Source: University of Oregon
Posted: December 28, 2006 - 12:00 PST
Summary:
An enzyme found at elevated levels in several human cancers has been linked to abnormal tumor growth in fruit flies, a discovery that provides a new model for understanding the link between stem cell biology and cancer, according to researchers at the University of Oregon.
Thursday, December 28, 2006
How Zebra Finches Learn Songs: Cellular Killer Also Important To Memory
Source: University of Illinois at Urbana-Champaign
Date: December 28, 2006
Summary:
Researchers at the University of Illinois at Urbana-Champaign have discovered that a protein known mainly for its role in killing cells also aids in memory formation. Their studies on how zebra finches learn songs could have implications for treatment of neurodegenerative conditions such as dementia and Alzheimer's disease.
Date: December 28, 2006
Summary:
Researchers at the University of Illinois at Urbana-Champaign have discovered that a protein known mainly for its role in killing cells also aids in memory formation. Their studies on how zebra finches learn songs could have implications for treatment of neurodegenerative conditions such as dementia and Alzheimer's disease.
Experimental Drug Shows Promise In Targeting Leukemic Stem Cells
Source: University of Texas M. D. Anderson Cancer Center
Date: December 28, 2006
Summary:
Researchers at The University of Texas M. D. Anderson Cancer Center have found, in laboratory studies, that the experimental drug ABT-737 which has shown promise in some cancers, can destroy acute myeloid leukemia (AML) blast, progenitor and even stem cells that are often resistant to standard chemotherapy treatment.
Date: December 28, 2006
Summary:
Researchers at The University of Texas M. D. Anderson Cancer Center have found, in laboratory studies, that the experimental drug ABT-737 which has shown promise in some cancers, can destroy acute myeloid leukemia (AML) blast, progenitor and even stem cells that are often resistant to standard chemotherapy treatment.
Tuesday, December 26, 2006
MIT creates 3-D scaffold for growing stem cells
Source: Public Library of Science
Date: December 26, 2006
Summary:
Massachusetts Institute of Technology (MIT) and Italian researchers grew, multiplied and differentiated stem cells into brain cells on a new three-dimensional scaffold of tiny protein fragments designed to be more like a living body than any other cell culture system.
Date: December 26, 2006
Summary:
Massachusetts Institute of Technology (MIT) and Italian researchers grew, multiplied and differentiated stem cells into brain cells on a new three-dimensional scaffold of tiny protein fragments designed to be more like a living body than any other cell culture system.
First Demonstration That Physical Topography Influences Human Stem Cell Self-Renewal
Source: The American Society for Cell Biology
Article Date: 26 Dec 2006 - 11:00 PST
Summary:
Nothing in the cellular world is flat. Even the flattest of basement membranes has topography; bumps, if you like, beneath the cellular mattress.
Article Date: 26 Dec 2006 - 11:00 PST
Summary:
Nothing in the cellular world is flat. Even the flattest of basement membranes has topography; bumps, if you like, beneath the cellular mattress.
How does a zebrafish grow a new tail? The answer may help treat human injuries.
Source: University of Washington
Date: December 26, 2006
Summary:
If a zebrafish loses a chunk of its tail fin, it'll grow back within a week. Like lizards, newts, and frogs, a zebrafish can replace surprisingly complex body parts. A tail fin, for example, has many different types of cells and is a very intricate structure. It is the fish version of an arm or leg. University of Washington researchers have discovered some of the genes and cell-to-cell communication pathways that enable zebrafish to restore their tail fins.
Date: December 26, 2006
Summary:
If a zebrafish loses a chunk of its tail fin, it'll grow back within a week. Like lizards, newts, and frogs, a zebrafish can replace surprisingly complex body parts. A tail fin, for example, has many different types of cells and is a very intricate structure. It is the fish version of an arm or leg. University of Washington researchers have discovered some of the genes and cell-to-cell communication pathways that enable zebrafish to restore their tail fins.
Stem Cells And Metastatic Cancer: Fatal Attraction?
Source: Public Library of Science
Date: December 26, 2006
Summary:
It is widely hoped that neural stem cells will eventually be useful for replacing nerves damaged by degenerative diseases like Alzheimer disease and multiple sclerosis. But there may also be another use for such stem cells--delivering anti-cancer drugs to cancer cells.
Date: December 26, 2006
Summary:
It is widely hoped that neural stem cells will eventually be useful for replacing nerves damaged by degenerative diseases like Alzheimer disease and multiple sclerosis. But there may also be another use for such stem cells--delivering anti-cancer drugs to cancer cells.
Sunday, December 24, 2006
Researchers Find Stem-cell Therapy Effective In Targeting Metastatic Cancer
Source: Public Library of Science
Date: December 24, 2006
Summary:
Researchers at City of Hope and St. Jude Children's Research Hospital may have found a way to treat cancers that have spread throughout the body more effectively. They used modified neural stem cells to activate and concentrate chemotherapeutic drugs predominately at tumor sites, so that normal tissue surrounding the tumor and throughout the body remain relatively unharmed.
Date: December 24, 2006
Summary:
Researchers at City of Hope and St. Jude Children's Research Hospital may have found a way to treat cancers that have spread throughout the body more effectively. They used modified neural stem cells to activate and concentrate chemotherapeutic drugs predominately at tumor sites, so that normal tissue surrounding the tumor and throughout the body remain relatively unharmed.
Saturday, December 23, 2006
New Insight Into How The Brain Regenerates After Stroke
Source: University of California - Los Angeles
Date: December 23, 2006
Summary:
When a stroke strikes, the supply of blood to the part of the brain affected is interrupted, starving it of oxygen. Brain cells can be seriously damaged or die, impairing local brain function. Within weeks of a stroke, new blood vessels begin to form, and newly born neurons migrate long distances to the damaged area to aid in the regeneration process of the brain. Using the mouse model, UCLA neurologists have identified the cellular cues that start this process, thus casually linking angiogenesis, the development of new blood vessels, and neurogenesis, the birth of new neurons.
Date: December 23, 2006
Summary:
When a stroke strikes, the supply of blood to the part of the brain affected is interrupted, starving it of oxygen. Brain cells can be seriously damaged or die, impairing local brain function. Within weeks of a stroke, new blood vessels begin to form, and newly born neurons migrate long distances to the damaged area to aid in the regeneration process of the brain. Using the mouse model, UCLA neurologists have identified the cellular cues that start this process, thus casually linking angiogenesis, the development of new blood vessels, and neurogenesis, the birth of new neurons.
Friday, December 22, 2006
Stem cells shown to pinpoint tumors: Study shows process targets chemotherapy
Source: Pasadena Star News
Posted: 12/22/2006 10:47:38 PM PST
Summary:
Neural stem cells could provide a powerful means to track and treat cancer that has spread throughout the body, new research from the City of Hope suggests.
Posted: 12/22/2006 10:47:38 PM PST
Summary:
Neural stem cells could provide a powerful means to track and treat cancer that has spread throughout the body, new research from the City of Hope suggests.
Stem Cell Loss in Aging Brain May Bring Poorer Memory
Source: HealthDay News
Date: December 22, 2006
Summary:
A new study in rats finds that stem cells in aging brains divide less frequently, leading to a dramatic drop in the number of new nerve cells being born in the hippocampus, the brain's learning and memory center. The finding, published in the journal Neurobiology of Aging, also suggests that it may be possible to stimulate the brain's ability to produce new brain nerve cells in order to treat neurodegenerative diseases such as Alzheimer's, depression and dementia, said the study's senior investigator
Date: December 22, 2006
Summary:
A new study in rats finds that stem cells in aging brains divide less frequently, leading to a dramatic drop in the number of new nerve cells being born in the hippocampus, the brain's learning and memory center. The finding, published in the journal Neurobiology of Aging, also suggests that it may be possible to stimulate the brain's ability to produce new brain nerve cells in order to treat neurodegenerative diseases such as Alzheimer's, depression and dementia, said the study's senior investigator
Thursday, December 21, 2006
VistaGen Therapeutics Announces 3 Significant Publications Supporting the Use of Embryonic Stem Cells for Drug Discovery and Development
Source: VistaGen Therapeutics, Inc.
Date: December 21, 2006
Summary:
VistaGen Therapeutics Inc., a biopharmaceutical company pioneering the use of embryonic stem cells for the treatment of diabetes and neurological diseases, announced today three recent publications highlighting important advances in the understanding of how embryonic stem cells can be efficiently and reproducibly differentiated into heart and liver cells.
Date: December 21, 2006
Summary:
VistaGen Therapeutics Inc., a biopharmaceutical company pioneering the use of embryonic stem cells for the treatment of diabetes and neurological diseases, announced today three recent publications highlighting important advances in the understanding of how embryonic stem cells can be efficiently and reproducibly differentiated into heart and liver cells.
Anti-Cancer 'Smart Bomb' Homes in on Deadly Tumors
Source: ABC NEWS
Date: Dec. 21, 2006
Summary:
Scientists report significant progress in developing a "smart bomb" that can deliver powerful cancer-fighting drugs directly to tumors scattered throughout the body, thus minimizing damage to healthy tissue and easing the debilitating side effects of chemotherapy. They are hopeful that clinical trials involving humans with advanced cancer can begin reasonably soon, possibly in less than a couple of years.
Date: Dec. 21, 2006
Summary:
Scientists report significant progress in developing a "smart bomb" that can deliver powerful cancer-fighting drugs directly to tumors scattered throughout the body, thus minimizing damage to healthy tissue and easing the debilitating side effects of chemotherapy. They are hopeful that clinical trials involving humans with advanced cancer can begin reasonably soon, possibly in less than a couple of years.
Stem Cell Technique Could Help Kids Avoid Root Canal: It allows the tooth's regenerative cells to continue making strong teeth
Source: HealthDay News
Date: December 21, 2006
Summary:
The promise of stem cells may someday help kids say goodbye to the dreaded root canal, scientists report. A new, less-invasive treatment leaves the soft inner pulp intact, allowing the young tooth's stem cells to continue tooth formation.
Date: December 21, 2006
Summary:
The promise of stem cells may someday help kids say goodbye to the dreaded root canal, scientists report. A new, less-invasive treatment leaves the soft inner pulp intact, allowing the young tooth's stem cells to continue tooth formation.
Genetically modified cells attack tumors
Source: St. Jude Children's Research Hospital
Date: December 21, 2006
Summary:
St. Jude researchers show genetically modified stem cells in the nervous system actively seek out even tiny tumors. Mice with neuroblastoma tumors have been successfully treated with genetically modified cells that sought out the cancer cells and activated a chemotherapy drug directly at those sites, according to investigators at St. Jude Children's Research Hospital and their colleagues at City of Hope National Medical Center (Duarte, Calif.) and the University of British Columbia (Vancouver, Canada). Neuroblastoma is a solid tumor that arises in the part of the nervous system outside the brain.
Date: December 21, 2006
Summary:
St. Jude researchers show genetically modified stem cells in the nervous system actively seek out even tiny tumors. Mice with neuroblastoma tumors have been successfully treated with genetically modified cells that sought out the cancer cells and activated a chemotherapy drug directly at those sites, according to investigators at St. Jude Children's Research Hospital and their colleagues at City of Hope National Medical Center (Duarte, Calif.) and the University of British Columbia (Vancouver, Canada). Neuroblastoma is a solid tumor that arises in the part of the nervous system outside the brain.
Dental stem cells creating new choppers?
Source: United Press International
Date: December 20, 2006
Summary:
Dentists at the University of Southern California School of Dentistry have created root and ligament structures able to support crown restorations from the extracted wisdom teeth of 18- to 20-year-olds by harvesting stem cells from the root apical papilla of the extracted teeth, which is responsible for the development of a tooth's root and periodontal ligaments.
Date: December 20, 2006
Summary:
Dentists at the University of Southern California School of Dentistry have created root and ligament structures able to support crown restorations from the extracted wisdom teeth of 18- to 20-year-olds by harvesting stem cells from the root apical papilla of the extracted teeth, which is responsible for the development of a tooth's root and periodontal ligaments.
Researchers 'grow' heart arteries
Source: BBC News
Posted: 20 December 2006, 12:37 GMT
Summary:
British scientists are attempting to "grow" test tube arteries for use in heart bypass operations. The researchers hope to prove arteries can be grown outside the body from human skin cells.
Posted: 20 December 2006, 12:37 GMT
Summary:
British scientists are attempting to "grow" test tube arteries for use in heart bypass operations. The researchers hope to prove arteries can be grown outside the body from human skin cells.
Electrical Activity Alters Language Used By Nerve Cells
Source: University of California, San Diego
Date: December 19, 2006
Summary:
UC San Diego biologists have shown that the chemical language with which neurons communicate depends on the pattern of electrical activity in the developing nervous system. The findings suggest that modification of nerve activity could have potential as a treatment for a wide range of brain disorders.
Date: December 19, 2006
Summary:
UC San Diego biologists have shown that the chemical language with which neurons communicate depends on the pattern of electrical activity in the developing nervous system. The findings suggest that modification of nerve activity could have potential as a treatment for a wide range of brain disorders.
Wednesday, December 20, 2006
STEM CELLS USED TO CREATE CRITICAL BRAIN BARRIER IN LAB
Source: University of Wisconsin-Madison
Date: December 20, 2006
Summary:
Using neural stem cells derived from the fetal brains of rats, a team of Wisconsin scientists has devised a rudimentary blood-brain barrier in the lab.
Date: December 20, 2006
Summary:
Using neural stem cells derived from the fetal brains of rats, a team of Wisconsin scientists has devised a rudimentary blood-brain barrier in the lab.
Researchers find stem-cell therapy effective in targeting metastatic cancer: Preclinical findings show tumors are attacked, not normal tissue
Source: Public Library of Science
Date: December 20, 2006
Summary:
Researchers at City of Hope and St. Jude Children's Research Hospital may have found a way to treat cancers that have spread throughout the body more effectively. They used modified neural stem cells to activate and concentrate chemotherapeutic drugs predominately at tumor sites, so that normal tissue surrounding the tumor and throughout the body remain relatively unharmed.
Date: December 20, 2006
Summary:
Researchers at City of Hope and St. Jude Children's Research Hospital may have found a way to treat cancers that have spread throughout the body more effectively. They used modified neural stem cells to activate and concentrate chemotherapeutic drugs predominately at tumor sites, so that normal tissue surrounding the tumor and throughout the body remain relatively unharmed.
USC-led researchers use stem cells to regenerate parts of teeth
Source: University of Southern California
Date: December 20, 2006
Summary:
A research team led by a researcher at the USC School of Dentistry has successfully regenerated tooth root and supporting periodontal ligaments to restore tooth function in an animal model. The resulting tooth restoration closely resembled the original tooth in function and strength. The breakthrough holds significant promise for clinical application in human patients. The study appears December 20 in the inaugural issue of PLoS ONE.
Date: December 20, 2006
Summary:
A research team led by a researcher at the USC School of Dentistry has successfully regenerated tooth root and supporting periodontal ligaments to restore tooth function in an animal model. The resulting tooth restoration closely resembled the original tooth in function and strength. The breakthrough holds significant promise for clinical application in human patients. The study appears December 20 in the inaugural issue of PLoS ONE.
US approves Aussie stem cell trial
Source: Australian Associated Press (AAP)
Date: December 20, 2006
Summary:
A WORLD-first Australian medical therapy that uses stem cells to treat degenerative spinal disease has been approved for testing on patients in the US. Researchers hope the treatment will replace painful bone grafts. It will be the first time that "off-the-shelf'' adult stem cells will be used to treat spinal disc disease in a genetically unrelated patient.
Date: December 20, 2006
Summary:
A WORLD-first Australian medical therapy that uses stem cells to treat degenerative spinal disease has been approved for testing on patients in the US. Researchers hope the treatment will replace painful bone grafts. It will be the first time that "off-the-shelf'' adult stem cells will be used to treat spinal disc disease in a genetically unrelated patient.
Stem Cells Found In Adult Hair Follicles May Provide Alternative To Embryonic Stem Cells
Source: Medical College of Wisconsin
Date: December 20, 2006
Summary:
Having recently identified the molecular signature of these epidermal neural crest stem cells in the mouse, their research resolves conflicting scientific opinions by showing that these cells are distinctly different from other types of skin-resident stem cells/progenitors. Their work provides a valuable resource for future mouse neural crest stem cell research.
Date: December 20, 2006
Summary:
Having recently identified the molecular signature of these epidermal neural crest stem cells in the mouse, their research resolves conflicting scientific opinions by showing that these cells are distinctly different from other types of skin-resident stem cells/progenitors. Their work provides a valuable resource for future mouse neural crest stem cell research.
Tuesday, December 19, 2006
MESOBLAST RECEIVES FDA CLEARANCE FOR PHASE 2 STEM CELL CLINICAL TRIAL
Source: Mesoblast Limited
Date: 18 December 2006
Summary:
Melbourne, Australia--Australia’s adult stem cell company, Mesoblast Limited (ASX:MSB), today announced that the United States Food and Drug Administration (US FDA) has cleared its Investigational New Drug Submission (IND) to commence a Phase 2 clinical trial for spinal fusion in the US.
Date: 18 December 2006
Summary:
Melbourne, Australia--Australia’s adult stem cell company, Mesoblast Limited (ASX:MSB), today announced that the United States Food and Drug Administration (US FDA) has cleared its Investigational New Drug Submission (IND) to commence a Phase 2 clinical trial for spinal fusion in the US.
Memory loss linked to old stem cells that forget to divide
Source: Newark Star-Ledger
Date: December 19, 2006
Summary:
Old stem cells never die, they just slow down. Researchers have found that memory loss and other cognitive problems associated with diseases like Alzheimer's are due to a decrease in stem cell replication, rather than a decline in the number of stem cells in the elderly brain.
Date: December 19, 2006
Summary:
Old stem cells never die, they just slow down. Researchers have found that memory loss and other cognitive problems associated with diseases like Alzheimer's are due to a decrease in stem cell replication, rather than a decline in the number of stem cells in the elderly brain.
Printing Muscle and Bone: Ink-jet printers allow tissue engineers to control cell development and could one day be used to construct complex cellular
Source: MIT Technology Review
Date: December 19, 2006
Summary:
Researchers at Carnegie Mellon University and the University of Pittsburgh have successfully directed adult stem cells from mice to develop into bone and muscle cells with the aid of a custom-designed ink-jet printer. They say it's a first step toward better understanding tissue regeneration, which may one day lead to therapies for repairing damaged tissues, as occurs in osteoarthritis.
