Tuesday, January 30, 2007

Robotics could speed up stem cell research

Source: DrugResearcher.com
Date: January 29, 2007

Summary:

Scientists hope to speed up the development of regenerative drugs for diseases such as cancer by using robotics to automate stem cell research. London-based biotechnology firm Plasticell hopes to use robotics to automate its Combicult technology to enable thousands of stem cell experiments to be conducted at once, rather than just a handful at a time by a single scientist.

Sunday, January 28, 2007

Gene knockouts reveal FoxOs' vital functions in cancer defense, health of stem cells

Source: Dana-Farber Cancer Institute
Date: January 26, 2007

Summary:

A team of Boston scientists has discovered that a trio of molecules, called FoxOs, are fundamentally critical in preventing some cancers, maintaining blood vessel stability, and in keeping blood-forming stem cells healthy. The discoveries reveal potential new targets for cancer drugs and could further research on stem-cell based therapies for degenerative diseases, said researchers at Dana-Farber Cancer Institute and Brigham and Women's Hospital, who are jointly publishing two reports in the Jan. 26 issue of Cell.

Friday, January 26, 2007

Cell discovery at UGA could open path to breakthroughs

Source: Atlanta Journal-Constitution
Date: January 26, 2007

Summary:

A University of Georgia scientist has discovered a way to quickly manufacture billions of a type of cell —- derived from embryonic stem cells —- that could grow into nerve and brain tissue, a development that could shorten by years the search for cures to debilitating conditions such as Alzheimer's and Parkinson's diseases as well as spinal cord injuries.

Thursday, January 25, 2007

Critical Stem Cell Survival Factors Found

Source: Howard Hughes Medical Institute
Date: January 25, 2007

Summary:

Researchers at Howard Hughes Medical Institute have identified a family of proteins that contributes to the survival and regenerative potential of blood-forming stem cells. According to the researchers, their findings in hematopoietic (blood) stem cells, might be relevant to stem cells in other tissues, and provide insights into potential strategies to enhance the longevity of stem cells. The new knowledge, obtained from animal studies, could help enhance the viability of blood stem cells used for bone marrow transplants for patients with leukemia.

Adult stem cells can at least make blood

Source: NewScientist.com news service
Posted: 12:42 25 January 2007

Summary:

NewScientist.com news service reports on a new finding that adult stem cells can form different types of blood cells:

"They were hailed as an “ethical” alternative to embryonic stem cells – adult stem cells that can turn into any of the body’s tissues. Doubts have grown, but now a prominent sceptic has shown that one claim seems true: they can form all of the cell types found in blood."

Stem Cells Cultured From Human Bone Marrow Behave Like Those Derived From Brain Tissue

Source: Cedars-Sinai Medical Center
Date: January 25, 2007

Summary:

"Stem cells taken from adult human bone marrow have been manipulated by scientists at the Maxine Dunitz Neurosurgical Institute at Cedars-Sinai Medical Center to generate aggregates of cells called spheres that are similar to those derived from neural stem cells of the brain. Results of the experiments, described in the February 2007 of the Journal of Neuroscience Research, support the concept of using bone marrow-derived stem cells to create therapies to treat brain tumors, strokes and neurodegenerative diseases."

Wednesday, January 24, 2007

Stem cell hope to defeat diabetes

Source: Daily Telegraph
Posted: 24 January 2007 1:55 A.M. GMT

Summary:

The Daily Telegraph reports:

"Cells passed from pregnant women to the foetus could hold the key to treating childhood diabetes, according to a new study. Scientists have discovered that stem cells are passed from mothers to unborn children with type 1 diabetes and may help repair the damage caused by immune attacks on insulin-producing cells thought responsible for the development of the disease."

Tuesday, January 23, 2007

New drug therapy to combat GVHD in stem-cell patients shows significant reduction in deaths

Source: Fred Hutchinson Cancer Research Center
Date: January 23, 2006

Summary:

Gastrointestinal graft-vs.-host disease is a common and potentially deadly side effect for patients who undergo an allogeneic stem-cell transplant to treat certain blood cancers. Now, new research from Fred Hutchinson Cancer Research Center shows that adding a widely used topical corticosteroid to the standard treatment for GVHD kept the disease in remission and significantly reduces deaths one year after therapy.

