Monday, April 30, 2007

Sentry enzyme blocks paths to Parkinson's disease

Source: St. Jude Children's Research Hospital
Date: April 30, 2007

Summary:

The degeneration of brain cells that occurs in Parkinson's disease may be caused by either externally provoked cell death or internally initiated suicide when the molecule that normally prevents these fatal alternatives is missing, according to studies in mouse models by investigators at St. Jude Children's Research Hospital.

Cure For Congenital Inability To Smell An Odor

Source: Federation of American Societies for Experimental Biology
Date: April 30, 2007

Summary:

New discoveries about the biochemical basis of the majority of cases of the congenital inability to smell any odor, no matter how strong, have enabled their discoverer, Dr. Robert I. Henkin, director of The Taste and Smell Clinic in Washington, DC, to treat such patients, enabling them to smell something for the first time in their lives.

Seed study might help stem cell research

Source: United Press International
Date: April 30, 2007

Summary:

German scientists have found genomic imprinting is not always essential for seed development -- a finding with implications for stem cell research.

Study: Stem cells report olfactory nerves

United Press International
Posted: April 30, 2007 5:18 PM ET

Summary:

U.S. researchers identified a "backup supply" of stem cells that can repair the most severely damaged nerves responsible for human olfactory sense.

Smelling for first time results from knowing abnormalities in congenital loss of smell

Source: Federation of American Societies for Experimental Biology
Date: April 30, 2007

Summary:

New discoveries about the biochemical basis of the majority of cases of the congenital inability to smell any odor, no matter how strong, have enabled their discoverer, Dr. Robert I. Henkin, director of The Taste and Smell Clinic in Washington, DC, to treat such patients, enabling them to smell something for the first time in their lives.

Aastrom Initiates Adult Stem Cell Clinical Trial for Peripheral Arterial Disease

Source: Aastrom Biosciences, Inc.
Date: April 30, 2007

Summary:

Aastrom Biosciences, Inc. (Nasdaq:ASTM), a regenerative medicine company, today announced that it has initiated its U.S. Phase IIb prospective, controlled, randomized, double-blind, multi-center clinical trial to treat patients suffering from peripheral arterial disease (PAD), a chronic disease that progressively restricts blood flow in the limbs and can lead to serious medical complications.

Sunday, April 29, 2007

Adult Stem/progenitor Cells Repair Of Damaged Brain, Pancreas, Kidney Cells Newly Understood

Source: Federation of American Societies for Experimental Biology
Date: April 29, 2007

Summary:

New studies by Tulane University researchers are shedding light on the previously mysterious mechanism through which even relatively small amounts of stem/progenitor cells taken from a patient’s own bone marrow enhance repair of damaged tissues. The cells not only differentiate to replace injured cells, as had been understood, but they also stimulate the proliferation and differentiation of stem cells already present in the injured tissue. The study's lead author says better understanding of the different mechanisms of these stem/progenitor cells suggests multiple strategies for developing new therapies for a broad range of diseases. It also may help make such treatments more effective and minimize potential dangers.

When smell cells fail they call in stem cell reserves

Source: Johns Hopkins Medical Institutions
Date: April 29, 2007

Summary:

Hopkins researchers have identified a backup supply of stem cells that can repair the most severe damage to the nerves responsible for our sense of smell. These reservists normally lie around and do nothing, but when neighboring cells die, the scientists say, the stem cells jump into action. A report on the discovery will appear online next week in Nature Neuroscience.

Scientists restore memory in mice with neurodegeneration

Source: Howard Hughes Medical Institute
Date: April 29, 2007

Summary:

Mice whose brains had lost a large number of neurons due to neurodegeneration regained long-term memories and the ability to learn after their surroundings were enriched with toys and other sensory stimuli, according to new studies by Howard Hughes Medical Institute researchers. The scientists were able to achieve the same results when they treated the mice with a specific type of drug that encourages neuronal growth.

Reversing cancer cells to normal cells: Tumor cells exposed to embryonic microenvironment of stem cells

Source: Northwestern University
Date: April 29, 2007

Summary:

A Northwestern University scientist describes new research that used an innovative experimental approach to provide unique insights into how scientists can change human metastatic melanoma cells back to normal-like skin cells -- by exposing the tumor cells to the embryonic microenvironment of human embryonic stem cells, the zebra fish and the chick embryo.

Friday, April 27, 2007

New gene discovered in human stem cells may benefit transplant patients

Source: University of Oxford
Date: April 27, 2007

Summary:

Oxford scientists have for the first time revealed a link between a gene and the activity of human stem cells, giving hope that stem cell transplant success for blood cancer patients may be significantly improved. It is hoped that the discovery may in the future lead to genes playing a clinical role in stem cell transplants particularly in the context of cord blood.

Stem Cell Propagation And Neurogenesis Can Now Be Studied In Cell Culture

Source: Max Delbrück Center for Molecular Medicine
Date: April 27, 2007

Summary:

Researchers are now able to study stem cells from the brains of adult mice and their neurogenesis in long-term cell cultures. Harish Babu an Dr. Gerd Kempermann (both from the Max Delbrück Center for Molecular Medicine, MDC, Berlin-Buch, the Volkswagenstiftung Research Group at the Charité – Universitätsmedizin Berlin, Germany) have developed a new method which allows them to generate exactly those neurons from stem cells in cell culture as those that would develop in the living brain.