Date: December 19, 2006
Summary:
Researchers at Carnegie Mellon University and the University of Pittsburgh have successfully directed adult stem cells from mice to develop into bone and muscle cells with the aid of a custom-designed ink-jet printer. They say it's a first step toward better understanding tissue regeneration, which may one day lead to therapies for repairing damaged tissues, as occurs in osteoarthritis.
Monday, December 18, 2006
Fewer Nerve Cells in Aging Brain's Memory Center Due to Slower Cell Division
Source: Senior Journal
Date: December 18, 2006
Summary:
A new discovery provides a new avenue to pursue in trying to combat the cognitive decline associated with conditions such as Alzheimer's disease and with aging in general, say neurobiologists. They have found why the aging brain produces progressively fewer nerve cells in its learning and short-term memory center – the hippocampus.
Date: December 18, 2006
Summary:
A new discovery provides a new avenue to pursue in trying to combat the cognitive decline associated with conditions such as Alzheimer's disease and with aging in general, say neurobiologists. They have found why the aging brain produces progressively fewer nerve cells in its learning and short-term memory center – the hippocampus.
Stem Cell Activity Deciphered In The Aging Brain
Source: Duke University Medical Center
Date: December 18, 2006
Summary:
Neurobiologists have discovered why the aging brain produces progressively fewer new nerve cells in its learning and memory center. The study's senior investigator said the finding, made in rodents, suggests the possibility of treating various neurodegenerative disorders, including Alzheimer's disease, dementia and depression, by stimulating the brain's ability to produce new nerve cells.
Date: December 18, 2006
Summary:
Neurobiologists have discovered why the aging brain produces progressively fewer new nerve cells in its learning and memory center. The study's senior investigator said the finding, made in rodents, suggests the possibility of treating various neurodegenerative disorders, including Alzheimer's disease, dementia and depression, by stimulating the brain's ability to produce new nerve cells.
The World's First Neural Stem Cell Transplant: In the coming decades this work could lead to treatments for neurodegenerative disorders that affect mi
Source: Scientific American
Date: December 18, 2006
Summary:
In a recent phase I clinical trial to treat children afflicted with Batten disease, a rare but fatal neurodegenerative disorder, neural stem cells were injected directly into the brain of a human subject. This work could lead to treatments for neurodegenerative disorders that affect millions, such as Huntington's, Alzheimer's and Parkinson's diseases.
Date: December 18, 2006
Summary:
In a recent phase I clinical trial to treat children afflicted with Batten disease, a rare but fatal neurodegenerative disorder, neural stem cells were injected directly into the brain of a human subject. This work could lead to treatments for neurodegenerative disorders that affect millions, such as Huntington's, Alzheimer's and Parkinson's diseases.
Sunday, December 17, 2006
Sensory Nerve Discovery In Diabetes Opens Door To New Treatment Strategies
Source: The Hospital For Sick Children
Date: December 17, 2006
Summary:
Researchers at The Hospital for Sick Children (SickKids), the University of Calgary and The Jackson Laboratory, Bar Harbor, Maine report in the December 15 issue of the journal Cell they have discovered that diabetes is controlled by abnormalities in the nerve endings that sense pain called the sensory nociceptor (pain-related) in the pancreatic islet cells that produce insulin. This discovery, a breakthrough that has long been the elusive goal of diabetes research, has led to new treatment strategies for diabetes, achieving reversal of the disease without severe, toxic immunosuppression.
Date: December 17, 2006
Summary:
Researchers at The Hospital for Sick Children (SickKids), the University of Calgary and The Jackson Laboratory, Bar Harbor, Maine report in the December 15 issue of the journal Cell they have discovered that diabetes is controlled by abnormalities in the nerve endings that sense pain called the sensory nociceptor (pain-related) in the pancreatic islet cells that produce insulin. This discovery, a breakthrough that has long been the elusive goal of diabetes research, has led to new treatment strategies for diabetes, achieving reversal of the disease without severe, toxic immunosuppression.
Saturday, December 16, 2006
Can stem cell transplantation stop a rare, fatal disease?
Source: San Diego Union-Tribune
Date: December 14, 2006
Summary:
A team of doctors at Doernbecher Children's Hospital at Oregon Health and Science University recently began testing an unprecedented, radical therapy for Batten disease, a fatal brain disorder. The phase-one clinical trial involves transplanting neural stem cells into the brains of six children afflicted by Batten's. The trial is believed to be the first time that a pure composition of neural stem cells has been used to treat a brain disorder. Doctors are conducting the trial to see if the brain-infused cells will make enough of the enzyme missing in Batten disease that cells throughout the brain will no longer become congested with unrecycled waste.
Date: December 14, 2006
Summary:
A team of doctors at Doernbecher Children's Hospital at Oregon Health and Science University recently began testing an unprecedented, radical therapy for Batten disease, a fatal brain disorder. The phase-one clinical trial involves transplanting neural stem cells into the brains of six children afflicted by Batten's. The trial is believed to be the first time that a pure composition of neural stem cells has been used to treat a brain disorder. Doctors are conducting the trial to see if the brain-infused cells will make enough of the enzyme missing in Batten disease that cells throughout the brain will no longer become congested with unrecycled waste.
Stem cell researchers see hope in 'virgin birth'
Source: Los Angeles Times
Date: December 16, 2006
Summary:
Harvard University researchers have found a way to use "virgin birth" in mice to produce stem cells that are not rejected as foreign tissue. The process is called parthenogenesis, in which unfertilized eggs are biochemically coaxed into embryonic development. The technique may foreshadow a relatively straightforward way of making patient-specific stem cells that bypasses the technical challenges of producing cloned human embryos.
Date: December 16, 2006
Summary:
Harvard University researchers have found a way to use "virgin birth" in mice to produce stem cells that are not rejected as foreign tissue. The process is called parthenogenesis, in which unfertilized eggs are biochemically coaxed into embryonic development. The technique may foreshadow a relatively straightforward way of making patient-specific stem cells that bypasses the technical challenges of producing cloned human embryos.
Aldagen To Launch Clinical Trial Using Stem Cells To Combat Disease In Arms, Legs
Source: Local Tech Wire, SC
Date: December 15, 2006
Summary:
Aldagen, a company focused on stem cell research, and the Texas Heart Institute are teaming up for a clinical trial in which humans will be tested for a potential treatment of limb ailments brought on by blood vessel problems. The treatment is based on the use of purified adult stem cells drawn from bone marrow.
Date: December 15, 2006
Summary:
Aldagen, a company focused on stem cell research, and the Texas Heart Institute are teaming up for a clinical trial in which humans will be tested for a potential treatment of limb ailments brought on by blood vessel problems. The treatment is based on the use of purified adult stem cells drawn from bone marrow.
Aldagen Announces Texas Heart Institute As First Site In Its Stem Cell Clinical Trial To Treat Critical Limb Ischemia
Source: Aldagen, Inc.
Date: December 15, 2006
Summary:
Aldagen, Inc. announced that the Texas Heart Institute at St. Luke’s Episcopal Hospital in Houston, Texas will be the first site for its clinical trial using Aldagen’s ALDESORT® product to isolate a unique stem cell population as therapy for critical limb ischemia (CLI) patients.
Date: December 15, 2006
Summary:
Aldagen, Inc. announced that the Texas Heart Institute at St. Luke’s Episcopal Hospital in Houston, Texas will be the first site for its clinical trial using Aldagen’s ALDESORT® product to isolate a unique stem cell population as therapy for critical limb ischemia (CLI) patients.
Friday, December 15, 2006
Breakthrough sheds light on cause of diabetes
Source: NewScientist.com news service
Posted: 15 December 2006 17:56 GMT
Summary:
Canadian researchers eliminated type 1 diabetes in diabetes-prone mice by knocking out a set of faulty sensory nerves in the pancreas. Researchers examined the nerves of the mice and compared them with normal mice, they found that the nerves of diabetes-prone mice do not producing enough substance P. This causes islet cells to overproduce insulin, leading to insulin-resistance and eventually islet-cell death. The researchers injected some directly into the pancreas. Symptoms of diabetes were eliminated and the mice remained diabetes-free for weeks, and even months in some cases. Researchers are hopeful that if the same process could work in humans, a single injection could allay symptoms of the disease for years. They also believe the finding could chart a new path in treatment of the disease in humans.
Posted: 15 December 2006 17:56 GMT
Summary:
Canadian researchers eliminated type 1 diabetes in diabetes-prone mice by knocking out a set of faulty sensory nerves in the pancreas. Researchers examined the nerves of the mice and compared them with normal mice, they found that the nerves of diabetes-prone mice do not producing enough substance P. This causes islet cells to overproduce insulin, leading to insulin-resistance and eventually islet-cell death. The researchers injected some directly into the pancreas. Symptoms of diabetes were eliminated and the mice remained diabetes-free for weeks, and even months in some cases. Researchers are hopeful that if the same process could work in humans, a single injection could allay symptoms of the disease for years. They also believe the finding could chart a new path in treatment of the disease in humans.
Adult Stem Cells Found in Hair Follicles: Researchers say finding means patients could be their own donors
Source: HealthDay News
Date: December 15, 2006
Summary:
Researchers at the Medical College of Wisconsin in Milwaukee report that adult stem cells found in the bulge of hair follicles may provide an alternative to embryonic stem cells, and may prove useful in treating a number of conditions, such as Parkinson's disease, multiple sclerosis and stroke.
Date: December 15, 2006
Summary:
Researchers at the Medical College of Wisconsin in Milwaukee report that adult stem cells found in the bulge of hair follicles may provide an alternative to embryonic stem cells, and may prove useful in treating a number of conditions, such as Parkinson's disease, multiple sclerosis and stroke.
New Hope for Stem-Cell Therapy: Stem cells derived via asexual reproduction could provide an efficient way to generate cells that are tissue-matched t
Source: MIT Technology Review
Date: December 15, 2006
Summary:
Scientists have created embryonic stem-cell lines that are a perfect tissue match to their mouse donors, allowing the cells to be transplanted without immune rejection. If similar methods succeed in humans, the technique could provide a way to generate patient-matched cells for transplant that doesn't require destruction of viable human embryos.
Date: December 15, 2006
Summary:
Scientists have created embryonic stem-cell lines that are a perfect tissue match to their mouse donors, allowing the cells to be transplanted without immune rejection. If similar methods succeed in humans, the technique could provide a way to generate patient-matched cells for transplant that doesn't require destruction of viable human embryos.
Neural stem cells repair brain tissue, study finds: Work at UCSF may help develop treatments for strokes and other trauma
Source: Inside Bay Area / Oakland Tribune
Date: December 15, 2006
Summary:
In some of the first research funded by California's stem cell agency, the California Institute for Regenerative Medicine (CIRM), scientists at the University of California, San Francisco, suggest that stem cells in the brain have a surprising capacity to repair damaged tissue. The findings could help in the quest for treatments of brain trauma such as stroke, researchers said.
For more information on the California Institute for Regenerative Medicine (CIRM) CKICK HERE.
Date: December 15, 2006
Summary:
In some of the first research funded by California's stem cell agency, the California Institute for Regenerative Medicine (CIRM), scientists at the University of California, San Francisco, suggest that stem cells in the brain have a surprising capacity to repair damaged tissue. The findings could help in the quest for treatments of brain trauma such as stroke, researchers said.
For more information on the California Institute for Regenerative Medicine (CIRM) CKICK HERE.
New stem cell technique -- no embryos used Only women could be treated with unfertilized egg method
Source: San Francisco Chronicle
Date: December 15, 2006
Summary:
Scientists have developed a way to make stem cells from unfertilized mouse eggs. The finding could provide an alternative to controversial and technically difficult embryo cloning. The ultimate goal of the experiment is to make stem cells that match a patient's genetic make-up in order to produce cells to treat diseases and injuries that are not rejected or destroyed by the patient's immune system.
Date: December 15, 2006
Summary:
Scientists have developed a way to make stem cells from unfertilized mouse eggs. The finding could provide an alternative to controversial and technically difficult embryo cloning. The ultimate goal of the experiment is to make stem cells that match a patient's genetic make-up in order to produce cells to treat diseases and injuries that are not rejected or destroyed by the patient's immune system.
Researchers Identify Genes That Allow Brain Cancer-causing Stem Cells To Resist Treatment
Source: Cedars-Sinai Medical Center
Date: December 15, 2006
Summary:
Researchers at Cedars-Sinai Medical Center have discovered genes and mechanisms that make cancer stem cells highly resistant to chemotherapy and other treatments. Even if a tumor is almost completely obliterated, it will regenerate from the surviving cancer stem cells and be even more resistant to treatment than before. They also allude to ongoing research aimed at developing methods for readily distinguishing cancer stem cells from normal neural stem cells, which could lead to therapies targeting the cancer-causing cells without damaging healthy ones.
Date: December 15, 2006
Summary:
Researchers at Cedars-Sinai Medical Center have discovered genes and mechanisms that make cancer stem cells highly resistant to chemotherapy and other treatments. Even if a tumor is almost completely obliterated, it will regenerate from the surviving cancer stem cells and be even more resistant to treatment than before. They also allude to ongoing research aimed at developing methods for readily distinguishing cancer stem cells from normal neural stem cells, which could lead to therapies targeting the cancer-causing cells without damaging healthy ones.
Stem cell work spurs hope: Research uses unfertilized eggs
Source: Boston Globe
Date: December 15, 2006
Summary:
Harvard University researchers reported that new stem cell experiments in mice may eventually enable women to harness their own eggs to help fight disease in themselves or their relatives. The scientists generated embryonic stem cells from an unfertilized mouse's egg and were able to select stem cells that were genetic matches for the mother's immune system, so that the cells could grow into new tissue in her body without being rejected and attacked by the immune system as foreign cells.
Date: December 15, 2006
Summary:
Harvard University researchers reported that new stem cell experiments in mice may eventually enable women to harness their own eggs to help fight disease in themselves or their relatives. The scientists generated embryonic stem cells from an unfertilized mouse's egg and were able to select stem cells that were genetic matches for the mother's immune system, so that the cells could grow into new tissue in her body without being rejected and attacked by the immune system as foreign cells.
Thursday, December 14, 2006
Stem cell scientists create 'virgin birth' breakthrough in mice
Source: Daily Mail
Posted: 14 December 2006 22:00 PM GMT
Summary:
Scientists at Children's Hospital Boston have created customised stem cells that avoid rejection by the human immune system using a controversial technique called 'virgin birth,' in which eggs are tricked into starting to develop into embryos without being fertilised by sperm. Although their experiments were carried out in mice, they believe it offers real hope for humans.
Posted: 14 December 2006 22:00 PM GMT
Summary:
Scientists at Children's Hospital Boston have created customised stem cells that avoid rejection by the human immune system using a controversial technique called 'virgin birth,' in which eggs are tricked into starting to develop into embryos without being fertilised by sperm. Although their experiments were carried out in mice, they believe it offers real hope for humans.
Virgin Births Lead to Transplantable Stem Cells: Stem cells created from unfertilized mice eggs are successfully transplanted without immune rejection
Source: Scientific American
Date: December 14, 2006
Summary:
Researchers at Children's Hospital Boston have developed a new procedure used on mice for making transplantable stem cells by extracting stem cells from embryolike clusters of cells grown from the unfertilized eggs of female mice and coaxing them into dividing. They then injected the stem cells back into related mice, where they grew without being rejected by immune cells. The new finding could lead to improved methods for creating human stem cells and potential treatments for spinal cord injuries and degenerative diseases such as Alzheimer's and Parkinson's.
Date: December 14, 2006
Summary:
Researchers at Children's Hospital Boston have developed a new procedure used on mice for making transplantable stem cells by extracting stem cells from embryolike clusters of cells grown from the unfertilized eggs of female mice and coaxing them into dividing. They then injected the stem cells back into related mice, where they grew without being rejected by immune cells. The new finding could lead to improved methods for creating human stem cells and potential treatments for spinal cord injuries and degenerative diseases such as Alzheimer's and Parkinson's.
Stem Cells Patch Holes in Brain without Prompting: New research finds that stem cells repair and reinforce brain cells in mice
Source: Scientific American
Date: December 14, 2006
Summary:
Scientists at the University of California, San Francisco found that mice genetically engineered to have holes in a region of their brain recovered due to the work of stem cells in the area. The findings will be published in the December 15 issue of the journal Cell. The finding could hasten recovery from stroke or brain or head injury.
Date: December 14, 2006
Summary:
Scientists at the University of California, San Francisco found that mice genetically engineered to have holes in a region of their brain recovered due to the work of stem cells in the area. The findings will be published in the December 15 issue of the journal Cell. The finding could hasten recovery from stroke or brain or head injury.
Stem cell study reveals cells' capability in mouse brain tissue repair
Source: University of California - San Francisco
Date: December 14, 2006
Summary:
UCSF scientists have determined that adult stem cells in a specific region of the mouse brain have a built-in mechanism that allows the cells to participate in the repair and remodeling of damaged tissue in the region. As the cells are also present in the human brain, the same capacity or potential may exist in humans, the researchers say. If it does, it is possible that the cells’ behavior could be enhanced to treat tissues damaged throughout the brain by disorders such as stroke and traumatic injury.
Date: December 14, 2006
Summary:
UCSF scientists have determined that adult stem cells in a specific region of the mouse brain have a built-in mechanism that allows the cells to participate in the repair and remodeling of damaged tissue in the region. As the cells are also present in the human brain, the same capacity or potential may exist in humans, the researchers say. If it does, it is possible that the cells’ behavior could be enhanced to treat tissues damaged throughout the brain by disorders such as stroke and traumatic injury.
Making Stem Cells in a Lab: Scientists Coax Unfertilized Eggs From Mice Into Embryonic Stem Cells
Source: WebMD
Date: December 14, 2006
Summary:
Scientists may have found a way to make embryonic stem cells from unfertilized eggs -- at least in mice. "This technique, if proven effective in humans, offers an efficient way of generating customized stem cells lines from women," lead researcher George Daley, MD, PhD. says in a Children's Hospital Boston news release.
Date: December 14, 2006
Summary:
Scientists may have found a way to make embryonic stem cells from unfertilized eggs -- at least in mice. "This technique, if proven effective in humans, offers an efficient way of generating customized stem cells lines from women," lead researcher George Daley, MD, PhD. says in a Children's Hospital Boston news release.
Stem cells gotten from unfertilized eggs
Source: Associated Press
Posted: December 14, 2006 11:02 AM PST
Summary:
A procedure that encourages an egg to begin embryo development without being fertilized could suggest a new way to produce stem cells, at least for certain patients. Researchers were able to get stem cells using unfertilized mouse eggs, they report in Thursday's online issue of the journal Science. They are now turning their attention to eggs from people, but several problems remain to be worked out.