Cells Passed From Mother To Child May Be First Step In Developing New Treatments For Type 1 Diabetes

Source: Fred Hutchinson Cancer Research Center
Date: January 23, 2007

Summary:

For the first time, scientists have discovered that cells passed from mother to child during pregnancy can differentiate into functioning islet beta cells that produce insulin in the child.

Researchers Make Stem Cell Breakthrough

Source: The Korea Times
Date: January 23, 2007

Summary:

The Korea Times reports "A team of South Korean scientists has grown pancreatic beta cells, which can help treat diabetes, from stem cells taken from the umbilical cord blood of new born babies. The team, headed by Prof. Kang Kyung-sun of Seoul National University, Tuesday announced they had differentiated stem cells from cord blood cells into ones that secrete insulin."

Diabetes repair 'occurs in womb'

Source: BBC News
Posted: 23 January 2007, 00:03 GMT

Summary:

BBC News reports:

"A mother's cells may try to repair the tissue damage in an unborn child that can result in type 1 diabetes, research suggests. US and UK researchers found unusually high levels of maternal DNA in children with type 1 diabetes - an indication of cell transfer from the mother. They also found these cells could go on to produce insulin, the hormone lacking in type 1 diabetes."

Monday, January 22, 2007

Scientists document the development of cancer stem cells

Source: Stowers Institute for Medical Research
Date: January 22, 2007

Summary:

Xi He, M.D., Research Specialist II, and Linheng Li, Ph.D., Associate Investigator, are the first and last authors, respectively, on a new publication that clarifies how normal stem cells become cancer stem cells and how cancer stem cells can cause the formation of tumors.

Motor protein plays key role in connecting neurons

Source: Medical College of Georgia
Date: January 22, 2007

Summary:

A motor protein called myosin X runs the main road of a developing neuron, delivering to its tip a receptor that enables it to communicate with other neurons, scientists say.

Scientists Create Heart Muscle With Built-In Blood Supply

Source: Technion-Israel Institute of Technology
Date: January 22, 2007

Summary:

"Researchers at the Technion-Israel Institute of Technology have created new heart muscle with its own blood supply using human embryonic stem cells. The researchers say the newly engineered muscle could replace cardiac tissue damaged in heart attacks."

Thursday, January 18, 2007

Stem cell test can predict risk of disease recurring

Source: Inside Bay Area
Posted: January 18, 2007 03:01:16 AM PST

Summary:

A study published in the New England Journal of Medicine found that a test using 186 genes from cancer stem cells can predict the risk of recurrence in patients with breast cancer, researchers at Stanford University School of Medicine reported. The same genes also predicted the recurrence of prostate and lung cancer and medulloblastoma, the most common form of childhood brain cancer.

Stem Cell Summit Aims To Help MS Patients

Source: KGO / ABC7 News - San Francisco, CA
Date: January 17, 2007

Summary:

An invitation-only stem cell summit is taking place in San Francisco this week, with the world's top scientists gathered to discuss the promise of stem cell research in multiple sclerosis. A video accompanies this story.

Wednesday, January 17, 2007

Geron research shows added benefits of stem cell therapy

Source: Pharmceutical Business Review
Date: 17th January 2007

Summary:

Geron Corporation has said that studies suggest that the its stem cell therapeutic produces multiple nerve growth factors that stimulate the survival and regeneration of neurons damaged during spinal cord injury.

Aastrom Treats Patients in Adult Stem Cell Clinical Trial for Osteonecrosis

Source: Aastrom Biosciences, Inc.
Date: January 17, 2007

Summary:

Aastrom Biosciences, Inc. (Nasdaq: ASTM), a company focused on the use of adult stem cells for regenerative medicine, today announced that the first two patients have been treated in a pivotal clinical trial utilizing the Company's Tissue Repair Cells (TRCs) for the treatment of osteonecrosis, or degeneration, of the femur.