Thursday, April 26, 2007

Canadian researchers 'create' leukemia stem cell, watch disease unfold

Source: Canadian Press
Date: April 26, 2007

Summary:

Canadian researchers have converted normal human blood cells into leukemia stem cells, then transplanted them into lab mice and witnessed the disease unfold. The groundbreaking research involved infecting cells from umbilical cord blood with a virus engineered to carry one of the genes known to cause certain types of leukemia. The genetic alteration created primitive leukemia stem cells, which were then injected into specially bred lab mice.

Scientists identify key to integrating transplanted nerve cells into injured tissue

Source: Schepens Eye Research Institute
Date: April 26, 2007

Summary:

Scientists at the Schepens Eye Research Institute, an affiliate of Harvard Medical School, have identified a key mechanism for successfully transplanting tissue into the adult central nervous system. The study found that a molecule known as MMP-2 (which is induced by stem cells) has the ability to break down barriers on the outer surface of a damaged retina and allow healthy donor cells to integrate and wire themselves into remaining recipient tissue.

Cancer scientists create 'human' leukemia process to map how disease begins, progresses

Source: Princess Margaret Hospital
Date: April 26, 2007

Summary:

Cancer researchers led by Dr. John Dick at Ontario Cancer Institute (OCI) have developed a method to convert normal human blood cells into "human" leukemia stem cells. The converted cells, when transplanted into special mice that permit the growth of human cells, can replicate the entire disease process from the very moment it begins. The findings are published in the journal Science.

Wednesday, April 25, 2007

Horses lead humans in stem cells race

Source: Reuters
Posted: April 25, 2007 10:19am ET

Summary:

Stem cell therapy may be controversial in human medicine but in the world of horse racing it is becoming the odds-on favorite for tackling tendon damage by extracting stem cells from the animal's own sternum and then purify and multiply them in a laboratory. Soon the same technology could be applied to humans.

Tuesday, April 24, 2007

Sea Squirt Study May Help Human Medicine

Source: United Press International
Date: April 24, 2007

Summary:

A U.S. study may lead to a major advance in human regenerative medicine, the Federation of American Societies for Experimental Biology says. Research conducted at Stanford University shows a human evolutionary ancestor, the sea squirt, can correct abnormalities during a series of generations, suggesting a similar regenerative process might be possible in humans.

Scientists make major breakthrough in regenerative medicine

Source: Federation of American Societies for Experimental Biology
Date: April 24, 2007

Summary:

Findings described in a new study by Stanford scientists may be the first step toward a major revolution in human regenerative medicine—a future where advanced organ damage can be repaired by the body itself. In the May 2007 issue of The FASEB Journal, researchers show that a human evolutionary ancestor, the sea squirt, can correct abnormalities over a series of generations, suggesting that a similar regenerative process might be possible in people.

Nanotechnology offers hope for treating spinal cord injuries, diabetes, and Parkinson's disease

Source: Project on Emerging Nanotechnologies
Date: April 24, 2007

Summary:

Scientists are combining nanotechnology and biology to enable the body to heal itself and mobilize the body’s own healing abilities to repair or regenerate damaged cells. The research could enable damaged organs—kidneys, liver, heart—to be stimulated to heal themselves and injured tissues to be repaired and completely and permanently relieve effects of neurodgenerative diseases such as Parkinson’s Disease or Alzheimer’s Disease.

Monday, April 23, 2007

Nanotechnology could be basis of future cures

Source: Chicago Tribune
Date: April 23, 2007

Summary:

The Chicago Tribune examines the application of nanotechnology to regenerative medicine in order to grow new brain tissue to treat degenerative conditions such as Parkinson's disease or Alzheimer's disease.

Cellerant stem cell transplantation process success in mice

Source: Pharmaceutical Business Review
Date: 23 April 2007

Summary:

Cellerant Therapeutics has published the results of a study showing that established autoimmune disease can be reversed or stabilized by the transplantation of purified allogeneic hematopoietic stem cells in a mouse study of lupus.

Cellerant Therapeutics Reversed Autoimmune Disease in Lupus Mice with Transplant of Purified Donor Blood Stem Cells

Source: Cellerant Therapeutics, Inc.
Posted: April 23, 2007 10:13 am ET

Summary:

Cellerant Therapeutics today announced the publication of data suggesting that established autoimmune disease can be reversed or stabilized by the transplantation of purified allogeneic (donated) hematopoietic (blood forming) stem cells (HSC) in a mouse study of Systemic Lupus Erythematosus (SLE). Subjects that underwent this procedure exhibited improved overall survival and decreased lupus symptoms.

Saturday, April 21, 2007

Insight: Questions follow reports of stem cell diabetes cure

Source: New Scientist
Date: 21 April 2007

Summary:

New Scientist reports on a trial conducted in Brazil that resulted in people with type 1 diabetes being able to live without injections of insulin for months - in one case for three years. However, the story also notes "It is unclear, however, whether the treatment constitutes a cure, or even whether any benefit was due to stem cells."

Inkjet innovation

Source: Winston-Salem Journal
Date: April 21, 2007

Summary:

At the Wake Forest Institute of Regenerative Medicine, scientists are using inkjet printers and the basics of inkjet technology to "print" human cells into the form of human organs and tissues -- a groundbreaking system that could change the way researchers study the field of tissue-engineering. The Wake Forest institute's inkjet system is used to build cells for the institute's tissue-engineering research.