Posted: December 14, 2006 11:02 AM PST
Summary:
A procedure that encourages an egg to begin embryo development without being fertilized could suggest a new way to produce stem cells, at least for certain patients. Researchers were able to get stem cells using unfertilized mouse eggs, they report in Thursday's online issue of the journal Science. They are now turning their attention to eggs from people, but several problems remain to be worked out.
Stem cells get a grip
Source: American Society for Cell Biology
Date: December 14, 2006
Summary:
In real estate, it's location, location, location. In stem cells, it's niche, niche, niche. Stems cells are regulated by "intrinsic factors" but it's also becoming increasingly clear that their "stemness" depends on the unique microenvironment called the stem cell niche. No adult or somatic stem cells have a more complex niche life than hematopoietic stem cells, which give rise to all the different types of blood and immune cells. The bone marrow is their niche.
Date: December 14, 2006
Summary:
In real estate, it's location, location, location. In stem cells, it's niche, niche, niche. Stems cells are regulated by "intrinsic factors" but it's also becoming increasingly clear that their "stemness" depends on the unique microenvironment called the stem cell niche. No adult or somatic stem cells have a more complex niche life than hematopoietic stem cells, which give rise to all the different types of blood and immune cells. The bone marrow is their niche.
Researchers create genetically matched embryonic stem cells for transplantation
Source: Children's Hospital Boston
Date: December 14, 2006
Summary:
Researchers at Children's Hospital Boston report a new and efficient strategy, using eggs alone, for creating mouse embryonic stem cells that can be transplanted without the risk of rejection because the cells are compatible with the recipient's immune system. The findings will be published online in the journal Science on December 14. Though done in mice, the work establishes the principle of using unfertilized eggs as a source of customized embryonic stem cells that are genetically matched to the egg donor at the genes that control recognition of cells by the immune system, making them potentially useful for transplantation therapies.
Date: December 14, 2006
Summary:
Researchers at Children's Hospital Boston report a new and efficient strategy, using eggs alone, for creating mouse embryonic stem cells that can be transplanted without the risk of rejection because the cells are compatible with the recipient's immune system. The findings will be published online in the journal Science on December 14. Though done in mice, the work establishes the principle of using unfertilized eggs as a source of customized embryonic stem cells that are genetically matched to the egg donor at the genes that control recognition of cells by the immune system, making them potentially useful for transplantation therapies.
Study: Stem cells can repair mouse brains
Source: United Press International
Date: December 14, 2006
Summary:
A U.S.-led study finds adult stem cells in a specific area of the mouse brain can participate in the repair and remodeling of damaged tissue.
Date: December 14, 2006
Summary:
A U.S.-led study finds adult stem cells in a specific area of the mouse brain can participate in the repair and remodeling of damaged tissue.
‘Virgin birth’ process can produce stem cells: Technique used to create mouse embryo may point to new source of cells
Source: Reuters
Posted: December 14, 2006 6:08pm ET
Summary:
Mouse embryos created through a “virgin birth” process called parthenogenesis show that egg cells can be a source of valued embryonic stem cells, researchers reported. The cells can be closely matched to the immune system of the recipient, making them a potential source for transplants, the researchers report in the December 15 issue of the journal Science.
Posted: December 14, 2006 6:08pm ET
Summary:
Mouse embryos created through a “virgin birth” process called parthenogenesis show that egg cells can be a source of valued embryonic stem cells, researchers reported. The cells can be closely matched to the immune system of the recipient, making them a potential source for transplants, the researchers report in the December 15 issue of the journal Science.
Neural Stem Cells Lend The Brain A Surprising Capacity For Self-repair
Source: Cell Press
Date: December 14, 2006
Summary:
The brain contains stem cells with a surprising capacity for repair, researchers report in the December 15 issue of the journal Cell, published by Cell Press. The novel insight into the brain's natural ability to heal might ultimately have clinical implications for the treatment of brain damage, according to the researchers.
Date: December 14, 2006
Summary:
The brain contains stem cells with a surprising capacity for repair, researchers report in the December 15 issue of the journal Cell, published by Cell Press. The novel insight into the brain's natural ability to heal might ultimately have clinical implications for the treatment of brain damage, according to the researchers.
Boy's Health Improves, Thanks To Stem Cell Procedure
Source: WKRN-TV - Nashville,TN
Posted: December 14, 2006
Here is a video news report on the recent stem cell trial to treat Batten Disease.
Posted: December 14, 2006
Here is a video news report on the recent stem cell trial to treat Batten Disease.
Wednesday, December 13, 2006
New treatment gives hope to patients with scleroderma: Stem cells play part in battle
Source: Houston Chronicle
Posted: December 13, 2006, 10:05PM
Summary:
The University of Texas Medical School at Houston is one of several institutions nationally enrolling patients in a study comparing the effectiveness of a standardized course of chemotherapy against high-dose chemotherapy, plus stem cell transplantation to treat scleroderma.
Posted: December 13, 2006, 10:05PM
Summary:
The University of Texas Medical School at Houston is one of several institutions nationally enrolling patients in a study comparing the effectiveness of a standardized course of chemotherapy against high-dose chemotherapy, plus stem cell transplantation to treat scleroderma.
Scientists Discover Early Key To Regeneration
Source: Forsyth Institute
Date: December 13, 2006
Summary:
Science may be one step closer to understanding how a limb can be grown or a spinal cord can be repaired. Scientists at The Forsyth Institute have discovered that some cells have to die for regeneration to occur. This research may provide insight into mechanisms necessary for therapeutic regeneration in humans, potentially addressing tissues that are lost, damaged or non- functional as a result of genetic syndromes, birth defects, cancer, degenerative diseases, accidents, aging and organ failure. Through studies of the frog (Xenopus) tadpole, the Forsyth team examined the cellular underpinnings of regeneration.
Date: December 13, 2006
Summary:
Science may be one step closer to understanding how a limb can be grown or a spinal cord can be repaired. Scientists at The Forsyth Institute have discovered that some cells have to die for regeneration to occur. This research may provide insight into mechanisms necessary for therapeutic regeneration in humans, potentially addressing tissues that are lost, damaged or non- functional as a result of genetic syndromes, birth defects, cancer, degenerative diseases, accidents, aging and organ failure. Through studies of the frog (Xenopus) tadpole, the Forsyth team examined the cellular underpinnings of regeneration.
Stem Cells have Help to Renew Themselves
Source: Max-Planck-Institute of Molecular Biomedicine
Date: December 13, 2006
Summary:
A small molecule makes stem cells able to reproduce and change. This simply structured moecule called SC1, which researchers at the Max Planck Institute for Molecular Biomedicine in Münster and their colleagues from California have discovered, encourages stem cells in the laboratory to renew themselves. As a result, the stem cells retain the ability to develop into many different types of cells. Up to now, keeping the cells pluripotent has only been possible with a great deal of effort.
Date: December 13, 2006
Summary:
A small molecule makes stem cells able to reproduce and change. This simply structured moecule called SC1, which researchers at the Max Planck Institute for Molecular Biomedicine in Münster and their colleagues from California have discovered, encourages stem cells in the laboratory to renew themselves. As a result, the stem cells retain the ability to develop into many different types of cells. Up to now, keeping the cells pluripotent has only been possible with a great deal of effort.
Stem-cell patient may return home: BOY IS FIRST TO TRY OUT PALO ALTO FIRM'S WORK
Source: San Jose Mercury News
Date: December 12, 2006
Summary:
The first child to undergo experimental brain surgery with a Silicon Valley company's proposed stem-cell treatment has recovered enough from the operation last month to return home, according to an official at the Oregon hospital where the procedure was done.
Date: December 12, 2006
Summary:
The first child to undergo experimental brain surgery with a Silicon Valley company's proposed stem-cell treatment has recovered enough from the operation last month to return home, according to an official at the Oregon hospital where the procedure was done.
Experimental stem cell operation puts OHSU in spotlight
Source: KATU-TV - Portland, Oregon
Posted: December 12, 2006 at 8:59 PM PST
This feature examines the recent clinical trial developed by Stem Cells Inc. conducted at Oregon Health & Sciences University to treat Batten Disease using stem cells from aborted fetuses.
Posted: December 12, 2006 at 8:59 PM PST
This feature examines the recent clinical trial developed by Stem Cells Inc. conducted at Oregon Health & Sciences University to treat Batten Disease using stem cells from aborted fetuses.
Forsyth scientists discover early key to regeneration
Source: Forsyth Institute
Date: December 13, 2006
Summary:
Science may be one step closer to understanding how a limb can be grown or a spinal cord can be repaired. Scientists at The Forsyth Institute have discovered that some cells have to die for regeneration to occur. This research may provide insight into mechanisms necessary for therapeutic regeneration in humans, potentially addressing tissues that are lost, damaged or non- functional as a result of genetic syndromes, birth defects, cancer, degenerative diseases, accidents, aging and organ failure. Through studies of the frog (Xenopus) tadpole, the Forsyth team examined the cellular underpinnings of regeneration.
Date: December 13, 2006
Summary:
Science may be one step closer to understanding how a limb can be grown or a spinal cord can be repaired. Scientists at The Forsyth Institute have discovered that some cells have to die for regeneration to occur. This research may provide insight into mechanisms necessary for therapeutic regeneration in humans, potentially addressing tissues that are lost, damaged or non- functional as a result of genetic syndromes, birth defects, cancer, degenerative diseases, accidents, aging and organ failure. Through studies of the frog (Xenopus) tadpole, the Forsyth team examined the cellular underpinnings of regeneration.
Tuesday, December 12, 2006
Newts which Regrow their Hearts: Max Planck scientists reveal the molecular details of regeneration in newts
Source: Max-Planck-Institute for Heart and Lung Research
Date: December 5, 2006
Summary:
When a newt loses a limb, the limb regrows. What is more, a newt can also completely repair damage to its heart. Scientists at the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now started to decode the cellular mechanisms in this impressive ability to regenerate and have discovered the remarkable plasticity of newt heart cells. As mammals, and therefore also humans, do not have this ability, the findings could contribute to new cell therapies for patients with damaged organs.
Date: December 5, 2006
Summary:
When a newt loses a limb, the limb regrows. What is more, a newt can also completely repair damage to its heart. Scientists at the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now started to decode the cellular mechanisms in this impressive ability to regenerate and have discovered the remarkable plasticity of newt heart cells. As mammals, and therefore also humans, do not have this ability, the findings could contribute to new cell therapies for patients with damaged organs.
Pittsburgh-based team engineers muscle, bone cell differentiation with aid of ink-jet printer
Source: Carnegie Mellon University
Date: December 10, 2006
Summary:
A Pittsburgh-based research team has created and used an innovative ink-jet system to print "bio-ink" patterns that direct muscle-derived stem cells from adult mice to differentiate into both muscle cells and bone cells. The results could revolutionize the design of replacement body tissues. The report is the first describing a system that can pattern the formation of multiple cell types within the same vessel from a single population of adult stem cells. The new preclinical advance in the field of regenerative medicine could one day benefit millions of people whose tissues are damaged from a variety of conditions, including fatal genetic diseases like Duchenne Muscular Dystrophy (DMD), wear and tear associated with aging joints, accidental trauma, and joint deterioration due to autoimmune disorders.
Date: December 10, 2006
Summary:
A Pittsburgh-based research team has created and used an innovative ink-jet system to print "bio-ink" patterns that direct muscle-derived stem cells from adult mice to differentiate into both muscle cells and bone cells. The results could revolutionize the design of replacement body tissues. The report is the first describing a system that can pattern the formation of multiple cell types within the same vessel from a single population of adult stem cells. The new preclinical advance in the field of regenerative medicine could one day benefit millions of people whose tissues are damaged from a variety of conditions, including fatal genetic diseases like Duchenne Muscular Dystrophy (DMD), wear and tear associated with aging joints, accidental trauma, and joint deterioration due to autoimmune disorders.
Aggressive Stem Cells Might Improve Transplant Outcome
Source: St. Jude Children's Research Hospital
Date: December 8, 2006
Summary:
Investigators at St. Jude Children's Research Hospital have demonstrated in mice a way that might reduce the time it takes for a bone marrow transplant to rebuild a child's immune system, and so reduce the risk of potentially fatal virus infections that can occur during this time. The finding is important because children whose own bone marrow stem cells have been destroyed by chemotherapy or radiation treatments for cancer routinely undergo bone marrow transplantation. Therefore, reducing the time it takes for the immune system to regenerate T lymphocytes would be an important step in reducing infection risk in these children and improving their long-term outcomes.
Date: December 8, 2006
Summary:
Investigators at St. Jude Children's Research Hospital have demonstrated in mice a way that might reduce the time it takes for a bone marrow transplant to rebuild a child's immune system, and so reduce the risk of potentially fatal virus infections that can occur during this time. The finding is important because children whose own bone marrow stem cells have been destroyed by chemotherapy or radiation treatments for cancer routinely undergo bone marrow transplantation. Therefore, reducing the time it takes for the immune system to regenerate T lymphocytes would be an important step in reducing infection risk in these children and improving their long-term outcomes.
Stem Cell Advances Offer Hope to Back Up the Hype
Source: National Geographic
Date: December 4, 2006
Summary:
Human stem cell treatments for diseases may in some cases be at least a decade away. But each new discovery has added to the notion that stem cell research is showing increasing signs of living up to the hype surrounding it.
Date: December 4, 2006
Summary:
Human stem cell treatments for diseases may in some cases be at least a decade away. But each new discovery has added to the notion that stem cell research is showing increasing signs of living up to the hype surrounding it.
Monday, December 11, 2006
Another Boost For Stem Cell Research
Source: University of New South Wales
Date: December 11, 2006
Summary:
University of New South Wales (UNSW) academics have proven that tumours can be prevented from forming when embryonic stem cells are transplanted. The team has shown that placing the embryonic cells inside microcapsules made from a product of seaweed, called alginate, prevents the formation of tumours when the encapsulated cells are transplanted into laboratory animals. The team has also shown that the encapsulation process does not stop the embryonic cells from differentiating. The finding could provide new evidence to increase support for embryonic stem cell research.
Date: December 11, 2006
Summary:
University of New South Wales (UNSW) academics have proven that tumours can be prevented from forming when embryonic stem cells are transplanted. The team has shown that placing the embryonic cells inside microcapsules made from a product of seaweed, called alginate, prevents the formation of tumours when the encapsulated cells are transplanted into laboratory animals. The team has also shown that the encapsulation process does not stop the embryonic cells from differentiating. The finding could provide new evidence to increase support for embryonic stem cell research.
Sunday, December 10, 2006
Detailed 3-D Image Catches A Key Regulator Of Neural Stem Cell Differentiation In Action
Source: Salk Institute
Date: December 10, 2006
Summary:
Researchers at the Salk Institute for Biological Studies in collaboration with scientists at the University of California, San Diego (UCSD) took a high resolution "action shot" of a protein switch that plays a crucial role in the development of the nervous system. A finely tuned network of molecular "on" and "off" switches regulates the differentiation of embryonic stem cells into different tissue types. Being able to manipulate individual switches would allow scientists to nudge embryonic stem cells into becoming specific cell types, a plus for both basic research and potential therapies.
Date: December 10, 2006
Summary:
Researchers at the Salk Institute for Biological Studies in collaboration with scientists at the University of California, San Diego (UCSD) took a high resolution "action shot" of a protein switch that plays a crucial role in the development of the nervous system. A finely tuned network of molecular "on" and "off" switches regulates the differentiation of embryonic stem cells into different tissue types. Being able to manipulate individual switches would allow scientists to nudge embryonic stem cells into becoming specific cell types, a plus for both basic research and potential therapies.
Friday, December 08, 2006
Diabetes cure first target for stem cell research
Source: NEWS.com.au - Australia
Posted: December 08, 2006 12:00 am
Summary:
The first big target for embryonic stem cell research in NSW will be a cure for Type 1, or juvenile diabetes, with a top researcher predicting major progress within four years. Scientists believe that once cells are studied in laboratories, they will be able to find out regulates the disease, how to can understand the disease process and how to go through drug discovery.
Posted: December 08, 2006 12:00 am
Summary:
The first big target for embryonic stem cell research in NSW will be a cure for Type 1, or juvenile diabetes, with a top researcher predicting major progress within four years. Scientists believe that once cells are studied in laboratories, they will be able to find out regulates the disease, how to can understand the disease process and how to go through drug discovery.
Brainstorming: Stem Cells Hold Hope for Cerebral Palsy Treatment
Source: Medical College of Georgia
Date: December 8, 2006
Summary:
The Medical College of Georgia reports on research using adult stem cells to treat animals with cerebral palsy:
"Adult stem cell therapy improves recovery of motor function in an animal model for the ischemic brain injury that strikes about 10 percent of babies with cerebral palsy, researchers report. Within two weeks, treated animals were about 20 percent less likely to favor the unaffected side of their bodies and experienced about a 25 percent improvement in balance, compared to untreated controls, Medical College of Georgia researchers said."
Date: December 8, 2006
Summary:
The Medical College of Georgia reports on research using adult stem cells to treat animals with cerebral palsy:
"Adult stem cell therapy improves recovery of motor function in an animal model for the ischemic brain injury that strikes about 10 percent of babies with cerebral palsy, researchers report. Within two weeks, treated animals were about 20 percent less likely to favor the unaffected side of their bodies and experienced about a 25 percent improvement in balance, compared to untreated controls, Medical College of Georgia researchers said."
A new approach to growing heart muscle: U-M team reports success of rapid 3-D cell-growth technique that produces pulsing, organized tissue
Source: University of Michigan Health System
Date: December 8, 2006
Summary:
It looks, contracts and responds almost like natural heart muscle – even though it was grown in the lab. And it brings scientists another step closer to the goal of creating replacement parts for damaged human hearts, or eventually growing an entirely new heart from just a spoonful of loose heart cells.
Date: December 8, 2006
Summary:
It looks, contracts and responds almost like natural heart muscle – even though it was grown in the lab. And it brings scientists another step closer to the goal of creating replacement parts for damaged human hearts, or eventually growing an entirely new heart from just a spoonful of loose heart cells.
Tuesday, December 05, 2006
Stem cells may provide cure for diabetes: expert
Source: Agence France-Presse (AFP)
Posted: December 5, 2006 5:52 AM ET
Summary:
Research is under way to try and covert embryonic and adult stem cells into insulin-producing pancreatic beta cells. The aim is to create a glucose-sensitive, insulin-producing cell which responds to changes in physiological glucose levels as though in a normal body.