Stem cells nurture damaged spine: study

Source: Reuters
Posted: January 17, 2007 10:21 AM ET

Summary:

BOSTON - Human embryonic stem cells can help regenerate damaged nerves in rats, producing compounds that nurture nerve cells and stimulate the growth of new ones, Geron Corp. said on Wednesday. Geron had earlier reported that human embryonic stem cells had helped replace myelin, a fatty covering on nerves that is vital to function.

Geron Reports Added Stem Cell Findings

Source: Associated Press
Posted: January 17, 2007 8:28 AM ET

Summary:

Geron Corp. reported news studies showing its human embryonic stem cell therapy produces multiple nerve growth factors, or proteins that stimulate the survival and regeneration of neurons damaged during acute spinal cord injury in animals.

STUDIES SHOW GERON’S STEM CELL THERAPEUTIC FOR SPINAL CORD INJURY PRODUCES NERVE GROWTH FACTORS

Source: Geron Corporation
Date: January 17, 2007

Summary:

Geron Corporation today reported that studies show GRNOPC1, the company’s human embryonic stem cell (hESC)-based neural stem cell therapy, produces multiple nerve growth factors, proteins that stimulate the survival and regeneration of neurons damaged during spinal cord injury.

Tuesday, January 16, 2007

Researchers Develop New Method For Fighting Leukemia

Source: Virginia Commonwealth University
Date: January 16, 2007

Summary:

Researchers at Virginia Commonwealth University's Massey Cancer Center have created a new method to improve the antileukemic activity of a novel agent that triggers programmed cell death, a development that could lead to more effective strategies for fighting leukemia and other malignancies.

Stem cell marker identified in head and neck cancer

Source: University of Michigan
Date: January 16, 2007

Summary:

Researchers have found a marker on head and neck tumor cells that indicates which cells are capable of fueling the cancer's growth. The finding is the first evidence of cancer stem cells in head and neck tumors.

UF to research stem cell treatments for heart disease

Source: University of Florida
Date: January 16, 2007

Summary:

University of Florida researchers will play a key role in a new national network designed to study stem cell treatments in patients with cardiovascular disease. The research will focus on adults with coronary artery disease, congestive heart failure or other conditions, including diabetes, that reduce blood flow to the heart, damaging heart muscle and hampering its ability to function properly. As part of a five-member consortium known as the Cardiovascular Cell Therapy Research Network, UF scientists will seek to identify and test new cell therapies to improve the structure and function of the heart and its blood vessels.

There goes the neighborhood: Vascular niche nurtures brain tumor stem cells

Source: Cell Press
Date: January 16, 2007

Summary:

Self-renewing cancer stem cells (CSCs) comprise only a tiny fraction of most brain tumors, but eliminating them is likely to have a profound impact on the ability of a tumor to survive and grow. However, CSCs might resist traditional therapies that target the great bulk of the cells in cancers. Now, new research published in the January 2007 issue of the journal Cancer Cell, published by Cell Press, reveals that small blood vessels associated with brain tumors orchestrate a distinct microenvironment that is critical for maintaining cancer stem cells (CSCs). Importantly, drugs that disrupt this microenvironment reduce the CSC population and arrest tumor growth.

Brain tumor researchers find their 'niche'

Source: St. Jude Children's Research Hospital
Date: january 16, 2007

Summary:

In a study conducted at St. Jude Children's Research Hospital, researchers discovered that special niches made of capillaries protect and stimulate cancer stem cells in the brain explains the origin of these cancers and their reappearance following treatment. Brain tumors appear to arise from cancer stem cells (CSCs) that live within microscopic protective "niches" formed by blood vessels in the brain; and disrupting these niches is a promising strategy for eliminating the tumors and preventing them from re-growing.

Stem cells replenish mice blood

Source: The Washington Times
Date: January 16, 2007

Summary:

Researchers at the University of Minnesota and Stanford University have successfully used adult stem cells from bone marrow to replace the radiation-ravaged immune system and bone marrow of mice, giving them a healthy new blood supply. The investigators believe the findings could eventually lead to new therapies for humans.

