Source: Purdue University
Date: November 8, 2009
Summary:
Researchers at Purdue University have discovered a new approach for repairing damaged nerve fibers in spinal cord injuries using nano-spheres that could be injected into the blood shortly after an accident. The synthetic "copolymer micelles" are drug-delivery spheres about 60 nanometers in diameter, or roughly 100 times smaller than the diameter of a red blood cell. Researchers have been studying how to deliver drugs for cancer treatment and other therapies using these spheres. Medications might be harbored in the cores and ferried to diseased or damaged tissue. Purdue researchers have now shown that the micelles themselves repair damaged axons, fibers that transmit electrical impulses in the spinal cord. Findings are detailed in a research paper appearing Sunday (Nov. 8) in the journal Nature Nanotechnology.
Showing posts with label nerve. Show all posts
Showing posts with label nerve. Show all posts
Sunday, November 08, 2009
Friday, January 11, 2008
Hair has promise in nerve repairs: Protein keratin aids cell regeneration, WFU research says
Source: Winston-Salem Journal
Date: January 11, 2008
Summary:
The Winston-Salem Journal reports researchers at the Wake Forest University School of Medicine have found that a protein found in human hair may enable nerve regeneration:
"Human hair could hold the key to accelerating the regeneration of nerve tissue that has been cut or damaged by trauma, the Wake Forest University School of Medicine said yesterday. ....The study, published in the current issue of Biomaterials, reported that the protein keratin found in human hair enhances nerve regeneration and improves nerve function - compared with current treatment options - in animal research. Keratin is believed to contain molecules that regulate cell behavior."
Date: January 11, 2008
Summary:
The Winston-Salem Journal reports researchers at the Wake Forest University School of Medicine have found that a protein found in human hair may enable nerve regeneration:
"Human hair could hold the key to accelerating the regeneration of nerve tissue that has been cut or damaged by trauma, the Wake Forest University School of Medicine said yesterday. ....The study, published in the current issue of Biomaterials, reported that the protein keratin found in human hair enhances nerve regeneration and improves nerve function - compared with current treatment options - in animal research. Keratin is believed to contain molecules that regulate cell behavior."
Wednesday, November 07, 2007
Sangamo BioSciences Announces ZFP Therapeutic Data From Nerve Regeneration Program at Society for Neuroscience Meeting
Source: Sangamo BioSciences, Inc.
Date: November 7, 2007
Summary:
Sangamo BioSciences, Inc. announced today the presentation of preclinical data from its ZFP Therapeutic(TM) program in nerve regeneration at Neuroscience 2007, the 37th Annual Meeting of the Society for Neuroscience. A statistically significant effect on both recovery of hind-limb function and spinal cord tissue preservation was demonstrated in a severe model of spinal cord injury (SCI) following treatment at the time of injury with a zinc finger DNA-binding protein activator of vascular endothelial growth factor (VEGF ZFP TF).
Date: November 7, 2007
Summary:
Sangamo BioSciences, Inc. announced today the presentation of preclinical data from its ZFP Therapeutic(TM) program in nerve regeneration at Neuroscience 2007, the 37th Annual Meeting of the Society for Neuroscience. A statistically significant effect on both recovery of hind-limb function and spinal cord tissue preservation was demonstrated in a severe model of spinal cord injury (SCI) following treatment at the time of injury with a zinc finger DNA-binding protein activator of vascular endothelial growth factor (VEGF ZFP TF).
Monday, November 05, 2007
New research reveals critical knowledge about the nervous system
Source: Rutgers University
Date: November 5, 2007
Summary:
Uncover the neural communication links involved in myelination, the process of protecting a nerve’s axon, and it may become possible to reverse the breakdown of the nervous system’s electrical transmissions in such disorders as multiple sclerosis, spinal cord injuries, diabetes and cancers of the nervous system.
Date: November 5, 2007
Summary:
Uncover the neural communication links involved in myelination, the process of protecting a nerve’s axon, and it may become possible to reverse the breakdown of the nervous system’s electrical transmissions in such disorders as multiple sclerosis, spinal cord injuries, diabetes and cancers of the nervous system.
Sunday, October 21, 2007
Stem Cells From Patient's Fat Used To Grow New Nerves
Source: Medical News Today
Article Date: 21 October 2007 - 0:00 PDT
Summary:
Stem cells from a patient's fat may be used to create new nerves that can repair severed peripheral nerves (nerves outside the spinal cord), say scientists from Manchester University, England. The researchers say this route for creating new nerves could be part of medical practice by the year 2011.
Article Date: 21 October 2007 - 0:00 PDT
Summary:
Stem cells from a patient's fat may be used to create new nerves that can repair severed peripheral nerves (nerves outside the spinal cord), say scientists from Manchester University, England. The researchers say this route for creating new nerves could be part of medical practice by the year 2011.