Posted: December 5, 2006 5:52 AM ET
Summary:
Research is under way to try and covert embryonic and adult stem cells into insulin-producing pancreatic beta cells. The aim is to create a glucose-sensitive, insulin-producing cell which responds to changes in physiological glucose levels as though in a normal body.
Stem cells found in adult hair follicles may provide alternative to embryonic stem cells
Source: Medical College of Wisconsin
Date: December 5, 2006
Summary:
Having recently identified the molecular signature of these epidermal neural crest stem cells in the mouse, their research resolves conflicting scientific opinions by showing that these cells are distinctly different from other types of skin-resident stem cells/progenitors. Their work provides a valuable resource for future mouse neural crest stem cell research.
Date: December 5, 2006
Summary:
Having recently identified the molecular signature of these epidermal neural crest stem cells in the mouse, their research resolves conflicting scientific opinions by showing that these cells are distinctly different from other types of skin-resident stem cells/progenitors. Their work provides a valuable resource for future mouse neural crest stem cell research.
Foetal cells 'to treat strokes'
Source: BBC News
Posted: 5 December 2006, 17:01 GMT
Summary:
ReNeuron, a UK company, is applying for permission to transplant stem cells made from human foetal tissue into the brains of stroke patients. The company claims it has convincing lab evidence that the cells could potentially regenerate brain cells damaged from a stroke.
Posted: 5 December 2006, 17:01 GMT
Summary:
ReNeuron, a UK company, is applying for permission to transplant stem cells made from human foetal tissue into the brains of stroke patients. The company claims it has convincing lab evidence that the cells could potentially regenerate brain cells damaged from a stroke.
Monday, December 04, 2006
Transplanted brain cells hold promise for Parkinson’s disease
Source: Medical College of Georgia
Date: December 4, 2006
Summary:
Transplanted neural stem cells hold promise for reducing the destruction of dopaminergic cells that occurs in Parkinson's disease and for replacing cells lost to the disease, scientists say. Research published in the current issue of The Journal of Neuroscience shows a human neural stem cell transplant essentially enables an animal with symptoms of Parkinson’s to continue functioning normally rather than displaying the progressive loss of movement control that characterizes the disease.
Date: December 4, 2006
Summary:
Transplanted neural stem cells hold promise for reducing the destruction of dopaminergic cells that occurs in Parkinson's disease and for replacing cells lost to the disease, scientists say. Research published in the current issue of The Journal of Neuroscience shows a human neural stem cell transplant essentially enables an animal with symptoms of Parkinson’s to continue functioning normally rather than displaying the progressive loss of movement control that characterizes the disease.
Transplanted brain cells hold promise for Parkinson's Disease
Source: Medical College of Georgia
Date: December 4, 2006
Summary:
Transplanted neural stem cells hold promise for reducing the destruction of dopaminergic cells that occurs in Parkinson's disease and for replacing cells lost to the disease, scientists say. Research published in the current issue of The Journal of Neuroscience shows a human neural stem cell transplant essentially enables an animal model for Parkinson’s to continue functioning normally rather than displaying the progressive loss of movement control that characterizes the disease.
Date: December 4, 2006
Summary:
Transplanted neural stem cells hold promise for reducing the destruction of dopaminergic cells that occurs in Parkinson's disease and for replacing cells lost to the disease, scientists say. Research published in the current issue of The Journal of Neuroscience shows a human neural stem cell transplant essentially enables an animal model for Parkinson’s to continue functioning normally rather than displaying the progressive loss of movement control that characterizes the disease.
Molecular 'marker' on stem cells aids research, perhaps therapies
Source: UT Southwestern Medical Center
Date: December 4, 2006
Summary:
A sugar molecule present on embryonic stem cells also has been found on the surface of a type of adult stem cell, a discovery that may help researchers isolate and purify adult stem cells for use in therapies aimed at bone healing, tendon repair and cartilage regeneration, researchers at UT Southwestern Medical Center report.
Date: December 4, 2006
Summary:
A sugar molecule present on embryonic stem cells also has been found on the surface of a type of adult stem cell, a discovery that may help researchers isolate and purify adult stem cells for use in therapies aimed at bone healing, tendon repair and cartilage regeneration, researchers at UT Southwestern Medical Center report.
Saturday, December 02, 2006
Stem cell cure for back pain 'in three years'
Source: Daily Telegraph
Date: December 1, 2006
Summary:
A researcher at the Manchester University School of Medicine has developed a new treatment chronic back pain using a patient's own stem cells, that rebuilds the soft, shock-absorbing discs that separate spinal vertebrae. The treatment has to be given only once and would not involve a hospital stay.
Date: December 1, 2006
Summary:
A researcher at the Manchester University School of Medicine has developed a new treatment chronic back pain using a patient's own stem cells, that rebuilds the soft, shock-absorbing discs that separate spinal vertebrae. The treatment has to be given only once and would not involve a hospital stay.
Friday, December 01, 2006
'Cancer Prognosis Gene' Found To Control The Fate Of Breast Cells
Source: University of California - San Francisco
Date: December 1, 2006
Summary:
Scientists have discovered an unsuspected role for a gene known to be one of the best predictors of human breast cancer outcome. The scientists hope that further investigation of the precise role of the gene in breast cancer can identify new ways of understanding, diagnosing and treating the disease.
Date: December 1, 2006
Summary:
Scientists have discovered an unsuspected role for a gene known to be one of the best predictors of human breast cancer outcome. The scientists hope that further investigation of the precise role of the gene in breast cancer can identify new ways of understanding, diagnosing and treating the disease.
Parkinson’s Approach With Stem Cells A Promising First Step
Source: University of Rochester Medical Center
Date: December 1, 2006
Summary:
Brain cells derived from human embryonic stem cells improved the condition of rats with Parkinson’s-like symptoms dramatically by transformed into neurons that produce dopamine, a crucial brain chemical lacking in patients with Parkinson’s. However, the treatment caused a significant problem – the appearance of brain tumors – that scientists are now working to solve. The study is featured on the cover of the November issue of Nature Medicine.
Date: December 1, 2006
Summary:
Brain cells derived from human embryonic stem cells improved the condition of rats with Parkinson’s-like symptoms dramatically by transformed into neurons that produce dopamine, a crucial brain chemical lacking in patients with Parkinson’s. However, the treatment caused a significant problem – the appearance of brain tumors – that scientists are now working to solve. The study is featured on the cover of the November issue of Nature Medicine.
Thursday, November 30, 2006
Substance Inhibits Progress Of Multiple Sclerosis In Animal Model
Source: SUNY Downstate Medical Center
Date: November 30, 2006
Summary:
Researchers at SUNY Downstate Medical Center have developed a substance that inhibits the progress of multiple sclerosis (MS) in an animal model. The agent, a novel calpain inhibitor, can be administered orally. In a paper published in the Journal of Neuroimmunology,researchers described the use of the calpain inhibitor for the treatment of a mouse model of MS. Whether administered by injection or by mouth, the inhibitor produced an almost complete cessation of the disease's progress.
Date: November 30, 2006
Summary:
Researchers at SUNY Downstate Medical Center have developed a substance that inhibits the progress of multiple sclerosis (MS) in an animal model. The agent, a novel calpain inhibitor, can be administered orally. In a paper published in the Journal of Neuroimmunology,researchers described the use of the calpain inhibitor for the treatment of a mouse model of MS. Whether administered by injection or by mouth, the inhibitor produced an almost complete cessation of the disease's progress.
"Cancer prognosis gene" found to control the fate of breast cells
Source: University of California - San Francisco
Date: November 30, 2006
Summary:
Scientists have discovered an unsuspected role for a gene known to be one of the best predictors of human breast cancer outcome. The scientists hope that further investigation of the precise role of the gene in breast cancer can identify new ways of understanding, diagnosing and treating the disease.
Date: November 30, 2006
Summary:
Scientists have discovered an unsuspected role for a gene known to be one of the best predictors of human breast cancer outcome. The scientists hope that further investigation of the precise role of the gene in breast cancer can identify new ways of understanding, diagnosing and treating the disease.
Stem cell trial may bring end of back pain for millions
Source: Evening Standard
Date: 30 November 2006
Summary:
Scientists at the University of Manchester, UK, reported the development of a radical new stem cell treatment that could totally regenerate damaged tissues and bring relief to millions of back pain sufferers.
Date: 30 November 2006
Summary:
Scientists at the University of Manchester, UK, reported the development of a radical new stem cell treatment that could totally regenerate damaged tissues and bring relief to millions of back pain sufferers.
Adult Stem Cells Proving Worth In Spinal Healing
Source: The Louisville Channel
POSTED: 3:10 pm EST November 30, 2006
UPDATED: 3:27 pm EST November 30, 2006
Summary:
A new groundbreaking study using stem cells from nasal passages to help rebuild damaged spinal cord tissue conducted at the University of Louisville’s School of Medicine may lead to a new therapy to reverse the disabling effects of spinal cord injuries.
POSTED: 3:10 pm EST November 30, 2006
UPDATED: 3:27 pm EST November 30, 2006
Summary:
A new groundbreaking study using stem cells from nasal passages to help rebuild damaged spinal cord tissue conducted at the University of Louisville’s School of Medicine may lead to a new therapy to reverse the disabling effects of spinal cord injuries.
Finding Offers New Path For Treatment Of Diabetes
Source: New York University
Date: November 30, 2006
Summary:
Researchers at New York University and the Scripps Research Institute have discovered a new enzyme, GAPDH, which regulates insulin pathways--a finding that offers a new direction for the treatment of diabetes. The research is reported in the most recent issue of the journal Nature Chemical Biology. The new-found enzyme provides another strategy to treat the disease.
Date: November 30, 2006
Summary:
Researchers at New York University and the Scripps Research Institute have discovered a new enzyme, GAPDH, which regulates insulin pathways--a finding that offers a new direction for the treatment of diabetes. The research is reported in the most recent issue of the journal Nature Chemical Biology. The new-found enzyme provides another strategy to treat the disease.
One-off treatment to stop back pain -- Using patients' own stem cells
Source: University of Manchester
Date: November 30, 2006
Summary:
A University of Manchester researcher has developed a treatment for lower back pain using the patient’s own stem cells, which could replace the use of strong painkillers or surgery that can cause debilitation, neither of which addresses the underlying cause.
Date: November 30, 2006
Summary:
A University of Manchester researcher has developed a treatment for lower back pain using the patient’s own stem cells, which could replace the use of strong painkillers or surgery that can cause debilitation, neither of which addresses the underlying cause.
Stem cell cure hope for back pain
Source: BBC NEWS
Posted: 30 November 2006, 18:04:20 GMT
Summary:
Researchers from the University of Manchester are working to develop a new treatment for chronic back pain that uses a patient's own stem cells to rebuild the soft shock-absorbing discs which separate the vertebrae in the spine. The group hopes their treatment will be available within three years.
Posted: 30 November 2006, 18:04:20 GMT
Summary:
Researchers from the University of Manchester are working to develop a new treatment for chronic back pain that uses a patient's own stem cells to rebuild the soft shock-absorbing discs which separate the vertebrae in the spine. The group hopes their treatment will be available within three years.
Wednesday, November 29, 2006
RejuvaCell's Breakthrough Stem Cell Therapy Demonstrates Potential to Revolutionize Treatment for Type-2 Diabetes
Source: RejuvaCell Inc.
Posted: November 29, 2006
Summary:
RejuvaCell Inc., a global leader in adult stem cell therapy for intractable Heart and Vascular diseases, achieves extraordinary advances in the treatment of type-2 diabetes. Over 200 patients treated to date, with 85% of 100 Patients at one year on, maintain significant improvement.
Posted: November 29, 2006
Summary:
RejuvaCell Inc., a global leader in adult stem cell therapy for intractable Heart and Vascular diseases, achieves extraordinary advances in the treatment of type-2 diabetes. Over 200 patients treated to date, with 85% of 100 Patients at one year on, maintain significant improvement.
Stem Cell Therapy International Reports the Successful Treatment of a Stroke Patient With Their Proprietary Stem Cell Transplantation Therapy
Source: Stem Cell Therapy International, Inc.
Posted: November 29, 2006 9:15 am ET
Summary:
TAMPA, FL -- Stem Cell Therapy International, Inc. (PINKSHEETS: SCII), a company in the field of research and development of stem cell transplantation therapy and regenerative medicine, announced the successful treatment of a stroke patient from the United States with its stem cell transplantation therapy protocol conducted at one of their affiliate clinics in Kiev, Ukraine.
Posted: November 29, 2006 9:15 am ET
Summary:
TAMPA, FL -- Stem Cell Therapy International, Inc. (PINKSHEETS: SCII), a company in the field of research and development of stem cell transplantation therapy and regenerative medicine, announced the successful treatment of a stroke patient from the United States with its stem cell transplantation therapy protocol conducted at one of their affiliate clinics in Kiev, Ukraine.
Tuesday, November 28, 2006
Master Gene Makes Skeletal Progenitor Cells Differentiate Into Cartilage Cells
Source: Baylor College of Medicine
Date: November 28, 2006
Summary:
Skeletal progenitor cells differentiate into cartilage cells when one master gene actually suppresses the action of another, said Baylor College of Medicine researchers in a report that appears online in the journal Proceedings of the National Academy of Sciences.
Date: November 28, 2006
Summary:
Skeletal progenitor cells differentiate into cartilage cells when one master gene actually suppresses the action of another, said Baylor College of Medicine researchers in a report that appears online in the journal Proceedings of the National Academy of Sciences.
Oncologists study colon cancer stem cells
Source: United Press International
Date: November 28, 2006
Summary:
Canadian and Italian scientists have identified and characterized a type of colon cancer cell capable of causing tumors in mice.
Date: November 28, 2006
Summary:
Canadian and Italian scientists have identified and characterized a type of colon cancer cell capable of causing tumors in mice.
Journal: Stem cell safeguards needed
Source: Associated Press
Posted: November 28, 2006, 11:14 a.m. PT
Summary:
The journal Science plans to adopt some stricter safeguards against fraud, in wake of a headline-grabbing South Korean cloning sham exposed a year ago.
Posted: November 28, 2006, 11:14 a.m. PT
Summary:
The journal Science plans to adopt some stricter safeguards against fraud, in wake of a headline-grabbing South Korean cloning sham exposed a year ago.
Revealed: how to fix a broken heart
Source: Daily Telegraph
Posted: November 28, 2006
Summary:
British scientists discovered that a specific protein is required for blood vessel and heart tissue development. By fully reactiviating this protein to guide progenitor cells from the rind of the heart to form new blood vessels within, it could be possible to restore blood flow to muscle that has been starved of oxygen. The protein could also help to solve a mystery about how experimental stem cell treatments work. Animal tests show that stem cells – bone marrow cells with the potential to turn into many types – can be infused into a heart after an attack and repair and regenerate damaged heart muscle, improving heart function and circulation.
Posted: November 28, 2006
Summary:
British scientists discovered that a specific protein is required for blood vessel and heart tissue development. By fully reactiviating this protein to guide progenitor cells from the rind of the heart to form new blood vessels within, it could be possible to restore blood flow to muscle that has been starved of oxygen. The protein could also help to solve a mystery about how experimental stem cell treatments work. Animal tests show that stem cells – bone marrow cells with the potential to turn into many types – can be infused into a heart after an attack and repair and regenerate damaged heart muscle, improving heart function and circulation.
Monday, November 27, 2006
New data from NIH lab confirms protocol to reverse type 1 diabetes in mice
Source: Massachusetts General Hospital
Date: November 27, 2006
Summary:
New data published in the Nov. 24 issue of Science provide further support for a protocol to reverse type 1 diabetes in mice and new evidence that adult precursor cells from the spleen can contribute to the regeneration of beta cells. In 2001 and 2003, researchers at Massachusetts General Hospital (MGH) demonstrated the efficacy of a protocol to reverse of type 1 diabetes in diabetic mice. Three studies from other institutions published in the March 24, 2006 issue of Science confirmed that the MGH-developed protocol can reverse the underlying disease but were inconclusive on the role of spleen cells in the recovery of insulin-producing pancreatic islets. The new data from a study performed at the National Institutes of Health (NIH), published as a technical comment, provides additional confirmation of the ability to reverse type 1 diabetes and on the role of the spleen cells in islet regeneration.
Date: November 27, 2006
Summary:
New data published in the Nov. 24 issue of Science provide further support for a protocol to reverse type 1 diabetes in mice and new evidence that adult precursor cells from the spleen can contribute to the regeneration of beta cells. In 2001 and 2003, researchers at Massachusetts General Hospital (MGH) demonstrated the efficacy of a protocol to reverse of type 1 diabetes in diabetic mice. Three studies from other institutions published in the March 24, 2006 issue of Science confirmed that the MGH-developed protocol can reverse the underlying disease but were inconclusive on the role of spleen cells in the recovery of insulin-producing pancreatic islets. The new data from a study performed at the National Institutes of Health (NIH), published as a technical comment, provides additional confirmation of the ability to reverse type 1 diabetes and on the role of the spleen cells in islet regeneration.
Parkinson's Mutation Stunts Neurons
Source: Cell Press
Date: November 27, 2006
Summary:
Mutations in a key brain protein known to underlie a form of Parkinson's disease (PD) wreaks its damage by stunting the normal growth and branching of neurons, researchers have found. They have pinpointed the malfunction of the protein made by mutant forms of the gene called LRRK2 and how it affects neurons, ultimately leading to their death. The loss of dopamine-producing neurons is central to the pathology of PD, and loss of connections among such neurons is an early feature of the PD disease process.
Date: November 27, 2006
Summary:
Mutations in a key brain protein known to underlie a form of Parkinson's disease (PD) wreaks its damage by stunting the normal growth and branching of neurons, researchers have found. They have pinpointed the malfunction of the protein made by mutant forms of the gene called LRRK2 and how it affects neurons, ultimately leading to their death. The loss of dopamine-producing neurons is central to the pathology of PD, and loss of connections among such neurons is an early feature of the PD disease process.
New Data Confirms Protocol To Reverse Type 1 Diabetes In Mice
Source: Massachusetts General Hospital
Date: November 27, 2006
Summary:
New data published in the Nov. 24 issue of Science provide further support for a protocol to reverse type 1 diabetes in mice and new evidence that adult precursor cells from the spleen can contribute to the regeneration of beta cells. In 2001 and 2003, researchers at Massachusetts General Hospital (MGH) demonstrated the efficacy of a protocol to reverse of type 1 diabetes in diabetic mice. Three studies from other institutions published in the March 24, 2006 issue of Science confirmed that the MGH-developed protocol can reverse the underlying disease but were inconclusive on the role of spleen cells in the recovery of insulin-producing pancreatic islets. The new data from a study performed at the National Institutes of Health (NIH), published as a technical comment, provides additional confirmation of the ability to reverse type 1 diabetes and on the role of the spleen cells in islet regeneration.