Monday, January 15, 2007

Researchers First to Map Gene that Regulates Adult Stem Cell Growth

Source: University of Kentucky
Date: January 15, 2007

Summary:

A new discovery in stem cell research may mean big things for cancer patients in the future. Gary Van Zant, Ph.D., and a research team at the University of Kentucky published their findings today in Nature Genetics. This particular gene is important because it helps regulate the number of adult stem cells in the body, particularly in bone marrow. Now that it has been identified, researchers hope the gene, along with its protein product Latexin, can be used clinically, such as for ramping up the stem cell count in cancer patients undergoing chemotherapy and bone marrow transplantation.

UC looks to grow blood vessels

Source: Cincinnati Enquirer
Date: January 15, 2007

Summary:

The Cincinnati Enquirer reports, "...doctors at the University of Cincinnati and other research centers across the country are testing a new technology to grow and harvest stem cells that they hope will let angina patients grow new coronary blood vessels to replace those damaged by blockages."

Adult Stem Cell Research Shows Promise For Transplant Therapies

Source: University of Minnesota
Date: January 15, 2007

Summary:

University of Minnesota stem cell researchers, together with collaborators at Stanford University, have successfully used adult stem cells to replace the immune system and bone marrow of mice, offering the promise of new therapies for people in the future. With this advance and other recent discoveries, the researchers are winning over previous skeptics.

Blood stem cells make mouse bone marrow,brain cells

Source: Reuters
Date: January 15, 2007

Summary:

Stem cells taken from bone marrow replenished the radiation-ravaged immune systems and bone marrow of mice and can also make brain and liver cells, scientists reported. The researchers said the findings suggest adult stem cells can be manipulated to regenerate a range of cells and tissues.

Brain Stem Cells Against Cancer?

Source: Swedish Research Council
Article Date: 15 Jan 2007 - 0:00 PST

Summary:

Gliomas are a group of brain tumors where the most common type is also the most aggressive one. New research at Lund University in Sweden provides hope that it may be possible in the future to develop stem cells from the brain into a new way to treat gliomas.

Sunday, January 14, 2007

UK researcher makes stem cell discovery

Source: Louisville Courier-Journal
Date: January 14, 2007

Summary:

A University of Kentucky researcher has found and mapped a gene that helps determine the number of adult stem cells in bone marrow — a discovery that promises to help cancer patients in the future.

Friday, January 12, 2007

Non-controversial form of stem cell treatment could regenerate heart tissue

Source: ABC7 - TV - Chicago, IL
Posted: January 12, 2007

Summary:

Rush University Medical Center is conducting trials to see if a patient's own stem cells, directly injected into the heart, can create new blood vessels.

Wednesday, January 10, 2007

Cleveland BioLabs Protectans Technology Yields Stem Cell Research Breakthrough

Source: Cleveland BioLabs, Inc.
Posted: January 10, 2007 12:14 PM ET

Summary:

Cleveland BioLabs, Inc. (Nasdaq: CBLI)(BSE: CFB), announced that through its research in the area of radiation protection, the Company has discovered a unique property of its Protectans 600 series, which has lead to a major breakthrough in the stem cell arena. A single administration of CBLB612, the lead compound in the Protectans 600 series, resulted in a three-fold increase in the number of progenitor (originator) stem cells in mouse bone marrow within 24 hours after administration. Moreover, the number of these stem cells in peripheral blood was increased 10-fold within four days of administration. This research indicates that CBLB612 and other compounds in the 600 series are not only potent stimulators of bone marrow stem cells, but also cause their mobilization and proliferation throughout the blood. This discovery opens a new way to approach a broad spectrum of human diseases, some of which currently lack effective treatment.

Potential for Adult Stem Cells to Repair Hearts Damaged by Severe Coronary Artery Disease Investigated by Rush Cardiologists

Source: Rush University Medical Center
Date: January 10, 2007

Summary:

Rush University Medical Center is participating in a novel clinical trial to determine if a subject’s own stem cells can treat a form of severe coronary artery disease. Researchers are hoping that the stem cells will be able to stimulate the growth of new blood vessels to bring more blood and oxygen to the heart muscle, so patients will have a better quality of life and less chest pain.