Friday, October 19, 2007
New nerves grown from fat cells
Source: BBC News
Posted: 19 October 2007, 23:48 GMT 00:48 UK
Summary:
BBC News reports British scientists have transformed stem cells from fat into nerve cells:
New nerves grown from stem cells taken from a patient's fat could be available by 2011, researchers have said. They could potentially be used to repair peripheral nerves left severed by surgery or accidents. Manchester University scientists plan to place the new nerve tissue inside a biodegradable plastic tube, which can be used to rejoin the two broken ends."
Posted: 19 October 2007, 23:48 GMT 00:48 UK
Summary:
BBC News reports British scientists have transformed stem cells from fat into nerve cells:
New nerves grown from stem cells taken from a patient's fat could be available by 2011, researchers have said. They could potentially be used to repair peripheral nerves left severed by surgery or accidents. Manchester University scientists plan to place the new nerve tissue inside a biodegradable plastic tube, which can be used to rejoin the two broken ends."
Monday, July 02, 2007
Mighty Mouse’s musk makes females smarter
Source: LiveScience
Posted: July 2, 2007 10:45 a.m. PT
Summary:
Animals often attract the opposite sex using chemicals in their scents known as pheromones. The areas of the brain that scientists think pheromones target are also where new cells most often grow in the adult brain — the olfactory bulb, which helps perceive odors, and the hippocampus, which helps store memories. Now researchers have discovered pheromones from dominant male mice stimulated the production of new neurons in female brains.
Posted: July 2, 2007 10:45 a.m. PT
Summary:
Animals often attract the opposite sex using chemicals in their scents known as pheromones. The areas of the brain that scientists think pheromones target are also where new cells most often grow in the adult brain — the olfactory bulb, which helps perceive odors, and the hippocampus, which helps store memories. Now researchers have discovered pheromones from dominant male mice stimulated the production of new neurons in female brains.
Pheromones trigger brain cell growth, say researchers
Source: Canadian Broadcasting Corporation
Posted: July 2, 2007 9:01 AM MDT
Summary:
The Canadian Broadcasting Corporation reports that pheromones could enable the growth of new brain cells:
"Pheromone signals from dominant males spark new brain cells in their female partners and could help repair injured brains, suggests a new study by a University of Calgary neuroscientist. Sam Weiss's findings, in the July issue of the journal Nature Neuroscience, provide evidence that pheromones — subtle chemical signatures that influence mating behaviour — can control stem cells in the brain."
Posted: July 2, 2007 9:01 AM MDT
Summary:
The Canadian Broadcasting Corporation reports that pheromones could enable the growth of new brain cells:
"Pheromone signals from dominant males spark new brain cells in their female partners and could help repair injured brains, suggests a new study by a University of Calgary neuroscientist. Sam Weiss's findings, in the July issue of the journal Nature Neuroscience, provide evidence that pheromones — subtle chemical signatures that influence mating behaviour — can control stem cells in the brain."
Wednesday, May 23, 2007
New Neurons in Old Brains Exhibit Babylike Plasticity
Source: Scientific American
Date: May 23, 2007
Summary:
Scientific American reports on new observations about the capabilities and functions of new nerve cells in adult brains:
"Researchers have identified a "critical period" during which new nerve cells in adult brains have the same capacity to learn as those in developing brains. The finding in mice, reported in this week's Neuron, provides the promise of therapies that may one day limit or perhaps even reverse the damage of neurodegenerative diseases such as multiple sclerosis and Parkinson's."
Date: May 23, 2007
Summary:
Scientific American reports on new observations about the capabilities and functions of new nerve cells in adult brains:
"Researchers have identified a "critical period" during which new nerve cells in adult brains have the same capacity to learn as those in developing brains. The finding in mice, reported in this week's Neuron, provides the promise of therapies that may one day limit or perhaps even reverse the damage of neurodegenerative diseases such as multiple sclerosis and Parkinson's."
Adult Brain Cells Rediscover Their Inner Child
Source: Johns Hopkins Medical Institutions
Date: May 23, 2007
Summary:
You may not be able to relive your youth, but part of your brain can. Johns Hopkins researchers have found that newly made nerves in an adult brain's learning center experience a one-month period when they are just as active as the nerves in a developing child. The study, appearing this week in Neuron, suggests that new adult nerves have a deeper role than simply replacing dead ones.
Date: May 23, 2007
Summary:
You may not be able to relive your youth, but part of your brain can. Johns Hopkins researchers have found that newly made nerves in an adult brain's learning center experience a one-month period when they are just as active as the nerves in a developing child. The study, appearing this week in Neuron, suggests that new adult nerves have a deeper role than simply replacing dead ones.