Date: November 27, 2006
Summary:
New data published in the Nov. 24 issue of Science provide further support for a protocol to reverse type 1 diabetes in mice and new evidence that adult precursor cells from the spleen can contribute to the regeneration of beta cells. In 2001 and 2003, researchers at Massachusetts General Hospital (MGH) demonstrated the efficacy of a protocol to reverse of type 1 diabetes in diabetic mice. Three studies from other institutions published in the March 24, 2006 issue of Science confirmed that the MGH-developed protocol can reverse the underlying disease but were inconclusive on the role of spleen cells in the recovery of insulin-producing pancreatic islets. The new data from a study performed at the National Institutes of Health (NIH), published as a technical comment, provides additional confirmation of the ability to reverse type 1 diabetes and on the role of the spleen cells in islet regeneration.
Some Stem Cell Transplant Recipients Face Long-Term Risk: Leukemia patients almost twice as likely to develop a solid cancer within 10 years
Source: HealthDay News
Date: November 27, 2006
Summary:
A new study by researchers from the University of British Columbia and the BC Cancer Agency. has found that Patients with diseases such as leukemia or myelodysplastic syndrome who receive a hematopoietic stem cell transplant (HSCT) have an increased long-term risk of developing a cancer.
Date: November 27, 2006
Summary:
A new study by researchers from the University of British Columbia and the BC Cancer Agency. has found that Patients with diseases such as leukemia or myelodysplastic syndrome who receive a hematopoietic stem cell transplant (HSCT) have an increased long-term risk of developing a cancer.
Stem cell transplant cancer risks studied
Source: United Press International
Date: November 27, 2006
Summary:
Canadian scientists report hematopoietic, or bone marrow, stem cell transplant recipients face a significant long-term risk of developing a second cancer.
Date: November 27, 2006
Summary:
Canadian scientists report hematopoietic, or bone marrow, stem cell transplant recipients face a significant long-term risk of developing a second cancer.
Stem cell transplants from women raise cancer risk
Source: NewScientist.com news service
Posted: 05:00 27 November 2006
Summary:
People who receive stem cell transplants for diseases such as leukaemia appear to face a higher risk of developing secondary cancers, especially if the cells come from a female donor, according to a preliminary study. The scientists behind the new report caution that future stem cell treatments for ailments such as spinal cord injury and heart failure might also carry a cancer risk. However, experts point out that the study is far from conclusive and more work needs to be done to confirm a link between stem cell transplants and tumours.
Posted: 05:00 27 November 2006
Summary:
People who receive stem cell transplants for diseases such as leukaemia appear to face a higher risk of developing secondary cancers, especially if the cells come from a female donor, according to a preliminary study. The scientists behind the new report caution that future stem cell treatments for ailments such as spinal cord injury and heart failure might also carry a cancer risk. However, experts point out that the study is far from conclusive and more work needs to be done to confirm a link between stem cell transplants and tumours.
Sunday, November 26, 2006
Long-term cancer risk follows stem cell transplant recipients
Source: John Wiley & Sons, Inc.
Date: November 27, 2006
Summary:
Hematopoietic stem cell transplant (HSCT) recipients face a significant long-term risk for developing a second cancer, particularly if they were older at the time of transplant or received stem cells from a female donor, according to a new study. Published in the January 1, 2007 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study reveals that within 10 years of an allogeneic HSCT, the relative risk of a second, solid cancer is almost twice that of the general population.
Date: November 27, 2006
Summary:
Hematopoietic stem cell transplant (HSCT) recipients face a significant long-term risk for developing a second cancer, particularly if they were older at the time of transplant or received stem cells from a female donor, according to a new study. Published in the January 1, 2007 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study reveals that within 10 years of an allogeneic HSCT, the relative risk of a second, solid cancer is almost twice that of the general population.
Heart attack hope after scientists discover 'master' stem cell
Source: Evening Standard
Date: 26 November 2006
Summary:
Scientists discovered a "master" cell in mouse embryos that appears to form all the major parts of the heart. Tests showed they were capable of differentiating into the three types of heart cells: contracting cardiac cells, smooth muscle, and the endothelial cells that line the walls of blood vessel. The scientists believe the cells could eventually be used to regenerate ailing hearts, as well as aid drug discovery and provide new models of human disease.
Date: 26 November 2006
Summary:
Scientists discovered a "master" cell in mouse embryos that appears to form all the major parts of the heart. Tests showed they were capable of differentiating into the three types of heart cells: contracting cardiac cells, smooth muscle, and the endothelial cells that line the walls of blood vessel. The scientists believe the cells could eventually be used to regenerate ailing hearts, as well as aid drug discovery and provide new models of human disease.
Friday, November 24, 2006
Tumor Starters: Stem Cells Eyed as Anti-Cancer Target
Source: ABC News
Posted: November 24, 2006
Summary:
Current cancer therapies attack tumors as if every cell in that tumor were the same. But now, scientific evidence suggests that only a small percentage of those tumor cells are responsible for the tumor's growth. Treatments that attack the whole tumor may be off target because they aren't designed to kill the cells at fault — stem cells. Called the cancer stem-cell hypothesis, it could revolutionize the way some cancers are treated, experts said.
Posted: November 24, 2006
Summary:
Current cancer therapies attack tumors as if every cell in that tumor were the same. But now, scientific evidence suggests that only a small percentage of those tumor cells are responsible for the tumor's growth. Treatments that attack the whole tumor may be off target because they aren't designed to kill the cells at fault — stem cells. Called the cancer stem-cell hypothesis, it could revolutionize the way some cancers are treated, experts said.
A stem cell first at OHSU: Hospital conducts experimental transplant on child with fatal disease
Source: Portland Tribune
Date: November 22, 2006
Summary:
Surgeons at Doernbecher Children’s Hospital at Oregon Health & Science University performed what is believed to be the first-ever transplant of fetal stem cells into a human brain. The cells, called purified neural stem cells, were injected directly into the brain of a child suffering from a rare and fatal neurodegenerative disorder called Batten disease.
Date: November 22, 2006
Summary:
Surgeons at Doernbecher Children’s Hospital at Oregon Health & Science University performed what is believed to be the first-ever transplant of fetal stem cells into a human brain. The cells, called purified neural stem cells, were injected directly into the brain of a child suffering from a rare and fatal neurodegenerative disorder called Batten disease.
Thursday, November 23, 2006
TB4 Is Essential For Blood Vessel Regeneration In Adult Hearts
Source: RegeneRx Biopharmaceuticals, Inc.
Posted: 23 Nov 2006 - 12:00pm (PST)
Summary:
REGENERX BIOPHARMACEUTICALS, INC. (AMEX: RGN) (http://www.regenerx.com/) report that a study published in the advanced online edition of the journal Nature supported and elaborated TB4's significant effects in the damaged hearts of mice and highlighted its therapeutic potential for the treatment of heart attacks and heart failure in humans.
Commentary: Maybe these results will lead to human clinical trials of TB4 for heart attacks and heart failure patients.
Posted: 23 Nov 2006 - 12:00pm (PST)
Summary:
REGENERX BIOPHARMACEUTICALS, INC. (AMEX: RGN) (http://www.regenerx.com/) report that a study published in the advanced online edition of the journal Nature supported and elaborated TB4's significant effects in the damaged hearts of mice and highlighted its therapeutic potential for the treatment of heart attacks and heart failure in humans.
Commentary: Maybe these results will lead to human clinical trials of TB4 for heart attacks and heart failure patients.
Study identifies possible master heart stem cell
Source: Reuters
Posted: November 23, 2006 9:56am ET
Summary:
Scientists studying mice said they have found what may be a master cardiac stem cell -- able to change into the three major cell types in a mammal's heart -- in a finding that could help guide heart repair in people.
Posted: November 23, 2006 9:56am ET
Summary:
Scientists studying mice said they have found what may be a master cardiac stem cell -- able to change into the three major cell types in a mammal's heart -- in a finding that could help guide heart repair in people.
Discovery Of Cardiac Stem Cells May Advance Regenerative Heart Therapy
Source: Cell Press
Date: November 23, 2006
Summary:
An immediate early publication of the journal Cell, published by Cell Press, on Nov. 22, 2006 points to the possible existence of master cardiac stem cells with the capacity to produce all three major tissues of the mammalian heart. A companion Cell paper also published online reports the discovery of a second population of cardiac progenitors, which are capable of forming both cardiac muscle and the smooth muscle found in the heart's blood vessel walls. The findings may also have important implications for regenerative medicine aimed at cardiac repair in patients with congenital or acquired heart disease, according to the researchers.
Date: November 23, 2006
Summary:
An immediate early publication of the journal Cell, published by Cell Press, on Nov. 22, 2006 points to the possible existence of master cardiac stem cells with the capacity to produce all three major tissues of the mammalian heart. A companion Cell paper also published online reports the discovery of a second population of cardiac progenitors, which are capable of forming both cardiac muscle and the smooth muscle found in the heart's blood vessel walls. The findings may also have important implications for regenerative medicine aimed at cardiac repair in patients with congenital or acquired heart disease, according to the researchers.
Researchers isolate a master heart cell
Source: Boston Globe
Posted: November 23, 2006
Summary:
A team of Harvard scientists announced the discovery of a single kind of cell that builds the three main types of heart tissue, an advance that boosts the prospects of using cells to treat heart disease, the nation's top killer. The team identified the heart cell in mice, and proved that it develops into the muscle cells that power the heart, the cells that make up blood vessels, and the smooth muscle cells that allow the vessels to expand and contract. If the human equivalent of the new cells is found, it could be given to patients to rebuild heart tissue that cannot be repaired today. The work could also give biologists new tools to look for heart drugs.
Posted: November 23, 2006
Summary:
A team of Harvard scientists announced the discovery of a single kind of cell that builds the three main types of heart tissue, an advance that boosts the prospects of using cells to treat heart disease, the nation's top killer. The team identified the heart cell in mice, and proved that it develops into the muscle cells that power the heart, the cells that make up blood vessels, and the smooth muscle cells that allow the vessels to expand and contract. If the human equivalent of the new cells is found, it could be given to patients to rebuild heart tissue that cannot be repaired today. The work could also give biologists new tools to look for heart drugs.
Cardiac master cells discovered
Source: BBC NEWS
Published: 23 November 2006 00:26:22 GMT
Summary:
Scientists have discovered what they believe could be cardiac master cells, capable of developing into different tissues in the heart. The breakthrough, published in the journal Cell, raises hopes for new treatments for heart disease.
Published: 23 November 2006 00:26:22 GMT
Summary:
Scientists have discovered what they believe could be cardiac master cells, capable of developing into different tissues in the heart. The breakthrough, published in the journal Cell, raises hopes for new treatments for heart disease.
Wednesday, November 22, 2006
Master cell could mend a broken heart - Stem-cell research uncovers the heart's foundations.
Source: Nature
Date: 22 November 2006
Summary:
Researchers have found a 'master' stem cell responsible for producing all the major tissues of the heart. The surprising finding brings fresh hope to the idea of using stem cells to repair heart damage.
Date: 22 November 2006
Summary:
Researchers have found a 'master' stem cell responsible for producing all the major tissues of the heart. The surprising finding brings fresh hope to the idea of using stem cells to repair heart damage.
Regenerative heart therapy may get boost from cardiac stem cells
Source: Agence France-Presse (AFP)
Posted: November 22, 2006 2:03 PM ET
Summary:
New research shows master cardiac stem cells may exist that can produce all three major tissues of the mammalian heart, news that could have far-reaching implications in regenerative cardiac repair.
Posted: November 22, 2006 2:03 PM ET
Summary:
New research shows master cardiac stem cells may exist that can produce all three major tissues of the mammalian heart, news that could have far-reaching implications in regenerative cardiac repair.
Finding a Master Heart Cell: Scientists have identified a cardiac stem cell that could be the basis for new heart therapies
Source: Time
Posted: November 22, 2006
Summary:
Scientists at Massachusetts General Hospital report that they have identified a similar mother stem cell from which most heart cells arise. Working with mice, the scientists isolated a cardiac stem cell that generates the three major cell types of the mammalian heart, while another group at the hospital found a stem cell that gives rise to the contracting and smooth muscle cells found in heart vessel walls. The findings could provide a basis for the development of new heart therapies, and become a source of healthy, replacement cells for heart tissue damaged after a heart attack or by heart disease.
Posted: November 22, 2006
Summary:
Scientists at Massachusetts General Hospital report that they have identified a similar mother stem cell from which most heart cells arise. Working with mice, the scientists isolated a cardiac stem cell that generates the three major cell types of the mammalian heart, while another group at the hospital found a stem cell that gives rise to the contracting and smooth muscle cells found in heart vessel walls. The findings could provide a basis for the development of new heart therapies, and become a source of healthy, replacement cells for heart tissue damaged after a heart attack or by heart disease.
Mass. General researchers identify master cardiac stem cell
Source: Massachusetts General Hospital
Date: November 22, 2006
Summary:
Researchers from the Massachusetts General Hospital (MGH) Cardiovascular Research Center have discovered what appears to be a master cardiac stem cell, capable of differentiating into the three major types of cells that make up the mammalian heart. The cells offer new prospects for drug discovery and genetically based models of human disease.
Date: November 22, 2006
Summary:
Researchers from the Massachusetts General Hospital (MGH) Cardiovascular Research Center have discovered what appears to be a master cardiac stem cell, capable of differentiating into the three major types of cells that make up the mammalian heart. The cells offer new prospects for drug discovery and genetically based models of human disease.
Discovery of cardiac stem cells may advance regenerative heart therapy
Source: Cell Press
Date: November 22, 2006
Summary:
A new study published in the journal Cell has revealed the possible existence of master cardiac stem cells with the capacity to produce all three major tissues of the mammalian heart. A companion Cell paper also published online reports the discovery of a second population of cardiac progenitors, which are capable of forming both cardiac muscle and the smooth muscle found in the heart's blood vessel walls. Researchers believe the findings may have important implications for regenerative medicine aimed at cardiac repair in patients with congenital or acquired heart disease, according to the researchers.
Date: November 22, 2006
Summary:
A new study published in the journal Cell has revealed the possible existence of master cardiac stem cells with the capacity to produce all three major tissues of the mammalian heart. A companion Cell paper also published online reports the discovery of a second population of cardiac progenitors, which are capable of forming both cardiac muscle and the smooth muscle found in the heart's blood vessel walls. Researchers believe the findings may have important implications for regenerative medicine aimed at cardiac repair in patients with congenital or acquired heart disease, according to the researchers.
Heart stem cells discovered by three teams
Source: NewScientist.com news service
Posted: 17:00 22 November 2006
Summary:
Three US research groups have identified cardiovascular “precursor” cells from cultures of mouse embryonic stem cells (ESCs). The researchers claim that the cells can produce stem cells that give rise to different tissues found in the mammalian heart. They believe it is very likely that these versatile cells will also be found in the embryonic human heart, raising hopes of one day repairing and “rejuvenating” damaged hearts by growing these embryonic stem cell lines in a lab.
Posted: 17:00 22 November 2006
Summary:
Three US research groups have identified cardiovascular “precursor” cells from cultures of mouse embryonic stem cells (ESCs). The researchers claim that the cells can produce stem cells that give rise to different tissues found in the mammalian heart. They believe it is very likely that these versatile cells will also be found in the embryonic human heart, raising hopes of one day repairing and “rejuvenating” damaged hearts by growing these embryonic stem cell lines in a lab.
Embryonic Stem Cells Yield Full Range of Heart Tissues: The finding brings experts a step closer to stem cell-based treatments
Source: HealthDay News
Posted: November 22, 2006
Summary:
Harvard University researchers have discovered that a "master" embryonic cardiac stem cell is able to produce all three types of cardiac tissue. In experiments using mice, the team was able to produce cardiac muscle, smooth muscle and "pacemaker" cardiac cells. According to experts, the findings, outlined in two reports published online Nov. 22 in the journal Cell, could enable doctors to repair hearts by growing new heart cells from embryonic stem cells, specialized cells that have can become any type of cell.
Posted: November 22, 2006
Summary:
Harvard University researchers have discovered that a "master" embryonic cardiac stem cell is able to produce all three types of cardiac tissue. In experiments using mice, the team was able to produce cardiac muscle, smooth muscle and "pacemaker" cardiac cells. According to experts, the findings, outlined in two reports published online Nov. 22 in the journal Cell, could enable doctors to repair hearts by growing new heart cells from embryonic stem cells, specialized cells that have can become any type of cell.
Enzyme may aid cancer fight, study shows
Source: The Argus
Posted: November 22, 2006 02:33:14 AM PST
Summary:
Scientists at Children's Hospital Oakland and Research Institute have identified a human enzyme that could help kill cancer cells by regulating cell growth and death by lowering the levels of a lipid called sphingosine-1-phosphate, or S1P. Studying colon cancer in human tissue and mice models, the researchers found that the presence of the enzyme SPL can make cancer cells more vulnerable to chemotherapy. Without the enzyme, cancer cells were more resistant to treatment. a recent study finds. The study, published in the November issue of the Proceedings of the National Academy of Sciences, indicates that boosting the enzymes could help fight cancer.
Posted: November 22, 2006 02:33:14 AM PST
Summary:
Scientists at Children's Hospital Oakland and Research Institute have identified a human enzyme that could help kill cancer cells by regulating cell growth and death by lowering the levels of a lipid called sphingosine-1-phosphate, or S1P. Studying colon cancer in human tissue and mice models, the researchers found that the presence of the enzyme SPL can make cancer cells more vulnerable to chemotherapy. Without the enzyme, cancer cells were more resistant to treatment. a recent study finds. The study, published in the November issue of the Proceedings of the National Academy of Sciences, indicates that boosting the enzymes could help fight cancer.
Tuesday, November 21, 2006
Adult Neurogenesis Newly Adult-born Neurons Are Functionally Similar To Mature Neurons
Source: Public Library of Science
Date: November 21, 2006
Summary:
Adult neurogenesis in the hippocampus generates neurons whose function is similar to that of neurons born during development, indicating at least some neurons that develop in adult brains can form connections identical to those formed by neurons that develop early in life. The finding may eventually enable physicians to repair damaged or deteriorated brain tissue.