Scientists discover stage at which an embryonic cell is fated to become a stem cell: Findings have important implications for stem-cell research

Source: University of Cambridge
Date: January 10, 2007

Summary:

Cambridge scientists have discovered the stage at which some of the cells of a fertilised mammalian egg are fated to develop into stem cells and why this occurs. The findings of the study, which overturn the long-held belief that cells are the same until the fourth cleavage (division) of the embryo, are reported in today's edition of Nature.

Tuesday, January 09, 2007

Stem Cells Found in Amniotic Fluid: Amniotic Fluid Stem Cells Can Become Brain, Bone, Liver Cells, and More

Source: WebMD
Date: January 09, 2007

Summary:

WebMD reports," Stem cells found in discarded amniotic fluid may hold the key to new treatments for disease and injury. The newly discovered amniotic fluid stem cells may not be "pluripotent," or capable of forming every type of adult tissue. But they come very close. When grown in the right environment, they can become fat cells, bone cells, brain cells, muscle cells, blood vessel cells, or liver cells."

Stem-cell research takes a promising turn: Researchers said stem cells can be taken from amniotic fluid with no harm to mother or fetus.

Source: Associated Press
Date; January 09, 2007

Summary:

"Researchers at Wake Forest University and Harvard University reported that the stem cells they drew from amniotic fluid donated by pregnant women hold much the same promise as embryonic stem cells. They reported they were able to extract the stem cells from the fluid, which cushions babies in the womb, without harm to mother or fetus and turn their discovery into several different tissue cell types, including brain, liver and bone."

New study supports a stem cell origin of cancer

Source: University of Southern California
Date: January 9, 2007

Summary:

Researchers at the University of Southern California (USC) recently made significant strides toward settling a decades-old debate centering on the role played by stem cells in cancer development.

Researchers expand stem cell horizon: Adult variety possesses different advantages

Source: Newark Star-Ledger
Date: January 9, 2007

Summary:

The Newark Star-Ledger examines the advantages of and breakthroughs in adult stem cell research that will enable scientists to better understand how they, and embryonic stem cells, function in order to potentially repair damaged bone, muscle and tissue.

Monday, January 08, 2007

Amniotic fluid a promising stem cell source: Political resistance to using human embryos drives research

Source: San Francisco Chronicle
Date: January 8, 2007

Summary:

The San Francisco Chronicle reports on the discovery of stem cells from amniotic fluid:

"...researchers offered new evidence that stem cells, very much like those derived from embryos, can be obtained from ordinary amniotic fluid, the liquid that bathes the fetus during pregnancy. Although such cells had been found before, a report in the journal Nature Biotechnology suggests they can be isolated from the fluid more easily than previously thought and coaxed into developing into muscle, bone, liver, brain and other major cell types in the search for new treatments for diabetes, paralysis and many other maladies."

StemPAC Form-letter: Tell Congress: Vote for Stem Cell Research

To all readers of Ben's Stem Cell News:

A critical vote on federal stem cell research funding legislation--H.R. 3: The Stem Cell Research Enhancement Act of 2007--will be taking place in the House of Representatives on THURSDAY, JANUARY 11, 2007. If you support stem cell research, please click on the title of this post, take a moment to complete the form-letter, and forward it around to everyone you can! For the complete text of H.R. 3, see the "Federal Stem Cell Legislation" section under the LINKS column on Ben's Stem Cell News.

Help make a difference!

THANKS FOR YOUR SUPPORT!

Ben Kaplan
Publisher
Ben's Stem Cell News

Cell Therapy For Parkinson's

Source: Fraunhofer-Gesellschaft
Article Date: 08 January 2007 - 0:00 PST

Summary:

To combat the decline in dopamine levels that occurs in patients with Parkinson's disease, researchers at NeuroProgen, a German biotechnology company, have developed a new drug on the basis of stem cells which is now being adapted to the regulatory standards of the pharmaceutical industry in partnership with the Fraunhofer Institute for Cell Therapy and Immunology IZI. Clinical trials of the cell-therapy drug could being in the next year as the first cell therapy employing neural stem cells.