Thursday, May 10, 2007
Breakdown of Myelin Implicated in Alzheimer’s, UCLA Research Shows
Source: University of California - Los Angeles
Date: May 10, 2007
Summary:
In a report in the April issue of the journal Alzheimer's & Dementia, UCLA researchers suggest that it is the breakdown of this late-stage myelin, the fatty sheath that coats the axons of the nerves, allowing for efficient conduction of nerve impulses, that promotes the buildup of toxic amyloid-beta fibrils that eventually deposit in the brain and become the plaques which have long been associated with Alzheimer's disease.
Date: May 10, 2007
Summary:
In a report in the April issue of the journal Alzheimer's & Dementia, UCLA researchers suggest that it is the breakdown of this late-stage myelin, the fatty sheath that coats the axons of the nerves, allowing for efficient conduction of nerve impulses, that promotes the buildup of toxic amyloid-beta fibrils that eventually deposit in the brain and become the plaques which have long been associated with Alzheimer's disease.
Sunday, April 29, 2007
When smell cells fail they call in stem cell reserves
Source: Johns Hopkins Medical Institutions
Date: April 29, 2007
Summary:
Hopkins researchers have identified a backup supply of stem cells that can repair the most severe damage to the nerves responsible for our sense of smell. These reservists normally lie around and do nothing, but when neighboring cells die, the scientists say, the stem cells jump into action. A report on the discovery will appear online next week in Nature Neuroscience.
Date: April 29, 2007
Summary:
Hopkins researchers have identified a backup supply of stem cells that can repair the most severe damage to the nerves responsible for our sense of smell. These reservists normally lie around and do nothing, but when neighboring cells die, the scientists say, the stem cells jump into action. A report on the discovery will appear online next week in Nature Neuroscience.
Friday, April 27, 2007
Stem Cell Propagation And Neurogenesis Can Now Be Studied In Cell Culture
Source: Max Delbrück Center for Molecular Medicine
Date: April 27, 2007
Summary:
Researchers are now able to study stem cells from the brains of adult mice and their neurogenesis in long-term cell cultures. Harish Babu an Dr. Gerd Kempermann (both from the Max Delbrück Center for Molecular Medicine, MDC, Berlin-Buch, the Volkswagenstiftung Research Group at the Charité – Universitätsmedizin Berlin, Germany) have developed a new method which allows them to generate exactly those neurons from stem cells in cell culture as those that would develop in the living brain.
Date: April 27, 2007
Summary:
Researchers are now able to study stem cells from the brains of adult mice and their neurogenesis in long-term cell cultures. Harish Babu an Dr. Gerd Kempermann (both from the Max Delbrück Center for Molecular Medicine, MDC, Berlin-Buch, the Volkswagenstiftung Research Group at the Charité – Universitätsmedizin Berlin, Germany) have developed a new method which allows them to generate exactly those neurons from stem cells in cell culture as those that would develop in the living brain.
Tuesday, March 20, 2007
Neuralstem raises $5.135 million to help fund first human trial
Source: Washington Business Journal
Posted: March 20, 2007 12:16 PM EDT
Summary:
Neuralstem hopes to begin its first human clinical trial on a stem-cell product sometime this year and has raised more than $5 million to help fund the trial. The Rockville-based biotechnology company, whose focus is treatments based on the transplantation of human neural stem cells, raised about $5.14 million in a private placement of more than 2 million units at $2.50 per unit to a group of institutional investors.
Posted: March 20, 2007 12:16 PM EDT
Summary:
Neuralstem hopes to begin its first human clinical trial on a stem-cell product sometime this year and has raised more than $5 million to help fund the trial. The Rockville-based biotechnology company, whose focus is treatments based on the transplantation of human neural stem cells, raised about $5.14 million in a private placement of more than 2 million units at $2.50 per unit to a group of institutional investors.
Thursday, February 22, 2007
Scientists Produce Neurons From Human Skin
Source: Université Laval
Date: February 22, 2007
Summary:
Scientists from Université Laval’s Faculty of Medicine have succeeded in producing neurons in vitro using stem cells extracted from adult human skin. This is the first time such an advanced state of nerve cell differentiation has been achieved from human skin, according to lead researcher Professor François Berthod. This breakthrough could eventually lead to revolutionary advances in the treatment of neurodegenerative illnesses such as Parkinson’s disease. Berthod and his team described the method used to produce these neurons in a recent issue of the Journal of Cellular Physiology.
