Source: New Scientist
Date: 30 June 2007
News Scientist reports that giving stem cells to a developing fetus could extend the lives of children with a hereditary bone disease:
"INJECTING stem cells into a developing fetus might sound risky, but it could prolong the lives of children with brittle bone disease. Nicholas Fisk and colleagues at Imperial College London studied mouse models of human type III brittle bone disease, or osteogenesis imperfecta (OI). The genetic defect - detected in human fetuses by DNA testing or ultrasound - disrupts collagen production, leading to weak bones and stunted growth. Those with type III OI suffer fractures while in the womb and rarely survive beyond early adulthood. Fisk's team injected human fetal mesenchymal stem cells through the wall of the uterus into 14-day mouse fetuses. At the age of 3 months, treated mice had suffered just one-third of the long-bone fractures compared with untreated mice. Their bones were also stronger and their leg bones longer."
Saturday, June 30, 2007
Friday, June 29, 2007
Stem Cell Therapy To Prevent Heart Attacks
Source: The Lancet via Medical News Today
Date: 29 June 2007 - 1:00 PDT
Summary:
The use of stem cell therapy to prevent heart attacks is explored in a Comment published in this week's edition of The Lancet. Professor Harald Arnesen and colleagues from the Ullevål University Hospital, Oslo, Norway looked at studies published to date on the relatively new technique of using of autologous cells derived from bone marrow cells (BMC) to strengthen cardiac function. Autologous cells are sourced from the patient they are used to treat. The authors refer to a trial done in 2002 in which such cells were administered into the heart with encouraging results. The authors say: "The results of this and several other small uncontrolled studies with the same method were encouraging. However, three randomised trials that tested therapy with BMC were negative for the primary endpoint, improvement in left ventricular ejection-fraction (LVEF)."
Date: 29 June 2007 - 1:00 PDT
Summary:
The use of stem cell therapy to prevent heart attacks is explored in a Comment published in this week's edition of The Lancet. Professor Harald Arnesen and colleagues from the Ullevål University Hospital, Oslo, Norway looked at studies published to date on the relatively new technique of using of autologous cells derived from bone marrow cells (BMC) to strengthen cardiac function. Autologous cells are sourced from the patient they are used to treat. The authors refer to a trial done in 2002 in which such cells were administered into the heart with encouraging results. The authors say: "The results of this and several other small uncontrolled studies with the same method were encouraging. However, three randomised trials that tested therapy with BMC were negative for the primary endpoint, improvement in left ventricular ejection-fraction (LVEF)."
Thursday, June 28, 2007
Stem Cells Help Urinary Incontinence?
Source: WebMD
Date: June 28, 2007
Summary:
Injections of stem cells and other cells obtained from a woman's own body can treat stress urinary incontinence with dramatically better results than conventional collagen injections, according to a new study from Austria.
Date: June 28, 2007
Summary:
Injections of stem cells and other cells obtained from a woman's own body can treat stress urinary incontinence with dramatically better results than conventional collagen injections, according to a new study from Austria.
Researchers Use Adult Stem Cells to Create Soft Tissue
Source: Columbia University Medical Center
Date: June 28, 2007
Summary:
Researchers from Columbia University Medical Center received a $2.5 million grant from the National Institute of Biomedical Imaging and Bioengineering to use stem cells to engineer soft tissue, developing a process that should ultimately allow scientists to use a patient’s own stem cells to develop tissue for facial reconstruction following disfiguring injuries from war, cancer surgery or accidents.
Date: June 28, 2007
Summary:
Researchers from Columbia University Medical Center received a $2.5 million grant from the National Institute of Biomedical Imaging and Bioengineering to use stem cells to engineer soft tissue, developing a process that should ultimately allow scientists to use a patient’s own stem cells to develop tissue for facial reconstruction following disfiguring injuries from war, cancer surgery or accidents.
New method for reading DNA sheds light on basis of cell identity
Source: Broad Institute of MIT and Harvard
Date: June 28, 2007
Summary:
As a fertilized egg develops into a full grown adult, mammalian cells make many crucial decisions — closing doors of opportunity as they adopt careers as liver cells, skin cells, or neurons. One of the most fundamental mysteries in biomedicine is how cells make such different career decisions despite having exactly the same DNA. By using a new kind of genomic technology, a new study unveils a special code — not within DNA, but within the so-called “chromatin” proteins surrounding it — that could unlock these mysterious choices underlying cell identity.
Date: June 28, 2007
Summary:
As a fertilized egg develops into a full grown adult, mammalian cells make many crucial decisions — closing doors of opportunity as they adopt careers as liver cells, skin cells, or neurons. One of the most fundamental mysteries in biomedicine is how cells make such different career decisions despite having exactly the same DNA. By using a new kind of genomic technology, a new study unveils a special code — not within DNA, but within the so-called “chromatin” proteins surrounding it — that could unlock these mysterious choices underlying cell identity.
Cambridge researchers find ‘missing link' stem cells
Source: University of Cambridge
Date: 28 June 2007
Summary:
Two independent teams of researchers based at the University of Cambridge and Oxford have discovered a new type of embryonic stem cell in mice and rats which is very similar to human embryonic stem cells. Both papers are published online this week in Nature. The discovery, and its virtually simultaneous verification, will change the way we think about human embryonic stem cells. It is likely to accelerate understanding of stem cell development and help the derivation of stem cells in other species - including livestock and disease-prone mice used in research - thereby providing better models for researchers involved in stem cell research.
Date: 28 June 2007
Summary:
Two independent teams of researchers based at the University of Cambridge and Oxford have discovered a new type of embryonic stem cell in mice and rats which is very similar to human embryonic stem cells. Both papers are published online this week in Nature. The discovery, and its virtually simultaneous verification, will change the way we think about human embryonic stem cells. It is likely to accelerate understanding of stem cell development and help the derivation of stem cells in other species - including livestock and disease-prone mice used in research - thereby providing better models for researchers involved in stem cell research.
New mouse stem cell is just like ours
Source: New Scientist and AFP
Posted: 28 June 2007 13:11 GMT
Summary:
New Scientist reports scientists have discovered a mouse embryonic stem cells with properties similar to those of human embryonic stem cells:
"The discovery of a mouse embryonic stem cell that is a near-perfect match to human cells will speed research in regenerative medicine and treatments for conditions such as Parkinson's and diabetes, researchers say. Roger Pedersen at Cambridge University, UK, and colleagues took cells from the mouse embryo at a later stage in its development, when it is an epiblast. They found that epiblast stem cells, taken from the innermost layer of week-old rodent embryos, shared many of the same properties of human embryonic stem cells."
Posted: 28 June 2007 13:11 GMT
Summary:
New Scientist reports scientists have discovered a mouse embryonic stem cells with properties similar to those of human embryonic stem cells:
"The discovery of a mouse embryonic stem cell that is a near-perfect match to human cells will speed research in regenerative medicine and treatments for conditions such as Parkinson's and diabetes, researchers say. Roger Pedersen at Cambridge University, UK, and colleagues took cells from the mouse embryo at a later stage in its development, when it is an epiblast. They found that epiblast stem cells, taken from the innermost layer of week-old rodent embryos, shared many of the same properties of human embryonic stem cells."
Researchers find ‘missing link’ stem cells
Source: University of Oxford
Date: June 28, 2007
Summary:
A team of scientists at Oxford University has discovered a new type of embryonic stem cell in mice and rats that is the closest counterpart yet to human embryonic stem cells. The cells are expected to serve as an improved model for human stem cells in studies of regeneration, disease pathology and basic stem cell biology, bringing scientists closer to realising the potential of stem cells in treatments for disease.
Date: June 28, 2007
Summary:
A team of scientists at Oxford University has discovered a new type of embryonic stem cell in mice and rats that is the closest counterpart yet to human embryonic stem cells. The cells are expected to serve as an improved model for human stem cells in studies of regeneration, disease pathology and basic stem cell biology, bringing scientists closer to realising the potential of stem cells in treatments for disease.
Scientists identify a mouse embryonic stem cell more like our own
Source: NIH/National Institute of Neurological Disorders and Stroke
Date: June 28, 2007
Summary:
Scientists have discovered a new type of mouse embryonic stem cell that is the closest counterpart yet to human embryonic stem (ES) cells, the National Institutes of Health (NIH) announced today. The cells are expected to serve as an improved model for human ES cells in studies of regeneration, disease pathology and basic stem cell biology.
Date: June 28, 2007
Summary:
Scientists have discovered a new type of mouse embryonic stem cell that is the closest counterpart yet to human embryonic stem (ES) cells, the National Institutes of Health (NIH) announced today. The cells are expected to serve as an improved model for human ES cells in studies of regeneration, disease pathology and basic stem cell biology.
Embryonic stem cells created from unfertilized eggs, not embryos, scientists report
Source: Associated Press
Date: June 28, 2007
Summary:
The Associated Press reports on an experiment in which embryonic stem cells were created from unfertilized eggs:
"Scientists say they've created embryonic stem cells by stimulating unfertilized eggs, a significant step toward producing transplant tissue that's genetically matched to women. The advance suggests that someday, a woman who wants a transplant to treat a condition like diabetes or a spinal cord injury could provide eggs to a lab, which in turn could create tissue that her body wouldn't reject."
Date: June 28, 2007
Summary:
The Associated Press reports on an experiment in which embryonic stem cells were created from unfertilized eggs:
"Scientists say they've created embryonic stem cells by stimulating unfertilized eggs, a significant step toward producing transplant tissue that's genetically matched to women. The advance suggests that someday, a woman who wants a transplant to treat a condition like diabetes or a spinal cord injury could provide eggs to a lab, which in turn could create tissue that her body wouldn't reject."
Mice stem cells to accelerate treatments
Source: Daily Telegraph
Posted: June 28, 2007 6:00pm BST
Summary:
The Daily Telegraph reports British scientist have discovered a type of mouse embryonic stem cell that is similar to human embryonic stem cells:
"A crucial advance in stem cell research, reported today by British scientists, will shave years off efforts to turn the cells into treatments for a vast range of ailments such as diabetes and cystic fibrosis, without the need to use human embryos. Scientists around the world are racing to turn stem cells into nerve, muscle and many other cell types. The long-term hope is to use them to grow tissue cells to repair damaged bodies. Now two independent teams at Cambridge and Oxford universities have discovered a type of embryonic stem cell in mice and rats which is strikingly similar to human embryonic stem cells. 'This new type provides the missing link between mouse and human embryonic stem cells,' said Prof Roger Pedersen, whose Medical Research Council-funded laboratory led the Cambridge study."
Posted: June 28, 2007 6:00pm BST
Summary:
The Daily Telegraph reports British scientist have discovered a type of mouse embryonic stem cell that is similar to human embryonic stem cells:
"A crucial advance in stem cell research, reported today by British scientists, will shave years off efforts to turn the cells into treatments for a vast range of ailments such as diabetes and cystic fibrosis, without the need to use human embryos. Scientists around the world are racing to turn stem cells into nerve, muscle and many other cell types. The long-term hope is to use them to grow tissue cells to repair damaged bodies. Now two independent teams at Cambridge and Oxford universities have discovered a type of embryonic stem cell in mice and rats which is strikingly similar to human embryonic stem cells. 'This new type provides the missing link between mouse and human embryonic stem cells,' said Prof Roger Pedersen, whose Medical Research Council-funded laboratory led the Cambridge study."
Wednesday, June 27, 2007
Stem cells from mice 'could be the key to finding new cures'
Source: Evening Standard
Date: 28 June 2007
Summary:
The Evening Standard reports researchers have discovered mouse embryonic stem cells that have traits similar to human embryonic stem cells:
"A breakthrough in stem cell technology could sweep away ethical concerns over embryo research and speed the development of treatments for incurable diseases. Researchers from Oxford and Cambridge universities have discovered that mice can produce embryonic stem cells very similar to those found in human embryos. The findings will make it easier to use mice, and other animals, to study human diseases and could lead to new treatments for conditions such as diabetes and cystic fibrosis in as little as five years."
Date: 28 June 2007
Summary:
The Evening Standard reports researchers have discovered mouse embryonic stem cells that have traits similar to human embryonic stem cells:
"A breakthrough in stem cell technology could sweep away ethical concerns over embryo research and speed the development of treatments for incurable diseases. Researchers from Oxford and Cambridge universities have discovered that mice can produce embryonic stem cells very similar to those found in human embryos. The findings will make it easier to use mice, and other animals, to study human diseases and could lead to new treatments for conditions such as diabetes and cystic fibrosis in as little as five years."
Stem cell discovery to speed treatments
Source: Financial Times
Published: June 28 2007 04:14 | Last updated: June 28 2007 04:14
Summary:
The Financial Times reports on a new discovery of a mouse embryonic stem cell that is similar to a human embryonic stem cell:
"Scientists at Oxford and Cambridge universities have made a breakthrough in understanding the biology of embryonic stem cells, which they say will accelerate the development of treatments for degenerative diseases. Working independently, the two teams used mouse embryos to derive a type of cell similar to a human embryonic stem cell. Roger Pedersen of Cambridge called it a 'missing link between mouse and human embryonic stem cells'".
Published: June 28 2007 04:14 | Last updated: June 28 2007 04:14
Summary:
The Financial Times reports on a new discovery of a mouse embryonic stem cell that is similar to a human embryonic stem cell:
"Scientists at Oxford and Cambridge universities have made a breakthrough in understanding the biology of embryonic stem cells, which they say will accelerate the development of treatments for degenerative diseases. Working independently, the two teams used mouse embryos to derive a type of cell similar to a human embryonic stem cell. Roger Pedersen of Cambridge called it a 'missing link between mouse and human embryonic stem cells'".
Peer Review Paper Reporting Creation of Human Stem Cell Lines That Can Become Any Cell Type Using Unfertilized Eggs,
Source: International Stem Cell Corporation
Posted: June 27, 2007 8:42 pm ET
Summary:
Scientists at Lifeline Cell Technology, LLC, a wholly owned subsidiary of International Stem Cell Corporation (OTCBB:ISCO), have successfully created six unique human stem cell lines that appear capable of differentiation into any cell type found in the human body using an efficient method that does not require the use of fertilized embryos.
Posted: June 27, 2007 8:42 pm ET
Summary:
Scientists at Lifeline Cell Technology, LLC, a wholly owned subsidiary of International Stem Cell Corporation (OTCBB:ISCO), have successfully created six unique human stem cell lines that appear capable of differentiation into any cell type found in the human body using an efficient method that does not require the use of fertilized embryos.
Stem cell scientists find almost perfect human match in mice
Source: Guardian Unlimited - UK
Date: June 27, 2007
Summary:
Scientists have found a stem cell in mice which is a near-perfect match for human cells. The discovery will speed research into incurable diseases such as diabetes and Parkinson's, and bring closer the mass production of body tissue to replace that damaged by disease.
Date: June 27, 2007
Summary:
Scientists have found a stem cell in mice which is a near-perfect match for human cells. The discovery will speed research into incurable diseases such as diabetes and Parkinson's, and bring closer the mass production of body tissue to replace that damaged by disease.
New stem cell could aid research
Source: BBC News
Posted: 27 June 2007, 23:04 GMT 00:04 UK
Summary:
BBC News reports on the discovery of a mouse stem cell which is similar to a human embryonic stem cell:
"UK scientists say the discovery of a new type of stem cell should aid research into cures for disease. The journal Nature features two studies in which scientists extracted rodent embryonic stem cells which closely resembled their human counterparts. Previously extracted animal stem cells behaved very differently. Substituting rodent for human embryonic stem cells could speed up research, as they would be easier to obtain, and less controversial to use."
Posted: 27 June 2007, 23:04 GMT 00:04 UK
Summary:
BBC News reports on the discovery of a mouse stem cell which is similar to a human embryonic stem cell:
"UK scientists say the discovery of a new type of stem cell should aid research into cures for disease. The journal Nature features two studies in which scientists extracted rodent embryonic stem cells which closely resembled their human counterparts. Previously extracted animal stem cells behaved very differently. Substituting rodent for human embryonic stem cells could speed up research, as they would be easier to obtain, and less controversial to use."
First Patient Treated in Aastrom Adult Stem Cell Trial for Critical Limb Ischemia
Source: Aastrom Biosciences, Inc.
Date: June 27, 2007
Summary:
In an official news release, Aastrom Biosciences, Inc., a regenerative medicine company, announced that the first critical limb ischemia (CLI) patient was treated at the Malcom Randall Veterans Affairs (VA) Medical Center in Gainesville, FL. The Company is evaluating its Vascular Repair Cell (VRC) product in a U.S. Phase IIb clinical trial to treat patients suffering from CLI, the most severe form of peripheral arterial disease (PAD).
Date: June 27, 2007
Summary:
In an official news release, Aastrom Biosciences, Inc., a regenerative medicine company, announced that the first critical limb ischemia (CLI) patient was treated at the Malcom Randall Veterans Affairs (VA) Medical Center in Gainesville, FL. The Company is evaluating its Vascular Repair Cell (VRC) product in a U.S. Phase IIb clinical trial to treat patients suffering from CLI, the most severe form of peripheral arterial disease (PAD).
More Humanlike Mouse Stem Cells Discovered
Source: Scientific American
Date: June 27, 2007
Scientific American reports on a discovery that mouse embryonic stem cells are can function like human embryonic stem cells, a finding that could potentially expedite the development of therapies for diseases from human embryonic stem cells:
"Two independent British research groups have discovered new stem cells in mouse embryos that could help enhance understanding of human embryonic stem cells as well as move scientists closer to harnessing these cells' full healing power."
The story continues to describe how the scientists made the discovery and potential applications in might have to the field of human embryonic stem cell research:
"...researchers report this week in Nature that they discovered a new mouse embryo–derived stem cell that behaves much like a human embryonic stem cell—which could make mouse models more valuable research tools. The teams, from the universities of Cambridge and Oxford in England, say the key may be in the timing: They plucked the cells from mouse embryos two days later than researchers ordinarily do. The scientists say these cells' humanlike quality can provide insight into how human embryonic cells operate."
Date: June 27, 2007
Scientific American reports on a discovery that mouse embryonic stem cells are can function like human embryonic stem cells, a finding that could potentially expedite the development of therapies for diseases from human embryonic stem cells:
"Two independent British research groups have discovered new stem cells in mouse embryos that could help enhance understanding of human embryonic stem cells as well as move scientists closer to harnessing these cells' full healing power."
The story continues to describe how the scientists made the discovery and potential applications in might have to the field of human embryonic stem cell research:
"...researchers report this week in Nature that they discovered a new mouse embryo–derived stem cell that behaves much like a human embryonic stem cell—which could make mouse models more valuable research tools. The teams, from the universities of Cambridge and Oxford in England, say the key may be in the timing: They plucked the cells from mouse embryos two days later than researchers ordinarily do. The scientists say these cells' humanlike quality can provide insight into how human embryonic cells operate."