New stem cells found: Scientist claims harvesting does not destroy embryos

Source: McClatchy Newspapers
Date: January 8, 2007

Summary:

WINSTON-SALEM, N.C. - A Wake Forest University scientist says he has discovered a new class of stem cells in women's wombs that may provide an alternative to highly controversial embryonic stem cells. The new cells, unlike embryonic cells, could be harvested without the destruction of early-stage human embryos. That means research and development of treatments using these cells would probably not be subject to the tight financial restrictions the Bush administration has imposed on scientific work involving embryonic stem cells.

Mothers' wombs could provide source of stem cells, without the ethical controversy

Source: Guardian Unlimited - UK
Date: January 8, 2007

Summary:

Scientists have found a new source of stem cells that does not involve destroying embryos. The cells can be harvested easily from the amniotic fluid surrounding developing babies in the womb and could help overcome ethical concerns.

Sunday, January 07, 2007

New Source of Stem Cells

Source: CBS News
Date: Calif., January 7, 2007

This is a video about the discovery of stem cells in amniotic fluid that might possess the flexibility of embryonic stem cells by researchers at Wake Forest University.

Cell might sub for embryonic stem cells

Source: United Press International
Date: January 7, 2006

Summary:

Researchers say a cell found in amniotic fluid of pregnant women has many of the same traits as embryonic stem cells, the Washington Post reported. The cells are able to grow into brain, muscle and other tissues that could be used to treat diseases, researchers said, and are easily retrieved during routine prenatal testing.

Stem cell breakthrough that could end the storm

Source: Daily Mail
Date: 7 January 2007

Summary:

Scientists have shown for the first time that amniotic fluid is a rich source of stem cells, suggesting the powerful cells can be ethically harvested. They found that human stem cells, shed by the unborn baby into the surrounding amniotic fluid, can be coaxed into turning into muscle, bone, fat, blood vessel, nerve and liver cells in the lab. When the nerve cells were transplanted into mice with a degenerative brain disease, they grew and repopulated the diseased areas. Bone and liver cells also functioned well, the journal Nature Biotechnology reports. In addition to being easily obtainable, the cells can be grown quickly in large quantities.

Stem cells from womb fluid could end ethical concerns

Source: The Times
Date: January 08, 2007

Summary:

Researchers from Wake Forest University School of Medicine in North Carolina and Harvard Medical School discovered a small number of stem cells in amniotic fluid. The scientists have called them amniotic fluid-derived stem (AFS) cells and said that they represented an “intermediate stage” between embryonic stem cells and adult stem cells. The cells have the same potential as embryonic stem cells and their ready availability makes them vital to research.

Stem cells in amniotic fluid show great promise, study says

Source: Los Angeles Times
Posted: January 7, 2007 2:28 PM PST

Summary:

Researchers at Wake Forest University have found stem cells in human amniotic fluid that appear to have many of the traits of embryonic stem cells while avoiding their ethical, medical and logistical pitfalls that have been associated with embryonic stem cell research, according to a study published online by the journal Nature Biotechnology.

New Class of Stem Cells Discovered

Source: Washington Post
Posted: January 7, 2007; 4:42 PM

Summary:

A type of cell that floats freely in the amniotic fluid of pregnant women has been found to have many of the same traits as embryonic stem cells, including an ability to grow into brain, muscle and other tissues that could be used to treat a variety of diseases. The study, published in the January 6 online edition of the journal Nature Biotechnology, shows that "amniotic fluid-derived stem cells" can be isolated as early as 10 weeks after conception from fluid extracted during tests widely done to detect birth defects.

New Source of Stem Cells Discovered

Source: HealthDay News
Date: January 7, 2006

Summary:

Scientists reported the discovery of a new source of human stem cells that have the capability to develop into many different types of cells, including muscle, bone, fat, blood vessel, nerve and liver cells. Since the cells are obtained from amniotic fluid, they could be a source of stem cells that avoid the ethical controversy associated with embryonic stem cells.

Stem cells extracted from amniotic fluid

Source: USA Today
Posted: January 7, 2007 3:20 PM ET

Summary:

Researchers at the Wake Forest University School of Medicine in Winston-Salem, N.C., have successfully obtained human stem cells from the amniotic fluid in the womb, potentially providing a source of stem cells that is readily available and avoids ethical controversy. The researchers made the amniotic cells become fat, bone, muscle, blood, nerve and liver cells.