Friday, April 20, 2007

Stem Cells May Be at Root of Cancer

Source: WebMD
Date: April 20, 2007

Summary:

Leading researchers say that cancer is, fundamentally, a stem cell problem -- and that therapy should be targeted at so-called cancer stem cells. This week at the annual meeting of the American Association for Cancer Research, researchers discussed new discoveries suggesting that stem cells in leukemia, breast, and colon cancer are at the root of many tumors.

Thursday, April 19, 2007

Scientists find that neural stem cell formation may be a factor in abnormal brain development

Source: The Hospital for Sick Children
Date: April 19, 2007

Summary:

Taking an innovative approach to the investigation of genetic syndromes causing learning disabilities and mental retardation, researchers at The Hospital for Sick Children (SickKids) and Harvard Medical School have found that neural stem cell development during embryogenesis may have a direct effect on abnormal brain development. This research is reported in the April 19 issue of Neuron.

Stem Cells Set to Stamp Out Infertility

Source: ABC News
Date: April 19, 2007

Summary:

The author of a new study on changing human bone marrow stem cells into immature sperm cells is optimistic that his work will eventually allow infertile men and lesbian couples to conceive by producing their own sperm.

Researchers unlock key to memory storage in brain

Source: University of California - Los Angeles
Date: April 19, 2007

Summary:

Scientists know little about how the brain assigns cells to participate in encoding and storing memories. Now a UCLA/University of Toronto team has discovered that a protein called CREB controls the odds of a neuron playing a role in memory formation. The April 20 edition of Science reports the findings, which suggest a new approach for preserving memory in people suffering from Alzheimer's or other brain injury.

Gene plays key role in embryonic, adult stem cells

Source: Reuters
Posted: April 19, 2007 2:00pm ET

Summary:

Reuters reports on the identification of a gene that regulates the renewal capabilities of stem cells:

"One gene directs both embryonic and adult stem cells to perform the self-renewal function that is crucial in their potential broad use in medical treatments, researchers said. While the biology of these types of stem cells is very different, a study published in the journal Cell showed that they share at least this one key feature -- a gene called Zfx that controls their ability to self-renew."

System For Expanding Stem Cells To Form Cartilage Tissue Under Development

Source: Centre for Synthesis and Chemical Biology
Date: April 19, 2007

Summary:

The Centre for Synthesis and Chemical Biology is studying and developing new techniques using adult stem cells to restore damaged knee cartilage tissue:

"Professor Mohamed Al-Rubeai, currently a UCD Professor of Biochemical Engineering and principal investigator with the Centre for Synthesis and Chemical Biology and UCD Conway Institute has developed an economical tissue engineering approach which could offer new possibilities for restoring damaged or lost knee cartilage tissue."

Wednesday, April 18, 2007

Stem Cells: Discoveries Thrust Cancer-Initiating Stem Cells into a Larger Role in Cancer Biology and Treatment

Source: American Association for Cancer Research
Date: April 18, 2007

Summary:

Recent discoveries about the role of stem cells in cancer have altered the landscape of cancer research. With each new study, scientists are learning more about cancer-initiating properties of stem cells at organ sites and throughout the body. Increasingly, stem cells are examined as the cause - and potential target of treatment - for many, if not all, cancers. At the 2007 Annual Meeting of the American Association for Cancer Research, researchers present new discoveries about stem cells in leukemia, breast and colon cancer that add to the growing evidence that perhaps cancer is, fundamentally, a stem cell problem.

Stem cells decrease ischemic injury and restore brain function

Source: Public Library of Science
Date: April 18, 2007

Summary:

This is the impressive result of a study carried out by a group of researchers coordinated by Dr. Maria Grazia De Simoni of the Mario Negri Institute in Milan, Italy in cooperation with the Istituto Neurologico Besta (Milan) and the University of Lausanne. The study appears in the April 18th issue of the international, peer-reviewed, open-access online journal of the Public Library of Science, PLoS ONE.

Discoveries thrust cancer-initiating stem cells into a larger role in cancer biology and treatment

Source: American Association for Cancer Research
Date: April 18, 2007

Summary:

New studies presented at the 2007 Annual Meeting of the American Association for Cancer Research are showing that stem cells could be a significant factor in determining the cause of and new treatments for cancers:

"Recent discoveries about the role of stem cells in cancer have altered the landscape of cancer research. With each new study, scientists are learning more about cancer-initiating properties of stem cells at organ sites and throughout the body. Increasingly, stem cells are examined as the cause - and potential target of treatment - for many, if not all, cancers."

Monday, April 16, 2007

Stem cell patch restores vision

Source: University of Melbourne University News
Date: April 16, 2007

Summary:

A team of researchers at the University of Melbourne’s Centre for Eye Research Australia (CERA) and the Bernard O’Brien Institute of Microsurgery (BOBIM) has successfully restored a patient's vision using a corneal patch, which replicates the cornea, grown from a single adult stem cell from a donor eye and was transplanted to the surface of the patient's eyes.

Sports Medicine Miracles? Stem Cell Research Hints at Promising Regenerative Therapies, but Real Results May Be Years Away

Source: ABC News
Date: April 16, 2007

Summary:

ABC News reports on future treatments for sports injuries with regenerative medicine:

"Designer 'spare parts' for ruptured tendons and torn ligaments. Stem cell injections to heal and build muscle. Medical therapeutics that would allow star athletes to extend their careers by years, if not decades. Welcome to what some envision as the new world of sports therapeutics. Proponents say that such regenerative treatments could be on the way in the years to come."