'Missing link' stem cells may shorten path to therapies
Source: Agence France Presse (AFP)
Posted: June 27, 2007 2:55 PM EDT
Summary:
Agence France Presse (AFP) reports scientist have discovered a mouse embryonic stem cell that is similar to human embryonic stem cell:
"The discovery of a mouse embryonic stem cell startlingly similar to its human counterpart will likely speed progress toward the regeneration of healthy cells and organ tissue in people, two studies reported. The newly-found "epiblast" stem cells, taken from the inner-most layer of week-old rodent embryos, will provide a better model in testing potential therapies for human diseases and injuries, the researchers said."
Posted: June 27, 2007 2:55 PM EDT
Summary:
Agence France Presse (AFP) reports scientist have discovered a mouse embryonic stem cell that is similar to human embryonic stem cell:
"The discovery of a mouse embryonic stem cell startlingly similar to its human counterpart will likely speed progress toward the regeneration of healthy cells and organ tissue in people, two studies reported. The newly-found "epiblast" stem cells, taken from the inner-most layer of week-old rodent embryos, will provide a better model in testing potential therapies for human diseases and injuries, the researchers said."
Researchers ID New Type of Mouse Stem Cell
Source: HealthDay News
Date: June 27, 2007
Summary:
HealthDay News reports on the discovery of a new type of mouse embryonic stem cell that is similar to a human embryonic stem cell:
"Scientists have discovered a new type of rodent embryonic stem cell that is more akin to its human counterparts than current mouse stem cells. The new mouse embryonic stem cells could provide a useful model to further understanding of human stem cells. The findings, by two different groups of researchers, are published online June 27 in the journal Nature."
Date: June 27, 2007
Summary:
HealthDay News reports on the discovery of a new type of mouse embryonic stem cell that is similar to a human embryonic stem cell:
"Scientists have discovered a new type of rodent embryonic stem cell that is more akin to its human counterparts than current mouse stem cells. The new mouse embryonic stem cells could provide a useful model to further understanding of human stem cells. The findings, by two different groups of researchers, are published online June 27 in the journal Nature."
Clinical Trial Suggests Bone Marrow Stem Cells Are Useful for Spinal Cord Injury; PrimeCell Therapeutics Provided Pre-Clinical Study
Source: PrimeCell Therapeutics LLC
Posted: June 27, 2007 02:28 PM EDT
Summary:
Prime Cell Therapeutics announced support for a new trial using patients' bone marrow stem cells to attempt to treat spinal cord injuries:
"PrimeCell™ Therapeutics LLC today announced that it provided research support and pre-clinical studies for a clinical trial to assess the safety, feasibility and efficacy of implanting autologous bone marrow stem cells into spinal cord injury (SCI) patients."
Posted: June 27, 2007 02:28 PM EDT
Summary:
Prime Cell Therapeutics announced support for a new trial using patients' bone marrow stem cells to attempt to treat spinal cord injuries:
"PrimeCell™ Therapeutics LLC today announced that it provided research support and pre-clinical studies for a clinical trial to assess the safety, feasibility and efficacy of implanting autologous bone marrow stem cells into spinal cord injury (SCI) patients."
Human therapeutic cloning moves closer to reality
Source: New Scientist
Date: 27 June 2007
Summary:
New Scientist reports researchers have derived stem cells from cloned money embryos, a development that could eventually lead to human therapeutic cloning:
"Human therapeutic cloning has moved one step closer to reality. Stem cells have been extracted from cloned monkey embryos for the first time - and if it works in monkey cells, why not in human cells too? 'It's proof of principle for human therapeutic cloning,' says team member Don Wolf of the Oregon National Primate Research Center in Beaverton. Wolf's colleague Shoukhrat Mitalipov announced the breakthrough on 18 June at a meeting of the International Society for Stem Cell Research in Cairns, Queensland, Australia. The Oregon team stripped the chromosomes from 278 rhesus monkey eggs and replaced them with the nuclei of skin cells from male monkeys. They derived two stem-cell lines from 21 embryos that developed into a hollow ball of cells known as a blastocyst."
Date: 27 June 2007
Summary:
New Scientist reports researchers have derived stem cells from cloned money embryos, a development that could eventually lead to human therapeutic cloning:
"Human therapeutic cloning has moved one step closer to reality. Stem cells have been extracted from cloned monkey embryos for the first time - and if it works in monkey cells, why not in human cells too? 'It's proof of principle for human therapeutic cloning,' says team member Don Wolf of the Oregon National Primate Research Center in Beaverton. Wolf's colleague Shoukhrat Mitalipov announced the breakthrough on 18 June at a meeting of the International Society for Stem Cell Research in Cairns, Queensland, Australia. The Oregon team stripped the chromosomes from 278 rhesus monkey eggs and replaced them with the nuclei of skin cells from male monkeys. They derived two stem-cell lines from 21 embryos that developed into a hollow ball of cells known as a blastocyst."
"Missing link" stem cells may speed race for cures
Source: Reuters
Posted: June 27, 2007 1:04 PM
Reuters reports on the discovery of a new type of stem cell that should hasten research into cures for diseases:
"Scientists have discovered a new type of embryonic stem cell in mice and rats that should speed up research into regenerative medicine and help in the hunt for cures to a range of diseases. Two independent teams from Britain's Oxford and Cambridge universities said on Wednesday that so-called rodent epiblast stem cells were very similar to human embryonic stem cells, making them particularly good models for analyzing human health."
The study's lead scientist at Cambridge University believes the similarities between the mouse and human cells will make it easier to use mouse embryonic stem cells to study human embryonic stem cells:
"The new cells effectively constitute a "missing link" between mouse and human embryonic stem cells, according to Roger Pedersen, leader of the Cambridge group. Laboratory mice have long been a favorite model for human disease but researchers have been frustrated by the fact that human and mouse stem cells behave very differently. Now scientists think they may have cracked the problem."
The story also notes that this discovery is a sign of progress in the field of embryonic stem cell research:
"The use of epiblast stem cells will not lead to immediate breakthroughs in clinical treatments but the fact that two teams made the discovery almost simultaneously is a sign of momentum picking up in stem cell research."
Posted: June 27, 2007 1:04 PM
Reuters reports on the discovery of a new type of stem cell that should hasten research into cures for diseases:
"Scientists have discovered a new type of embryonic stem cell in mice and rats that should speed up research into regenerative medicine and help in the hunt for cures to a range of diseases. Two independent teams from Britain's Oxford and Cambridge universities said on Wednesday that so-called rodent epiblast stem cells were very similar to human embryonic stem cells, making them particularly good models for analyzing human health."
The study's lead scientist at Cambridge University believes the similarities between the mouse and human cells will make it easier to use mouse embryonic stem cells to study human embryonic stem cells:
"The new cells effectively constitute a "missing link" between mouse and human embryonic stem cells, according to Roger Pedersen, leader of the Cambridge group. Laboratory mice have long been a favorite model for human disease but researchers have been frustrated by the fact that human and mouse stem cells behave very differently. Now scientists think they may have cracked the problem."
The story also notes that this discovery is a sign of progress in the field of embryonic stem cell research:
"The use of epiblast stem cells will not lead to immediate breakthroughs in clinical treatments but the fact that two teams made the discovery almost simultaneously is a sign of momentum picking up in stem cell research."
Tuesday, June 26, 2007
Umbilical cord blood may help children with diabetes
Source: Guardian Unlimited - UK
Date: June 27, 2007
Summary:
The Guardian reports on a finding by scientists at the University of Florida that umbilical cord stem cells reduced symptoms of type 1 diabetes in children with the disease:
"Children with type 1 diabetes can have the severity of their disease reduced if they are infused with blood saved from their umbilical cords, a study has found. Scientists think the infusion resets the body's immune system, stopping it from destroying insulin-producing cells that are needed to control blood sugar levels."
Date: June 27, 2007
Summary:
The Guardian reports on a finding by scientists at the University of Florida that umbilical cord stem cells reduced symptoms of type 1 diabetes in children with the disease:
"Children with type 1 diabetes can have the severity of their disease reduced if they are infused with blood saved from their umbilical cords, a study has found. Scientists think the infusion resets the body's immune system, stopping it from destroying insulin-producing cells that are needed to control blood sugar levels."
First study transplanting angina patients' purified stem cells shows safety and symptom relief
Source: Northwestern University
Date: June 26, 2007
Summary:
CHICAGO --- The first U.S. study to transplant a potent form of purified adult stem cells into the heart muscle of patients with severe angina provided evidence that the procedure is safe and produced a reduction in angina pain as well as improved functioning in patients' daily lives, reports the lead researcher at Northwestern University's Feinberg School of Medicine.
Date: June 26, 2007
Summary:
CHICAGO --- The first U.S. study to transplant a potent form of purified adult stem cells into the heart muscle of patients with severe angina provided evidence that the procedure is safe and produced a reduction in angina pain as well as improved functioning in patients' daily lives, reports the lead researcher at Northwestern University's Feinberg School of Medicine.
Scientists discover a new line of communication between nervous system cells
Source: American Committee for the Weizmann Institute of Science
Date: June 26, 2007
Summary:
In a host of neurological diseases, including multiple sclerosis (MS) and several neuropathies, the protective covering surrounding the nerves – an insulating material called myelin – is damaged. Scientists at the Weizmann Institute of Science have now discovered an important new line of communication between nervous system cells that is crucial to the development of myelinated nerves – a discovery that may aid in restoring the normal function of the affected nerve fibers.
Date: June 26, 2007
Summary:
In a host of neurological diseases, including multiple sclerosis (MS) and several neuropathies, the protective covering surrounding the nerves – an insulating material called myelin – is damaged. Scientists at the Weizmann Institute of Science have now discovered an important new line of communication between nervous system cells that is crucial to the development of myelinated nerves – a discovery that may aid in restoring the normal function of the affected nerve fibers.
Intercytex artificial skin heals wounds in tests
Source: Reuters
Posted: June 26, 2007 5:45AM EDT
Summary:
Reuters reports that Intercytex, a biotechnology company in the field of stem cell research, announced it has created artificial skin to improve wound healing:
"A British biotechnology company has developed a long-lasting artificial skin that has produced promising results in healing wounds in early clinical trials. Scientists said the advance could mark a breakthrough in regenerative medicine. Intercytex Group Plc, which specializes in cell therapy, said on Tuesday its laboratory-made living skin was fully and consistently integrated into the human body. The new skin appears to work better than other substitutes tried in the past, which biodegrade in situ after a few weeks...Intercytex now plans to test ICX-SKN on larger wounds and move on to pivotal clinical trials that would generate sufficient data to seek a marketing license."
Posted: June 26, 2007 5:45AM EDT
Summary:
Reuters reports that Intercytex, a biotechnology company in the field of stem cell research, announced it has created artificial skin to improve wound healing:
"A British biotechnology company has developed a long-lasting artificial skin that has produced promising results in healing wounds in early clinical trials. Scientists said the advance could mark a breakthrough in regenerative medicine. Intercytex Group Plc, which specializes in cell therapy, said on Tuesday its laboratory-made living skin was fully and consistently integrated into the human body. The new skin appears to work better than other substitutes tried in the past, which biodegrade in situ after a few weeks...Intercytex now plans to test ICX-SKN on larger wounds and move on to pivotal clinical trials that would generate sufficient data to seek a marketing license."
Artificial skin 'cuts scarring'
Source: BBC News
Posted: 26 June 2007, 05:07 GMT 06:07 UK
BBC News reports UK-based Intercytex, a biotechnology company in the field of stem cell research, has developed a prototype artificial skin used to heal wounds:
"A prototype artificial skin used to heal wounds has been developed by British researchers.
Writing in the journal Regenerative Medicine, UK-based company Intercytex said it had produced promising results in early trials. It said the skin seemed to incorporate itself much better with real tissue than any other skin substitutes tried in the past. The researchers hope it might provide an alternative to skin grafts."
Posted: 26 June 2007, 05:07 GMT 06:07 UK
BBC News reports UK-based Intercytex, a biotechnology company in the field of stem cell research, has developed a prototype artificial skin used to heal wounds:
"A prototype artificial skin used to heal wounds has been developed by British researchers.
Writing in the journal Regenerative Medicine, UK-based company Intercytex said it had produced promising results in early trials. It said the skin seemed to incorporate itself much better with real tissue than any other skin substitutes tried in the past. The researchers hope it might provide an alternative to skin grafts."
Monday, June 25, 2007
Cord blood may preserve insulin levels in children with type 1 diabetes
Source: University of Florida
Date: June 25, 2007
Summary;
Umbilical cord blood may safely preserve insulin production in children newly diagnosed with type 1 diabetes, according to findings from a small national pilot study presented today (June 25) at the American Diabetes Association’s 67th Scientific Sessions in Chicago.
Date: June 25, 2007
Summary;
Umbilical cord blood may safely preserve insulin production in children newly diagnosed with type 1 diabetes, according to findings from a small national pilot study presented today (June 25) at the American Diabetes Association’s 67th Scientific Sessions in Chicago.
Cord blood helped in type 1 diabetes: study
Source: Reuters
Posted: June 25, 2007 4:27 PM ET
Summary:
Reuters reports infusions of cord blood reduced children's type 1 diabetes symptoms:
"Giving children with type 1 diabetes an infusion of blood saved from their own umbilical cords helped reduce the severity of their disease, U.S. researchers said on Monday. They said the blood -- which is rich in immune regulatory cells -- may re-start the children's immune systems, but the effect likely will not last and will need more study."
Posted: June 25, 2007 4:27 PM ET
Summary:
Reuters reports infusions of cord blood reduced children's type 1 diabetes symptoms:
"Giving children with type 1 diabetes an infusion of blood saved from their own umbilical cords helped reduce the severity of their disease, U.S. researchers said on Monday. They said the blood -- which is rich in immune regulatory cells -- may re-start the children's immune systems, but the effect likely will not last and will need more study."
First Use of Cord Blood to Alter Course of Type 1 Diabetes
Source: American Diabetes Association
Date: June 25, 2007
Summary:
The American Diabetes Association announced the results of a small study in which patients' own cord blood stem cells reduced symptoms of their type 1 diabetes:
"In a small pilot study, transfusion of stored, autologous (i.e. the person's own), umbilical cord blood into a group of children newly diagnosed with type 1 diabetes appears to have reduced their disease severity, possibly re-setting the immune system and slowing the destruction of their insulin-producing cells, according to a report presented today at the American Diabetes Association's 67th Annual Scientific Sessions."
Date: June 25, 2007
Summary:
The American Diabetes Association announced the results of a small study in which patients' own cord blood stem cells reduced symptoms of their type 1 diabetes:
"In a small pilot study, transfusion of stored, autologous (i.e. the person's own), umbilical cord blood into a group of children newly diagnosed with type 1 diabetes appears to have reduced their disease severity, possibly re-setting the immune system and slowing the destruction of their insulin-producing cells, according to a report presented today at the American Diabetes Association's 67th Annual Scientific Sessions."
Sunday, June 24, 2007
Can you hear me now? Stem cells enhance hearing recovery
Source: American Journal of Pathology
Date: June 25, 2007
Summary:
Tokyo, Japan -- Researchers have shown that bone marrow stem cells injected into a damaged inner ear can speed hearing recovery after partial hearing loss. The related report by Kamiya et al, “Mesenchymal stem cell transplantation accelerates hearing recovery through the repair of injured cochlear fibrocytes,” appears in the July issue of The American Journal of Pathology.
Date: June 25, 2007
Summary:
Tokyo, Japan -- Researchers have shown that bone marrow stem cells injected into a damaged inner ear can speed hearing recovery after partial hearing loss. The related report by Kamiya et al, “Mesenchymal stem cell transplantation accelerates hearing recovery through the repair of injured cochlear fibrocytes,” appears in the July issue of The American Journal of Pathology.
Stem cells could treat diabetes
Source: CNN Money
Posted: June 24, 2007: 1:30 PM EDT
Summary:
CNN reports on a new study in mice showing adult blood cells could potentially be a better source of insulin than embryonic stem cells for the development of a potential diabetes treatment:
"Early-stage studies in mice have shown that adult blood could be a richer source of insulin-creating stem cells than fertilized eggs, according to Dr. Yong Zhao, assistant professor at the University of Illinois. If these test results are repeated in humans, it could possibly lead to a diabetes treatment that would avoid the controversy surrounding embryonic stem cells."
Posted: June 24, 2007: 1:30 PM EDT
Summary:
CNN reports on a new study in mice showing adult blood cells could potentially be a better source of insulin than embryonic stem cells for the development of a potential diabetes treatment:
"Early-stage studies in mice have shown that adult blood could be a richer source of insulin-creating stem cells than fertilized eggs, according to Dr. Yong Zhao, assistant professor at the University of Illinois. If these test results are repeated in humans, it could possibly lead to a diabetes treatment that would avoid the controversy surrounding embryonic stem cells."
Saturday, June 23, 2007
Apollo's Human Proteins Boost Stem Cell Research
Source: Apollo Life Sciences Limited
Date: June 23, 2007 - 1:00 PDT
Summary:
Apollo Life Sciences Limited, a biotechnology company in the field of protein development, announced new applications for the company's human proteins to stem cell research:
"At a time when Australian scientists are fighting hard to keep pace with overseas research and development, an Australian biotech company is leading the world in the production of human proteins for stem cell research. Apollo Life Sciences CEO John Priest said the company's human proteins are unique in the way they help stem cells to develop into specific cell types such as heart, nerve and muscle cells. Human proteins are used in research because they provide greater control over stem cell growth and also work faster than non-human proteins."
Date: June 23, 2007 - 1:00 PDT
Summary:
Apollo Life Sciences Limited, a biotechnology company in the field of protein development, announced new applications for the company's human proteins to stem cell research:
"At a time when Australian scientists are fighting hard to keep pace with overseas research and development, an Australian biotech company is leading the world in the production of human proteins for stem cell research. Apollo Life Sciences CEO John Priest said the company's human proteins are unique in the way they help stem cells to develop into specific cell types such as heart, nerve and muscle cells. Human proteins are used in research because they provide greater control over stem cell growth and also work faster than non-human proteins."
Friday, June 22, 2007
Company says grows embryo-safe stem cells
Source: Reuters
Posted: June 22, 2007 2:47pm ET
Summary:
Researchers at Advanced Cell Technology Inc., a U.S. company trying to push the margins of stem cell research, said on Friday they had grown human embryonic stem cells using a non-controversial method that did not harm the embryos. They said they had grown several lines, or batches, of the cells using a single cell taken from an embryo, which they then froze unharmed.
Posted: June 22, 2007 2:47pm ET
Summary:
Researchers at Advanced Cell Technology Inc., a U.S. company trying to push the margins of stem cell research, said on Friday they had grown human embryonic stem cells using a non-controversial method that did not harm the embryos. They said they had grown several lines, or batches, of the cells using a single cell taken from an embryo, which they then froze unharmed.