Commentary: This finding could have implications for treating neurological diseases, injuries and disorders in humans.
Date: November 21, 2006
Summary:
Adult neurogenesis in the hippocampus generates neurons whose function is similar to that of neurons born during development, indicating at least some neurons that develop in adult brains can form connections identical to those formed by neurons that develop early in life. The finding may eventually enable physicians to repair damaged or deteriorated brain tissue.
Commentary: This finding could have implications for treating neurological diseases, injuries and disorders in humans.
Biothera tests stem cell-mobilizer drug
Source: Biothera
Posted: November 21, 2006
Summary:
Biothera, a biotechnology company dedicated to improving immune health, announced it has begun a Phase I/II clinical trial to test the effects of its lead drug compound Imprime PGG used with in combination with another drug, G-CSF, to help move bone-marrow stem cells into the blood. The full news release can be found here:
Posted: November 21, 2006
Summary:
Biothera, a biotechnology company dedicated to improving immune health, announced it has begun a Phase I/II clinical trial to test the effects of its lead drug compound Imprime PGG used with in combination with another drug, G-CSF, to help move bone-marrow stem cells into the blood. The full news release can be found here:
Abbott experimental drug kills leukemia cells
Source: Pharmaceutical Business Review
Date: 20th November 2006
Summary:
Researchers at the University of Texas MD Anderson Cancer Center have found that Abbott Laboratories' experimental drug ABT-737 can destroy acute myeloid leukemia cells. The drug was powerful in its own right, the researchers say, but they found that some acute myeloid (AML) cells were themselves resistant to ABT-737, so they added another drug that knocked out this secondary resistance. Together, these agents may provide a powerful therapy against AML, and could form the basis of a new way to treat the cancer, say the scientists.
Date: 20th November 2006
Summary:
Researchers at the University of Texas MD Anderson Cancer Center have found that Abbott Laboratories' experimental drug ABT-737 can destroy acute myeloid leukemia cells. The drug was powerful in its own right, the researchers say, but they found that some acute myeloid (AML) cells were themselves resistant to ABT-737, so they added another drug that knocked out this secondary resistance. Together, these agents may provide a powerful therapy against AML, and could form the basis of a new way to treat the cancer, say the scientists.
Adult Stem Cells Give Hope for Healing
Source: Fox News
Posted: November 20, 2006
This post is a feature that examines and explains adult stem cell research.
Posted: November 20, 2006
This post is a feature that examines and explains adult stem cell research.
'Cancer stem cells' behind colon cancer: research
Source: Agence-France Presse (AFP)
Date: November 21, 2006 12:39 AM ET
Summary:
A few bad stem cells may be responsible for most cancers, Canadian scientists looking into the root causes of colon cancer reported, indicating hope for better cancer treatments in the next decade. Abnormal stem cells have also been identified as the source of the disease in certain types of leukemia, as well as in breast and brain tumors. Researchers hope the findings may lead to better cancer treatments that target these stem cells.
Date: November 21, 2006 12:39 AM ET
Summary:
A few bad stem cells may be responsible for most cancers, Canadian scientists looking into the root causes of colon cancer reported, indicating hope for better cancer treatments in the next decade. Abnormal stem cells have also been identified as the source of the disease in certain types of leukemia, as well as in breast and brain tumors. Researchers hope the findings may lead to better cancer treatments that target these stem cells.
Monday, November 20, 2006
Advance helps explain stem cell behavior
Source: Oregon State University
Date: November 20, 2006
Summary:
Biochemists at Oregon State University have developed a new method to identify the "DNA-binding transcription factors" that help steer stem cells into forming the wide variety of cells that ultimately make up all the organs and parts of a living vertebrate animal.
Date: November 20, 2006
Summary:
Biochemists at Oregon State University have developed a new method to identify the "DNA-binding transcription factors" that help steer stem cells into forming the wide variety of cells that ultimately make up all the organs and parts of a living vertebrate animal.
Colon cancer stem cells identified
Source: The Scientist
Posted: 20th November 2006 02:21 PM GMT
Summary:
Scientists have identified a population of human colon cancer stem cells that can initiate tumor growth and differentiate into mature tumors
Posted: 20th November 2006 02:21 PM GMT
Summary:
Scientists have identified a population of human colon cancer stem cells that can initiate tumor growth and differentiate into mature tumors
Stem Cells May Trigger Tumors
Source: Medical News Today
Posted 20 November 2006 - 10:00am (PST)
Summary:
In two separate studies published in the journal Nature, scientists discovered that colon (cancer) stem cells were causing colon cancer tumors in mice. The researchers say cancer treatments will have to target cancer stem cells.
Commentary: This finding could provide scientists and researchers with new strategies to develop cancer treatments.
Posted 20 November 2006 - 10:00am (PST)
Summary:
In two separate studies published in the journal Nature, scientists discovered that colon (cancer) stem cells were causing colon cancer tumors in mice. The researchers say cancer treatments will have to target cancer stem cells.
Commentary: This finding could provide scientists and researchers with new strategies to develop cancer treatments.
Cancer stem cells start tumors in mice
Source: Reuters
Posted: November 20, 2006 8:23am ET
Summary:
Stem cells -- the master cells that give rise to all the blood and tissue in the body -- may also be responsible for tumors, according to two separate studies. Canadian and Italian researchers both found that specialized colon cancer stem cells appeared to be the sources of colon cancer tumors in mice. Their findings, published in the journal Nature, support the belief that future cancer treatments will have to home in on cancer stem cells.
Posted: November 20, 2006 8:23am ET
Summary:
Stem cells -- the master cells that give rise to all the blood and tissue in the body -- may also be responsible for tumors, according to two separate studies. Canadian and Italian researchers both found that specialized colon cancer stem cells appeared to be the sources of colon cancer tumors in mice. Their findings, published in the journal Nature, support the belief that future cancer treatments will have to home in on cancer stem cells.
Stem cells core of more cancers: New discoveries that pinpoint bad seeds leading to a major redirection of research
Source: The Globe and Mail
Posted: November 20, 2006 3:47 AM EST
Summary:
New discoveries about the basic biology of cancer are revealing that the root cause of the disease is not tumors, as had long been previously thought, but stem cells that become cancerous. In a new study published the journal Nature, researchers have found that abnormal stem cells are the source of colon cancer. The finding is leading scientists to change the focus of their research to target the cells.
Commentary: This finding is significant, as it could provide physicians with new strategies to detect cancers early and treat them effectively before they spread.
Posted: November 20, 2006 3:47 AM EST
Summary:
New discoveries about the basic biology of cancer are revealing that the root cause of the disease is not tumors, as had long been previously thought, but stem cells that become cancerous. In a new study published the journal Nature, researchers have found that abnormal stem cells are the source of colon cancer. The finding is leading scientists to change the focus of their research to target the cells.
Commentary: This finding is significant, as it could provide physicians with new strategies to detect cancers early and treat them effectively before they spread.
One step closer to cancer's Holy Grail: Treating 'stem cells' like treating root of weed, scientist proclaims
Source: Toronto Star
Posted: November 20, 2006. 05:17 AM
Summary:
Scientists have found strong evidence that only a small proportion of cells drive the formation of tumors causing to colon cancer. Colon cancer is the fourth type of cancer in which stem cells have been found to be its root cause, lending credibility to the idea that the cells may be the source of all cancers. The discovery could lead to earlier dection and produce more effective treatments for the disease.
Posted: November 20, 2006. 05:17 AM
Summary:
Scientists have found strong evidence that only a small proportion of cells drive the formation of tumors causing to colon cancer. Colon cancer is the fourth type of cancer in which stem cells have been found to be its root cause, lending credibility to the idea that the cells may be the source of all cancers. The discovery could lead to earlier dection and produce more effective treatments for the disease.
Another Boost For Stem Cell Research
Source: University of New South Wales
Posted: November 20, 2006
Summary:
Australian researchers have proven that tumours can be prevented from forming when embryonic stem cells are transplanted by placing the embryonic cells inside microcapsules made from a product of seaweed, called alginate. The discovery removes an obstacle to human embryonic stem cell research, and could ultimately lead to safer embryonic stem cell treatments for patients.
Posted: November 20, 2006
Summary:
Australian researchers have proven that tumours can be prevented from forming when embryonic stem cells are transplanted by placing the embryonic cells inside microcapsules made from a product of seaweed, called alginate. The discovery removes an obstacle to human embryonic stem cell research, and could ultimately lead to safer embryonic stem cell treatments for patients.
Nerve Fibers Need Specific Growth Factor Chemical To Form Connections Within The Brain
Source: University of California - Irvine
Date: November 20, 2006
Summary:
A discovery on how neural circuitry develops to aid proper cerebral cortex activity may help explain the memory and cognitive decline seen in Alzheimer's disease patients – a discovery that could point toward potential treatments, according to UC Irvine scientists.
Date: November 20, 2006
Summary:
A discovery on how neural circuitry develops to aid proper cerebral cortex activity may help explain the memory and cognitive decline seen in Alzheimer's disease patients – a discovery that could point toward potential treatments, according to UC Irvine scientists.
Sunday, November 19, 2006
Colon cancer appears to arise from cancer stem cells, mice study shows
Source: Canadian Press
Posted: November 19, 2006 5:00 PM
Summary:
Scientists have discovered that colon cancer arises from stem cells specific to the tumour after human colorectal tumour cells were implanted in mice. The finding could lead to more targeted treatments to prevent recurrence of the disease.
Posted: November 19, 2006 5:00 PM
Summary:
Scientists have discovered that colon cancer arises from stem cells specific to the tumour after human colorectal tumour cells were implanted in mice. The finding could lead to more targeted treatments to prevent recurrence of the disease.
Scientists Regenerate Wing In Chick Embryo
Source: Salk Institute
Date: November 19, 2006
Summary:
Most animals have lost the ability to replace missing limbs. Now, a research team at the Salk Institute for Biological Studies has been able to regenerate a wing in a chick embryo -- a species not known to be able to regrow limbs - suggesting that the potential for such regeneration exists innately in all vertebrates, including humans.
Date: November 19, 2006
Summary:
Most animals have lost the ability to replace missing limbs. Now, a research team at the Salk Institute for Biological Studies has been able to regenerate a wing in a chick embryo -- a species not known to be able to regrow limbs - suggesting that the potential for such regeneration exists innately in all vertebrates, including humans.
Saturday, November 18, 2006
Stem cells treat wasted muscles: Dogs with muscular dystrophy walk better after injections.
Source: Nature
Date: 15 November 2006
Summary:
An infusion of stem cells scraped from blood vessels has helped dogs with a form of muscular dystrophy to walk more normally, perhaps heralding a treatment for the human disease.
Date: 15 November 2006
Summary:
An infusion of stem cells scraped from blood vessels has helped dogs with a form of muscular dystrophy to walk more normally, perhaps heralding a treatment for the human disease.
Neural stem cell growth stimulated
Source: Los Angeles Times
Date: November 18, 2006
Summary:
Researchers have found a way to stimulate the growth of neural stem cells in the brains of adult mice, potentially eventually utilizing the the brain's natural capacity for repair to help people with diseases such as Alzheimer's.
Date: November 18, 2006
Summary:
Researchers have found a way to stimulate the growth of neural stem cells in the brains of adult mice, potentially eventually utilizing the the brain's natural capacity for repair to help people with diseases such as Alzheimer's.
Friday, November 17, 2006
Targeting Leukemic Stem Cells By BCL-2 Inhibition
Source: University of Texas M. D. Anderson Cancer Center
Date: November 17, 2006
Summary:
Researchers at The University of Texas M. D. Anderson Cancer Center have found, in laboratory studies, that the experimental drug ABT-737 which has shown promise in some cancers, can destroy acute myeloid leukemia (AML) blast, progenitor and even stem cells that are often resistant to standard chemotherapy treatment.
The drug was powerful in its own right, the researchers say, but they found that some AML cells were themselves resistant to ABT-737, so they added another drug that knocked out this secondary resistance. Together, these agents may provide a powerful therapy against AML, and could form the basis of a new way to treat the cancer, say the scientists, whose study was published in the November 14 issue of the journal, Cancer Cell.
Date: November 17, 2006
Summary:
Researchers at The University of Texas M. D. Anderson Cancer Center have found, in laboratory studies, that the experimental drug ABT-737 which has shown promise in some cancers, can destroy acute myeloid leukemia (AML) blast, progenitor and even stem cells that are often resistant to standard chemotherapy treatment.
The drug was powerful in its own right, the researchers say, but they found that some AML cells were themselves resistant to ABT-737, so they added another drug that knocked out this secondary resistance. Together, these agents may provide a powerful therapy against AML, and could form the basis of a new way to treat the cancer, say the scientists, whose study was published in the November 14 issue of the journal, Cancer Cell.
Scripps researchers find new method for eye repair
Source: San Diego Daily Transcript via Yahoo! News
Date: November 17, 2006
Summary:
Researchers at The Scripps Institute in San Diego have found a way to repair and normalize blood vessels in the eyes of mice using stem cells obtained from bone marrow. The findings could have implications for developing human treatments for a certain type of eye diseases, such as a type of blindness that can occur in people with diabetes called diabetic retinopathy or retinopathy of prematurity.
Date: November 17, 2006
Summary:
Researchers at The Scripps Institute in San Diego have found a way to repair and normalize blood vessels in the eyes of mice using stem cells obtained from bone marrow. The findings could have implications for developing human treatments for a certain type of eye diseases, such as a type of blindness that can occur in people with diabetes called diabetic retinopathy or retinopathy of prematurity.
Bioheart, Inc. Expands Clinical Trials Of Adult Myogenic Stem Cell Treatment For Heart Attack And Advanced Heart Failure Patients
Source: Bioheart, Inc.
Date: November 17, 2006
Summary:
Bioheart, Inc., a biotechnology company focused on the development of innovative cell therapies designed to repair areas of damaged muscle tissue in a patient's heart and improve cardiac function, is expanding its United States and European clinical trials of its MyoCell(TM) adult myogenic (muscle) stem cell composition and MyoCath(R) needle-injection catheter product candidates.
Date: November 17, 2006
Summary:
Bioheart, Inc., a biotechnology company focused on the development of innovative cell therapies designed to repair areas of damaged muscle tissue in a patient's heart and improve cardiac function, is expanding its United States and European clinical trials of its MyoCell(TM) adult myogenic (muscle) stem cell composition and MyoCath(R) needle-injection catheter product candidates.
Stem cell hope for chemotherapy patients
Source: Apollo Life Sciences
Date: November 17, 2006
Summary:
In a world first, Apollo Life Sciences has revealed that two of its human proteins, which are wholly derived from human cells, are up to 53% faster in generating vital white blood cells used in the treatment of chemotherapy patients. This means cancer patients who normally have to wait for up to three weeks for white blood cell levels to regenerate before embarking on subsequent courses of chemotherapy can access potentially life saving treatments earlier. In the future, it is anticipated that patients will benefit from quicker recovery times from chemotherapy, as well as avoiding a host of side effects involved in their treatment.
Date: November 17, 2006
Summary:
In a world first, Apollo Life Sciences has revealed that two of its human proteins, which are wholly derived from human cells, are up to 53% faster in generating vital white blood cells used in the treatment of chemotherapy patients. This means cancer patients who normally have to wait for up to three weeks for white blood cell levels to regenerate before embarking on subsequent courses of chemotherapy can access potentially life saving treatments earlier. In the future, it is anticipated that patients will benefit from quicker recovery times from chemotherapy, as well as avoiding a host of side effects involved in their treatment.
Investigators Discover Modified Growth Control in Human Embryonic Stem Cells
Source: University of Massachusetts Medical School, Worcester
Date: November 17, 2006
Summary:
Two papers published by University of Massachusetts Medical School (UMMS) Department of Cell Biology and Cancer Center investigators report striking changes in control of growth in human embryonic stem cells. The studies were carried out on a National Institutes of Health funded grant using two of the six federal government approved human embryonic stem cell lines.
The implications of this work are significant. There is a pressing need to enhance capabilities for tissue regeneration, particularly for the treatment of age-related skeletal degenerative diseases that include osteoporosis and osteoarthritis, that can be met by stem cells. Utilizing human embryonic stem cells to reverse the catastrophic complications associated with diabetes, renal failure, multiple sclerosis, muscular dystrophy and Alzheimer’s with stem cells is a realistic expectation.
Date: November 17, 2006
Summary:
Two papers published by University of Massachusetts Medical School (UMMS) Department of Cell Biology and Cancer Center investigators report striking changes in control of growth in human embryonic stem cells. The studies were carried out on a National Institutes of Health funded grant using two of the six federal government approved human embryonic stem cell lines.
The implications of this work are significant. There is a pressing need to enhance capabilities for tissue regeneration, particularly for the treatment of age-related skeletal degenerative diseases that include osteoporosis and osteoarthritis, that can be met by stem cells. Utilizing human embryonic stem cells to reverse the catastrophic complications associated with diabetes, renal failure, multiple sclerosis, muscular dystrophy and Alzheimer’s with stem cells is a realistic expectation.
Penn Prof. Makes 'Hair'-Raising Stem Cell Discovery
Source: Evening Bulletin - Philadelphia, PA
Posted: November 17, 2006
Summary:
A pathology researcher at the University of Pennsylvania discovered a new type of adult stem cell that can be obtained from human hair follicles. The hair spheres can be harvested and so far differentiated into six different cells, including neurons, adipose, and muscle tissue, among others. The finding could have a broad clinical application for treating Alzheimer's disease and muscular dystrophy.
Posted: November 17, 2006
Summary:
A pathology researcher at the University of Pennsylvania discovered a new type of adult stem cell that can be obtained from human hair follicles. The hair spheres can be harvested and so far differentiated into six different cells, including neurons, adipose, and muscle tissue, among others. The finding could have a broad clinical application for treating Alzheimer's disease and muscular dystrophy.
Thursday, November 16, 2006
Researchers Stimulate Growth of Neural Stem Cells in Adult Brain for Treatment of Neurological Disorders
Source: California Institute of Technology
Date: November 15. 2006
Summary:
In a development that could potentially benefit victims of degenerative neurological diseases, researchers have succeeded in stimulating the growth of neural stem cells in the adult brain. Such cells could then be directed towards repairing one's own brain.
Commentary: It will be important for any human trials of this new procedure to be closely monitored in order to minimize health risks to patients and ensure that any intended treatment that is part of the trial is both safe and effective.
Date: November 15. 2006
Summary:
In a development that could potentially benefit victims of degenerative neurological diseases, researchers have succeeded in stimulating the growth of neural stem cells in the adult brain. Such cells could then be directed towards repairing one's own brain.