Stem Cells Shed Light on ALS Cure

Source: The Harvard Crimson
Posted: April 16, 2007 1:48 AM

Summary:

Researchers from Harvard and Columbia have moved one step closer to discovering the cause of the fatal neurodegenerative Lou Gehrig’s disease through a novel use of embryonic stem cells from mice. The researchers have harnessed stem cells from mice embryos, which can develop into any kind of tissue, to create mutant nerve cells for studying the early stages of disease. The scientists announced they discovered that a toxic molecule produced by non-neuron support cells causes the patterns of nerve cell death found in sufferers of Lou Gehrig’s disease, also known as Amyotrophic Lateral Sclerosis.

Stem cells provide new tool for studying disease and identifying ALS drugs

Source: PROJECT A.L.S.
Date: April 16, 2007 12:11 EST

Summary:

Results of two studies funded by Project A.L.S. and appearing in today's advance online publication of Nature Neuroscience demonstrate that embryonic stem cells may provide a new tool for studying disease mechanisms and for identifying drugs to slow ALS, also known as Lou Gehrig's disease.

STEM CELL RESEARCH OPENS NEW DOORS: If replacement therapy doesn't cure disease, it unlocks mysteries of how neurons operate

Source: San Francisco Chronicle
Date: April 16, 2007

Summary:

One argument for stem cell research is that it might generate fresh replacement cells for those destroyed by such horrific diseases as ALS, the paralyzing nervous system disorder popularly known as Lou Gehrig's disease. The latest research suggests those predictions might be unrealistic: Replacing cells that die off in a disease still leaves open the question of why the cells died in the first place, which is the critical issue in any autoimmune disease, or degenerative diseases such as Alzheimer's or Parkinson's. The findings may be the most dramatic example yet of the idea that stem cells are more valuable as a "disease model" -- used to study disease -- rather than a simple source of replacement parts.

Research offers insights into how ALS wreaks its havoc

Source: Boston Globe
Date: April 16, 2007

Summary:

A pair of studies has elucidated the mechanisms underlying some forms of amyotrophic lateral sclerosis, or ALS, and has shown the usefulness of stem cells in modeling the disease and pointing out new possibilities for treatment.

Researchers discover gene crucial for nerve cell insulation

Source: National Institute of Child Health and Human Development
Date: April 16, 2007

Summary:

Researchers funded by the National Institutes of Health have discovered how a defect in a single master gene disrupts the process by which several genes interact to create myelin, a fatty coating that covers nerve cells and increases the speed and reliability of their electrical signals.

Adult stem cells may have smarts to guard against cancer, Stanford researchers find

Source: Stanford University Medical Center
Date: April 16, 2007

Summary:

Some bewildering behavior seen in the stem cells of muscles has led researchers at the Stanford University School of Medicine to an unexpected discovery that could explain why cancer isn’t more common.

Sunday, April 15, 2007

Diseased Brain Cells More Involved In ALS-associated Motor Neuron Death

Source: Columbia University Medical Center
Date: April 15, 2007

Summary:

Two papers by Columbia and Harvard researchers report for the first time that astrocytes (the most abundant non-neuronal cells in the central nervous system), which carry a mutated gene known to cause some cases of amyotrophic lateral sclerosis (ALS/Lou Gehrig’s disease), induce motor neuron death. This indicates that astrocytes may contribute to ALS by releasing a toxic factor that damages neurons. These findings, posted online by Nature Neuroscience on April 15, suggest that developing an effective therapy for ALS would require overcoming the destructive effects of astrocytes and replacing the damaged motor neurons, possibly by transplanting motor neurons derived from embryonic stem cells.

Stem cell study zeroes in on ALS cause

Source: Reuters
Posted: April 15, 2007 8:06 p.m.

Summary:

Cells that are supposed to nourish and support other nerve cells instead secrete the poisons that cause amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, researchers reported. Two reports published in the journal Nature Neuroscience may show new ways to treat the degenerative nerve disease, which slowly paralyzes its victims until they die.

Stem Cells Provide New Tool For Studying Disease And Identifying ALS Drugs

Source: Project A.L.S.
Date: April 15, 2007

Summary:

Results of two studies funded by Project A.L.S. and appearing in today's advance online publication of Nature Neuroscience demonstrate that embryonic stem cells may provide a new tool for studying disease mechanisms and for identifying drugs to slow ALS, also known as Lou Gehrig's disease.

Friday, April 13, 2007

Bone stem cells turned into primitive sperm cells

Source: NewScientist.com news service
Posted: 13 April 2007 12:35 AM

Summary:

In a first step towards creating artificial sperm cells, researchers have turned human bone marrow tissue into primitive sperm cells. If these precursor cells can be coaxed into becoming fully functioning sperm cells, the technique could allow infertile men to father their own children, and even allow women to produce their own sperm. But experts caution that provoking the sperm precursors to fully mature presents a serious challenge.

Human Bone Marrow Used to Create Early Stage Sperm Cells

Source: HealthDay News
Date: April 13, 2007

Summary:

"For the first time, scientists have used human bone marrow to create early stage sperm cells, a research advance that will help improve understanding about how sperm cells are created, a new study says."

Early-stage sperm cells created from human bone marrow

Source: University of Newcastle upon Tyne
Date: April 13, 2007

Summary:

Human bone marrow has been used to create early-stage sperm cells for the first time, a scientific step forward that will help researchers understand more about how sperm cells are created.

Doctor touts heart breakthrough

Source: The Arizona Republic
Posted: April 13, 2007 12:00 AM

Summary:

An Arizona cardiologist has succeeded in what appears to be promising research that repairs damaged muscle in heart attack patients. The breakthrough involves use of a catheter to deliver stem cells from a patient's thigh muscle to the heart, restoring heart function.