Study Will Test Stem Cells Against Heart Attack
Source: HealthDay News
Posted: June 22, 2007 10:00 AM CDT
Summary:
HealthDay News reports on a new clinical trial using patients' own bone marrow stem cells to attempt to repair heart muscle damage from a heart attack:
"In a first-of-a-kind study, patients who've recently had a major heart attack and are undergoing coronary bypass surgery will be injected with selected stem cells harvested from their own bone marrow. The study of 60 patients by researchers at the University of Bristol in the United Kingdom will examine whether those stem cells can repair heart muscle cells damaged by heart attack. Specifically, the researchers want to determine if the stem cells can prevent late scar formation and the impaired heart contraction that can result from that scarring."
Posted: June 22, 2007 10:00 AM CDT
Summary:
HealthDay News reports on a new clinical trial using patients' own bone marrow stem cells to attempt to repair heart muscle damage from a heart attack:
"In a first-of-a-kind study, patients who've recently had a major heart attack and are undergoing coronary bypass surgery will be injected with selected stem cells harvested from their own bone marrow. The study of 60 patients by researchers at the University of Bristol in the United Kingdom will examine whether those stem cells can repair heart muscle cells damaged by heart attack. Specifically, the researchers want to determine if the stem cells can prevent late scar formation and the impaired heart contraction that can result from that scarring."
Heart attack patients to receive stem cell test treatment
Source: Guardian Unlimited - UK
Date: June 22, 2007
Summary:
The Guardian reports on a new trial using adult bone marrow stem cells to treat heart attack patients:
"British scientists are to try out a new way to repair damage caused by heart attacks. By injecting patients' damaged hearts with stem cells from their own bone marrow scientists hope to regenerate tissue."
Date: June 22, 2007
Summary:
The Guardian reports on a new trial using adult bone marrow stem cells to treat heart attack patients:
"British scientists are to try out a new way to repair damage caused by heart attacks. By injecting patients' damaged hearts with stem cells from their own bone marrow scientists hope to regenerate tissue."
Thursday, June 21, 2007
Study identifies novel Parkinson's disease drug target
Source: Massachusetts General Hospital
Date: June 21, 2007
Summary:
Researchers at the MassGeneral Institute for Neurodegenerative Disease (MGH-MIND) have identified a potential new drug target for the treatment of Parkinson’s disease and possibly for other degenerative neurological disorders.
Date: June 21, 2007
Summary:
Researchers at the MassGeneral Institute for Neurodegenerative Disease (MGH-MIND) have identified a potential new drug target for the treatment of Parkinson’s disease and possibly for other degenerative neurological disorders.
Paving The Way Toward A Vaccine Against Alzheimer's Disease
Source: American Society for Biochemistry and Molecular Biology
Date: June 21, 2007
Summary:
Scientists have provided new details about how proteins used to destroy bacteria and viruses may help treat Alzheimer’s disease. Gunnar K. Gouras, associate professor of neurology and neuroscience at Weill Medical College of Cornell University, New York, and colleagues provide new insights into how these proteins, called antibodies, reduce the main hallmarks of Alzheimer’s disease and raise hopes for a vaccine against the disease.
Date: June 21, 2007
Summary:
Scientists have provided new details about how proteins used to destroy bacteria and viruses may help treat Alzheimer’s disease. Gunnar K. Gouras, associate professor of neurology and neuroscience at Weill Medical College of Cornell University, New York, and colleagues provide new insights into how these proteins, called antibodies, reduce the main hallmarks of Alzheimer’s disease and raise hopes for a vaccine against the disease.
Cardiac team in stem-cell tests
Source: BBC News
Posted: 21 June 2007, 23:44 GMT 00:44 UK
Summary:
BBC News reports British doctors are conducting a clinical trial to determine the effectiveness of a patient's own bone marrow stem cells in treating damaged heart muscle from a heart attack:
"Pioneering research to test if stem cells can repair heart muscle damage by a heart attack is beginning in the UK. Sixty patients have volunteered to take part and will be injected with their own bone marrow stem cells during routine coronary bypass surgery. The Bristol surgeons say this should reduce scarring in the heart, thereby improving its pumping action and guard against future heart complications."
Posted: 21 June 2007, 23:44 GMT 00:44 UK
Summary:
BBC News reports British doctors are conducting a clinical trial to determine the effectiveness of a patient's own bone marrow stem cells in treating damaged heart muscle from a heart attack:
"Pioneering research to test if stem cells can repair heart muscle damage by a heart attack is beginning in the UK. Sixty patients have volunteered to take part and will be injected with their own bone marrow stem cells during routine coronary bypass surgery. The Bristol surgeons say this should reduce scarring in the heart, thereby improving its pumping action and guard against future heart complications."
Stem Cells To Repair Damaged Heart Muscle
Source: University of Bristol
Date: June 21, 2007
Summary:
Stem cell researchers at the University of Bristol in the United Kingdom have announced the start of a clinical trial to treat heart heart attack patients with their own bone marrow stem cells:
"In the first trial of its kind in the world, 60 patients who have recently suffered a major heart attack will be injected with selected stem cells from their own bone marrow during routine coronary bypass surgery. The Bristol trial will test whether the stem cells will repair heart muscle cells damaged by the heart attack, by preventing late scar formation and hence impaired heart contraction."
Date: June 21, 2007
Summary:
Stem cell researchers at the University of Bristol in the United Kingdom have announced the start of a clinical trial to treat heart heart attack patients with their own bone marrow stem cells:
"In the first trial of its kind in the world, 60 patients who have recently suffered a major heart attack will be injected with selected stem cells from their own bone marrow during routine coronary bypass surgery. The Bristol trial will test whether the stem cells will repair heart muscle cells damaged by the heart attack, by preventing late scar formation and hence impaired heart contraction."
Advanced Cell Technology Develops First Human Embryonic Stem Cell Line without Destroying an Embryo
Source: Advanced Cell Technology, Inc.
Posted: June 21, 2007 09:35 AM EDT
Summary:
Advanced Cell Technology, Inc. has successfully produced a human embryonic stem cell (hESC) line without destroying an embryo at its lab in Worcester, Massachusetts.
Posted: June 21, 2007 09:35 AM EDT
Summary:
Advanced Cell Technology, Inc. has successfully produced a human embryonic stem cell (hESC) line without destroying an embryo at its lab in Worcester, Massachusetts.
Stem cell test is another success
Source: Bloomberg News
Posted: June 21, 2007 04:25:31 AM PDT
Summary:
Bloomberg News reports scientists at Advanced Cell Technology Inc. said they grew embryonic stem cells without harming embryos:
"Scientists said they grew colonies of human stem cells without harming the embryos from which they came, 10 months after making a similar announcement, only to acknowledge the embryos they used were destroyed. Researchers led by Robert Lanza at Alameda-based Advanced Cell Technology Inc. said they took stem cells from embryos, which were then frozen. That would allow the embryos to be used to help women who want to get pregnant. Lanza said Advanced Cell is asking the National Institutes of Health for funding to increase production.
The story also mentions the potential of these findings to end the ethical controversy that has stymied the field of embryonic stem cell research and describes the how the stem cells are derived:
"The research may help allay the concerns of some stem-cell research opponents, who say destroying an embryo in the process of extracting cells is equal to taking a life. It may also spur U.S.-funded studies of the cells, which can turn into any other cell and may one day lead to treatments for diseases including cancer, diabetes, Alzheimer's and Parkinson's. Obtaining the stem cells involves removing a single cell from an eight-cell human blastocyst."
Posted: June 21, 2007 04:25:31 AM PDT
Summary:
Bloomberg News reports scientists at Advanced Cell Technology Inc. said they grew embryonic stem cells without harming embryos:
"Scientists said they grew colonies of human stem cells without harming the embryos from which they came, 10 months after making a similar announcement, only to acknowledge the embryos they used were destroyed. Researchers led by Robert Lanza at Alameda-based Advanced Cell Technology Inc. said they took stem cells from embryos, which were then frozen. That would allow the embryos to be used to help women who want to get pregnant. Lanza said Advanced Cell is asking the National Institutes of Health for funding to increase production.
The story also mentions the potential of these findings to end the ethical controversy that has stymied the field of embryonic stem cell research and describes the how the stem cells are derived:
"The research may help allay the concerns of some stem-cell research opponents, who say destroying an embryo in the process of extracting cells is equal to taking a life. It may also spur U.S.-funded studies of the cells, which can turn into any other cell and may one day lead to treatments for diseases including cancer, diabetes, Alzheimer's and Parkinson's. Obtaining the stem cells involves removing a single cell from an eight-cell human blastocyst."
Wednesday, June 20, 2007
Study Tests Blood Stem Cells to Boost Immune System
Source: HealthDay News
Date: June 20, 2007
Summary:
A new method of increasing blood stem cells could one day promote quicker recovery of immune system function in patients who've undergone chemotherapy or bone marrow transplant for leukemia and other cancers, researchers say.
Date: June 20, 2007
Summary:
A new method of increasing blood stem cells could one day promote quicker recovery of immune system function in patients who've undergone chemotherapy or bone marrow transplant for leukemia and other cancers, researchers say.
Advanced Cell Technology Announces Critical Advancements in its RPE Program for the Treatment of Macular Degeneration and Other Retinal Degenerative D
Source: Advanced Cell Technology, Inc.
Posted: June 20, 2007 07:30 AM
Summary:
Advanced Cell Technology, Inc. today announced major advancements in the process of bringing its Retinal Pigment Epithelial (RPE) program into the clinic to treat various retinal degenerative diseases, including Age-Related Macular Degeneration (AMD).
Posted: June 20, 2007 07:30 AM
Summary:
Advanced Cell Technology, Inc. today announced major advancements in the process of bringing its Retinal Pigment Epithelial (RPE) program into the clinic to treat various retinal degenerative diseases, including Age-Related Macular Degeneration (AMD).
Scientists move closer to human therapeutic cloning
Source: Reuters
Posted: June 20, 2007 3:09AM EDT
Summary:
Reuters reports an advance of stem cell research that could move the field closer to human therapeutic cloning:
"Human therapeutic cloning has moved a step closer after U.S. researchers said they had successfully created embryonic stem cells from monkey embryos. In what would be a world-first breakthrough, scientists told a stem cell research conference in the Australian city of Cairns this week that they had successfully created two batches of embryonic stem cells from cloned rhesus monkey embryos."
Posted: June 20, 2007 3:09AM EDT
Summary:
Reuters reports an advance of stem cell research that could move the field closer to human therapeutic cloning:
"Human therapeutic cloning has moved a step closer after U.S. researchers said they had successfully created embryonic stem cells from monkey embryos. In what would be a world-first breakthrough, scientists told a stem cell research conference in the Australian city of Cairns this week that they had successfully created two batches of embryonic stem cells from cloned rhesus monkey embryos."
Tuesday, June 19, 2007
Genes that give stem cells their oomph identified
Source: The Globe and Mail
Posted: June 19, 2007 at 10:15 PM EDT
Summary:
The Globe and Mail reports Canadian researchers have identified genes that enable embryonic stem cells to become any of the human tissue types:
"Canadian researchers say they have identified the genes that give embryonic stem cells their superhero-like abilities. Working with mice, the University of Ottawa's Michael Rudnicki and his colleagues have figured out what makes stem cells so special – at a molecular level. They say they have identified the network of genes at work during the unique period when stem cells are building a body."
The story also describes the potential insights the research could provide scientists in order to better understand the function of stem cells:
"The Canadian work, published Tuesday in the online journal Public Library of Science, adds detail to the understanding of the mysterious circuitry of stem cells. It may help scientists turn normal adult cells into embryonic stem cells by turning on specific genes."
Posted: June 19, 2007 at 10:15 PM EDT
Summary:
The Globe and Mail reports Canadian researchers have identified genes that enable embryonic stem cells to become any of the human tissue types:
"Canadian researchers say they have identified the genes that give embryonic stem cells their superhero-like abilities. Working with mice, the University of Ottawa's Michael Rudnicki and his colleagues have figured out what makes stem cells so special – at a molecular level. They say they have identified the network of genes at work during the unique period when stem cells are building a body."
The story also describes the potential insights the research could provide scientists in order to better understand the function of stem cells:
"The Canadian work, published Tuesday in the online journal Public Library of Science, adds detail to the understanding of the mysterious circuitry of stem cells. It may help scientists turn normal adult cells into embryonic stem cells by turning on specific genes."
Study identifies 5 genetic themes key to keeping stem cells in a primitive, flexible state
Source: Public Library of Science
Date: June 19, 2007
Summary:
The Public Library of Science reports on a new study in which scientists identified five genes that are key to keeping stem cells in a flexible, undifferentiated state:
"For more than 25 years, stem cells have been defined based on what they can become: more of themselves, as well as multiple different specialized cell types. But as genetic techniques have become increasingly powerful, many scientists have sought a more molecular definition of stem cells, based on the genes they express."
"Now, a team of Canadian scientists has identified 1,155 genes under the control of a gene called Oct4 considered to be the master regulator of the stem cell state. A comprehensive molecular definition of stem cells is emerging: according to this research, stem cells are cells that keep their DNA packaged in a flexible format, keep cell division tightly controlled, prevent signals that might trigger death, repair DNA very effectively, and reinforce all of these characteristics by tightly controlling how molecules can move within the nucleus. The study will be published in the June 20 edition of the online, open-access journal PLoS ONE."
Date: June 19, 2007
Summary:
The Public Library of Science reports on a new study in which scientists identified five genes that are key to keeping stem cells in a flexible, undifferentiated state:
"For more than 25 years, stem cells have been defined based on what they can become: more of themselves, as well as multiple different specialized cell types. But as genetic techniques have become increasingly powerful, many scientists have sought a more molecular definition of stem cells, based on the genes they express."
"Now, a team of Canadian scientists has identified 1,155 genes under the control of a gene called Oct4 considered to be the master regulator of the stem cell state. A comprehensive molecular definition of stem cells is emerging: according to this research, stem cells are cells that keep their DNA packaged in a flexible format, keep cell division tightly controlled, prevent signals that might trigger death, repair DNA very effectively, and reinforce all of these characteristics by tightly controlling how molecules can move within the nucleus. The study will be published in the June 20 edition of the online, open-access journal PLoS ONE."
Modeling Cell Division: How A Cell Interacts With Its Microenvironment
Source: Institut Curie
Date: June 19, 2007
Summary:
Division is a key step in the life of cells and involves complex dynamic interplay between a large number of molecular components. Biologists and theoretical physicists have now devised a theoretical model of cell division of great predictive value. They have used microtechnology to study individual cell divisions as their environment changes. Based on observations of a great many cells, the researchers have devised a theoretical model that predicts the orientation of cell division. The model, which is reported in the 24 May 2007 issue of Nature, is based on calculation of the forces exerted on the mitotic spindle within the cell, and describes how cells divide normally and what happens when something goes awry. The model shows that certain configurations of the microenvironment induce asymmetric cell division. Once applied to tissues, the model will enable diagnoses to be refined, by describing the abnormal division of diseased cells.
Date: June 19, 2007
Summary:
Division is a key step in the life of cells and involves complex dynamic interplay between a large number of molecular components. Biologists and theoretical physicists have now devised a theoretical model of cell division of great predictive value. They have used microtechnology to study individual cell divisions as their environment changes. Based on observations of a great many cells, the researchers have devised a theoretical model that predicts the orientation of cell division. The model, which is reported in the 24 May 2007 issue of Nature, is based on calculation of the forces exerted on the mitotic spindle within the cell, and describes how cells divide normally and what happens when something goes awry. The model shows that certain configurations of the microenvironment induce asymmetric cell division. Once applied to tissues, the model will enable diagnoses to be refined, by describing the abnormal division of diseased cells.
Scientists find new source of stem cells
Source: Scotsman
Date: June 19, 2007
Summary:
SCIENTISTS in Edinburgh have discovered a new source of stem cells for research into diseases such as Alzheimer's and Parkinson's. The team from Roslin Cells, a spin-off of the Roslin Institute, which created Dolly the Sheep, have created a stem cell line from a clinically unusable human egg.
Date: June 19, 2007
Summary:
SCIENTISTS in Edinburgh have discovered a new source of stem cells for research into diseases such as Alzheimer's and Parkinson's. The team from Roslin Cells, a spin-off of the Roslin Institute, which created Dolly the Sheep, have created a stem cell line from a clinically unusable human egg.
Roslin experts reveal major stem-cell breakthrough
Source: Scotsman, United Kingdom
Date: June 19, 2007
Summary:
For the first time, scientists from Roslin have managed to create new stem cells from a clinically unusable human egg. In the long-term, the development could have major implications for research into illnesses such as Alzheimer's, Parkinson's, liver disease and diabetes as well as offering hope to infertile couples. With a major shortage of embryos available for research, the announcement means these eggs could now still be used to produce embryonic stem cells. Stem cell researchers can study diseases and develop new treatments, such as drugs for the prevention of illnesses like cancer.
Date: June 19, 2007
Summary:
For the first time, scientists from Roslin have managed to create new stem cells from a clinically unusable human egg. In the long-term, the development could have major implications for research into illnesses such as Alzheimer's, Parkinson's, liver disease and diabetes as well as offering hope to infertile couples. With a major shortage of embryos available for research, the announcement means these eggs could now still be used to produce embryonic stem cells. Stem cell researchers can study diseases and develop new treatments, such as drugs for the prevention of illnesses like cancer.
RESEARCH DOCUMENTS SCALABLE PRODUCTION, SURVIVAL FOLLOWING ENGRAFTMENT AND POSITIVE IMPACT ON CARDIAC FUNCTION IN INFARCTED RATS FOR GERON'S HUMAN EMB
Source: Geron Corporation
Date: June 19, 2007
Summary:
Geron Corporation (Nasdaq: GERN) today reported that research documenting the scalable production, survival following engraftment and positive impact on cardiac function in infarcted rats was presented today for GRNCM1, the company's human embryonic stem cell (hESC)-based therapeutic for heart failure, at the International Society for Stem Cell Research (ISSCR) Annual Meeting in Cairns, Australia.
Date: June 19, 2007
Summary:
Geron Corporation (Nasdaq: GERN) today reported that research documenting the scalable production, survival following engraftment and positive impact on cardiac function in infarcted rats was presented today for GRNCM1, the company's human embryonic stem cell (hESC)-based therapeutic for heart failure, at the International Society for Stem Cell Research (ISSCR) Annual Meeting in Cairns, Australia.
Northwestern Finds Drug that Rejuvenates Neurons to Protect Against Parkinson's Disease
Source: Northwestern University
Date: June 19, 2007
Summary:
Northwestern University researchers have discovered a drug that slows - and may even halt - the progression of Parkinson's disease. The drug rejuvenates aging dopamine cells - whose death in the brain causes the symptoms of this devastating and widespread disease.
Date: June 19, 2007
Summary:
Northwestern University researchers have discovered a drug that slows - and may even halt - the progression of Parkinson's disease. The drug rejuvenates aging dopamine cells - whose death in the brain causes the symptoms of this devastating and widespread disease.
