Tuesday, April 26, 2005

Brain Power Creates Insulin

Source: Wired
Date: April 26, 2005

Summary:

Wired magazine reports on research by scientists at Stanford University to turn neurons from fetal brains in to insulin-producing cells:

"Scientists at Stanford have coaxed neurons from fetal brains to become cells that produce insulin. The cells aren't ready for human transplantation yet, but the advance brings researchers one step closer to a diabetes cure. The researchers created the cells in a dish by mixing up a recipe of chemicals that changed neurons into beta cells, also known as islet cells. When they injected the cells into normal mice, the cells responded to increased glucose levels by pumping out insulin. The next step will be for the researchers to inject the cells into diabetic mice to see if they can reverse the disease."

Monday, April 25, 2005

STEM CELLS FROM BRAIN TRANSFORMED TO PRODUCE INSULIN AT STANFORD

Source: Stanford University School of Medicine
Date: Aprll 25, 2005

Summary:

Researchers at Stanford University have coaxed stem cells from the brain to form insulin-producing cells that mimic those missing in people with diabetes. Although the work is not yet ready for human patients, the lead author and assistant professor of developmental biology at the Stanford University School of Medicine, said it could lead to new ways of transplanting insulin-producing cells into people with diabetes, eventually providing a cure for the disease.

Brain stem cells to cure diabetes

Source: BBC News
Posted: 25 April, 2005, 23:14 GMT 00:14 UK

Summary:

Scientists believe they could use brain stem cells to cure diabetes. Although the work is not yet ready to be tested on human patients, results in animals have been promising, say the Stanford University researchers. They were able to coax the immature brain cells to develop into the insulin-producing islet cells that are lacking in diabetes. Eventually, these could be used for curative transplants.

Monday, April 11, 2005

Researcher Takes Stem Cell Research Another Step

Source: New Jersey Institute Of Technology
Posted: April 11, 2005

Summary:

Treena Arinzeh, PhD, assistant professor of biomedical engineering at NJIT, is researching the use of stem cells to induce bone repair. Her research will help diabetics whose impaired bones will not properly heal. She is using adult stem cells, in combination with allografts – donated bone tissue - to regenerate and repair the patients’ damaged bones. She is performing tests on diabetic animals, after which she’ll test patients at the clinical level.

Monday, April 04, 2005

Growing Your Own Replacement Teeth? Not Science Fiction!

Source: International & American Association For Dental Research
Posted: April 4, 2005

Summary:

Researchers from the Forsyth Institute (Boston, MA) and the University of Texas Health Science Center at San Antonio will describe successful experiments in bioengineering mineralized tissues, including periodontal tissues and replacement tooth phenotypes. This research is supported by the National Institute of Dental and Craniofacial Research, one of the National Institutes of Health (Bethesda, MD).

Human blood cells coaxed to produce insulin

Source: New Scientist
Date: 04 April 2005

Summary:

New Scientist reports on new experiments which have shown that human blood stem cells can be made to produce insulin:

"Experiments that seem to have made human blood cells start producing insulin have raised the prospect of a new treatment for diabetes. Although the treatment has only been tried in mice so far, it might mean people can be cured with implants of their own cells."

Monday, March 28, 2005

Researchers Closer To Helping Hearing-Impaired Using Stem Cells

Source: Indiana University School Of Medicine
Posted: March 28, 2005

Summary:

Researchers at Indiana University School of Medicine are several steps closer to the day when a profoundly deaf patient's own bone marrow cells could be used to let him or her hear the world. They were able able to transform, in the laboratory, stem cells taken from adult bone marrow into cells with many of the characteristics of sensory nerve cells -- neurons -- found in the ear. The results suggest that these adult stem cells could be used to treat deaf patients in the future.

Friday, March 25, 2005

Placenta Is A Rich Source Of Blood Stem Cells

Source: Children's Hospital Boston
Date: March 25, 2005

Summary:

Meticulous experiments in mice revealed that the placenta harbors a large supply of hematopoietic (blood-forming) stem cells. These cells, which appear very early in development, are able to generate more blood stem cells and can give rise to a complete blood system when transplanted into an adult. Unlike other sites where blood stem cells are found during embryonic development, such as the liver, the stem cells in the placenta can increase in number without giving rise to mature, specialized cells.

Monday, March 21, 2005

Adult Stem Cells Can Produce Brain Cells: In chick embryos, specific chemical environment brings results

Source: HealthDay News
Date: March 21, 2005

Summary:

Experiments involving chicken eggs may have hatched a major advance in stem cell research, as investigators watched adult human stem cells develop into functioning brain cells. Experts hope that, someday, adult stem cells from a patient's own bone marrow might be used to regrow and replace brain or spinal cord cells lost to injury or disease.