Human stem cells found in amniotic fluid: report

Source: Reuters
Posted: January 7, 2007 2:53pm ET

Summary:

Stem cells with traits similar to embryonic stem cells can be found in the amniotic fluid that protects babies in the womb, U.S. researchers reported. They used them to create muscle, bone, fat, blood vessel, nerve and liver cells in the laboratory and said they believe the placenta and amniotic fluid can provide one more source of the valued cells, which scientists hope will someday transform medicine.

Report: Amniotic Fluid Yields Stem Cells

Source: Associated Press
Posted: January 7, 2007 10:22 AM PST

Summary:

Scientists at Wake Forest University and Harvard University announced the discovery of a plentiful source of stem cells in amniotic fluid, the fluid that cushions babies in the womb, and produced a variety of tissue types from these cells — avoiding the controversy over destroying embryos for research.

New Source of Stem Cells: Amniotic Fluid

Source: Scientific American
Date: January 7, 2007

Summary:

Scientists at the Wake Forest University School of Medicine and Harvard School of Medicine report they have isolated stem cells from a new source: amniotic fluid. The researchers not only succeeded in separating the progenitor cells from the many cells residing in the watery fluid in the placenta surrounding an embryo, but were also able to coax the cells to differentiate into muscle, bone, fat, blood vessel, liver and nerve cells.

A New Era Begins: Stem cells derived from amniotic fluid show great promise in the lab and may end the divisive ethical debate once and for all.

Source: Newsweek
Date: January 7, 2007

Summary:

New research reported by a team of scientists from Wake Forest University supports the idea of a new category of stem cells that are readily available, perhaps ethically trouble-free and possibly as powerful and flexible in function as their embryonic counterparts: "amniotic-fluid stem cells," found in both the placenta and the liquid that surrounds growing fetuses.

Scientist finds new kind of stem cells

Source: The News & Observer
Date: January 7, 2007

Summary:

A Wake Forest University scientist says he has discovered a new class of stem cells in women's wombs that may provide an alternative to highly controversial embryonic stem cells.

'Ethical' stem cells that arrive with baby

Source: NewScientist.com news service
Posted: 18:00 07 January 2007

Summary:

New research from the Wake Forest University School of Medicine has demonstrated for the first time that amniotic fluid-derived stem (AFS) cells can be extracted and turned into many tissue types. The discovery of the versatile stem cells could pave the way for human stem cell treatments that avoid the ethical questions surrounding embryonic stem cells and the risk of tissue rejection by the immune system.

Scientists discover new, readily available source of stem cells

Source: Wake Forest University Baptist Medical Center
Date: January 7, 2007

Summary:

Scientists have discovered a new source of stems cells and have used them to create muscle, bone, fat, blood vessel, nerve and liver cells in the laboratory. The first report showing the isolation of broad potential stem cells from the amniotic fluid that surrounds developing embryos was published today in Nature Biotechnology.

Research hopes to create new line of stem cells, possible alternative to embryonic studies

Source: Winston-Salem Journal
Date: January 7, 2007

Summary:

Wake Forest University researchers have discovered a new source of stem cells in the amniotic fluid that surrounds fetuses in the womb, and have turned the cells into a functioning liver and other types of cells that may eventually be used in treating disease.

Stem cells discovered in amniotic fluid, placenta

Source: Canadian Press (CP)
Posted: January 7, 2007

Summary:

U.S. scientists say they have derived a new type of stem cell, root cells which form all of the human cell types, from amniotic fluid surrounding the fetus and from the placenta, called "amniotic fluid-derived stem (AFS) cells." The scientists believe the discovery could eventually provide a new source of cells that could be used for repairing or replacing diseased organs in patients. The AFS cells have characteristics of both human embryonic stem cells and adult stem cells.

Liver cell created from subcutaneous fat

Source: Daily Yomiuri Online / The Yomiuri Shimbun
Date: January 7, 2007

Summary:

A team of doctors at the National Cancer Center Research Institute and the International Medical Center of Japan has succeeded in creating a hepatic cell out of subcutaneous fat, a development that might lead to a regenerative medicine technique that would enable patients with hepatitis or cirrhosis to have their livers repaired.