Stem cells spawn kidneys in mice
Source: Newsday
Date: June 19, 2007
Summary:
Newsday reports Japanese researchers have created functioning kidneys in mice from stem cells derived from a mouse embryo:
"Using stem cells from a mouse embryo, Japanese scientists say they have generated functioning kidneys in three mice, an advance applauded yesterday by American scientists who see the development as a significant step toward stem cell-derived kidneys for humans. Hiromitsu Nakauchi of the University of Tokyo presented his studies yesterday in Australia at the International Society for Stem Cell Research. Mouse embryos engineered to lack a critical gene needed to grow their own kidneys were injected with stem cells before implantation into surrogate mothers. When the mice were born, they had functioning kidneys, Nakauchi told the meeting. Only one mouse had minor abnormalities."
Date: June 19, 2007
Summary:
Newsday reports Japanese researchers have created functioning kidneys in mice from stem cells derived from a mouse embryo:
"Using stem cells from a mouse embryo, Japanese scientists say they have generated functioning kidneys in three mice, an advance applauded yesterday by American scientists who see the development as a significant step toward stem cell-derived kidneys for humans. Hiromitsu Nakauchi of the University of Tokyo presented his studies yesterday in Australia at the International Society for Stem Cell Research. Mouse embryos engineered to lack a critical gene needed to grow their own kidneys were injected with stem cells before implantation into surrogate mothers. When the mice were born, they had functioning kidneys, Nakauchi told the meeting. Only one mouse had minor abnormalities."
Stem cells created from cloned primates
Source: Australian Broadcasting Corporation
Date: June 19, 2007
Summary:
The Australian Broadcasting Corporation reports scientists have derived stem cells from clone primate embryos, an advance at could eventually enable human therapeutic cloning for stem cell treatments:
"US scientists say they have for the first time created stem cells from cloned primate embryos, bringing human therapeutic cloning one step closer. The announcement was made by Dr Shoukhrat Mitalipov, from the Oregon National Primate Research Centre in Portland, at the International Society for Stem Cell Research meeting in Cairns this week. Australian stem cell expert Professor Alan Trounson, who was at the meeting, says the development means that human therapeutic cloning is a step closer to reality."
Date: June 19, 2007
Summary:
The Australian Broadcasting Corporation reports scientists have derived stem cells from clone primate embryos, an advance at could eventually enable human therapeutic cloning for stem cell treatments:
"US scientists say they have for the first time created stem cells from cloned primate embryos, bringing human therapeutic cloning one step closer. The announcement was made by Dr Shoukhrat Mitalipov, from the Oregon National Primate Research Centre in Portland, at the International Society for Stem Cell Research meeting in Cairns this week. Australian stem cell expert Professor Alan Trounson, who was at the meeting, says the development means that human therapeutic cloning is a step closer to reality."
Scientists announce stem cell line from new source
Source: University of Manchester
Date: 19 June 2007
Summary:
Scientists have created a new stem cell line from a clinically unusable human egg in a development that could have major implications for research into illnesses such as Alzheimer's, Parkinson's, liver disease and diabetes. The breakthrough, by Roslin Cells Ltd, a spin out company established in 2006 by Roslin Institute, and scientists at The University of Manchester, demonstrates for the first time that eggs which are incapable of becoming viable embryos can be used as a source for stem cells. The move could help accelerate the development of regenerative medicine, where there is currently an acute shortage of embryos available for stem cell research.
Date: 19 June 2007
Summary:
Scientists have created a new stem cell line from a clinically unusable human egg in a development that could have major implications for research into illnesses such as Alzheimer's, Parkinson's, liver disease and diabetes. The breakthrough, by Roslin Cells Ltd, a spin out company established in 2006 by Roslin Institute, and scientists at The University of Manchester, demonstrates for the first time that eggs which are incapable of becoming viable embryos can be used as a source for stem cells. The move could help accelerate the development of regenerative medicine, where there is currently an acute shortage of embryos available for stem cell research.
Monday, June 18, 2007
Blood vessels in rats made from stem cells: study
Source: Reuters
Posted: June 18, 2007 11:36AM EDT
Summary:
Reuters reports scientists have made new blood vessels for transplants from muscle stem cells:
"Stem cells taken from muscle tissue can be used to build new blood vessels for transplants, researchers reported...They grew these stem cells on elastic biodegradable tubes to engineer new blood vessels for rats within days of extracting the cells. The finding, presented at a meeting in Toronto, might lead to a way to create customized blood vessel grafts to use in patients with heart and kidney disease, the researchers said."
Posted: June 18, 2007 11:36AM EDT
Summary:
Reuters reports scientists have made new blood vessels for transplants from muscle stem cells:
"Stem cells taken from muscle tissue can be used to build new blood vessels for transplants, researchers reported...They grew these stem cells on elastic biodegradable tubes to engineer new blood vessels for rats within days of extracting the cells. The finding, presented at a meeting in Toronto, might lead to a way to create customized blood vessel grafts to use in patients with heart and kidney disease, the researchers said."
StemCells, Inc. Announces Important Milestone in Batten Disease Clinical Trial
Source: StemCells, Inc.
Date: June 18, 2007
Summary:
StemCells, Inc. (NASDAQ: STEM) today announced that the Phase I clinical trial of its proprietary HuCNS-SC(TM) product candidate (purified human neural stem cells) has successfully completed enrollment of the low-dose cohort and will proceed to the high-dose cohort.
Date: June 18, 2007
Summary:
StemCells, Inc. (NASDAQ: STEM) today announced that the Phase I clinical trial of its proprietary HuCNS-SC(TM) product candidate (purified human neural stem cells) has successfully completed enrollment of the low-dose cohort and will proceed to the high-dose cohort.
Embryonic Stem Cells May Generate Kidneys in Mice, Study Shows
Source: Bloomberg News
Date: June 18, 2007, Last Updated: June 18, 2007 02:49 EDT
Summary:
Bloomberg News reports Japanese researchers have used mouse embryonic stem cells to grow kidneys in mice:
"Researchers at the University of Tokyo used stem cells from a mouse embryo to grow kidneys in mice lacking the organs, a step toward creating human body parts for transplants patients. Scientists led by Hiromitsu Nakauchi at the university's Laboratory of Stem Cell Therapy injected embryonic stem cells into juvenile mouse embryos lacking a crucial gene needed to grow kidneys. Once implanted into the uterus, the embryos grew into fetuses with kidneys."
Researchers believe this development may eventually lead to the creation of natural human organs, eliminating the need for human organ transplants:
"The research may spur the production of replacement organs that would avoid the need for patients to wait for life-saving transplants. About 100,000 people are waiting for donors in the U.S., the Organ Procurement and Transplantation Network said on its Web site. Kidneys are the most needed body parts, followed by livers, lungs and hearts."
Date: June 18, 2007, Last Updated: June 18, 2007 02:49 EDT
Summary:
Bloomberg News reports Japanese researchers have used mouse embryonic stem cells to grow kidneys in mice:
"Researchers at the University of Tokyo used stem cells from a mouse embryo to grow kidneys in mice lacking the organs, a step toward creating human body parts for transplants patients. Scientists led by Hiromitsu Nakauchi at the university's Laboratory of Stem Cell Therapy injected embryonic stem cells into juvenile mouse embryos lacking a crucial gene needed to grow kidneys. Once implanted into the uterus, the embryos grew into fetuses with kidneys."
Researchers believe this development may eventually lead to the creation of natural human organs, eliminating the need for human organ transplants:
"The research may spur the production of replacement organs that would avoid the need for patients to wait for life-saving transplants. About 100,000 people are waiting for donors in the U.S., the Organ Procurement and Transplantation Network said on its Web site. Kidneys are the most needed body parts, followed by livers, lungs and hearts."
Saturday, June 16, 2007
Injection of brain cells offers hope for Parkinson's
Source: NewScientist
Date: 16 June 2007
Summary:
STEM cell therapies for human brain diseases may have come a step closer, after monkeys with symptoms of Parkinson's disease showed marked improvement following a single injection of neural stem cells.
Date: 16 June 2007
Summary:
STEM cell therapies for human brain diseases may have come a step closer, after monkeys with symptoms of Parkinson's disease showed marked improvement following a single injection of neural stem cells.
Friday, June 15, 2007
Pluristem's stem cell therapy shows promise for Parkinson's disease
Source: Pharmaceutical Business Review
Date: 15 June 2007
Summary:
Israeli biotechnology company Pluristem Life Systems said that its placenta-derived stem cell therapy has demonstrated potential to treat Parkinson's disease. The in vitro assay demonstrated that Pluristem's PLX cells can be differentiated into dopaminergic neurons. These neurons were found to have properties favorable to cells, which are known to be helpful in treating PD.
Date: 15 June 2007
Summary:
Israeli biotechnology company Pluristem Life Systems said that its placenta-derived stem cell therapy has demonstrated potential to treat Parkinson's disease. The in vitro assay demonstrated that Pluristem's PLX cells can be differentiated into dopaminergic neurons. These neurons were found to have properties favorable to cells, which are known to be helpful in treating PD.
Some Blood Diseases May Stem from Cells' Environment
Source: Scientific American
Date: June 15, 2007
Summary:
Scientific American reports researchers have discovered that a excess of stem cells could be a cause of blood disorders:
"Researchers believe they may have unlocked the mystery behind a set of blood disorders called myeloproliferative syndromes—precursors to conditions such as leukemia that are triggered by an excess of stem cells. If so, the finding could set the stage for ways to prevent and treat such conditions—some of which can lead to heart disease, abnormal bleeding and even death."
Date: June 15, 2007
Summary:
Scientific American reports researchers have discovered that a excess of stem cells could be a cause of blood disorders:
"Researchers believe they may have unlocked the mystery behind a set of blood disorders called myeloproliferative syndromes—precursors to conditions such as leukemia that are triggered by an excess of stem cells. If so, the finding could set the stage for ways to prevent and treat such conditions—some of which can lead to heart disease, abnormal bleeding and even death."
University of Pittsburgh School of Medicine researchers develop 'off-the-shelf' vascular grafts
Source: University of Pittsburgh Schools of the Health Sciences
Date: June 15, 2007
Summary:
University of Pittsburgh School of Medicine investigators have engineered artificial blood vessels from muscle-derived stem cells (MDSCs) and a biodegradable polymer that exhibit extensive remodeling and remain free of blockages when grafted into rats. The results of their study has potentially significant implications for the treatment of heart and kidney diseases, where there is a critical need for new sources of blood vessels for vascular grafts.
Date: June 15, 2007
Summary:
University of Pittsburgh School of Medicine investigators have engineered artificial blood vessels from muscle-derived stem cells (MDSCs) and a biodegradable polymer that exhibit extensive remodeling and remain free of blockages when grafted into rats. The results of their study has potentially significant implications for the treatment of heart and kidney diseases, where there is a critical need for new sources of blood vessels for vascular grafts.
Cancer Stem Cells Similar To Normal Stem Cells Can Thwart Anti-cancer Agents
Source: University of Pittsburgh Schools of the Health Sciences
Date: June 15, 2007
Summary:
Current cancer therapies often succeed at initially eliminating the bulk of the disease, including all rapidly proliferating cells, but are eventually thwarted because they cannot eliminate a small reservoir of multiple-drug-resistant tumor cells, called cancer stem cells, which ultimately become the source of disease recurrence and eventual metastasis.
Date: June 15, 2007
Summary:
Current cancer therapies often succeed at initially eliminating the bulk of the disease, including all rapidly proliferating cells, but are eventually thwarted because they cannot eliminate a small reservoir of multiple-drug-resistant tumor cells, called cancer stem cells, which ultimately become the source of disease recurrence and eventual metastasis.
Thursday, June 14, 2007
Protein is linked to functional development of brain neurons
Source: Rockefeller University
Date: June 14, 2007
Summary:
Rockefeller University investigators say that a molecule that helps transport cargo inside nerve cells may have another, critically important, role related to how developing neurons sprout the projections that relay electrical signals within the brain.
Date: June 14, 2007
Summary:
Rockefeller University investigators say that a molecule that helps transport cargo inside nerve cells may have another, critically important, role related to how developing neurons sprout the projections that relay electrical signals within the brain.
University of Pittsburgh researchers culture blood-forming stem cells from human fat tissue
Source: University of Pittsburgh Schools of the Health Sciences
Date: June 14, 2007
Summary:
Researchers at the University of Pittsburgh School of Medicine have successfully isolated and cultured human hematopoietic stem cells from fat, or adipose, tissue, suggesting that they have found another important source of cells for reconstituting the bone marrow of patients undergoing intensive radiation therapy for blood cancers.
Date: June 14, 2007
Summary:
Researchers at the University of Pittsburgh School of Medicine have successfully isolated and cultured human hematopoietic stem cells from fat, or adipose, tissue, suggesting that they have found another important source of cells for reconstituting the bone marrow of patients undergoing intensive radiation therapy for blood cancers.
Pluristem's PLX Cells Demonstrate Potential to Treat Parkinson's Disease
Source: Pluristem Life Systems, Inc.
Posted: June 14, 2007 8:00 am ET
Summary:
Pluristem Life Systems, Inc., a bio-therapeutics Company dedicated to the commercialization of products for a variety of malignant, degenerative and auto-immune indications, announced today that Pluristem's PLacenta eXpanded (PLX) cells have been demonstrated in vitro to have properties that the company believes gives these cells the potential to treat Parkinson's Disease (PD). PLX cells are Pluristem's placental-derived mesenchymal stem cells (MSCs) that have been expanded in the Company's proprietary PluriX(TM) 3-D bioreactor. The lab experiment demonstrated that Pluristem's PLX cells can be differentiated into dopaminergic neurons. These neurons were found to have properties favorable to cells, which are known to be helpful in treating PD.
Posted: June 14, 2007 8:00 am ET
Summary:
Pluristem Life Systems, Inc., a bio-therapeutics Company dedicated to the commercialization of products for a variety of malignant, degenerative and auto-immune indications, announced today that Pluristem's PLacenta eXpanded (PLX) cells have been demonstrated in vitro to have properties that the company believes gives these cells the potential to treat Parkinson's Disease (PD). PLX cells are Pluristem's placental-derived mesenchymal stem cells (MSCs) that have been expanded in the Company's proprietary PluriX(TM) 3-D bioreactor. The lab experiment demonstrated that Pluristem's PLX cells can be differentiated into dopaminergic neurons. These neurons were found to have properties favorable to cells, which are known to be helpful in treating PD.
Primate Parkinson's Treatment Reveals New Side of Stem Cells
Source: Wired
Posted: June 14, 2007 2:00 AM EDT
Summary:
Wired reports on a new experiments in which scientists successfully treated Parkinson's disease in monkeys using fetal cells:
"Stem cells work in mysterious ways. That's the tantalizing finding from scientists who treated monkeys with Parkinson's disease using fetal stem cells. Their results mark the first successful stem cell therapy for Parkinson's in primates. The big news, however, is not simply that the treatment worked, but how it worked: by rescuing and rejuvenating, rather than replacing, diseased cells."
Posted: June 14, 2007 2:00 AM EDT
Summary:
Wired reports on a new experiments in which scientists successfully treated Parkinson's disease in monkeys using fetal cells:
"Stem cells work in mysterious ways. That's the tantalizing finding from scientists who treated monkeys with Parkinson's disease using fetal stem cells. Their results mark the first successful stem cell therapy for Parkinson's in primates. The big news, however, is not simply that the treatment worked, but how it worked: by rescuing and rejuvenating, rather than replacing, diseased cells."
Wednesday, June 13, 2007
Gene therapy on stem cells has great potential
Source: New Scientist
Date: 13 June 2007
Summary:
New Scientist reports on research using correct diseases by targeting therapeutic genes to stem cells already resident in the body:
"GENE therapy meets stem cells. That is the wave of the future, if the recent annual meeting of the American Society of Gene Therapy in Seattle is any guide. There was a palpable buzz around efforts to correct diseases by targeting therapeutic genes to stem cells already resident in the body. Clinical trials are on the horizon for treatments for diabetes and a group of fatal neurodegenerative conditions called lysosomal storage diseases. Meanwhile, gene therapists are also using their skills to make "improved" stem cells for regenerative therapies (see "Stem cell enhancement"). "
Date: 13 June 2007
Summary:
New Scientist reports on research using correct diseases by targeting therapeutic genes to stem cells already resident in the body:
"GENE therapy meets stem cells. That is the wave of the future, if the recent annual meeting of the American Society of Gene Therapy in Seattle is any guide. There was a palpable buzz around efforts to correct diseases by targeting therapeutic genes to stem cells already resident in the body. Clinical trials are on the horizon for treatments for diabetes and a group of fatal neurodegenerative conditions called lysosomal storage diseases. Meanwhile, gene therapists are also using their skills to make "improved" stem cells for regenerative therapies (see "Stem cell enhancement"). "
Stem cell genes may provide medicine's dream ticket
Source: New Scientist
Date: 13 June 2007
Summary:
Researchers at the annual meeting of the American Society of Gene Therapy report progress in targeting gene therapy to stem cells in order to treat fatal neurodegenerative conditions known as lysosomal storage diseases:
"Clinical trials are on the horizon for treatments for diabetes and a group of fatal neurodegenerative conditions called lysosomal storage diseases. Meanwhile, gene therapists are also using their skills to make "improved" stem cells for regenerative therapies (see "Stem cell enhancement")."
Date: 13 June 2007
Summary:
Researchers at the annual meeting of the American Society of Gene Therapy report progress in targeting gene therapy to stem cells in order to treat fatal neurodegenerative conditions known as lysosomal storage diseases:
"Clinical trials are on the horizon for treatments for diabetes and a group of fatal neurodegenerative conditions called lysosomal storage diseases. Meanwhile, gene therapists are also using their skills to make "improved" stem cells for regenerative therapies (see "Stem cell enhancement")."
Tuesday, June 12, 2007
Blood Pressure Drug, Stem Cell Transplant Seen as Possible New Parkinson's Treatments
Source: Scientific American
Date: June 12, 2007
Summary:
Scientists announced that they successfully reversed Parkinson-like symptoms in several monkeys by transplanting human neural stem cells into their brains.
Date: June 12, 2007
Summary:
Scientists announced that they successfully reversed Parkinson-like symptoms in several monkeys by transplanting human neural stem cells into their brains.
Cancer cell line behaves as stem cells
Source: United Press International
Posted: June 12, 2007 1:42 PM EDT
Summary:
An international team of U.S.-led scientists has determined a breast cancer cell line established a long time ago behaves much as do cancer stem cells. The finding supports the observation that although cancer stem cells are rare, a single cancer stem cell is sufficient to initiate and maintain a malignant tumor.
Posted: June 12, 2007 1:42 PM EDT
Summary:
An international team of U.S.-led scientists has determined a breast cancer cell line established a long time ago behaves much as do cancer stem cells. The finding supports the observation that although cancer stem cells are rare, a single cancer stem cell is sufficient to initiate and maintain a malignant tumor.
Neural stem cells reduce Parkinson's symptoms in monkeys
Source: Yale University
Date: June 12, 2007
Summary:
New Haven, Conn.—Primates with severe Parkinson’s disease were able to walk, move, and eat better, and had diminished tremors after being injected with human neural stem cells, a research team from Yale, Harvard, the University of Colorado, and the Burnham Institute report today in Proceedings of the National Academy of Sciences.