Tuesday, March 15, 2005

Researchers Devise Way To Mass-produce Embryonic Stem Cells

Source: Ohio State University
Date: March 15, 2005

Summary:

Researchers at Ohio State University have developed a method for mass-producing embryonic stem cells. That's important because traditional laboratory methods used to grow these cells are costly and don't produce cells fast enough to respond to increasing demands for human embryonic stem cells. Mass-producing cells like this could reduce stem cell production costs by at least 80 percent, as it requires less equipment and monitoring.

Wednesday, February 23, 2005

Scientists Identify Stem Cell On/Off Switch

Source: HealthDay News
Date: February 23, 2005

Summary:

In experiments with mice, scientists believe they've discovered a new class of gene signals that either prevent or permit stem cells to develop into specific cell types. This is an important advance because to keep stem cells useful therapeutically, doctors will have to preserve them as undifferentiated stem cells for as long as possible.

Newly-discovered Class Of Genes Determines -- And Restricts -- Stem Cell Fate

Source: University Of Pennsylvania Medical Center
Date: February 23, 2005

Summary:

Research on adult stem cells found in the skin hints at a new class of genes, according to a study from investigators at the University of Pennsylvania School of Medicine. These genes dubbed pangenes can both govern a stem cell's fate and put a hold on future differentiation until the time is right. Understanding the molecular control of these genes has implications for therapies that involve tissue regeneration.

Stem Cell Therapy For Spinal Injury

Source: Karolinska Institutet
Date: February 23, 2005

Summary:

Researchers at Karolinska Institutet have shown how the transplantation of stem cells improves recovery from spinal injury. However, a painful condition can also develop, which can be prevented if the stem cells are supplemented with a certain gene that controls their maturing process. The results are important for planning of stem cell therapy trials on patients with spinal injury.

Thursday, February 10, 2005

Research May Hold Promise For Treating Alzheimer's

Source: University Of Central Florida
Date: February 10, 2005

Summary:

A compound similar to the components of DNA may improve the chances that stem cells transplanted from a patient's bone marrow to the brain will take over the functions of damaged cells and help treat Alzheimer's disease and other neurological illnesses. A research team at the University of Central Florida found that treating bone marrow cells in laboratory cultures with bromodeoxyuridine, a compound that becomes part of DNA, made adult human stem cells more likely to develop as brain cells after they were implanted in adult rat brains.

Sunday, January 30, 2005

Human Stem Cells Become Nerve Cells in Study

Source: Reuters
Date: Sun Jan 30, 2005 02:07 PM ET

Summary:

Stem cells taken from human embryos were coaxed into becoming motor neurons in an experiment that might one day help scientists repair damaged nervous systems

Wednesday, January 19, 2005

Spleen May Be Source Of Versatile Stem Cells

Source: Massachusetts General Hospital
Date: January 19, 2005

Summary:

Massachusetts General Hospital (MGH) researchers report that potential adult stem cells derived from the human spleen produce a protein previously believed to be present only during the embryonic development of mammals. The finding both supports the existence of these splenic stem cells and also suggests they may be able to produce an even greater variety of tissues.

Saturday, January 15, 2005

A Stroke Treatment from Stem Cells?

Source: Stanford Magazine
Date: January / February 2005

Summary:

Stanford Magazine reports on a possible stroke treatment using human fetal stem cells:

"'STROKE, the leading cause of serious, long-term disability in the United States, “is a disease where we do not have good treatments,” says neurosurgeon Gary Steinberg. Americans spend $30 billion a year on stroke recovery and rehabilitation, but doctors have no way to repair the damaged brain tissue. That may soon change. Researchers in Steinberg’s lab have demonstrated that human fetal stem cells, when transplanted into the brains of laboratory rats with induced strokes, can migrate toward the damaged location and turn into neurons and support cells.'"

Tuesday, December 07, 2004

Pitt clones monkey embryos for stem cells

Source: Pittsburgh Tribune-Review
Date: December 7, 2004

Summary:

The Pittsburgh Tribune-Review reports researchers at the University of Pittsburgh obtained embryonic stem cells from cloned monkey embryos:

"University of Pittsburgh reproductive biologists have taken one small step for basic science that could bring about one giant leap for public health. Using techniques developed earlier this year by South Korean researchers, Pitt scientists cloned monkey embryos that survived long enough to develop the precursors to embryonic stem cells, the universal cells hailed for their potential to cure Alzheimer's disease, diabetes, spinal cord injuries and other ailments."

Wednesday, August 04, 2004

Stem cells fill gap left by stroke, researchers find. Next step is to determine whether cells can restore normal brain function

Source: Stanford Report
Date: August 4, 2004

Summary:

Researchers at Stanford University medical school report the first success using stem cells to populate the damaged region with new neurons in rats. If those cells also replace the function of the lost cells, they could help people recover after a stroke.

Monday, August 02, 2004

Stem Cell Research Targets Cerebral Palsy

Source: Medical College of Georgia
Date: August 2004

Summary:

Natural chemicals that assist healing may one day help transplanted adult stem cells integrate into an injured brain, helping children with cerebral palsy recover lost function, according to researchers at the Medical College of Georgia.