Wednesday, April 11, 2007

Key Player In Embryonic Muscle Development Discovered

Source: Weizmann Institute of Science
Date: April 11, 2007

Summary:

Muscle fibers are large cells that contain many nuclei. They begin, like all animal cells, as naive embryonic cells. These cells differentiate, producing intermediate cells called myoblasts that are now destined to become muscle. New myoblasts then seek out other myoblasts, and when they find each other, they stick together like best friends. In the final stage of muscle fiber development, the cell membranes of attached myoblasts open up and fuse together, forming one large, unified cell. How myoblasts identify other myoblasts and how they cling together had been established, but the way that the cell membranes fuse into one has remained a mystery. Now, a study by Weizmann Institute scientists has shed light on this mystery.

Liver regeneration may be simpler than previously thought

Source: American Society for Biochemistry and Molecular Biology
Date: April 11, 2007

Summary:

The way the liver renews itself may be simpler than what scientists had been assuming. A new study, appearing in the April 13 issue of The Journal of Biological Chemistry, provides new information on the inner workings of cells from regenerating livers that could significantly affect the way physicians make livers regrow in patients with liver diseases such as cirrhosis, hepatitis, or cancer.

Rebooting the Immune System of Diabetics: Preliminary results show that transplants of adult stem cells help diabetics.

Source: MIT Technology Review
Date: April 11, 2007

Summary:

MIT Technology Review reports on the new study carried out by researchers at the University of Sao Paulo, in Brazil, and Northwestern University, in Chicago, using adult stem cells to treat type 1 diabetes:

"A combination of stem cells derived from patients' blood and immunosuppression to eliminate a faulty immune system can help keep newly diagnosed diabetics off insulin, according to a preliminary study published today. The findings, which still need to be verified in larger groups, are part of a growing effort to use immunotherapy to halt the progress of Type 1 diabetes."

The story continues:

"Previous studies of antibodies that block destructive immune cells have shown success for a limited period of time. The new study, which combines immunotherapy and stem-cell transplants, seems to improve beta-cell function. The combination therapy has previously been used in other autoimmune disorders, such as lupus, but this is the first trial that tests it in diabetes."

Commentary: Replication of this finding over a large and heterogeneous population that is monitored over a long time will be important in order to determine how effective it is in treating patients.

Hope, risk in diabetes trial

Source: Chicago Tribune
Date: April 11, 2007

Summary:

The Chicago Tribune examines the potential benefits and risks of a human trial of a new treatment for Type 1 diabetes:

"A new diabetes treatment developed at Northwestern University has allowed some patients to stop taking insulin for more than two years, but it also has spurred ethical objections from researchers who say the trial put Brazilian children at unnecessary risk."

Diabetics cured by stem-cell treatment

Source: The Times
Date: April 11, 2007

Summary:

The Times reports on a new stem cell trial using adult stem cells to treat type 1 diabetes that has yielded encouraging results:

"Diabetics using stem-cell therapy have been able to stop taking insulin injections for the first time, after their bodies started to produce the hormone naturally again. In a breakthrough trial, 15 young patients with newly diagnosed type 1 diabetes were given drugs to suppress their immune systems followed by transfusions of stem cells drawn from their own blood. The results show that insulin-dependent diabetics can be freed from reliance on needles by an injection of their own stem cells."

Study Suggests New Avenue on Diabetes

Source: New York Times
Date: April 11, 2007

Summary:

The New York Times reports on a recent study using adult stem cells to attempt to treat diabetes:

"Thirteen young diabetics in Brazil have been able to stop receiving insulin after being treated with stem cells taken from their own blood, researchers are reporting. The experimental procedure has enabled the young people, who have Type 1 diabetes, to live free of insulin shots for as long as three years so far, according to the study, being published Wednesday in The Journal of the American Medical Association."

National Stem Cell Announces Publication of Sponsored Research Findings for Type I Diabetes

Source: National Stem Cell Holding, Inc.
Posted: April 11, 2007 1:06 pm ET

Summary:

National Stem Cell Holding, Inc. announced a new study that uses embryonic germ cells to potentially treat type 1 (juvenile) diabetes:

"National Stem Cell has announced the publication of sponsored research whose findings suggest the discovery of a potential source of insulin-producing cells to treat Type I Diabetes. Type I Diabetes, sometimes referred to as Juvenile Diabetes--although it can strike at any age, affects millions of people worldwide. According to the abstract, the scientists were able to, ``show that cells derived from human embryonic germ (EG) cells express markers of definitive endoderm, pancreatic and B-cell development, glucose sensing, and production of mature insulin."

Stem Cell Transplants In Diabetes Type 1 Patients Kick Starts Own Insulin Production

Source: Medical News Today
Posted: April 11 2007 - 0:00 PDT

Summary:

A Brazilian study has shown that stem cell transplants in patients with diabetes type 1 may kick start the pancreas into producing insulin again. It is still too early to tell if the effect is permanent, but some patients have remained insulin free for over 20 months. The study is published in the Journal of the American Medical Association (JAMA). This study is the first to combine both the immunosuppression and the stem cell transplant in newly diagnosed type 1 diabetes patients.

Stem cell study offers hope for diabetics

Source: Guardian Unlimited - UK
Date: April 11, 2007

Summary:

Scientists have managed through stem cell transplants to free a small group of diabetics from their dependence on insulin injections. The experiment suggests that type 1 diabetes, which is genetic, unlike obesity-related type 2, could one day be prevented or reversed, according to the Journal of the American Medical Association.