Date: June 12, 2007
Summary:
New Haven, Conn.—Primates with severe Parkinson’s disease were able to walk, move, and eat better, and had diminished tremors after being injected with human neural stem cells, a research team from Yale, Harvard, the University of Colorado, and the Burnham Institute report today in Proceedings of the National Academy of Sciences.
Stem cell first for Parkinson's
Source: BBC News
Posted: 12 June 2007, 09:18 GMT 10:18 UK
Summary:
BBC News reports on an experiment in which human neural stem cells were injected into monkeys with Parkinson's Disease and reduced symptoms of the disease:
"US researchers have for the first time injected human stem cells into monkeys with Parkinson's symptoms, seen as a key step in the fight to find a cure. The stem cells, which have been injected into rodents in the past, initially stopped the monkeys' damaged brain cells from deteriorating. The primates' condition did however start to slide after four months, the study in the PNAS journal said."
Posted: 12 June 2007, 09:18 GMT 10:18 UK
Summary:
BBC News reports on an experiment in which human neural stem cells were injected into monkeys with Parkinson's Disease and reduced symptoms of the disease:
"US researchers have for the first time injected human stem cells into monkeys with Parkinson's symptoms, seen as a key step in the fight to find a cure. The stem cells, which have been injected into rodents in the past, initially stopped the monkeys' damaged brain cells from deteriorating. The primates' condition did however start to slide after four months, the study in the PNAS journal said."
Monday, June 11, 2007
Making new teeth
Source: Public Library of Science
Date: June 11, 2007
Summary:
Although mammals have a limited capacity to regenerate teeth, mouse incisors contain stem cells and grow continuously throughout life. Using a combination of mouse mutant analyses, organ culture experiments, and gene expression studies, Xiu-Ping Wang and colleagues identify the key signaling molecules that regulate epithelial stem cell proliferation in the stem cell niche. Their work is published online this week in the open-access journal PLoS Biology.
Date: June 11, 2007
Summary:
Although mammals have a limited capacity to regenerate teeth, mouse incisors contain stem cells and grow continuously throughout life. Using a combination of mouse mutant analyses, organ culture experiments, and gene expression studies, Xiu-Ping Wang and colleagues identify the key signaling molecules that regulate epithelial stem cell proliferation in the stem cell niche. Their work is published online this week in the open-access journal PLoS Biology.
Cancer stem cells can go it alone
Source: Salk Institute
Date: June 11, 2007
Summary:
At the heart of most, if not all cancers, lie a handful of wayward stem cells that feed the ever growing tumor mass, but their scarcity make it difficult for scientists to study them. Now, times of plenty may lie ahead as a breast cancer cell line -- established long ago -- turned out to behave a lot like cancer stem cells.
Date: June 11, 2007
Summary:
At the heart of most, if not all cancers, lie a handful of wayward stem cells that feed the ever growing tumor mass, but their scarcity make it difficult for scientists to study them. Now, times of plenty may lie ahead as a breast cancer cell line -- established long ago -- turned out to behave a lot like cancer stem cells.
Human stem cells treat Parkinson's in monkeys
Source: New Scientist
Posted: 11 June 2007 22:00
Summary:
New Scientist reports on new research using stem cells to improve symptoms of Parkinson's Disease in monkeys:
"A single injection of neural stem cells has markedly improved the symptoms of Parkinson's disease in monkeys, paving the way for stem-cell therapies in humans with the condition. Richard Sidman at the Harvard Institutes of Medicine in Boston, US, and colleagues recreated the symptoms of Parkinson's in African green monkeys by injecting them with a chemical that damages neurons that make dopamine – a neurotransmitter vital for controlling movement. They then injected the monkeys' brains with neural stem cells taken from human fetuses that had been miscarried at 13 weeks. A month later, the monkeys showed marked recoveries."
Posted: 11 June 2007 22:00
Summary:
New Scientist reports on new research using stem cells to improve symptoms of Parkinson's Disease in monkeys:
"A single injection of neural stem cells has markedly improved the symptoms of Parkinson's disease in monkeys, paving the way for stem-cell therapies in humans with the condition. Richard Sidman at the Harvard Institutes of Medicine in Boston, US, and colleagues recreated the symptoms of Parkinson's in African green monkeys by injecting them with a chemical that damages neurons that make dopamine – a neurotransmitter vital for controlling movement. They then injected the monkeys' brains with neural stem cells taken from human fetuses that had been miscarried at 13 weeks. A month later, the monkeys showed marked recoveries."
Stem cells help primates with Parkinson's: Monkey studies highlight multiple stem cell abilities.
Source: Nature
Date: 11 June 2007
Summary:
The journal Nature reports a new study in which human stem cell transplants reduced symptoms of Parkinson's disease in monkeys:
"Human stem cell transplants have eased the symptoms of Parkinson's disease in a monkey model of the brain disorder. The study, which brings the prospect of human trials one step closer, hints that stem cells do more than just replace cells -- they may help persuade the brain to heal itself."
The study also describes how scientists used fetal cells to treat monkeys afflicted with the disease and the encouraging results that followed after the injection of fetal cells into the monkeys' brains:
"'In the current study, published in Proceedings of the National Academy of Sciences, researchers isolated stem cells from the brains of aborted fetuses and grew them into large numbers in the laboratory. The cells were then injected into the brains of monkeys with a severe form of chemically induced Parkinson's disease. Before the treatment, the animals couldn't walk unaided, struggled to use their hands and were sometimes unable to move at all. But two months afterwards, they could walk, feed themselves and move more normally. "'They're not as good as normal monkeys, but the improvement is still dramatic,' says team-member and neuroscientist Richard Sidman from the Harvard Institutes of Medicine, Boston, Massachusetts."
Date: 11 June 2007
Summary:
The journal Nature reports a new study in which human stem cell transplants reduced symptoms of Parkinson's disease in monkeys:
"Human stem cell transplants have eased the symptoms of Parkinson's disease in a monkey model of the brain disorder. The study, which brings the prospect of human trials one step closer, hints that stem cells do more than just replace cells -- they may help persuade the brain to heal itself."
The study also describes how scientists used fetal cells to treat monkeys afflicted with the disease and the encouraging results that followed after the injection of fetal cells into the monkeys' brains:
"'In the current study, published in Proceedings of the National Academy of Sciences, researchers isolated stem cells from the brains of aborted fetuses and grew them into large numbers in the laboratory. The cells were then injected into the brains of monkeys with a severe form of chemically induced Parkinson's disease. Before the treatment, the animals couldn't walk unaided, struggled to use their hands and were sometimes unable to move at all. But two months afterwards, they could walk, feed themselves and move more normally. "'They're not as good as normal monkeys, but the improvement is still dramatic,' says team-member and neuroscientist Richard Sidman from the Harvard Institutes of Medicine, Boston, Massachusetts."
Geron says its stem cells evade immune system hit
Source: Reuters
Posted: June 11, 2007 9:14AM EDT
Summary:
Reuters reports on an experimental spinal cord injury treatment being developed by Geron Corporation which may reduce the need for immuno-suppressive drugs:
"Geron Corporation, which is developing stem cell-based therapies, said on Monday its experimental spinal cord injury treatment may cut the need for drugs that suppress the immune system. The company said its stem cell therapy, GRN0PC1, is not directly attacked by the immune system, thus requiring lower or fewer doses of drugs that suppress the immune system than are typically required with solid organ transplants. Drugs that suppress the immune system are used to prevent the body from rejecting transplanted organs."
Posted: June 11, 2007 9:14AM EDT
Summary:
Reuters reports on an experimental spinal cord injury treatment being developed by Geron Corporation which may reduce the need for immuno-suppressive drugs:
"Geron Corporation, which is developing stem cell-based therapies, said on Monday its experimental spinal cord injury treatment may cut the need for drugs that suppress the immune system. The company said its stem cell therapy, GRN0PC1, is not directly attacked by the immune system, thus requiring lower or fewer doses of drugs that suppress the immune system than are typically required with solid organ transplants. Drugs that suppress the immune system are used to prevent the body from rejecting transplanted organs."
Research Indicates Geron’s Human Embryonic Stem Cell-Based Therapeutic for Spinal Cord Injury Evades Direct Attack by the Human Immune System
Source: Geron Corporation
Posted: June 11, 2007 07:30 AM EDT
Summary:
In an official company news release, Geron Corporation (Nasdaq:GERN) today announced the presentation of research studies indicating that GRNOPC1, the company’s human embryonic stem cell (hESC)-based therapeutic for the treatment of spinal cord injury, evades a direct attack by the human immune system. The findings could mean that patients treated with GRNOPC1 would require significantly lower doses and/or shorter courses of immunosuppression than what are required for patients who undergo solid organ transplants.
Posted: June 11, 2007 07:30 AM EDT
Summary:
In an official company news release, Geron Corporation (Nasdaq:GERN) today announced the presentation of research studies indicating that GRNOPC1, the company’s human embryonic stem cell (hESC)-based therapeutic for the treatment of spinal cord injury, evades a direct attack by the human immune system. The findings could mean that patients treated with GRNOPC1 would require significantly lower doses and/or shorter courses of immunosuppression than what are required for patients who undergo solid organ transplants.
Friday, June 08, 2007
Stem Cells Can Be Cancer Cell Lookalikes
Source: HealthDay News
Date: June 8, 2007
Summary:
U.S. researchers have discovered that bone marrow stem cells attracted to an area of cancer growth frequently take on the outward appearance of the cancer cells around them. But they say it's not clear that these stem cells actually help cancer develop.
Date: June 8, 2007
Summary:
U.S. researchers have discovered that bone marrow stem cells attracted to an area of cancer growth frequently take on the outward appearance of the cancer cells around them. But they say it's not clear that these stem cells actually help cancer develop.
Thursday, June 07, 2007
Stem Cell Breakthrough?
Source: CBS News
Date: June 7, 2007
Summary:
CBS News video reports scientists have taken adult cells and reversed them into an embryonic state, without destroying embryos, a development that could alter the debate over embryonic stem cell research.
Date: June 7, 2007
Summary:
CBS News video reports scientists have taken adult cells and reversed them into an embryonic state, without destroying embryos, a development that could alter the debate over embryonic stem cell research.
Embryonic Stem Cells—Without Embryos?
Source: Newsweek
Date: June 7, 2007
Summary:
Newsweek covers a new study that may change the ethical debate over embryonic stem cell research:
"Four papers published on June 5 may help scientists clear both those hurdles. Researchers at Harvard University, the Massachusetts Institute of Technology, The University of California-Los Angeles and Kyoto University reported in three papers that a new technique had bestowed all the powerful transformative properties of embryonic stem cells on older, more differentiated cells from adult mice. The fourth paper, meanwhile, opens up the possibility of a new and fairly large source of cells—one that won't require women to go through the painful process of egg donation purely for research."
Date: June 7, 2007
Summary:
Newsweek covers a new study that may change the ethical debate over embryonic stem cell research:
"Four papers published on June 5 may help scientists clear both those hurdles. Researchers at Harvard University, the Massachusetts Institute of Technology, The University of California-Los Angeles and Kyoto University reported in three papers that a new technique had bestowed all the powerful transformative properties of embryonic stem cells on older, more differentiated cells from adult mice. The fourth paper, meanwhile, opens up the possibility of a new and fairly large source of cells—one that won't require women to go through the painful process of egg donation purely for research."
DNA damage to stem cells is central to ageing
Source: University of Oxford
Date: 7 June 2007
Summary:
DNA damage is a major mechanism behind the loss of adult stem cells over time, according to a Nature paper by Oxford University researchers and international colleagues. The finding has implications for the use of adult stem cells in transplantation and, more broadly, for understanding the process of ageing itself, since stem cells are essential for repairing and regenerating tissue.
Date: 7 June 2007
Summary:
DNA damage is a major mechanism behind the loss of adult stem cells over time, according to a Nature paper by Oxford University researchers and international colleagues. The finding has implications for the use of adult stem cells in transplantation and, more broadly, for understanding the process of ageing itself, since stem cells are essential for repairing and regenerating tissue.
Adults’ new brain cells may revive old neurons
Source: LiveScience
Posted: June 7, 2007 10:42 a.m. PT
Summary:
The brains of adult mammals are slowly, constantly churning out new brain cells. Previously scientists assumed the fresh neurons acted simply as replacements for old and dying cells. But recent research suggests that these new adult neurons may help old cells adapt to new experiences and could someday be used to rejuvenate aging brains. The study, detailed in the May 24 issue of the journal Neuron, shows new brain cells act just as youthful in adult mammals as those generated in young ones.
Posted: June 7, 2007 10:42 a.m. PT
Summary:
The brains of adult mammals are slowly, constantly churning out new brain cells. Previously scientists assumed the fresh neurons acted simply as replacements for old and dying cells. But recent research suggests that these new adult neurons may help old cells adapt to new experiences and could someday be used to rejuvenate aging brains. The study, detailed in the May 24 issue of the journal Neuron, shows new brain cells act just as youthful in adult mammals as those generated in young ones.
Stem-Cell Advance May Skirt Ethical Debate
Source: Wall Street Journal
Date: June 7, 2007
Summary:
The Wall Street Journal reports on an advance in turning mature skin cells into cells with traits similar to embryonic stem cells that could end the ethical debate over embryonic stem cell research:
"Scientists have created embryonic stem cells without using eggs or destroying embryos, an advance that may sidestep the knottiest ethical dilemmas that have slowed stem-cell research. In experiments on mice, four independent teams pulled off a feat that is the biological equivalent of turning back time: They returned mature cells -- such as those from skin -- to a primordial, embryonic state. Further experiments showed that those reprogrammed cells had the same properties as true embryonic stem cells, such as the ability to turn into muscle, heart, nerve and other tissue types -- no matter what kind of mature cell they had started as."
Date: June 7, 2007
Summary:
The Wall Street Journal reports on an advance in turning mature skin cells into cells with traits similar to embryonic stem cells that could end the ethical debate over embryonic stem cell research:
"Scientists have created embryonic stem cells without using eggs or destroying embryos, an advance that may sidestep the knottiest ethical dilemmas that have slowed stem-cell research. In experiments on mice, four independent teams pulled off a feat that is the biological equivalent of turning back time: They returned mature cells -- such as those from skin -- to a primordial, embryonic state. Further experiments showed that those reprogrammed cells had the same properties as true embryonic stem cells, such as the ability to turn into muscle, heart, nerve and other tissue types -- no matter what kind of mature cell they had started as."
Scientists Use Skin To Create Stem Cells
Source: Washington Post
Date: June 7, 2007
Summary:
The Washington Post reports scientists have successfully turned mouse skin cells into cells that, like embryonic stem cells, can become any tissue in the body. If the procedure can be repeated in humans, it could end the bioethical controversy that has surrounded the field of embryonic stem cell research:
"Three teams of scientists said yesterday they had coaxed ordinary mouse skin cells to become what are effectively embryonic stem cells without creating or destroying embryos in the process -- an advance that, if it works with human cells, could revolutionize stem cell research and quench one of the hottest bioethical controversies of the decade. In work being published today, the scientists describe a method for turning back the biological clocks of skin cells growing in laboratory dishes. Thus rejuvenated, the cells give rise to daughter cells that are able to become all the parts needed to make a new mouse."
Date: June 7, 2007
Summary:
The Washington Post reports scientists have successfully turned mouse skin cells into cells that, like embryonic stem cells, can become any tissue in the body. If the procedure can be repeated in humans, it could end the bioethical controversy that has surrounded the field of embryonic stem cell research:
"Three teams of scientists said yesterday they had coaxed ordinary mouse skin cells to become what are effectively embryonic stem cells without creating or destroying embryos in the process -- an advance that, if it works with human cells, could revolutionize stem cell research and quench one of the hottest bioethical controversies of the decade. In work being published today, the scientists describe a method for turning back the biological clocks of skin cells growing in laboratory dishes. Thus rejuvenated, the cells give rise to daughter cells that are able to become all the parts needed to make a new mouse."
Stem cell results called 'exciting,' promising step
Source: Associated Press
Date: June 7, 2007
Summary:
The Associated Press reports scientists have created mouse skin cells with the differentiation properties of embryonic stem cells, a development that could dissolve the ethical controversy over embryonic stem cell research:
"In a leap forward for stem cell research, three independent teams of scientists reported that they have produced the equivalent of embryonic stem cells in mice using skin cells without the controversial destruction of embryos. If the same could be done with human cells - a big if - the procedure could lead to breakthrough medical treatments without the contentious ethical and political debates surrounding the use of embryos."
Date: June 7, 2007
Summary:
The Associated Press reports scientists have created mouse skin cells with the differentiation properties of embryonic stem cells, a development that could dissolve the ethical controversy over embryonic stem cell research:
"In a leap forward for stem cell research, three independent teams of scientists reported that they have produced the equivalent of embryonic stem cells in mice using skin cells without the controversial destruction of embryos. If the same could be done with human cells - a big if - the procedure could lead to breakthrough medical treatments without the contentious ethical and political debates surrounding the use of embryos."
A door opens for easing stem cell ethical dilemma
Source: San Francisco Chronicle
Date: June 7, 2007
Summary:
The San Francisco Chronicle reports on a new way to change skin cells into cells with a key trait of embryonic stem cells: the ability to turn into any of the human body's cell types:
"Scientists showed how it might be possible to turn an ordinary skin cell into an embryonic stem cell, offering a template for producing just about any kind of cell needed to study or treat disease. The experiments, done in mice, essentially rewind the process of embryonic development, suggesting in principle that the same thing can be done in humans."
The article also discusses the potential this finding might have to reshape the debate over embryonic stem cell research:
"If human experiments work, and there is no guarantee, the new findings could blunt -- and eventually could even render moot -- some of the main ethical objections and practical limitations of human embryonic stem cell research. That's because it might not be necessary to destroy viable human embryos, or solicit women to donate fresh human eggs, to carry out some of the critical stem cell experiments."
Christopher Scott, a cell biologist and director of the Program on Stem Cells and Society at Stanford University, said the finding provides researchers with new information about stem cell function:
"It's a very interesting result that gives us more information about how this very unusual process of reprogramming works." However, he is uncertain as to whether it will take the place of therapeutic cloning:
""Will it be a substitute for nuclear transfer? I don't know. Other people will need to try it, and we need to see how complete the reprogramming mechanism is and whether the mice and cells will be completely normal."
A University of California at San Francisco stem cell researcher cautions that the procedure still has yet to be proven effective in humans.
Date: June 7, 2007
Summary:
The San Francisco Chronicle reports on a new way to change skin cells into cells with a key trait of embryonic stem cells: the ability to turn into any of the human body's cell types:
"Scientists showed how it might be possible to turn an ordinary skin cell into an embryonic stem cell, offering a template for producing just about any kind of cell needed to study or treat disease. The experiments, done in mice, essentially rewind the process of embryonic development, suggesting in principle that the same thing can be done in humans."