Commentary: It will be important for any human trials of this new procedure to be closely monitored in order to minimize health risks to patients and ensure that any intended treatment that is part of the trial is both safe and effective.
Aussie scientists solve stem cell problem
Source: United Press International
Posted: November 14, 2006
Summary:
Australian researchers have found a way of allowing stem cells to differentiate into mature cells while preventing cancer tumors from forming when the cells are implanted by placing them in a capsule made from seaweed, which has been the fear of some doctors in using stem cells to treat disease.
Commentary: This finding could have implications for improving the safety of human stem cell transplants.
Posted: November 14, 2006
Summary:
Australian researchers have found a way of allowing stem cells to differentiate into mature cells while preventing cancer tumors from forming when the cells are implanted by placing them in a capsule made from seaweed, which has been the fear of some doctors in using stem cells to treat disease.
Commentary: This finding could have implications for improving the safety of human stem cell transplants.
Muscular dystrophy treatment studied
Source: United Press International
Date: November 16, 2006
Summary:
Italian scientists using dogs have demonstrated a potential stem cell treatment for muscular dystrophy that corrects most dystrophic abnormalities.
Date: November 16, 2006
Summary:
Italian scientists using dogs have demonstrated a potential stem cell treatment for muscular dystrophy that corrects most dystrophic abnormalities.
Doernbecher Children's Hospital Team Completes First-Ever Stem Cell Transplant in Human Brain
Source: Oregon Health & Science University
Date: November 16, 2006
Summary:
Neurosurgeons and physicians at Doernbecher Children's Hospital, Oregon Health & Science University, yesterday, Nov. 14, performed the first transplant of purified human fetal neural stem cells into the brain of a study participant with neuronal ceroid lipofuscinosis (NCL), also known as Batten disease. NCL is a rare and fatal neurodegenerative disorder that affects infants and children. The transplant is part of a Phase 1 clinical trial to evaluate the safety and preliminary efficacy of a human central nervous stem cell product developed by StemCells, Inc., Palo Alto, Calif. This one-year trial will involve up to six children with NCL.
Date: November 16, 2006
Summary:
Neurosurgeons and physicians at Doernbecher Children's Hospital, Oregon Health & Science University, yesterday, Nov. 14, performed the first transplant of purified human fetal neural stem cells into the brain of a study participant with neuronal ceroid lipofuscinosis (NCL), also known as Batten disease. NCL is a rare and fatal neurodegenerative disorder that affects infants and children. The transplant is part of a Phase 1 clinical trial to evaluate the safety and preliminary efficacy of a human central nervous stem cell product developed by StemCells, Inc., Palo Alto, Calif. This one-year trial will involve up to six children with NCL.
First Human Brain Stem Cell Transplant
Source: KOIN 6 - TV / KOIN.com - Portland, OR
Posted: November 16, 2006
Summary:
In a pioneering surgery, neurosurgeons at Oregon Health and Science University transplanted fetal stem cells into the brain of a child with Batten disease, a rare and fatal neurodegenerative disorder that affects infants and small children. The transplant is part of a clinical trial to test the procedure's safety effectiveness.
Posted: November 16, 2006
Summary:
In a pioneering surgery, neurosurgeons at Oregon Health and Science University transplanted fetal stem cells into the brain of a child with Batten disease, a rare and fatal neurodegenerative disorder that affects infants and small children. The transplant is part of a clinical trial to test the procedure's safety effectiveness.
Stem Cells Help Dogs With Muscular Dystrophy
Source: Medical News Today
Posted: 16 November 2006 - 4:00am (PST)
Summary:
Dogs with Duchenne muscular dystrophy experienced a return of muscle strength after receiving stem cell therapy, say scientists from Italy and France in a study in the journal Nature. Duchenne muscular dystrophy affects about one in every 3,500 male humans - a genetic mutation means a gene lacks dystrophin, a crucial protein for muscle health. The patient's muscles gradually weaken, he eventually loses mobility and usually dies young. The scientists believe this study could eventually lead the way to effective treatment for humans with muscular dystrophy (MD)
Posted: 16 November 2006 - 4:00am (PST)
Summary:
Dogs with Duchenne muscular dystrophy experienced a return of muscle strength after receiving stem cell therapy, say scientists from Italy and France in a study in the journal Nature. Duchenne muscular dystrophy affects about one in every 3,500 male humans - a genetic mutation means a gene lacks dystrophin, a crucial protein for muscle health. The patient's muscles gradually weaken, he eventually loses mobility and usually dies young. The scientists believe this study could eventually lead the way to effective treatment for humans with muscular dystrophy (MD)
Heart 'can carry out own repairs'
Source: BBC NEWS
Posted: 16 November 2006, 00:38 GMT
Summary:
Scientists have shown that cells in the heart's outer layer can migrate deeper into a failing organ to carry out essential repairs.
The migration of progenitor cells is controlled by a protein called thymosin beta 4, already known to help reduce muscle cell loss after a heart attack. The discovery opens up the possibility of using the protein to develop more effective treatments for heart disease.
Posted: 16 November 2006, 00:38 GMT
Summary:
Scientists have shown that cells in the heart's outer layer can migrate deeper into a failing organ to carry out essential repairs.
The migration of progenitor cells is controlled by a protein called thymosin beta 4, already known to help reduce muscle cell loss after a heart attack. The discovery opens up the possibility of using the protein to develop more effective treatments for heart disease.
Wednesday, November 15, 2006
Stem Cells Show Versatility
Source: Associated Press
Posted: November 15, 2006; 2:27 PM ET
Summary:
Stem cells are once again demonstrating their flexibility in being able to possibly be applied to treat a variety of human diseases and medical conditions One new study finds that they can ease symptoms of muscular dystrophy in dogs, a possibly eventually leading to a human therapy. Another revealed that stem cells recovered from amniotic fluid can be used to grow heart valves.
Posted: November 15, 2006; 2:27 PM ET
Summary:
Stem cells are once again demonstrating their flexibility in being able to possibly be applied to treat a variety of human diseases and medical conditions One new study finds that they can ease symptoms of muscular dystrophy in dogs, a possibly eventually leading to a human therapy. Another revealed that stem cells recovered from amniotic fluid can be used to grow heart valves.
Dog helps find cure for fatal muscle disease
Source: Daily Telegraph
Posted: 15 November 2006
Summary:
A stem-cell treatment for muscular dystrophy, a degenerative and fatal disease, which mostly affects boys and young men, could be available for testing on patients within two years, following a series of experiments by Italian researchers on dogs that have Duchenne muscular dystrophy, a form of muscular dystrophy caused by a lack of the protein dystrophin in muscle fibres.
Posted: 15 November 2006
Summary:
A stem-cell treatment for muscular dystrophy, a degenerative and fatal disease, which mostly affects boys and young men, could be available for testing on patients within two years, following a series of experiments by Italian researchers on dogs that have Duchenne muscular dystrophy, a form of muscular dystrophy caused by a lack of the protein dystrophin in muscle fibres.
Amniotic Stem Cells Offer Hope Against Congenital Heart Defects
Source: HealthDay News
Date: November 14, 2006
Summary:
If findings from a new Swiss study are valid, in the future doctors will be able to use a simple procedure to treat congenital heart defects by extracting stem cells from the mother's amniotic fluid and use them to make a new heart valve, ready to place in the baby as soon as it is born.
Date: November 14, 2006
Summary:
If findings from a new Swiss study are valid, in the future doctors will be able to use a simple procedure to treat congenital heart defects by extracting stem cells from the mother's amniotic fluid and use them to make a new heart valve, ready to place in the baby as soon as it is born.
Heart Valves Grown From Womb Fluid Cells
Source: Associated Press
Posted: November 15, 2006 11:29 AM
Summary:
Scientists have created human heart valves using stem cells from the fluid that cushions babies in the womb - offering a revolutionary approach that may eventually be used to treat damaged hearts.
Posted: November 15, 2006 11:29 AM
Summary:
Scientists have created human heart valves using stem cells from the fluid that cushions babies in the womb - offering a revolutionary approach that may eventually be used to treat damaged hearts.
Muscular Dystrophy: Stem Cell Help? Stem Cell Treatment Shows Potential in Lab Tests on Dogs
Source: WebMD Medical News
Date: November 15, 2006
Summary:
Italian researchers report in the journal Nature that lab tests on dogs show that adult stem cells may help treat a certain type of muscular dystrophy, say Italian researchers, paving the way for start of "clinical experimentation" for Duchenne muscular dystrophy.
Date: November 15, 2006
Summary:
Italian researchers report in the journal Nature that lab tests on dogs show that adult stem cells may help treat a certain type of muscular dystrophy, say Italian researchers, paving the way for start of "clinical experimentation" for Duchenne muscular dystrophy.
Stem Cell Injections Help Dogs With Muscular Dystrophy
Source: Associated Press
Posted: November 15, 2006 10 00 AM
Summary:
In promising new research, stem cells worked remarkably well at easing symptoms of muscular dystrophy in dogs, an experiment that experts call a significant step toward treating people. The cells helped strengthen muscle by fusing with regenerating muscle fibers and pumping out a protein that's missing in dogs with the disease.
Posted: November 15, 2006 10 00 AM
Summary:
In promising new research, stem cells worked remarkably well at easing symptoms of muscular dystrophy in dogs, an experiment that experts call a significant step toward treating people. The cells helped strengthen muscle by fusing with regenerating muscle fibers and pumping out a protein that's missing in dogs with the disease.
Stem Cells: New Hope on the Horizon
Source: American Heart Association's Scientific Sessions 2006 via (Ivanhoe Newswire
Date: November 15, 2006
Summary:
Researchers at the American Heart Association's Scientific Sessions 2006 in Chicago are reporting on three breakthrough ways to use a patient's own stem cells to help repair heart damage: (1) Amniotic stem cells (2) Fat stem cells and (3) Human and animal stem cells.
Date: November 15, 2006
Summary:
Researchers at the American Heart Association's Scientific Sessions 2006 in Chicago are reporting on three breakthrough ways to use a patient's own stem cells to help repair heart damage: (1) Amniotic stem cells (2) Fat stem cells and (3) Human and animal stem cells.
Stem cell tests offer muscular dystrophy hope
Source: Reuters
Posted: November 15, 2006 1:06pm ET
Summary:
A new stem cell treatment developed by Italian scientists has improved the ability of dogs with muscular dystrophy to walk. The treatment could have future implications for treating Duchenne muscular dystrophy in humans.
Posted: November 15, 2006 1:06pm ET
Summary:
A new stem cell treatment developed by Italian scientists has improved the ability of dogs with muscular dystrophy to walk. The treatment could have future implications for treating Duchenne muscular dystrophy in humans.
Stem cells 'treat muscle disease'
Source: BBC NEWS
Posted: 15 November 2006, 18:00 GMT
Summary:
A team of French and Italian scientists transplanted a form of stem cells, gathered from blood vessels that naturally become muscle cells, into dogs with a form of muscular dystrophy (MD). The stem cell treatment signficantly improved symptoms of muscular dystrophy. Scientists said the finding was important progress that bolstered the idea that stem cells could be used to treat MD. They called the experiment a a significant advance that could lead to future trials in humans.
Posted: 15 November 2006, 18:00 GMT
Summary:
A team of French and Italian scientists transplanted a form of stem cells, gathered from blood vessels that naturally become muscle cells, into dogs with a form of muscular dystrophy (MD). The stem cell treatment signficantly improved symptoms of muscular dystrophy. Scientists said the finding was important progress that bolstered the idea that stem cells could be used to treat MD. They called the experiment a a significant advance that could lead to future trials in humans.
StemCells, Inc. Announces First Human Neural Stem Cell Transplant
Source: StemCells, Inc.
Posted: November 15, 2006
Summary:
StemCells, Inc. (NASDAQ: STEM) today announced that the first transplantation of the Company's proprietary human neural stem cell product--HuCNS-SC(TM)-- took place yesterday at the Oregon Health & Science University's (OHSU) Doernbecher Children's Hospital. This transplant is the first of six that are planned as part of the Company's Phase I clinical trial designed to evaluate the safety and preliminary efficacy of HuCNS-SC as a treatment for infantile and late infantile neuronal ceroid lipofuscinosis (NCL). NCL, which is often referred to as Batten disease, is a rare and fatal neurodegenerative condition afflicting infants and children.
Commentary: This seems to be a significant step toward understanding and treating neurolgical disorders in humans.
Posted: November 15, 2006
Summary:
StemCells, Inc. (NASDAQ: STEM) today announced that the first transplantation of the Company's proprietary human neural stem cell product--HuCNS-SC(TM)-- took place yesterday at the Oregon Health & Science University's (OHSU) Doernbecher Children's Hospital. This transplant is the first of six that are planned as part of the Company's Phase I clinical trial designed to evaluate the safety and preliminary efficacy of HuCNS-SC as a treatment for infantile and late infantile neuronal ceroid lipofuscinosis (NCL). NCL, which is often referred to as Batten disease, is a rare and fatal neurodegenerative condition afflicting infants and children.
Commentary: This seems to be a significant step toward understanding and treating neurolgical disorders in humans.
Protein aids in brain repair
Source: Pasadena Star-News
Posted: November 14, 2006 11:26:08 PM PST
Summary:
Scientists at the California Institute of Technology have discovered how to increase the number of new brain stem cells in mice, paving the way for advancements in understandingn neurological diseases and conditions such as Alzheimer's, Parkinson's and multiple sclerosis.
Posted: November 14, 2006 11:26:08 PM PST
Summary:
Scientists at the California Institute of Technology have discovered how to increase the number of new brain stem cells in mice, paving the way for advancements in understandingn neurological diseases and conditions such as Alzheimer's, Parkinson's and multiple sclerosis.
Tuesday, November 14, 2006
Using The Body's Own Stem Cells To Grow New Arteries
Source: ABC 7 / KGO-TV - San Francisco
Posted: November 12, 2006
Summary:
Doctors have developed a new treatment for blocked arteries using adult stem cells that allows patients to grow new healthy blood vessels to improve circulation.
Commentary: Early trials of this new treatment appear to be promising. Maybe it will be able to be tried in a larger number of patients and treat them successfully.
Posted: November 12, 2006
Summary:
Doctors have developed a new treatment for blocked arteries using adult stem cells that allows patients to grow new healthy blood vessels to improve circulation.
Commentary: Early trials of this new treatment appear to be promising. Maybe it will be able to be tried in a larger number of patients and treat them successfully.
Researchers spur growth of adult brain stem cells
Source: Reuters via Yahoo! News
Posted: November 14, 2006 5:18 PM ET
Summary:
Researchers have found a way to spur the growth of neural stem cells in the brains of adult mice with an eye toward harnessing the brain's innate capacity for repair to help people with diseases such as Alzheimer's. Determining how these stem cells can be deployed to replace cells in mice whose brains are damaged in ways resembling Parkinson's disease, Alzheimer's disease and multiple sclerosis in people is the next key step, researchers said.
Commentary: Further research on this new technique might provide researchers with new insights into how to enable adult neural stem cell proliferation in humans.
Posted: November 14, 2006 5:18 PM ET
Summary:
Researchers have found a way to spur the growth of neural stem cells in the brains of adult mice with an eye toward harnessing the brain's innate capacity for repair to help people with diseases such as Alzheimer's. Determining how these stem cells can be deployed to replace cells in mice whose brains are damaged in ways resembling Parkinson's disease, Alzheimer's disease and multiple sclerosis in people is the next key step, researchers said.
Commentary: Further research on this new technique might provide researchers with new insights into how to enable adult neural stem cell proliferation in humans.
Researchers spur growth of adult brain stem cells
Source: Reuters
Posted: November 14, 2006 5:18pm ET
Summary:
Researchers have found a way to spur the growth of neural stem cells in the brains of adult mice with an eye toward harnessing the brain's innate capacity for repair to help people with diseases such as Alzheimer's. Determining how these stem cells can be deployed to replace cells in mice whose brains are damaged in ways resembling Parkinson's disease, Alzheimer's disease and multiple sclerosis in people is the next key step, researchers said.
Commentary: Further research on this new technique might provide researchers with new insights into how to enable adult neural stem cell proliferation in humans.
Posted: November 14, 2006 5:18pm ET
Summary:
Researchers have found a way to spur the growth of neural stem cells in the brains of adult mice with an eye toward harnessing the brain's innate capacity for repair to help people with diseases such as Alzheimer's. Determining how these stem cells can be deployed to replace cells in mice whose brains are damaged in ways resembling Parkinson's disease, Alzheimer's disease and multiple sclerosis in people is the next key step, researchers said.
Commentary: Further research on this new technique might provide researchers with new insights into how to enable adult neural stem cell proliferation in humans.
Amniotic Stem Cells Offer Hope Against Congenital Heart Defects
Source: HealthDay News
Posted: November 14, 2006
Summary:
If findings from a Swiss study are confirmed, doctors will be able to use a simple procedure to extract and use them to make a new heart valve, ready to to place in the baby as soon as it is born. The potential implications of the procedure could reveolutionize treatment for congenital heart defects using stem cells from the mother's amniotic fluid.
Posted: November 14, 2006
Summary:
If findings from a Swiss study are confirmed, doctors will be able to use a simple procedure to extract and use them to make a new heart valve, ready to to place in the baby as soon as it is born. The potential implications of the procedure could reveolutionize treatment for congenital heart defects using stem cells from the mother's amniotic fluid.
Adult Pig Stem Cells Show Promise In Repairing Animals' Heart Attack Damage
Source: Johns Hopkins Medical Institutions
Date: November 14, 2006
Summary:
Johns Hopkins scientists have successfully grown large numbers of stem cells taken from adult pigs' healthy heart tissue and used the cells to repair some of the tissue damage done to those organs by lab-induced heart attacks. Pigs' hearts closely resemble those in humans, making them a useful model in such research. They are believed to be the first results in animal studies to show that so-called cardiac stem cell therapy can be successfully applied with minimally invasive methods to circumstances closely resembling those in humans.
Date: November 14, 2006
Summary:
Johns Hopkins scientists have successfully grown large numbers of stem cells taken from adult pigs' healthy heart tissue and used the cells to repair some of the tissue damage done to those organs by lab-induced heart attacks. Pigs' hearts closely resemble those in humans, making them a useful model in such research. They are believed to be the first results in animal studies to show that so-called cardiac stem cell therapy can be successfully applied with minimally invasive methods to circumstances closely resembling those in humans.