Date: February 22, 2007
Summary:
Scientists from Université Laval’s Faculty of Medicine have succeeded in producing neurons in vitro using stem cells extracted from adult human skin. This is the first time such an advanced state of nerve cell differentiation has been achieved from human skin, according to lead researcher Professor François Berthod. This breakthrough could eventually lead to revolutionary advances in the treatment of neurodegenerative illnesses such as Parkinson’s disease. Berthod and his team described the method used to produce these neurons in a recent issue of the Journal of Cellular Physiology.
Tuesday, February 20, 2007
Pregnancy Hormone Key To Repairing Nerve Cell Damage - MS Society Of Canada
Source: Multiple Sclerosis Society of Canada
Date: February 20, 2007
Summary:
The mystery of why multiple sclerosis (MS) tends to go into remission while women are pregnant may be the secret to overcoming the devastating neurodegenerative disease, according to University of Calgary researchers who have shown that a pregnancy-related hormone is responsible for rebuilding the protective coating around nerve cells.
Date: February 20, 2007
Summary:
The mystery of why multiple sclerosis (MS) tends to go into remission while women are pregnant may be the secret to overcoming the devastating neurodegenerative disease, according to University of Calgary researchers who have shown that a pregnancy-related hormone is responsible for rebuilding the protective coating around nerve cells.
Friday, January 26, 2007
Cell discovery at UGA could open path to breakthroughs
Source: Atlanta Journal-Constitution
Date: January 26, 2007
Summary:
A University of Georgia scientist has discovered a way to quickly manufacture billions of a type of cell —- derived from embryonic stem cells —- that could grow into nerve and brain tissue, a development that could shorten by years the search for cures to debilitating conditions such as Alzheimer's and Parkinson's diseases as well as spinal cord injuries.
Date: January 26, 2007
Summary:
A University of Georgia scientist has discovered a way to quickly manufacture billions of a type of cell —- derived from embryonic stem cells —- that could grow into nerve and brain tissue, a development that could shorten by years the search for cures to debilitating conditions such as Alzheimer's and Parkinson's diseases as well as spinal cord injuries.
Friday, December 22, 2006
Stem cells shown to pinpoint tumors: Study shows process targets chemotherapy
Source: Pasadena Star News
Posted: 12/22/2006 10:47:38 PM PST
Summary:
Neural stem cells could provide a powerful means to track and treat cancer that has spread throughout the body, new research from the City of Hope suggests.
Posted: 12/22/2006 10:47:38 PM PST
Summary:
Neural stem cells could provide a powerful means to track and treat cancer that has spread throughout the body, new research from the City of Hope suggests.
Sunday, December 10, 2006
Detailed 3-D Image Catches A Key Regulator Of Neural Stem Cell Differentiation In Action
Source: Salk Institute
Date: December 10, 2006
Summary:
Researchers at the Salk Institute for Biological Studies in collaboration with scientists at the University of California, San Diego (UCSD) took a high resolution "action shot" of a protein switch that plays a crucial role in the development of the nervous system. A finely tuned network of molecular "on" and "off" switches regulates the differentiation of embryonic stem cells into different tissue types. Being able to manipulate individual switches would allow scientists to nudge embryonic stem cells into becoming specific cell types, a plus for both basic research and potential therapies.
Date: December 10, 2006
Summary:
Researchers at the Salk Institute for Biological Studies in collaboration with scientists at the University of California, San Diego (UCSD) took a high resolution "action shot" of a protein switch that plays a crucial role in the development of the nervous system. A finely tuned network of molecular "on" and "off" switches regulates the differentiation of embryonic stem cells into different tissue types. Being able to manipulate individual switches would allow scientists to nudge embryonic stem cells into becoming specific cell types, a plus for both basic research and potential therapies.
Wednesday, July 12, 2006
New source of multipotent adult stem cells discovered in human hair follicles: Implications for personalized approaches to transplants
Source: University of Pennsylvania School of Medicine
Posted: July 12, 2006
Summary:
In a finding that may accelerate the pace of discovery in the field of stem cell research, researchers at the University of Pennsylvania School of Medicine have isolated a new source of adult stem cells that appear to have the potential to differentiate into several cell types. If their approach to growing these cells can be scaled up and proves to be safe and effective in animal and human studies, it could one day provide the tissue needed by an individual for treating a host of disorders, including peripheral nerve disease, Parkinson's disease, and spinal cord injury.
Posted: July 12, 2006
Summary:
In a finding that may accelerate the pace of discovery in the field of stem cell research, researchers at the University of Pennsylvania School of Medicine have isolated a new source of adult stem cells that appear to have the potential to differentiate into several cell types. If their approach to growing these cells can be scaled up and proves to be safe and effective in animal and human studies, it could one day provide the tissue needed by an individual for treating a host of disorders, including peripheral nerve disease, Parkinson's disease, and spinal cord injury.
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