The article also discusses the potential this finding might have to reshape the debate over embryonic stem cell research:
"If human experiments work, and there is no guarantee, the new findings could blunt -- and eventually could even render moot -- some of the main ethical objections and practical limitations of human embryonic stem cell research. That's because it might not be necessary to destroy viable human embryos, or solicit women to donate fresh human eggs, to carry out some of the critical stem cell experiments."
Christopher Scott, a cell biologist and director of the Program on Stem Cells and Society at Stanford University, said the finding provides researchers with new information about stem cell function:
"It's a very interesting result that gives us more information about how this very unusual process of reprogramming works." However, he is uncertain as to whether it will take the place of therapeutic cloning:
""Will it be a substitute for nuclear transfer? I don't know. Other people will need to try it, and we need to see how complete the reprogramming mechanism is and whether the mice and cells will be completely normal."
A University of California at San Francisco stem cell researcher cautions that the procedure still has yet to be proven effective in humans.
A Long, Uncertain Path for New Cell Technique
Source: New York Times
Date: June 7, 2007
Summary:
The New York Times reports on both the potential benefits and risks of new method of turning a skin cell of a mouse back to an embryonic state.
"While intriguing, a new approach for producing embryonic stem cells faces considerable hurdles before it can be used to develop medical treatments, executives from stem cell and other biotechnology companies said yesterday. In particular, they said, the technique involves genetically altering cells, which could introduce new safety risks and make it harder to obtain regulatory approval."
Date: June 7, 2007
Summary:
The New York Times reports on both the potential benefits and risks of new method of turning a skin cell of a mouse back to an embryonic state.
"While intriguing, a new approach for producing embryonic stem cells faces considerable hurdles before it can be used to develop medical treatments, executives from stem cell and other biotechnology companies said yesterday. In particular, they said, the technique involves genetically altering cells, which could introduce new safety risks and make it harder to obtain regulatory approval."
Biologists Make Skin Cells Work Like Stem Cells
Source: New York Times
Date: June 7, 2007
Summary:
The New York Times reports scientists have successfully reprogrammed adult stem cells from mice into cells like embryonic stem cells that are capable of becoming any of the human tissue types:
"In a surprising advance that could sidestep the ethical debates surrounding stem cell biology, researchers have come much closer to a major goal of regenerative medicine, the conversion of a patient’s cells into specialized tissues that might replace those lost to disease. The advance is an easy-to-use technique for reprogramming a skin cell of a mouse back to the embryonic state. Embryonic cells can be induced in the laboratory to develop into many of the body’s major tissues. If the technique can be adapted to human cells, researchers could use a patient’s skin cells to generate new heart, liver or kidney cells that might be transplantable and would not be rejected by the patient’s immune system. But scientists say they cannot predict when they can overcome the considerable problems in adapting the method to human cells."
Date: June 7, 2007
Summary:
The New York Times reports scientists have successfully reprogrammed adult stem cells from mice into cells like embryonic stem cells that are capable of becoming any of the human tissue types:
"In a surprising advance that could sidestep the ethical debates surrounding stem cell biology, researchers have come much closer to a major goal of regenerative medicine, the conversion of a patient’s cells into specialized tissues that might replace those lost to disease. The advance is an easy-to-use technique for reprogramming a skin cell of a mouse back to the embryonic state. Embryonic cells can be induced in the laboratory to develop into many of the body’s major tissues. If the technique can be adapted to human cells, researchers could use a patient’s skin cells to generate new heart, liver or kidney cells that might be transplantable and would not be rejected by the patient’s immune system. But scientists say they cannot predict when they can overcome the considerable problems in adapting the method to human cells."
Researchers produce stem cells from skin
Source: Financial Times
Posted: June 7, 2007 03:00 GMT
Summary:
The Financial Times reports scientists have reprogrammed adult skin cells to function like embryonic stem cells. A second study also mentions that fertilized eggs, as opposed to unfertilized eggs, can be used to breed cloned mice, a finding that could lead to a new source of stem cells for human therapeutic cloning purposes:
"Three scientific teams published separate studies yesterday showing that embryonic stem cells can be made by reprogramming some of the genes in adult skin cells, without having to create an embryo - at least in mice. Separately, a fourth scientific paper showed that newly fertilised eggs could be used instead of unfertilised eggs to produce cloned mice. If this technique were extended to humans, it might open up a new source of stem cells for therapeutic cloning research: frozen -early-stage human embryos, which are much more plentiful than human eggs."
Posted: June 7, 2007 03:00 GMT
Summary:
The Financial Times reports scientists have reprogrammed adult skin cells to function like embryonic stem cells. A second study also mentions that fertilized eggs, as opposed to unfertilized eggs, can be used to breed cloned mice, a finding that could lead to a new source of stem cells for human therapeutic cloning purposes:
"Three scientific teams published separate studies yesterday showing that embryonic stem cells can be made by reprogramming some of the genes in adult skin cells, without having to create an embryo - at least in mice. Separately, a fourth scientific paper showed that newly fertilised eggs could be used instead of unfertilised eggs to produce cloned mice. If this technique were extended to humans, it might open up a new source of stem cells for therapeutic cloning research: frozen -early-stage human embryos, which are much more plentiful than human eggs."
Wednesday, June 06, 2007
Stem cells: From adult to embryo
Source: New Scientist
Date: 06 June 2007
Summary:
It is stem cell research's ultimate prize - stem cells made from an individual's own cells without the need for a donated egg or embryo. Now, three research groups claim to have done just that - by reprogramming adult mouse cells into cells that are virtually indistinguishable from embryonic stem cells (ESCs). If they can repeat their success in humans, hopes are high that such cells could one day be used to regenerate healthy tissues in people with a range of illnesses.
Date: 06 June 2007
Summary:
It is stem cell research's ultimate prize - stem cells made from an individual's own cells without the need for a donated egg or embryo. Now, three research groups claim to have done just that - by reprogramming adult mouse cells into cells that are virtually indistinguishable from embryonic stem cells (ESCs). If they can repeat their success in humans, hopes are high that such cells could one day be used to regenerate healthy tissues in people with a range of illnesses.
Scientists lauding breakthrough in stem cell research
Source: Rocky Mountain News
Date: June 6, 2007
Summary:
The Rocky Mountain News reports on a new advance in stem cell research that could end the ethical controversy surrounding embryonic stem cell research:
"Scientists hailed a breakthrough in stem cell research that they said could end the ethical debate over research involving embryos while saving thousands of lives. The new technique turns mature cells into primitive cells, the type that are able to be coaxed into any kind of specialized cell to fight maladies such as Alzheimer’s and Parkinson’s disease. And the technique does so without involving the embryo, so it has a better chance of withstanding criticism from groups who equate embryonic stem cell research to abortion. The research is reported in the current issue of the British science journal Nature."
Date: June 6, 2007
Summary:
The Rocky Mountain News reports on a new advance in stem cell research that could end the ethical controversy surrounding embryonic stem cell research:
"Scientists hailed a breakthrough in stem cell research that they said could end the ethical debate over research involving embryos while saving thousands of lives. The new technique turns mature cells into primitive cells, the type that are able to be coaxed into any kind of specialized cell to fight maladies such as Alzheimer’s and Parkinson’s disease. And the technique does so without involving the embryo, so it has a better chance of withstanding criticism from groups who equate embryonic stem cell research to abortion. The research is reported in the current issue of the British science journal Nature."
Scientists claim embryonic stem cell advance
Source: Associated Press / NBC News
Posted: June 6, 2007 4:34 p.m. PT
Summary:
NBC News and the Associated Press report on a new advance in stem cell research where scientists have turned mouse skin cells into cells that can act like embryonic stem cells and become all of the cell types in the human body:
"In a leap forward for stem cell research, three independent teams of scientists reported Wednesday that they have produced the equivalent of embryonic stem cells in mice using skin cells without the controversial destruction of embryos. If the same could be done with human skin cells — a big if — the procedure could lead to breakthrough medical treatments without the contentious ethical and political debates surrounding the use of embryos."
An NBC News video accompanies this story.
Posted: June 6, 2007 4:34 p.m. PT
Summary:
NBC News and the Associated Press report on a new advance in stem cell research where scientists have turned mouse skin cells into cells that can act like embryonic stem cells and become all of the cell types in the human body:
"In a leap forward for stem cell research, three independent teams of scientists reported Wednesday that they have produced the equivalent of embryonic stem cells in mice using skin cells without the controversial destruction of embryos. If the same could be done with human skin cells — a big if — the procedure could lead to breakthrough medical treatments without the contentious ethical and political debates surrounding the use of embryos."
An NBC News video accompanies this story.
Ordinary cells can be reprogrammed to mirror stem cells, studies find
Source: Los Angeles Times
Posted: June 6, 2007, 8:15 PM PDT
Summary:
The Los Angeles Times reports scientists have devised way to reverse the development process of adult stem cells to make them function like embryonic stem cells:
"Scientists have succeeded in reprogramming ordinary cells from the tips of mouse tails and rewinding their developmental clocks so they are virtually indistinguishable from embryonic stem cells, according to studies published today. If the discovery applies to human cells — and researchers are optimistic that it will — it would offer a straightforward method for creating a limitless supply of cell lines tailor-made for patients without ethical strings attached."
Posted: June 6, 2007, 8:15 PM PDT
Summary:
The Los Angeles Times reports scientists have devised way to reverse the development process of adult stem cells to make them function like embryonic stem cells:
"Scientists have succeeded in reprogramming ordinary cells from the tips of mouse tails and rewinding their developmental clocks so they are virtually indistinguishable from embryonic stem cells, according to studies published today. If the discovery applies to human cells — and researchers are optimistic that it will — it would offer a straightforward method for creating a limitless supply of cell lines tailor-made for patients without ethical strings attached."
Major breakthrough in stem cell research
Source: San Jose Mercury News
Posted: 06/06/2007 06:56:23 PM PDT
Summary:
Three separate teams of scientists on Wednesday claimed to have made a breakthrough involving what has become the Holy Grail of stem-cell research: producing a cell that can grow into any type of tissue without destroying an embryo.
Posted: 06/06/2007 06:56:23 PM PDT
Summary:
Three separate teams of scientists on Wednesday claimed to have made a breakthrough involving what has become the Holy Grail of stem-cell research: producing a cell that can grow into any type of tissue without destroying an embryo.
Scientists: Stem cells can make blind see
Source: United Press International
Date: June 6, 2007
Summary:
British researchers hope to make stem-cell treatment of blindness caused by macular degeneration routine within a decade.
Date: June 6, 2007
Summary:
British researchers hope to make stem-cell treatment of blindness caused by macular degeneration routine within a decade.
Technique moves stem cell research ahead
Source: United Press International
Date: June 6, 2007
Summary:
Scientists say an advance by a Japanese researcher moves them closer to developing a way to turn human skin cells into major body tissues.
Date: June 6, 2007
Summary:
Scientists say an advance by a Japanese researcher moves them closer to developing a way to turn human skin cells into major body tissues.
Breakthrough In Stem Cell Production: Major Advance In Stem Cell Research
Source: ABC 7 / KGO-TV - San Francisco, CA
Date: June 6. 2007
Summary:
ABC 7 / KGO-TV, San Francisco reports on a breakthrough in stem cell research that could eliminate the ethical controversy which has thus far surrounded the field:
"Of mice and medicine. Science makes a major advance in stem cell research by turning back the clock. They've taken adult cells in mice and turned them into the building blocks of life."
The report continues: "Scientists have succeeded in re-programming mature skin cells of mice into an embryonic state without cloning. Those cells were then successfully grown into mice. It's research that's now been replicated by several different independent laboratories."
An ABC 7 news streaming video broadcast accompanies this story.
Date: June 6. 2007
Summary:
ABC 7 / KGO-TV, San Francisco reports on a breakthrough in stem cell research that could eliminate the ethical controversy which has thus far surrounded the field:
"Of mice and medicine. Science makes a major advance in stem cell research by turning back the clock. They've taken adult cells in mice and turned them into the building blocks of life."
The report continues: "Scientists have succeeded in re-programming mature skin cells of mice into an embryonic state without cloning. Those cells were then successfully grown into mice. It's research that's now been replicated by several different independent laboratories."
An ABC 7 news streaming video broadcast accompanies this story.
Skin tests offer stem cell hope
Source: BBC News
Posted: 6 June 2007, 23:47 GMT 00:47 UK
Summary:
BBC News reports on new research in which scientists were able to reversing skin cells to a state in which the cells possessed traits of embryonic stem cells:
"New experiments carried out on mice suggest it may be possible to replicate embryonic stem cells from skin patches, rather than having to use embryos. Japanese and US researchers made the discovery, which represents a key breakthrough in stem cell research. If the same can be done in humans, it could lessen or remove the need for the controversial use of embryos. It is hoped stem cells will one day be used to replace tissue damaged by diseases like Parkinson's and MS."
Posted: 6 June 2007, 23:47 GMT 00:47 UK
Summary:
BBC News reports on new research in which scientists were able to reversing skin cells to a state in which the cells possessed traits of embryonic stem cells:
"New experiments carried out on mice suggest it may be possible to replicate embryonic stem cells from skin patches, rather than having to use embryos. Japanese and US researchers made the discovery, which represents a key breakthrough in stem cell research. If the same can be done in humans, it could lessen or remove the need for the controversial use of embryos. It is hoped stem cells will one day be used to replace tissue damaged by diseases like Parkinson's and MS."
Scientists Hail Advance in Creating Stem Cells
Source: National Public Radio (NPR) - All Things Considered
Date: June 6, 2007
Summary:
NPR's All Things Considered reports on a breakthrough in converting skin cells into cells with embryonic stem cell-like traits, an advancement that could reshape the debate surrounding the field of embryonic stem cell research:
"At Whitehead Institute in Boston, researchers have succeeded in modifying a skin cell so it behaves like an embryonic stem cell. And at Harvard University, scientists have shown that it's possible to make clone mice from previously fertilized eggs." A streaming NPR radio broadcast accompanies this story.
Date: June 6, 2007
Summary:
NPR's All Things Considered reports on a breakthrough in converting skin cells into cells with embryonic stem cell-like traits, an advancement that could reshape the debate surrounding the field of embryonic stem cell research:
"At Whitehead Institute in Boston, researchers have succeeded in modifying a skin cell so it behaves like an embryonic stem cell. And at Harvard University, scientists have shown that it's possible to make clone mice from previously fertilized eggs." A streaming NPR radio broadcast accompanies this story.
Analysis: Stem cells without the embryo
Source: United Press International
Posted: June 6, 2007 at 5:20 PM EDT
Summary:
Scientists say they have developed a method in mice for creating the equivalent of embryonic stem cells without using eggs or destroying an embryo, a finding that could help circumvent the controversy surrounding the promising research.
Posted: June 6, 2007 at 5:20 PM EDT
Summary:
Scientists say they have developed a method in mice for creating the equivalent of embryonic stem cells without using eggs or destroying an embryo, a finding that could help circumvent the controversy surrounding the promising research.
Stem Cells from Skin Cells:
Source: Scientific American
Date: June 6, 2007
Summary:
Scientific American reports on two new advancements that could reshape the ethical debate over embryonic stem cells:
"Two methods for creating embryonic stem cells just got a big boost. In one development, three teams of scientists report they have turned back the clock on mouse skin cells, changing them into embryolike cells by introducing a cocktail of four genes. If extended to humans, the technique would allow researchers to create potentially all-purpose stem cells without using embryos. However, experts say they will still have to study cells from human embryos to figure out how to make the jump to humans and, beyond that, how the two kinds of cell would stack up as ways of regenerating diseased tissue."
"In a second approach, a group of researchers successfully cloned mice from fertilized embryos instead of unfertilized eggs. Because fertilized human embryos are far more accessible than unfertilized eggs, which cannot be frozen and stored, extending the result to humans could lower the practical barriers against creating human embryonic stem cells to study and potentially treat disease. Neither technique works outside of mice yet, but researchers are optimistic they can apply at least some of the findings to human cells."
Date: June 6, 2007
Summary:
Scientific American reports on two new advancements that could reshape the ethical debate over embryonic stem cells:
"Two methods for creating embryonic stem cells just got a big boost. In one development, three teams of scientists report they have turned back the clock on mouse skin cells, changing them into embryolike cells by introducing a cocktail of four genes. If extended to humans, the technique would allow researchers to create potentially all-purpose stem cells without using embryos. However, experts say they will still have to study cells from human embryos to figure out how to make the jump to humans and, beyond that, how the two kinds of cell would stack up as ways of regenerating diseased tissue."
"In a second approach, a group of researchers successfully cloned mice from fertilized embryos instead of unfertilized eggs. Because fertilized human embryos are far more accessible than unfertilized eggs, which cannot be frozen and stored, extending the result to humans could lower the practical barriers against creating human embryonic stem cells to study and potentially treat disease. Neither technique works outside of mice yet, but researchers are optimistic they can apply at least some of the findings to human cells."
New Ways to Make Embryonic Stem Cells: If replicated in humans, new procedures developed in mice could be a huge boon to the field.
Source: MIT Technology Review
Date: June 06, 2007
Summary:
Scientists at Harvard announced that they can generate cloned stem-cell lines from fertilized eggs in mice. If replicated in humans, the findings could provide a huge boon to the field of human therapeutic cloning.
Date: June 06, 2007
Summary:
Scientists at Harvard announced that they can generate cloned stem-cell lines from fertilized eggs in mice. If replicated in humans, the findings could provide a huge boon to the field of human therapeutic cloning.
A twist of fate -- Reprogrammed fibroblasts resemble embryonic stem cells
Source: Cell Press
Date: June 6, 2007
Summary:
Stem cell biology takes another exciting leap forward as scientists report that normal tissue cells can be reprogrammed to exhibit many of the properties that are characteristic of embryonic stem cells, including the ability to give rise to multiple cell types and contribute to the germline. These findings, published in the inaugural issue of the journal Cell Stem Cell, published by Cell Press, provide strong support for the rationale that it may be possible to generate stem cells with nearly unlimited potential directly from a patient’s own cells, an idea that has significant implications for regenerative therapeutics.
Date: June 6, 2007
Summary:
Stem cell biology takes another exciting leap forward as scientists report that normal tissue cells can be reprogrammed to exhibit many of the properties that are characteristic of embryonic stem cells, including the ability to give rise to multiple cell types and contribute to the germline. These findings, published in the inaugural issue of the journal Cell Stem Cell, published by Cell Press, provide strong support for the rationale that it may be possible to generate stem cells with nearly unlimited potential directly from a patient’s own cells, an idea that has significant implications for regenerative therapeutics.
New Stem Cell Methods May Avoid Embryo Destruction
Source: Bloomberg News
Date: June 6, 2007
Summary:
Bloomberg News covers a new experiment in which stem cells with embryonic stem cell-like traits were created out destroying embryos, a breakthrough that could diffuse the ethical controversy which has dogged the field of embryonic stem cell research:
"Stem cells may be produced without destroying embryos or requiring women to donate eggs, say scientists from Harvard University, California and Japan. Harvard researchers led by Kevin Eggan showed in mice they can make copies of cells, using a new version of the cloning process used for Dolly the sheep 11 years ago. Three other groups were able to take ordinary skin cells from mice and get them to act like embryonic cells, with their unlimited potential to become other cell types. The findings, if reproduced in humans, may mute criticism from religious leaders and the U.S. government, which has limited federal funding for scientists who work with most embryonic cells."