Stem cells shown to rein in Type 1 diabetes

Source: Los Angeles Times
Date: April 11, 2007

Summary:

Researchers have demonstrated for the first time that the progression of Type 1 diabetes can be halted — and possibly reversed — by a bone marrow stem-cell transplant that preserves the body's diminishing ability to make insulin, according to a study published today.

Tuesday, April 10, 2007

Diabetes 'blocked by stem cells'

Source: BBC News
Posted: 11 April 2007, 05:09 GMT 06:09 UK

Summary:

Brazilian and US scientists have used transfusions of patients' own stem cells to reverse type 1 diabetes. The researchers, from the University of Sao Paulo, gave the patients powerful drugs to suppress their immune systems in an attempt to stop further destruction of pancreatic cells, followed by transfusions of stem cells taken from their own blood, in effect designed to restart the immune system.

URGENT! Senate Plans Stem Cell Vote Tuesday, April 10, 2007!

To all readers of Ben's Stem Cell News:

The U.S. Senate plans to continue consideration of and possibly vote on a bill, S. 5, on Wednesday, April 11, 2007 to allow government financing of new embryonic stem cell research, defying a presidential veto threat. Here are the details on the schedule of the vote from the U.S. Senate Legislative Calendar:

  • Senate Floor Schedule

  • Wednesday, April 11, 2007
    9:30 a.m.: Convene and resume concurrent consideration of S. 5 and S. 30, on stem cells.

    It has been reported there are currently 66 senators planning to vote for the bill, but 67 votes are needed to override an expected Presidential veto. It is possible that
  • Sen. John Sununu (R - New Hamphshire)
  • could be the key vote to reach 67 votes. If you support stem cell research, please take a moment to complete one of the form-letters below, send it to your Senators,
  • and also to Senator Sununu by clicking here
  • , and forward it around to everyone you can telling them to do the same!

    For the complete text of S. 5, see the "Federal Stem Cell Legislation" section under the LINKS column on Ben's Stem Cell News.


  • To find your senator, click here


  • Christopher and Dana Reeve Foundation form-e-mail to send to your senators


  • StemPAC form e-mail to send to your senators


  • Campaign to Defend the Constitution (DefCon) form-e-mail to send to your senators


  • HELP MAKE A DIFFERENCE!

    THANKS FOR YOUR SUPPORT!

    Ben Kaplan
    Publisher
    Ben's Stem Cell News

    New Research In CA Could Squash Stem Cell Debate

    Source: KGO-TV Bay Area
    Date: April 10, 2007

    Summary:

    Researchers at Alameda, CA-based biotechnology company Advanced Cell Technology have proved it is possible to make embryonic stem cells from that single cell that was already removed without destroying the embryo. The research is leading to new techniques that could make the debate moot. A video segment accompanies this story.

    Stem Cells May Stop Type 1 Diabetes

    Source: WebMD
    Date: April 10, 2007

    Summary:

    WebMD covers the new finding that may have implications for treating Type 1 diabetes:

    "After transplants of their own blood stem cells, 14 of 15 type 1 diabetes patients are insulin free for one to 36 months -- and counting, according to a new studying by researchers at f the University of São Paulo, Brazil. The finding marks the first time the treatment has been used in type 1 diabetes, although it's helped patients with other autoimmune diseases. The early success is encouraging -- but nobody is using the word 'cure.'"

    "Researchers caution it is still unclear exactly how the stem cell treatment works, or even whether it truly works at all. And it's far from clear how long treated patients will remain insulin free. They warn that longer follow-up of trial patients, further biological studies, and a clinical trial will be needed to confirm that the treatment works. Their report appears in the April 11 issue of The Journal of the American Medical Association."

    Risky Brazil experiment enables Type I diabetics to live without insulin, other medicines

    Source: Associated Press
    Posted: April 10, 2007, 4:49 PM CDT

    Summary:

    The Associated Press reports on the new clinical trial using patients' own blood stem cells to attempt to treat Type 1 diabetes:

    "Thirteen young diabetics in Brazil have ditched their insulin shots and need no other medication thanks to a risky, but promising treatment with their own stem cells – apparently the first time such a feat has been accomplished. Though too early to call it a cure, the procedure has enabled the young people, who have Type I diabetes, to live insulin-free so far, some as long as three years."

    First Look: Stem Cell Research

    Source: CBS News
    Date: April 10, 2007

    This is a CBS News video feature by Dr. Jon Lapook on the new study using adult stem cells to treat Type 1 diabetes.

    Stem Cells To Treat Diabetes?

    Source: CBS News
    April 10, 2007

    CBS News.com Video reports on a new study that uses adult stem cells to attempt to treat Type 1 diabetes.

    Stem cell experiment lets diabetics forgo insulin

    Source: Associated Press / NBC News
    Posted: 4:43 p.m. PT April 10, 2007

    Summary:

    The Associated Press reports on a new treatment for type 1 diabetes enabling patients to be independent of insulin:

    "Thirteen young diabetics in Brazil have ditched their insulin shots and need no other medication thanks to a risky, but promising treatment with their own stem cells — apparently the first time such a feat has been accomplished. Though too early to call it a cure, the procedure has enabled the young people, who have type 1 diabetes, to live insulin-free so far, some as long as three years. The treatment involves stem cell transplants from the patients’ own blood."

    An NBC News video accompanies this story.

