principal investigator with the Centre for Synthesis and Chemical Biology and UCD Conway Institute has developed an economical tissue engineering approach which could offer new possibilities for restoring damaged or lost knee cartilage tissue."
Monday, February 05, 2007
Woven Scaffolds Could Improve Cartilage Repair
Source: Duke University Medical Center
Date: February 5, 2007
Summary:
DURHAM, N.C. -- Using a unique weaving machine of their design, Duke University Medical Center researchers have created a three-dimensional fabric "scaffold" that could greatly improve the ability of physicians to repair damaged joints with the patient's own stem cells.
Date: February 5, 2007
Summary:
DURHAM, N.C. -- Using a unique weaving machine of their design, Duke University Medical Center researchers have created a three-dimensional fabric "scaffold" that could greatly improve the ability of physicians to repair damaged joints with the patient's own stem cells.
Tuesday, April 04, 2006
Factor Stimulates Cartilage Growth From Stem Cells
Source: Duke University Medical Center
Date: April 4, 2006
Summary:
A novel growth factor significantly improves the ability of specialized stem cells derived from human fat to be transformed into cartilage cells, according to Duke University Medical Center and Pratt School of Engineering researchers.
Date: April 4, 2006
Summary:
A novel growth factor significantly improves the ability of specialized stem cells derived from human fat to be transformed into cartilage cells, according to Duke University Medical Center and Pratt School of Engineering researchers.
Wednesday, November 16, 2005
Scientists Use Stem Cells To Grow Cartilage
Source: Imperial College London
Posted: November 16, 2005
Summary:
Scientists from Imperial College London have successfully converted human embryonic stem cells into cartilage cells, offering encouragement that replacement cartilage could one day be grown for transplantation.
Posted: November 16, 2005
Summary:
Scientists from Imperial College London have successfully converted human embryonic stem cells into cartilage cells, offering encouragement that replacement cartilage could one day be grown for transplantation.
Monday, June 27, 2005
A Step Forward In Stem Cell Research
Source: Memorial Sloan-Kettering Cancer Center
Posted: June 27, 2005
Summary:
Investigators from Memorial Sloan-Kettering Cancer Center (MSKCC) have used new techniques in the laboratory that allowed them for the first time to derive unlimited numbers of purified mesenchymal precursor cells from human embryonic stem cells (HESCs). Mesenchymal precursor cells are capable of giving rise to fat, cartilage, bone, and skeletal muscle cells, and may potentially be used for regenerative stem cell therapy in bone, cartilage, or muscle replacement.
Posted: June 27, 2005
Summary:
Investigators from Memorial Sloan-Kettering Cancer Center (MSKCC) have used new techniques in the laboratory that allowed them for the first time to derive unlimited numbers of purified mesenchymal precursor cells from human embryonic stem cells (HESCs). Mesenchymal precursor cells are capable of giving rise to fat, cartilage, bone, and skeletal muscle cells, and may potentially be used for regenerative stem cell therapy in bone, cartilage, or muscle replacement.
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