Date: June 6, 2007
Summary:
Bloomberg News covers a new experiment in which stem cells with embryonic stem cell-like traits were created out destroying embryos, a breakthrough that could diffuse the ethical controversy which has dogged the field of embryonic stem cell research:
"Stem cells may be produced without destroying embryos or requiring women to donate eggs, say scientists from Harvard University, California and Japan. Harvard researchers led by Kevin Eggan showed in mice they can make copies of cells, using a new version of the cloning process used for Dolly the sheep 11 years ago. Three other groups were able to take ordinary skin cells from mice and get them to act like embryonic cells, with their unlimited potential to become other cell types. The findings, if reproduced in humans, may mute criticism from religious leaders and the U.S. government, which has limited federal funding for scientists who work with most embryonic cells."
Progress in cloned stemcells could defuse ethics storm: studies
Source: Agence France Presse (AFP)
Posted: June 6, 2007 5:13 PM ET
Summary:
US scientists say they reprogrammed normal tissue cells in mice to mimic the properties of embryonic stem cells, an advance that could lead to breakthrough treatments for chronic and terminal diseases in humans.
Posted: June 6, 2007 5:13 PM ET
Summary:
US scientists say they reprogrammed normal tissue cells in mice to mimic the properties of embryonic stem cells, an advance that could lead to breakthrough treatments for chronic and terminal diseases in humans.
New Success in Making Stem Cells
Source: WebMD
Date: June 6, 2007
Summary:
Scientists announced that they have coaxed normal cells from mice into embryonic-like stem cells. If the strategy works in human cells, doctors may one day be able to tweak a patient's cells as part of stem cell therapy.
Date: June 6, 2007
Summary:
Scientists announced that they have coaxed normal cells from mice into embryonic-like stem cells. If the strategy works in human cells, doctors may one day be able to tweak a patient's cells as part of stem cell therapy.
Stem Cell Advances Announced: Findings could surmount ethical, technical issues surrounding the research
Source: HealthDay News
Date:: June 6, 2007
Summary:
A pair of stem cell discoveries may one day surmount both the ethical and technical hurdles confronting such research, setting the stage for medical advances, researchers say. In the first study, scientists at the Harvard Stem Cell Institute managed to create stem cells from non-viable mouse embryos, potentially opening a new source of cells for experiments and research. In the second study, investigators at the Whitehead Institute for Biomedical Research in Cambridge, Mass., succeeding in creating cells identical to embryonic stem cells from adult skin cells in mice, bypassing both the need for eggs and the need to destroy early embryos.
Date:: June 6, 2007
Summary:
A pair of stem cell discoveries may one day surmount both the ethical and technical hurdles confronting such research, setting the stage for medical advances, researchers say. In the first study, scientists at the Harvard Stem Cell Institute managed to create stem cells from non-viable mouse embryos, potentially opening a new source of cells for experiments and research. In the second study, investigators at the Whitehead Institute for Biomedical Research in Cambridge, Mass., succeeding in creating cells identical to embryonic stem cells from adult skin cells in mice, bypassing both the need for eggs and the need to destroy early embryos.
A Leap Forward for Stem Cells
Source: Time
Date: June 6, 2007
Summary:
Time reports on new research in which adult stem cells were turned into cells with traits of embryonic stem cells:
"...researchers in the U.S. and Japan announced exciting advances in their ability to turn back the clock on older, adult cells and get them to generate embryonic stem cells. The findings could expand the ways that doctors and patients eventually generate customized stem cells for treatments."
Date: June 6, 2007
Summary:
Time reports on new research in which adult stem cells were turned into cells with traits of embryonic stem cells:
"...researchers in the U.S. and Japan announced exciting advances in their ability to turn back the clock on older, adult cells and get them to generate embryonic stem cells. The findings could expand the ways that doctors and patients eventually generate customized stem cells for treatments."
Stem cell scientists report potential breakthrough
Source: San Francisco Chronicle
Posted: June 6. 2007 13:29 PDT
Summary:
The San Francisco Chronicle reports on a new technique to turn human skin cells into cells with traits of embryonic stem cells that could be an ethical way around the controversy over embryonic stem cell research:
"Scientists reported today that they have developed a promising new way to generate stem cells that carry DNA matching that of an adult, without having to resort to controversial cloning experiments involving viable human embryos. The work so far has been done only in mice. If replicated in humans -- and it's not clear how soon that might be -- it could be the first workable recipe for producing patient-specific stem cells for transplants or research." The new method, devised by separate teams of scientists in Japan and at stem cell affiliates of Harvard University and the Whitehead Institute in Cambridge, Mass., demonstrates that ordinary cells can be reprogrammed to a state that appears indistinguishable from that of an embryonic stem cell.
Posted: June 6. 2007 13:29 PDT
Summary:
The San Francisco Chronicle reports on a new technique to turn human skin cells into cells with traits of embryonic stem cells that could be an ethical way around the controversy over embryonic stem cell research:
"Scientists reported today that they have developed a promising new way to generate stem cells that carry DNA matching that of an adult, without having to resort to controversial cloning experiments involving viable human embryos. The work so far has been done only in mice. If replicated in humans -- and it's not clear how soon that might be -- it could be the first workable recipe for producing patient-specific stem cells for transplants or research." The new method, devised by separate teams of scientists in Japan and at stem cell affiliates of Harvard University and the Whitehead Institute in Cambridge, Mass., demonstrates that ordinary cells can be reprogrammed to a state that appears indistinguishable from that of an embryonic stem cell.
3 teams of scientists mimic embryonic stem cells using ordinary skin cells in mice
Source: Associated Press
Posted: June 6, 2007 12:24 p.m. PDT
Summary:
The Associated Press reports on new research coaxing skin cells into cells that function like embryonic stem cells:
"...three teams of researchers said they had found a way to do just that – but in mice. They got ordinary skin cells to act like the embryonic cells." Researchers said their work was not an attempt to evade the ethical objections to embryo destruction. Instead, they said, the goal was to learn how cell reprogramming works. Now scientists have to figure out how to reproduce the success with human cells – no small task – and change the reprogramming procedure to make it safe for use in treatments."
Despite this finding, scientists still emphasized the need to continue embryonic stem cell research, which has stirred ethical controversy:
"In any case, scientists said, the advance does not mean that research that involves getting stem cells from human embryos should now be abandoned. 'We simply don't know which approach ... will work the best,' said researcher Konrad Hochedlinger of the Harvard Stem Cell Institute, who led one of the three teams."
The study appears in the inaugural issue of the journal Cell Stem Cell. (The first word in the journal's name refers to its publisher, Cell Press).
The Associated Press also mentions a second study where skin cells were induced to function like embryonic stem cells:
"The other two teams reported their results Wednesday on the Web site of the journal Nature. Rudolf Jaenisch of the Whitehead Institute in Cambridge, Mass., is the senior author of one paper, and the work behind the other paper was led by Shinya Yamanaka of Kyoto University in Japan. The new work builds on a landmark paper Yamanaka published last August. He found that by slipping four genes into mouse skin cells called fibroblasts, he could make the altered cells behave much like embryonic stem cells in lab tests."
The story also mentions future obstacles to and potential applications for human stem cell treatment:
"If the technique can be harnessed for people, the iPS cells and the tissue they develop into would provide a genetic match to the person who donated the skin cells. That would make them suitable for transplant to that person, theoretically without fear of rejection."
Posted: June 6, 2007 12:24 p.m. PDT
Summary:
The Associated Press reports on new research coaxing skin cells into cells that function like embryonic stem cells:
"...three teams of researchers said they had found a way to do just that – but in mice. They got ordinary skin cells to act like the embryonic cells." Researchers said their work was not an attempt to evade the ethical objections to embryo destruction. Instead, they said, the goal was to learn how cell reprogramming works. Now scientists have to figure out how to reproduce the success with human cells – no small task – and change the reprogramming procedure to make it safe for use in treatments."
Despite this finding, scientists still emphasized the need to continue embryonic stem cell research, which has stirred ethical controversy:
"In any case, scientists said, the advance does not mean that research that involves getting stem cells from human embryos should now be abandoned. 'We simply don't know which approach ... will work the best,' said researcher Konrad Hochedlinger of the Harvard Stem Cell Institute, who led one of the three teams."
The study appears in the inaugural issue of the journal Cell Stem Cell. (The first word in the journal's name refers to its publisher, Cell Press).
The Associated Press also mentions a second study where skin cells were induced to function like embryonic stem cells:
"The other two teams reported their results Wednesday on the Web site of the journal Nature. Rudolf Jaenisch of the Whitehead Institute in Cambridge, Mass., is the senior author of one paper, and the work behind the other paper was led by Shinya Yamanaka of Kyoto University in Japan. The new work builds on a landmark paper Yamanaka published last August. He found that by slipping four genes into mouse skin cells called fibroblasts, he could make the altered cells behave much like embryonic stem cells in lab tests."
The story also mentions future obstacles to and potential applications for human stem cell treatment:
"If the technique can be harnessed for people, the iPS cells and the tissue they develop into would provide a genetic match to the person who donated the skin cells. That would make them suitable for transplant to that person, theoretically without fear of rejection."
Harvard, Whitehead scientists report embryonic stem cell advances
Source: Boston Globe
Date: June 6, 2007
Summary:
The Boston Globe reports on a breakthrough in stem cell research by Harvard University and Japanese researchers in which skin stem cells were reversed into cells that can function like embryonic stem cells and become all of the human cell types:
"Scientists in Massachusetts and Japan say they have created embryonic stem cells using procedures that might overcome some of the ethical objections to the controversial research as well as a major scientific hurdle. Most dramatically, three of the four research findings announced today used a highly experimental approach that avoids the destruction of embryos, which critics equate to taking a life. Instead, they used genes and retroviruses to coax adult cells back to an embryo-like state."
The report also mentions new source of stem cells that could expedite efforts by researchers Harvard University to make clone human stem cells to match a patient's genetic make-up, avoiding immune system rejection:
"The other project, meanwhile, points to a new, readily available source of embryonic stem cells, which would allow researchers to bypass a bottleneck in current efforts at Harvard University to clone human stem cells genetically matched to a patient with a particular disease -- the inability to find women willing to donate unfertilized eggs for the research. All of the research reported in today's Nature and Cell Stem Cell involved mice, but scientists say they believe the results could be replicated in humans."
Date: June 6, 2007
Summary:
The Boston Globe reports on a breakthrough in stem cell research by Harvard University and Japanese researchers in which skin stem cells were reversed into cells that can function like embryonic stem cells and become all of the human cell types:
"Scientists in Massachusetts and Japan say they have created embryonic stem cells using procedures that might overcome some of the ethical objections to the controversial research as well as a major scientific hurdle. Most dramatically, three of the four research findings announced today used a highly experimental approach that avoids the destruction of embryos, which critics equate to taking a life. Instead, they used genes and retroviruses to coax adult cells back to an embryo-like state."
The report also mentions new source of stem cells that could expedite efforts by researchers Harvard University to make clone human stem cells to match a patient's genetic make-up, avoiding immune system rejection:
"The other project, meanwhile, points to a new, readily available source of embryonic stem cells, which would allow researchers to bypass a bottleneck in current efforts at Harvard University to clone human stem cells genetically matched to a patient with a particular disease -- the inability to find women willing to donate unfertilized eggs for the research. All of the research reported in today's Nature and Cell Stem Cell involved mice, but scientists say they believe the results could be replicated in humans."
New Stem Cell Breakthrough Avoids Destroying Human Embryos
Source: ABC News
Date: June 6, 2007
Summary:
ABC News reports on new research in which adult stem cells were made to function like embryonic stem cells:
"Stem cell researchers may have taken the first steps toward conducting stem cell research without having to take the controversial step of destroying human embryos. Rudolf Jaenisch of MIT's Whitehead Institute, Shinya Yamanaka of Kyoto University and Konrad Hochedlinger of the Harvard Stem Cell Institute published papers in Nature and the new journal Cell Stem Cell that reveal a genetic fountain of youth that "rewinds the clock" on adult mouse cells." The researchers successfully used adult tissue to yield cells that look and function like stem cells. They hope that the findings will eventually lead to the creation of the same type of stem cell in humans that could be used in medical research.
An ABC News.com video accompanies this story.
Date: June 6, 2007
Summary:
ABC News reports on new research in which adult stem cells were made to function like embryonic stem cells:
"Stem cell researchers may have taken the first steps toward conducting stem cell research without having to take the controversial step of destroying human embryos. Rudolf Jaenisch of MIT's Whitehead Institute, Shinya Yamanaka of Kyoto University and Konrad Hochedlinger of the Harvard Stem Cell Institute published papers in Nature and the new journal Cell Stem Cell that reveal a genetic fountain of youth that "rewinds the clock" on adult mouse cells." The researchers successfully used adult tissue to yield cells that look and function like stem cells. They hope that the findings will eventually lead to the creation of the same type of stem cell in humans that could be used in medical research.
An ABC News.com video accompanies this story.
UCLA researchers reprogram normal tissue cells into embryonic stem cells
Source: University of California - Los Angeles
Date: June 6, 2007
Summary:
Researchers at the Institute for Stem Cell Biology and Medicine at UCLA were able to take normal tissue cells and reprogram them into cells with the same unlimited properties as embryonic stem cells, the cells that are able to give rise to every cell type found in the body.
Date: June 6, 2007
Summary:
Researchers at the Institute for Stem Cell Biology and Medicine at UCLA were able to take normal tissue cells and reprogram them into cells with the same unlimited properties as embryonic stem cells, the cells that are able to give rise to every cell type found in the body.
Studies find new ways to make embryonic stem cells
Source: Reuters
Posted: June 6, 2007 1:37PM EDT
Summary:
Reuters reports on a the discovery of a new method to make skin stem cells possess traits of embryonic stem cells, perhaps ending the ethical controversy that has surrounded embryonic stem cell research:
"Researchers have taken ordinary skin cells from a mouse and reprogrammed them to look and act like embryonic stem cells in a long-promised experiment that provides an alternative way to get the valued and controversial cells." Researchers caution that the finding is not yet ready to be tested using human cells and may not be for some time.
Stem cell researcher Dr. Rudolf Jaenisch of the Whitehead Institute in Cambridge, Massachusetts describes how the function of proteins are involved in changing the cells in order to give them greater flexibility:
"They identified four proteins, called factors, that are active only in mouse embryonic stem cells and not in adult cells. "You introduce those four factors, which induce or kick these cells into a process which we call the reprogramming process," Jaenisch said in a telephone interview. The ordinary skin cells, which normally would only make skin and which would die in the lab after a while, instead proliferated in lab dishes. And when injected into other mouse embryos, they created chimeras -- animals with the genetic characteristics of two different individuals." He believes this finding could potentially enable genetic diseases to be treated using stem cells.
Posted: June 6, 2007 1:37PM EDT
Summary:
Reuters reports on a the discovery of a new method to make skin stem cells possess traits of embryonic stem cells, perhaps ending the ethical controversy that has surrounded embryonic stem cell research:
"Researchers have taken ordinary skin cells from a mouse and reprogrammed them to look and act like embryonic stem cells in a long-promised experiment that provides an alternative way to get the valued and controversial cells." Researchers caution that the finding is not yet ready to be tested using human cells and may not be for some time.
Stem cell researcher Dr. Rudolf Jaenisch of the Whitehead Institute in Cambridge, Massachusetts describes how the function of proteins are involved in changing the cells in order to give them greater flexibility:
"They identified four proteins, called factors, that are active only in mouse embryonic stem cells and not in adult cells. "You introduce those four factors, which induce or kick these cells into a process which we call the reprogramming process," Jaenisch said in a telephone interview. The ordinary skin cells, which normally would only make skin and which would die in the lab after a while, instead proliferated in lab dishes. And when injected into other mouse embryos, they created chimeras -- animals with the genetic characteristics of two different individuals." He believes this finding could potentially enable genetic diseases to be treated using stem cells.
Simple switch turns cells embryonic
Source: Nature
Date: 6 June 2007
Summary:
Nature is reporting a major breakthrough in embryonic stem cell research. A straightforward procedure using mouse fibroblasts harvested from the skin can be used to produce pluripotent stem cells that can potentially become any other cell in the body. Not only can Yamanaka's method use the most basic cells, it can be accomplished with simple lab techniques. Possible applications of this breakthrough are to check molecular changes in cells as certain conditions develop. Stem cells produced using this procedure, however, can not be use to safely to make genetically matched cells for transplant."
Date: 6 June 2007
Summary:
Nature is reporting a major breakthrough in embryonic stem cell research. A straightforward procedure using mouse fibroblasts harvested from the skin can be used to produce pluripotent stem cells that can potentially become any other cell in the body. Not only can Yamanaka's method use the most basic cells, it can be accomplished with simple lab techniques. Possible applications of this breakthrough are to check molecular changes in cells as certain conditions develop. Stem cells produced using this procedure, however, can not be use to safely to make genetically matched cells for transplant."
Loss of Stem Cells Correlates with Premature Aging in Animal Study, Penn Researchers Find
Source: University of Pennsylvania Health System
Date: June 6, 2007
Summary:
Researchers at the Abramson Family Cancer Research Institute of the University of Pennsylvania have found that deleting a gene important in embryo development leads to premature aging and loss of stem cell reservoirs in adult mice. This gene, ATR, is essential for the body’s response to damaged DNA, and mutations in proteins in the DNA damage response underlie certain types of cancer and other disorders in humans. This work appears in the inaugural issue of Cell Stem Cell.
Date: June 6, 2007
Summary:
Researchers at the Abramson Family Cancer Research Institute of the University of Pennsylvania have found that deleting a gene important in embryo development leads to premature aging and loss of stem cell reservoirs in adult mice. This gene, ATR, is essential for the body’s response to damaged DNA, and mutations in proteins in the DNA damage response underlie certain types of cancer and other disorders in humans. This work appears in the inaugural issue of Cell Stem Cell.
Aging Stem Cells in Mice May Hold Answers to Diseases of the Aged, Stanford Study Finds
Source: Stanford University Medical Center
Posted: June 6 2007, 10:00 AM EST
Summary:
As stem cells in the blood grow older, genetic mutations accumulate that could be at the root of blood diseases that strike people as they age, according to work done in mice by researchers at the Stanford University School of Medicine.
Posted: June 6 2007, 10:00 AM EST
Summary:
As stem cells in the blood grow older, genetic mutations accumulate that could be at the root of blood diseases that strike people as they age, according to work done in mice by researchers at the Stanford University School of Medicine.