    Stem cells could spell end for diabetes jabs

    Source: Evening Standard
    Date: 10 April 2007

    Summary:

    The Evening Standard reports on a new study using patients' own bone marrow stem cells to treat type 1 diabetes:

    "Scientists revealed findings of a study which shows that 15 young patients with type one diabetes overcame their dependence on insulin after being treated with their own stem cells. A team of US and Brazilian scientists gave the patients powerful drugs to suppress their immune systems followed by injections of stem cells drawn from their own blood. And so far, one patient has been free of insulin dependency for 35 months."

    Stem cell transplant promising for type 1 diabetes

    Source: Reuters Health
    Posted: April 10, 2007 6:33pm ET

    Summary:

    Reuters reports on a new procedure using adult stem cells to potentially treat type-1 diabetes:

    "Stem cells taken from the blood of a few diabetes patients have "re-set" their immune systems, helping 14 out of 15 live for months and even years without insulin, researchers reported. While they are not claiming to have cured the patients, they said their experiment shows it may be possible to at least interrupt the mistaken immune response that destroys insulin-producing cells in type-1 diabetes."

    Stem cell success in Type 1 diabetes

    Source: Los Angeles Times
    Posted: April 10, 2007 2:28 PM PDT

    Summary:

    Researchers have demonstrated for the first time that the progression of Type 1 diabetes can be halted — and possibly reversed — by a stem-cell transplant that preserves the body's diminishing ability to make insulin, according to a new study.

    Study suggests use of stem cell transplantation is beneficial treatment of type 1 diabetes

    Source: JAMA and Archives Journals
    Date: April 10, 2007

    Summary:

    A therapy that includes stem cell transplantation induced extended insulin independence in patients with type 1 diabetes mellitus (DM), according to a preliminary study in the April 11 issue of the Journal of the American Medical Association (JAMA). Researchers at the University of São Paulo, Ribeirão Preto, Brazil, in collaboration with the Northwestern University Feinberg School of Medicine, Chicago conducted a study to examine the effect of high-dose immunosuppression followed by transplanting a patient's own hematopoietic (bone marrow) stem cells to preserve function of pancreatic beta-cells in 15 newly diagnosed patients with type 1 DM. During a long-term follow-up, 14 patients became insulin-free (one for 35 months, four for at least 21 months, seven for at least six months; and two with late response were insulin-free for one and five months, respectively). Further follow-up is necessary to confirm the duration of insulin independence and the mechanisms of action of the procedure.

    'Rebuilt' immune system shakes off diabetes

    Source: NewScientist.com news service
    Posted: 10 April 2007 21:00 GMT

    Summary:

    Diabetics appear to have been cured with a one-off treatment that rebuilds their immune system, according to a new study published in the Journal of the American Medical Association (vol 297, p 1568). The technique, which uses patients' own bone marrow cells, has freed 14 of 15 patients with type 1 diabetes from their dependence on insulin medication. So far, participants in the trial have gone 18 months without insulin therapy following the procedure, on average. One patient has lasted three years without needing such injections.

    Stem Cells -- a Possible Cure for Diabetes: Stem Cell Transplants Slow Type 1 Diabetes Progression but Definitive Remedy Still Far Off

    Source: ABC News
    Date: April 10, 2007

    Summary:

    An injection of stem cells could one day serve as a therapy for diabetes, a new study suggests, as injections of stem cells harvested from a patient's own blood may keep type 1 diabetes at bay, demonstrating yet another application for the versatile stem cell approach. The injections work by using the patient's own stem cells to replace the defective cells that cause the disease.

    Blood cells help treat diabetes patients: study

    Source: Reuters
    Posted: April 10, 2007 4:28PM EDT

    Summary:

    Stem cells taken from the blood of a few diabetes patients have "re-set" their immune systems, helping 14 out of 15 live for months and even years without insulin, researchers reported. While they are not claiming to have cured the patients, they said their experiment shows it may be possible to at least interrupt the mistaken immune response that destroys insulin-producing cells in type-1 diabetes.

    Stem Cell Therapy May Combat Type 1 Diabetes

    Source: HealthDay News
    Date: April 10, 2007

    Summary:

    A pilot study of people newly diagnosed with type 1 diabetes found that stem cell therapy eliminated the need for insulin therapy for varying periods of time. This is the first trial to look at stem cell therapy in humans with this form of the disease. But experts stressed that the research is preliminary and urged caution when interpreting the results, which are published in the April 11 issue of the Journal of the American Medical Association.

    Stem Cell Therapeutics Corp. Announces Positive Interim Results From its Currently Enrolling Phase IIa Clinical Program for NTx(TM)-265 in Acute Strok

    Source: Stem Cell Therapeutics Corp
    Posted: April 10, 2007 - 08:30 ET

    Summary:

    Stem Cell Therapeutics Corp. announced positive interim results from its currently enrolling Phase IIa- Safety Trial for NTxTM-265, the company's new stem cell stroke treatment. Results demonstrated the treatment could be safely administered to a population of patients with acute stroke.

    New stem cell therapy gives relief for type 1 diabetes: study

    Source: Agence France Presse (AFP)
    Posted: April 10, 2007 07:29 AM EDT

    Summary:

    An experimental stem cell therapy designed to reverse the course of type 1 diabetes by using patients' own stem cells to rebuild their immune systems allowed patients to go treatment-free for months and in one case, three years, a study released today said. Thirteen of the 15 patients who took part in testing the therapy were able to quit the insulin injections that most diabetics depend on and remain insulin-free today, the researchers reported in the Journal of the American Medical Association (JAMA).