Saturday, January 06, 2007

Stem cells regenerate parts of teeth: animal study

Source: Reuters
Posted: January 6, 2007 3:17pm ET

Summary:

Researchers at the University of Southern California School of Dentistry successfully used stem cells harvested from the extracted wisdom teeth of young adults to create tooth root and supporting tooth ligaments to support a crown restoration, in experiments using miniature pigs.

Cancer warning over stem cell therapies

Source: New Scientist
Date: 06 January 2007

Summary:

Two groups have independently shown that stem cells can trigger cancers, and offer an explanation as to why this is. They also suggest a way of screening cells to reduce the risk.

Friday, January 05, 2007

Cancer-killing Invention Also Harvests Stem Cells

Source: University of Rochester, School of Engineering and Applied Sciences
Date: January 5, 2007

Summary:

Associate Professor Michael King of the University of Rochester Biomedical Engineering Department has invented a device that filters the blood for cancer and stem cells. When he captures cancer cells, he kills them. When he captures stem cells, he harvests them for later use in tissue engineering, bone marrow transplants, and other applications that treat human disease and improve health.

Tengion Launches First Phase II Clinical Trial of Regenerated Human Organ

Source: Tengion, Inc.
Date: January 5, 2007

Summary:

Tengion, Inc., a biotechnology company in the field of adult stem cell research for developing organs and tissues using a patient's own cells, announced it has initiated a Phase II multi-center clinical study for its urinary neo-bladder construct. The study is being conducted in pediatric patients with spina bifida who have failing bladders that predispose them to a risk of kidney failure and incontinence even when they receive optimal medical therapy.

Wednesday, January 03, 2007

Stem cells regenerate teeth in pigs, study says

Source: Reuters
Posted: Wed January 3, 2007 5:27pm ET

Summary:

Using stem cells harvested from the extracted wisdom teeth of young adults, researchers have successfully generated tooth root and supporting tooth ligaments to support a crown restoration in experiments using miniature pigs. The restored tooth mirrored the original tooth in function and strength, the research team reports in the December issue of the open access medical journal PLoS ONE. The technique holds promise for use in humans, the investigators say.

Uric acid and spinal cord injury treatment

Source: Rutgers, the State University of New Jersey
Date: January 3, 2007

Summary;

Researchers at Rutgers University have discovered that uric acid, commonly associated with the excruciatingly painful joint disease known as gout, can also play a crucial role in the treatment of spinal cord injury and other central nervous system disorders, such as stroke, multiple sclerosis and Parkinson's disease.

Cytori to Begin Stem Cell Trial for Heart Disease

Source: Cytori Therapeutics, Inc.
Date: January 3, 2007

Summary:

Cytori Therapeutics (NASDAQ:CYTX) (FWB:XMPA) received approvals to initiate a clinical trial in Spain to investigate the use of adipose, or fat-derived, stem and regenerative cells for the treatment of cardiovascular disease. The cells will be obtained at the bedside from the patients' own fat tissue, the richest source of adult stem cells, and made available in real-time using Cytori's Celution(TM) stem and regenerative cell processing system. Patient enrollment will begin imminently.

Tuesday, January 02, 2007

New Nerve Cells In Diseased Brain - Nerve Cells Generated From Stem Cells In An Adult

Source: Swedish Research Council
Article Date: 02 Jan 2007 - 0:00 PST

Summary:

New findings, by EuroStemCell researchers at Lund University in Sweden, are published in the journal Neuron this week have revealed that nerve cells generated from stem cells in an adult diseased and damaged brain function as normal nerve cells. The new cells also seem to counteract the effects of neurological diseases. The new nerve cells also seem to have a positive function, namely, to counteract the disease in the brain.

Monday, January 01, 2007

Zebrafish Study Yield Novel Genes Critical In Organ Development

Source: University of Minnesota News Release
Date: January 1, 2007

Summary:

Researchers at the University of Minnesota have identified a group of novel genes that are critical in organ development.

The original news release can be found here:

http://www.ahc.umn.edu/news/releases/genes122006/home.html