Reprogrammed fibroblasts identical to embryonic stem cells
Source: Whitehead Institute for Biomedical Research
Date: June 6, 2007
Summary:
Scientists at Whitehead Institute have demonstrated that embryonic stem cells can be created without eggs. By genetically manipulating mature skin cells taken from a mouse, the scientists have transformed these cells back into a pluripotent state, one that appears identical to an embryonic stem cell in every way. No eggs were used, and no embryos destroyed.
Date: June 6, 2007
Summary:
Scientists at Whitehead Institute have demonstrated that embryonic stem cells can be created without eggs. By genetically manipulating mature skin cells taken from a mouse, the scientists have transformed these cells back into a pluripotent state, one that appears identical to an embryonic stem cell in every way. No eggs were used, and no embryos destroyed.
Stem cells 'to provide blindness cure'
Source: Daily Telegraph - UK
Posted: 6 June 2007 2:17 A.M. BST
Summary:
The Daily Telegraph reports on new research by British scientists using stem cells to treat macular degeneration, a progressive eye disease:
"Pioneering stem call transplants to restore the sight of people affected by a leading cause of blindness could start within five years, according to a British team which has reported the successful implant of human eye cells into rats." To prepare for the groundbreaking procedure, the researchers have repaired the vision of patients with macular degeneration with tissue from their own eyes. This study, however,uses stem cells derived from human embryos. The researchers hope to begin human clinical trials in five years.
Posted: 6 June 2007 2:17 A.M. BST
Summary:
The Daily Telegraph reports on new research by British scientists using stem cells to treat macular degeneration, a progressive eye disease:
"Pioneering stem call transplants to restore the sight of people affected by a leading cause of blindness could start within five years, according to a British team which has reported the successful implant of human eye cells into rats." To prepare for the groundbreaking procedure, the researchers have repaired the vision of patients with macular degeneration with tissue from their own eyes. This study, however,uses stem cells derived from human embryos. The researchers hope to begin human clinical trials in five years.
Tuesday, June 05, 2007
UCL leads London project to beat blindness
Source: University College London
Date: 5 June 2007
Summary:
The UCL Institute of Ophthalmology is leading a project launched today to develop a therapy that could restore the sight of a quarter of over-60s in the UK. The London Project to Cure AMD (Age-Related Macular Degeneration) will develop a surgical therapy to stabilise and restore vision in people who go blind due to faulty retinal cells. AMD affects around a quarter of people over the age of 60 in the UK, and 14 million people across Europe. The radical approach of the London Project to Cure AMD will involve producing a cell replacement therapy from human embryonic stem cells. Trials using patients’ own cells have proved that this approach can work.
Date: 5 June 2007
Summary:
The UCL Institute of Ophthalmology is leading a project launched today to develop a therapy that could restore the sight of a quarter of over-60s in the UK. The London Project to Cure AMD (Age-Related Macular Degeneration) will develop a surgical therapy to stabilise and restore vision in people who go blind due to faulty retinal cells. AMD affects around a quarter of people over the age of 60 in the UK, and 14 million people across Europe. The radical approach of the London Project to Cure AMD will involve producing a cell replacement therapy from human embryonic stem cells. Trials using patients’ own cells have proved that this approach can work.
UK scientists set their sights on cure for AMD
Source: University College London
Date: June 5, 2007
Summary:
A groundbreaking surgical therapy capable of stabilising and restoring vision in the vast majority of patients who currently suffer blindness through Age-Related Macular Degeneration (AMD) is to be taken to clinical trial by scientists and clinicians at the UCL Institute of Ophthalmology, Moorfields Eye Hospital and the University of Sheffield. The therapy, using cells derived from human embryonic stem cells to replace the faulty retinal cells that cause AMD, will be developed by the London Project to Cure AMD, a collaborative project launched today bringing together some of the leading specialists in the field.
Date: June 5, 2007
Summary:
A groundbreaking surgical therapy capable of stabilising and restoring vision in the vast majority of patients who currently suffer blindness through Age-Related Macular Degeneration (AMD) is to be taken to clinical trial by scientists and clinicians at the UCL Institute of Ophthalmology, Moorfields Eye Hospital and the University of Sheffield. The therapy, using cells derived from human embryonic stem cells to replace the faulty retinal cells that cause AMD, will be developed by the London Project to Cure AMD, a collaborative project launched today bringing together some of the leading specialists in the field.
Scientists plan stem cell cure for blindness
Source: Reuters
Posted: June 5, 2007 12:31pm ET
Summary:
Reuters reports on new research by British scientists using embryonic stem cells to treat patients with age-related macular degeneration (AMD), a leading cause of blindness among the elderly:
"British scientists plan to use stem cells to cure a common form of blindness, with the first patients receiving test treatment in five years. The pioneering project, launched on Tuesday, aims to repair damaged retinas with cells derived from human embryonic stem cells. Its backers say it involves simple surgery that could one day become as routine as cataract operations.
Posted: June 5, 2007 12:31pm ET
Summary:
Reuters reports on new research by British scientists using embryonic stem cells to treat patients with age-related macular degeneration (AMD), a leading cause of blindness among the elderly:
"British scientists plan to use stem cells to cure a common form of blindness, with the first patients receiving test treatment in five years. The pioneering project, launched on Tuesday, aims to repair damaged retinas with cells derived from human embryonic stem cells. Its backers say it involves simple surgery that could one day become as routine as cataract operations.
Scientists seek stem cell cure for blindness
Source: Guardian Unlimited - UK
Date: June 5, 2007
Summary:
The Guardian reports British scientists have begun a new study to investigate treatments for blindness to restore lost sight due to age-related macular degeneration (AMD) using adult eye stem cells to grow new retinal cells:
"British scientists have launched an ambitious project to cure the most common cause of age-related blindness by growing human eye tissue from stem cells."
The story also describes the procedure researchers will perform to obtain and transplant the cells into patients:
"Scientists at the University of Sheffield will grow the stem cells in 4-6mm oval patches, to the standards required for clinical use. First, healthy cells are harvested from a patient's own eyes, then they are transplanted into the damaged area behind the centre of the retina. However, the procedure is difficult and can be fraught with complications." Researchers hope to eventually be able to make the operation a routine procedure, similar to surgery to remove cataracts.
Date: June 5, 2007
Summary:
The Guardian reports British scientists have begun a new study to investigate treatments for blindness to restore lost sight due to age-related macular degeneration (AMD) using adult eye stem cells to grow new retinal cells:
"British scientists have launched an ambitious project to cure the most common cause of age-related blindness by growing human eye tissue from stem cells."
The story also describes the procedure researchers will perform to obtain and transplant the cells into patients:
"Scientists at the University of Sheffield will grow the stem cells in 4-6mm oval patches, to the standards required for clinical use. First, healthy cells are harvested from a patient's own eyes, then they are transplanted into the damaged area behind the centre of the retina. However, the procedure is difficult and can be fraught with complications." Researchers hope to eventually be able to make the operation a routine procedure, similar to surgery to remove cataracts.
Stem cell therapy for eye disease
Source: BBC News
Posted: 5 June 2007, 11:45 GMT 12:45 UK
Summary:
BBC News reports on new research using embryonic stem cells to treat macular degeneration, which may have also application for treating other eye diseases:
"UK scientists are attempting to restore vision in people with a leading cause of blindness using stem cells. The team has already repaired the vision of a handful of patients with age-related macular degeneration using cells from the patients' own eyes. With the help of a £4m donation, they are now planning to carry out the same operation using retinal cells grown from stem cells in the lab. It is hoped the first patients would be treated within five years."
Posted: 5 June 2007, 11:45 GMT 12:45 UK
Summary:
BBC News reports on new research using embryonic stem cells to treat macular degeneration, which may have also application for treating other eye diseases:
"UK scientists are attempting to restore vision in people with a leading cause of blindness using stem cells. The team has already repaired the vision of a handful of patients with age-related macular degeneration using cells from the patients' own eyes. With the help of a £4m donation, they are now planning to carry out the same operation using retinal cells grown from stem cells in the lab. It is hoped the first patients would be treated within five years."
Stem cell treatment 'to cure blindness in five years'
Source: Evening Standard
Date: 5 June 2007
Summary:
The Evening Standard reports on the development of a new technique by British Scientists which uses human embryonic stem cells (hESC's) to cure blindness:
"A revolutionary technique being developed by British scientists could cure blindness in millions of people around the world. The treatment centres on human embryonic stem cells grown in a laboratory. These are "blank" cells with the power to turn into different cell types and are used to create small patches identical to the cells damaged in the eyes of AMD sufferers. Packaged into a syringe, the patch is injected into the back of the eye where it replaces damaged cells and restores sight."
Date: 5 June 2007
Summary:
The Evening Standard reports on the development of a new technique by British Scientists which uses human embryonic stem cells (hESC's) to cure blindness:
"A revolutionary technique being developed by British scientists could cure blindness in millions of people around the world. The treatment centres on human embryonic stem cells grown in a laboratory. These are "blank" cells with the power to turn into different cell types and are used to create small patches identical to the cells damaged in the eyes of AMD sufferers. Packaged into a syringe, the patch is injected into the back of the eye where it replaces damaged cells and restores sight."
StemCells, Inc. Announces Publication Describing Non-Invasive Tracking of Human Neural Stem Cells Transplanted in Vivo
Source: StemCells, Inc.
Date: June 5, 2007
Summary:
In an official news release, StemCells, Inc. (NASDAQ: STEM) today announced the publication of a paper describing a new technique for non-invasive tracking of human neural stem cells transplanted into the brains of mice. Dr. Stephen Huhn, Vice President and Head of Stem Cells, Inc.'s Neural Program, called the experiment a step forward in scientists' understanding of how stem cells function in the human brain:
"This is an important contribution to the field of human cellular transplantation. The ability to track non- invasively human neural stem cells transplanted into the brain could enhance our knowledge and understanding of where the cells go, how they get there and how they behave when they get to their final destination." He also believes the finding could eventually help to move human cellular transplants into clinical practice.
Date: June 5, 2007
Summary:
In an official news release, StemCells, Inc. (NASDAQ: STEM) today announced the publication of a paper describing a new technique for non-invasive tracking of human neural stem cells transplanted into the brains of mice. Dr. Stephen Huhn, Vice President and Head of Stem Cells, Inc.'s Neural Program, called the experiment a step forward in scientists' understanding of how stem cells function in the human brain:
"This is an important contribution to the field of human cellular transplantation. The ability to track non- invasively human neural stem cells transplanted into the brain could enhance our knowledge and understanding of where the cells go, how they get there and how they behave when they get to their final destination." He also believes the finding could eventually help to move human cellular transplants into clinical practice.
Killer gene targets cancerous cells
Source: Baltimore Examiner
Posted: Jun 5, 2007 12:00 AM EDT
Summary:
Scientists at Johns Hopkins Medicine have discovered a gene that, when working correctly, kills cancer cells. But when malfunctioning, it allows potentially lethal tumors to grow unchecked.
Posted: Jun 5, 2007 12:00 AM EDT
Summary:
Scientists at Johns Hopkins Medicine have discovered a gene that, when working correctly, kills cancer cells. But when malfunctioning, it allows potentially lethal tumors to grow unchecked.
Monday, June 04, 2007
Researchers pinpoint colon cancer stem cells
Source: Reuters
Posted: June 4, 2007 5:09PM EDT
Summary:
Reuters reports researchers at Stanford University have discovered stem cells that cause colon cancer:
"A small population of stem cells drives tumor growth in colon cancer, researchers said on Monday in a discovery that could lead to a new approach to tackle the deadly disease." The study's lead researcher believes the finding, published in the Proceedings of the National Academy of Sciences, might lead to treatments to wipe out these cells and eradicate the cancer.
Posted: June 4, 2007 5:09PM EDT
Summary:
Reuters reports researchers at Stanford University have discovered stem cells that cause colon cancer:
"A small population of stem cells drives tumor growth in colon cancer, researchers said on Monday in a discovery that could lead to a new approach to tackle the deadly disease." The study's lead researcher believes the finding, published in the Proceedings of the National Academy of Sciences, might lead to treatments to wipe out these cells and eradicate the cancer.
Stemlike Cells May Fuel Colorectal Cancer
Source: Scientific American
Date: June 4, 2007
Summary:
Scientific American reports on a discovery by stem cell researchers at Stanford University that colon tumors contain stem cells may fuel Colorectal Cancer:
"A newly discovered group of cells present in colorectal tumors may be the source of the cancer's ability to grow unchecked. Researchers found that tumor cells containing a combination of three proteins were capable of becoming tumors again when injected into mice. They speculate that the cells may be offshoots of healthy stem cells that no longer respond to the body's natural checks against aggressive, uncontrolled growth."
Date: June 4, 2007
Summary:
Scientific American reports on a discovery by stem cell researchers at Stanford University that colon tumors contain stem cells may fuel Colorectal Cancer:
"A newly discovered group of cells present in colorectal tumors may be the source of the cancer's ability to grow unchecked. Researchers found that tumor cells containing a combination of three proteins were capable of becoming tumors again when injected into mice. They speculate that the cells may be offshoots of healthy stem cells that no longer respond to the body's natural checks against aggressive, uncontrolled growth."
Researchers find mechanisms that may unlock answers to Alzheimer's disease
Source: University of Missouri-Columbia
Date: June 4, 2007
Summary:
Four million people in the United States and 15 to 20 million people worldwide are affected by Alzheimer’s disease. These numbers are likely to triple by 2050 due to the fact that 24 percent of the population will be more than 65 years old. In their attempt to combat the disease, two University of Missouri-Columbia professors have identified new mechanisms that could have major implications in the development of treatments for the disease. The National Institutes of Health recently awarded a $6 million grant to the Mizzou researchers to continue their study.
Date: June 4, 2007
Summary:
Four million people in the United States and 15 to 20 million people worldwide are affected by Alzheimer’s disease. These numbers are likely to triple by 2050 due to the fact that 24 percent of the population will be more than 65 years old. In their attempt to combat the disease, two University of Missouri-Columbia professors have identified new mechanisms that could have major implications in the development of treatments for the disease. The National Institutes of Health recently awarded a $6 million grant to the Mizzou researchers to continue their study.
Stanford researchers find cancer stem cells in colorectal tumors
Source: Stanford University Medical Center
Date: June 4, 2007
Summary:
Researchers at the Stanford University School of Medicine have identified the cancer stem cells that propagate tumors in colon and rectal cancer, a discovery that could lead to improved treatment of this deadly cancer. The work was supported by the National Institutes of Health, the Virginia and D.K. Ludwig Foundation, the California Institute for Regenerative Medicine (CIRM), and the Fondazione Italiana per la Ricerca sul Cancro.
Date: June 4, 2007
Summary:
Researchers at the Stanford University School of Medicine have identified the cancer stem cells that propagate tumors in colon and rectal cancer, a discovery that could lead to improved treatment of this deadly cancer. The work was supported by the National Institutes of Health, the Virginia and D.K. Ludwig Foundation, the California Institute for Regenerative Medicine (CIRM), and the Fondazione Italiana per la Ricerca sul Cancro.
Stanford researchers track human stem cells transplanted into rat brain
Source: Stanford University Medical Center
Date: June 4, 2007
Summary:
Researchers at the Stanford University School of Medicine have illuminated the path taken by human neural stem cells that were transplanted into the brains of rats and mice, and found that the cells successfully navigate toward areas damaged by stroke. With the ability to monitor where the human stem cells go in real time, researchers will have an easier time learning the best way of using the cells to treat human neural disorders, such as stroke, traumatic brain injury, Parkinson’s disease or radiation damage.
Date: June 4, 2007
Summary:
Researchers at the Stanford University School of Medicine have illuminated the path taken by human neural stem cells that were transplanted into the brains of rats and mice, and found that the cells successfully navigate toward areas damaged by stroke. With the ability to monitor where the human stem cells go in real time, researchers will have an easier time learning the best way of using the cells to treat human neural disorders, such as stroke, traumatic brain injury, Parkinson’s disease or radiation damage.
Saturday, June 02, 2007
Genetically Modified Stem Cells May Have Therapeutic Application to X-SCID
Source: American Society of Gene Therapy (ASGT)
Date: June 2, 2007
Summary:
A study demonstrating therapeutic utilization of human stem cells, including potential application to X-linked Severe Combined Immunodeficiency (XSCID or "Bubble-Boy" disease) was presented at the 10th Annual Meeting of the American Society of Gene Therapy (ASGT) in Seattle.
Date: June 2, 2007
Summary:
A study demonstrating therapeutic utilization of human stem cells, including potential application to X-linked Severe Combined Immunodeficiency (XSCID or "Bubble-Boy" disease) was presented at the 10th Annual Meeting of the American Society of Gene Therapy (ASGT) in Seattle.
Friday, June 01, 2007
Enzyme Delivered In Smaller Package Protects Cells from Radiation Damage
Source: University of Pittsburgh Schools of the Health Sciences
Date: June 1, 2007
Summary:
A University of Pittsburgh School of Medicine research team, collaborating with scientists from Stanford University, have developed a new, smaller gene therapy vector that may be effective in delivering a radioprotective enzyme systemically throughout the body which may spare healthy tissue the long-term consequences of therapeutic irradiation. These results are being presented at the 10th annual meeting of the American Society of Gene Therapy, being held May 30 to June 3 at the Washington State Convention & Trade Center, Seattle.
Date: June 1, 2007
Summary:
A University of Pittsburgh School of Medicine research team, collaborating with scientists from Stanford University, have developed a new, smaller gene therapy vector that may be effective in delivering a radioprotective enzyme systemically throughout the body which may spare healthy tissue the long-term consequences of therapeutic irradiation. These results are being presented at the 10th annual meeting of the American Society of Gene Therapy, being held May 30 to June 3 at the Washington State Convention & Trade Center, Seattle.
Pediatric cancer stem cell identified
Source: Children's Hospital Boston
Date: June 1, 2007
Summary:
Researchers from Children's Hospital Boston and the Dana-Farber Cancer Institute have identified the cancer stem cell for rhabdomyosarcoma, the most common soft-tissue sarcoma of childhood. They report their findings in the June 1 issue of Genes & Development.
Date: June 1, 2007
Summary:
Researchers from Children's Hospital Boston and the Dana-Farber Cancer Institute have identified the cancer stem cell for rhabdomyosarcoma, the most common soft-tissue sarcoma of childhood. They report their findings in the June 1 issue of Genes & Development.
Muscle Repair Depends on Multiple Cell Types
Source: Howard Hughes Medical Institute
Date: June 1, 2007
Summary:
Researchers have identified a new population of stem cells that act to repair muscle after damage. Until now, researchers had assumed that all of these cells, which are called satellite cells, had similar properties. They all seemed to follow the same developmental path to becoming mature muscle. The new discoveries show that the developmental fate of a given satellite cell depends on its physical orientation immediately after cell division.
Date: June 1, 2007
Summary:
Researchers have identified a new population of stem cells that act to repair muscle after damage. Until now, researchers had assumed that all of these cells, which are called satellite cells, had similar properties. They all seemed to follow the same developmental path to becoming mature muscle. The new discoveries show that the developmental fate of a given satellite cell depends on its physical orientation immediately after cell division.
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