    Stem Cell Therapeutics reports positive interim results from stroke study

    Source: Canada.com
    Date: April 10, 2007

    Summary:

    Stem Cell Therapeutics Corp. (TSXV:SSS) reported it received "positive" interim results from a Phase 2a safety trial study for an acute stroke treatment. The Calgary-based drug developer said the trial of the combined treatments labelled NTx-265 could be safely administered to a population of patients with acute stroke.

    Female stem cells better at making new muscle cells

    Source: Pittsburgh Post-Gazette
    Date: April 10, 2007

    Summary:

    Female stem cells are more able than male ones to do the heavy lifting of regenerating muscle. Researchers at Children's Hospital and the University of Pittsburgh School of Medicine have found that stem cells derived from female muscle tissue make more muscle cells than those that come from males. The findings were published in yesterday's Journal of Cell Biology.

    Monday, April 09, 2007

    The sturdier sex? Study finds female stem cells work better

    Source: Children's Hospital of Pittsburgh
    Date: April 9, 2007

    Summary:

    Female stem cells derived from muscle have a greater ability to regenerate skeletal muscle tissue than male cells, according to a study at Children’s Hospital of Pittsburgh of UPMC.

    Children's Hospital study: Female stem cells are superior

    Source: Pittsburgh Tribune-Review
    Date: April 9, 2007

    Summary:

    Stem cells from the muscles of female mice are, on average, twice as good at growing muscle tissue as stem cells from male mice, according to Children's Hospital of Pittsburgh research published today in the Journal of Cell Biology.

    Saturday, April 07, 2007

    Heart breakthrough in Chandler: Doc refines cell repair prodedure

    Source: The Arizona Republic
    Posted: April 7, 2007 12:00 AM

    Summary:

    A cardiologist working out of Chandler Regional Hospital and Mercy Gilbert Medical Center has succeeded in what appears to be promising research that repairs damaged muscle in heart attack patients. The breakthrough involves use of a catheter to deliver stem cells taken from the thigh muscle of the patient and transplanting them into the damaged muscle, restoring heart function.

    Thursday, April 05, 2007

    Isolation Of Stem Cells May Lead To A Treatment For Hearing Loss

    Source: Case Western Reserve University
    Date: April 5, 2007

    Summary:

    Members of the National Center for Regenerative Medicine research team, Dr. Robert Miller and Dr. Kumar Alagramam, both of Case Western Reserve University School of Medicine, recently published research findings in Developmental Neuroscience which suggest new ways of treating hearing loss. These researchers have isolated "cochlear stem cells" located in the inner ear and already primed for development into ear-related tissue due to their proximity to the ear and expression of certain genes necessary for the development of hearing.

    New stem cell treatments on the way

    Source: CNNMoney.com
    Posted: April 5, 2007: 11:43 AM EDT

    Summary:

    Two new stem cell treatments could be entering the U.S. market next year. Two biotechs, Cytori Therapeutics and Osiris Therapeutics, each hope to get their experimental stem cell products approved by the Food and Drug Administration and into the U.S. market by 2008. Both outfits work with stem cells that are derived from adult tissue, not embryos, so they're insulated from the controversy surrounding the use of stem cells harvested from human embryos.

    Monday, April 02, 2007

    Joslin study indicates insulin receptors play a critical role in promoting islet growth

    Source: Joslin Diabetes Center
    Date: April 2, 2007

    Summary:

    A new Joslin-led study has identified the insulin receptor as an important protein that promotes islet cell growth in mice whose bodies are unable to use insulin properly, or are insulin resistant, a precursor to type 2 diabetes. Since the body's natural response to insulin resistance is to increase insulin secretion from the pancreas and grow more islet cells, also known as beta cells, harnessing this growth response could lead to new treatments for type 2 diabetes. The study appears in the early online edition of this week's Proceedings of the National Academy of Sciences.

    Local scientists making progress in stem cell research

    Source: ABC / KTRK 13 TV Texas
    Date: April 2, 2007

    Summary:

    An ABC / KTRK 13 TV, Houston, Texas feature story, which includes a TV news video segment, examines advancements in stem cell research being made my research institutions in Texas and the impact of federal stem cell funding restrictions on those intuitions. University of Texas at Houston scientists are the first to turn embryonic stem cells into usable lung cells and using embryonic stem cells to create, bone, cartilage and fat. At UT they're also using adult stem cells to treat head trauma in children. Researchers at Texas Heart Institute, are turning adult stem cells into heart cells. Three studies are underway, with more planned.

    British team grows human heart valve from stem cells

    Source: Guardian Unlimited - UK
    Date: April 2, 2007

    Summary:

    A British research team led by the world's leading heart surgeon has grown part of a human heart from stem cells for the first time. If animal trials scheduled for later this year prove successful, replacement tissue could be used in transplants for the hundreds of thousands of people suffering from heart disease within three years.

    Sunday, April 01, 2007

    Heart valve grown from stem cells

    Source: BBC NEWS
    Posted: 2007/04/02 04:47:28 GMT

    Summary:

    BBC News reports on a new study using adult stem cells to grow human heart valves:

    "British scientists have grown part of a human heart using stem cells extracted from bone marrow and cultivated them into heart valve cells. The lead researcher involved in the study said doctors could be using artificially-grown heart components in transplants within three years. His team at Harefield hospital managed to grow tissue that works in the same way as human heart valves. Researchers will see their achievement as a major step towards growing entire organs for transplant."