Stem cell breakthrough
Source: Courier Mail
Posted: November 13, 2006 11:00pm
Summary:
A new discovery by Australian scientists has reveal that seaweed can be used to overcome a major medical risk that can arise when embryonic stem cells are implanted in humans. Researchers at the University of New South Wales have devised a technique that prevents the cells from forming tumors when they are injected into the body by encasing each cell in a tiny capsule made from a seaweed extract, called alginate, before transplantation.
Posted: November 13, 2006 11:00pm
Summary:
A new discovery by Australian scientists has reveal that seaweed can be used to overcome a major medical risk that can arise when embryonic stem cells are implanted in humans. Researchers at the University of New South Wales have devised a technique that prevents the cells from forming tumors when they are injected into the body by encasing each cell in a tiny capsule made from a seaweed extract, called alginate, before transplantation.
U researchers making strides in stem cell technology: Working with St. Paul's BioE Inc., researchers successfully grew lung cells.
Source: Minnesota Daily
Posted: November 14, 2006
Summary:
Researchers at the University of Minnesota in partnership with BioE, a St. Paul-based biotechnology company, successfully transformed stem cells found in umbilical cord blood into a kind of cell found in the lungs called type II alveolar cells, which prevent air sacs in the lungs from collapsing, helping people breathe. Presently, the cells could enable researchers to test for latent effects of smoking, pollution or even medications on the respiratory system. The researchers believe the cells may eventually be able to be used to treat diseases such as emphysema or cystic fibrosis.
Posted: November 14, 2006
Summary:
Researchers at the University of Minnesota in partnership with BioE, a St. Paul-based biotechnology company, successfully transformed stem cells found in umbilical cord blood into a kind of cell found in the lungs called type II alveolar cells, which prevent air sacs in the lungs from collapsing, helping people breathe. Presently, the cells could enable researchers to test for latent effects of smoking, pollution or even medications on the respiratory system. The researchers believe the cells may eventually be able to be used to treat diseases such as emphysema or cystic fibrosis.
Scientists create artificial liver from stem cells
Source: The Yomiuri Shimbun
Posted: November 10, 2006
Summary:
Japanese Researchers have created an artificial liver from embryonic stem cells and implanted it in mice with liver failure, improving their condition. The research is expected to be applied to assist with devices for patients with lowered liver functions from hepatitis or other diseases.
Posted: November 10, 2006
Summary:
Japanese Researchers have created an artificial liver from embryonic stem cells and implanted it in mice with liver failure, improving their condition. The research is expected to be applied to assist with devices for patients with lowered liver functions from hepatitis or other diseases.
Monday, November 13, 2006
Stem cell threat weeded out
Source: Sydney Morning Herald
Posted: November 14, 2006
Summary:
Researchers have discovered that tumor formation can be prevented by encasing the cells in microscopic capsules made from a seaweed extract before they are transplanted. The advance overcomes a major obstacle that has hindered the progress of embryonic stem cell research and could improve the safety of human embyonic stem cell treatments.
Posted: November 14, 2006
Summary:
Researchers have discovered that tumor formation can be prevented by encasing the cells in microscopic capsules made from a seaweed extract before they are transplanted. The advance overcomes a major obstacle that has hindered the progress of embryonic stem cell research and could improve the safety of human embyonic stem cell treatments.
Initial Trials Indicate Reduced Intensity Stem Cell Transplant Safe For Scleroderma Patients
Source: American College of Rheumatology
Posted: November 13, 2006
Summary:
Early-stage clinical trials showed that reduced intensity hematopoietic stem cell transplantation (HSCT) in patients with systemic sclerosis (scleroderma) has proven safe and well tolerated, according new research. If results from the trial are valid over a long period of time, HSCT may become an acceptable therapeutic option for more individuals afflicted with severe forms of autoimmune disease.
Posted: November 13, 2006
Summary:
Early-stage clinical trials showed that reduced intensity hematopoietic stem cell transplantation (HSCT) in patients with systemic sclerosis (scleroderma) has proven safe and well tolerated, according new research. If results from the trial are valid over a long period of time, HSCT may become an acceptable therapeutic option for more individuals afflicted with severe forms of autoimmune disease.
Identification Of A Key Gene Required For Brain Neural Circuit Formation
Source: Institut de recherches cliniques de Montreal
Date: November 13, 2006
Summary:
An international team of scientists have discovered that a gene called Sonic Hedgehog (Shh) is an axonal attractant for brain and spinal cord neurons, which could help treat spinal cord injuries and neurodegenerative diseases. They showed that Shh exerts its attractive effect through a novel receptor named Boc. Remarkably, this novel Shh receptor is absolutely required for the axon guidance role of Shh and the role of Shh in brain neural circuit formation. The findings could provide a better understanding of the structure and formation of the spinal cord and nervous system and identify new strategies to treat neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, or brain and spinal cord injuries.
Date: November 13, 2006
Summary:
An international team of scientists have discovered that a gene called Sonic Hedgehog (Shh) is an axonal attractant for brain and spinal cord neurons, which could help treat spinal cord injuries and neurodegenerative diseases. They showed that Shh exerts its attractive effect through a novel receptor named Boc. Remarkably, this novel Shh receptor is absolutely required for the axon guidance role of Shh and the role of Shh in brain neural circuit formation. The findings could provide a better understanding of the structure and formation of the spinal cord and nervous system and identify new strategies to treat neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, or brain and spinal cord injuries.
Scientists Discover Way To Block Growth Of Prostate Cancer Cells
Source: European Organisation for Research and Treatment of Cancer
Date: November 13, 2006
Summary:
Scientists have discovered for the first time a specific biochemical pathway by which the sex hormone, androgen, increases levels of harmful chemicals called reactive oxygen species (ROS) in the prostate gland that play a role in the development of prostate cancer.
Date: November 13, 2006
Summary:
Scientists have discovered for the first time a specific biochemical pathway by which the sex hormone, androgen, increases levels of harmful chemicals called reactive oxygen species (ROS) in the prostate gland that play a role in the development of prostate cancer.
Sunday, November 12, 2006
Cell Transplants Restore Vision in Mice: Breakthrough used 'precursor' cells destined to work in the retina
Source: HealthDay News
Date: November 8, 2006
Summary:
Scientists report they have restored the vision of blind mice by introducing cells the eye uses to sense light, called photoreceptor precursor cells", into the rodents' retinas. The breakthrough could lead to transplants that might someday restore the vision of people who who have conditions caused by a loss of these photoreceptors, such as diabetes or age-related macular degeneration.
Date: November 8, 2006
Summary:
Scientists report they have restored the vision of blind mice by introducing cells the eye uses to sense light, called photoreceptor precursor cells", into the rodents' retinas. The breakthrough could lead to transplants that might someday restore the vision of people who who have conditions caused by a loss of these photoreceptors, such as diabetes or age-related macular degeneration.
Stem cell cure hope for diabetes
Source: BBC NEWS
Posted: 2006/11/12 00:20:17 GMT
Summary:
Scientists have used stem cells from human bone marrow to repair defective insulin-producing pancreatic cells responsible for diabetes in mice. The treatment also halted damaging changes taking place in the glomeruli, the bulb-like structures in the kidneys that filter the blood.caused by the condition.
Commentary: If this finding can be replicated safely and successfully, it might eventually lead to effective treatments for diabetes in humans.
Posted: 2006/11/12 00:20:17 GMT
Summary:
Scientists have used stem cells from human bone marrow to repair defective insulin-producing pancreatic cells responsible for diabetes in mice. The treatment also halted damaging changes taking place in the glomeruli, the bulb-like structures in the kidneys that filter the blood.caused by the condition.
Commentary: If this finding can be replicated safely and successfully, it might eventually lead to effective treatments for diabetes in humans.
Saturday, November 11, 2006
Human stem cells stimulate insulin in diabetic mice
Source: Reuters
Posted: November 9, 2006 9:22am ET
Summary:
Transplantation of human stromal cells into diabetic mice stimulated native mouse beta cells to produce insulin, researchers report in the latest issue of Proceedings of the National Academy of Sciences. The researchers say it is possible that multipotent stromal cell infusions may correct the metabolic disorders and heal some of the damage caused by diabetes in diabetic patients in the future.
Posted: November 9, 2006 9:22am ET
Summary:
Transplantation of human stromal cells into diabetic mice stimulated native mouse beta cells to produce insulin, researchers report in the latest issue of Proceedings of the National Academy of Sciences. The researchers say it is possible that multipotent stromal cell infusions may correct the metabolic disorders and heal some of the damage caused by diabetes in diabetic patients in the future.
How To Grow Muscle Cells In A Dish
Source: Journal of Clinical Investigation
Date: November 11, 2006
Summary:
In a new study, researchers at the University of Minnesota Medical School demonstrated that Smooth muscle cells can be generated from multipotent adult progenitor cells (MAPCs) isolated from the bone marrow of rats, mice, pigs, and humans. This study therefore identifies a model system for studying the effects of potential therapeutics on SMC development and SMCs. It also describes a potential source of SMCs for engineering tissues.
Date: November 11, 2006
Summary:
In a new study, researchers at the University of Minnesota Medical School demonstrated that Smooth muscle cells can be generated from multipotent adult progenitor cells (MAPCs) isolated from the bone marrow of rats, mice, pigs, and humans. This study therefore identifies a model system for studying the effects of potential therapeutics on SMC development and SMCs. It also describes a potential source of SMCs for engineering tissues.
Friday, November 10, 2006
In Stem-Cell Transplants, Timing Is Everything
Source: National Public Radio
Date: November 10, 2006
Summary:
National Public radio reports on the recent discovery that mice with a condition similar to macular degeneration in humans had their sight restored with an injection of retinal stem cells.
Date: November 10, 2006
Summary:
National Public radio reports on the recent discovery that mice with a condition similar to macular degeneration in humans had their sight restored with an injection of retinal stem cells.
Cord stem cells turned into lung cells
Source: United Press International
Date: November 10, 2006
Summary:
Researchers at the University of Minnesota report that Umbilical cord blood stem cells have been altered into lung cells, which could enable the development of treatments for several lung diseases.
Commentary: Hopefully further research will produce effective treatments for lung diseases in humans.
Date: November 10, 2006
Summary:
Researchers at the University of Minnesota report that Umbilical cord blood stem cells have been altered into lung cells, which could enable the development of treatments for several lung diseases.
Commentary: Hopefully further research will produce effective treatments for lung diseases in humans.
In Young Rats, Researchers Find a Reaction to Spinal Cord Injury That Speeds Recovery
Source: Georgetown University Medical Center
Date: November 10, 2006
Summary:
Neuroscientists had long believed that the only way to repair a spinal cord injury was to grow new neural connections, but researchers at Georgetown University Medical Center have found that, especially in young rats, powerful cells near the injury site also work overtime to restrict nerve damage and restore movement and sensation. They say that now that they know such a mechanism exists, it may be possible one day to “switch” these cells on therapeutically and possibly help humans function better following serious spinal cord injuries. These new findings might also be relevant to multiple sclerosis, a disease caused by loss of an axon’s protective myelin sheath.
Date: November 10, 2006
Summary:
Neuroscientists had long believed that the only way to repair a spinal cord injury was to grow new neural connections, but researchers at Georgetown University Medical Center have found that, especially in young rats, powerful cells near the injury site also work overtime to restrict nerve damage and restore movement and sensation. They say that now that they know such a mechanism exists, it may be possible one day to “switch” these cells on therapeutically and possibly help humans function better following serious spinal cord injuries. These new findings might also be relevant to multiple sclerosis, a disease caused by loss of an axon’s protective myelin sheath.
Thursday, November 09, 2006
Heart attack patients to have stem cell treatment
Source: Pharmaceutical Business Review
Posted: November 9, 2006, 6:01 PM EST
Summary:
Heart attack patients are to have their own stem cells injected into their hearts within hours of a heart attack to see if the stem cells can limit damage that often leads to heart failure, in a pioneering trial to be held in the UK. A stem cell sample will be taken from the patient's bone marrow then the patient will receive the prepared cells into the blocked artery, to further limit the damage caused by the heart attack.
Posted: November 9, 2006, 6:01 PM EST
Summary:
Heart attack patients are to have their own stem cells injected into their hearts within hours of a heart attack to see if the stem cells can limit damage that often leads to heart failure, in a pioneering trial to be held in the UK. A stem cell sample will be taken from the patient's bone marrow then the patient will receive the prepared cells into the blocked artery, to further limit the damage caused by the heart attack.
Stem Cells May Lead to Cancer Vaccine: Tests on Mice Suggest Vaccine for Lung Cancer Might Be Possible, but Long Way Off
Source: WebMD
Posted: November 9, 2006
Summary:
Early lab tests on mice conducted by researchers at the Universty of Louisville have shown that embryonic stem cells could potentially be used to create a cancer vaccine. The embryonic stem cells were taken from mouse embryos to make two experimental vaccines against mouse lung cancer. One of the vaccines contained only embryonic stem cells. The other vaccine contained embryonic stem cells plus a growth factor to boost immune response. This strategy might eventually be able to innoculate humans who have a high risk for development of cancer.
Posted: November 9, 2006
Summary:
Early lab tests on mice conducted by researchers at the Universty of Louisville have shown that embryonic stem cells could potentially be used to create a cancer vaccine. The embryonic stem cells were taken from mouse embryos to make two experimental vaccines against mouse lung cancer. One of the vaccines contained only embryonic stem cells. The other vaccine contained embryonic stem cells plus a growth factor to boost immune response. This strategy might eventually be able to innoculate humans who have a high risk for development of cancer.
Growth of spinal nerves is improved: Could play a role in spinal cord repair
Source: Harvard University
Date: November 9, 2006
Summary:
Nerves that control the highest level of voluntary movements have been isolated and secrets of their growth revealed for the first time. The discovery has researchers talking about new ways to treat ALS, or Lou Gehrig's disease, and other paralyzing disorders, as well as regenerating spinal nerves that have been damaged by falls, crashes, and combat.
Date: November 9, 2006
Summary:
Nerves that control the highest level of voluntary movements have been isolated and secrets of their growth revealed for the first time. The discovery has researchers talking about new ways to treat ALS, or Lou Gehrig's disease, and other paralyzing disorders, as well as regenerating spinal nerves that have been damaged by falls, crashes, and combat.
Blind mice treated with stem cells regain sight: Scientists have taken big step towards helping humans
Source: The Times
Posted: November 9, 2006
Summary:
British scientists have enabledmake blind mice see by transplanting retinal cells into mice that were blind as a result of a genetic defect, the effects of which are very similar to the human disease retinitis pigmentosa. The breakthrough that could open the way to treating millions of people who lose their sight.
Posted: November 9, 2006
Summary:
British scientists have enabledmake blind mice see by transplanting retinal cells into mice that were blind as a result of a genetic defect, the effects of which are very similar to the human disease retinitis pigmentosa. The breakthrough that could open the way to treating millions of people who lose their sight.
Cell Transplants Restore Sight in Blind Mice
Source: Washington Post
Posted: November 9, 2006
Summary:
Scientists reported that blind mice regained some ability to see after getting transplants of cells taken from the eyes of other mice, strengthening the prospect that it may someday be possible to restore vision in some people who have lost most or all of their eyesight. They said the new study showed for the first time that light-detecting retina cells -- which in this case were taken from other animals but which scientists have begun to grow from human embryonic stem cells -- can orient themselves properly after being injected into a blind eye, connect to other nerve cells and communicate appropriately with visual centers in the brain.
Commentary: if further studies in animals are successful and the results can be safely and successfully replicated in humans, this discovery might eventually lead to treatments for eye diseases and disorders.
Posted: November 9, 2006
Summary:
Scientists reported that blind mice regained some ability to see after getting transplants of cells taken from the eyes of other mice, strengthening the prospect that it may someday be possible to restore vision in some people who have lost most or all of their eyesight. They said the new study showed for the first time that light-detecting retina cells -- which in this case were taken from other animals but which scientists have begun to grow from human embryonic stem cells -- can orient themselves properly after being injected into a blind eye, connect to other nerve cells and communicate appropriately with visual centers in the brain.
Commentary: if further studies in animals are successful and the results can be safely and successfully replicated in humans, this discovery might eventually lead to treatments for eye diseases and disorders.
Wednesday, November 08, 2006
Cells implanted in mice light path for restoring vision
Source: New York Times News Service
Posted: November 8, 2006 11:14 PM CST
Summary:
British researchers announced that they have restored vision in mice by implanting light-sensing cells that provide night vision, known as "rods," from a healthy mouse into blind ones. The procedure is a groundbreaking experiment that might eventually be able to restore sight to people with visual impairments. The researchers also believe a similar method could also be used to replace the cells that provide daytime color vision.
Posted: November 8, 2006 11:14 PM CST
Summary:
British researchers announced that they have restored vision in mice by implanting light-sensing cells that provide night vision, known as "rods," from a healthy mouse into blind ones. The procedure is a groundbreaking experiment that might eventually be able to restore sight to people with visual impairments. The researchers also believe a similar method could also be used to replace the cells that provide daytime color vision.
Treating Heart Attack Patients With Their Own Stem Cells
Source: Medical News Today
Posted: 08 Nov 2006 - 10:00am (PST)
Summary:
British scientists are conducting a trial to determine whether a heart attack patient's own bone marrow stem cells can be injected back into him/her to repair the damaged heart muscle. The stem cells would be injected into the patient within five hours of the heart attack. Researchers believe the experiment will avoid ethical controversy commonly associated with embryonic stem cell research and the chances of immune rejection will be minimized since the patient's own cells will be used in the trial.
Commentary: Successful results from this trial could lead to further human trials of this procedure and possibly an eventual stem cell treatment for heart attack.
Posted: 08 Nov 2006 - 10:00am (PST)
Summary:
British scientists are conducting a trial to determine whether a heart attack patient's own bone marrow stem cells can be injected back into him/her to repair the damaged heart muscle. The stem cells would be injected into the patient within five hours of the heart attack. Researchers believe the experiment will avoid ethical controversy commonly associated with embryonic stem cell research and the chances of immune rejection will be minimized since the patient's own cells will be used in the trial.
Commentary: Successful results from this trial could lead to further human trials of this procedure and possibly an eventual stem cell treatment for heart attack.
'Stunning' breakthrough in search for blindness cure
Source: Manchester Evening News - Manchester, UK
Posted: November 8, 2006
Summary:
British researchers restored sight to blind mice by implanting immature "precursor" cells into their eyes. The cells then developed into fully functioning, cells specialized to sense or receive light called photoreceptors. The researchers are calling the study a "stunning" breakthrough that could lead to the same result in humans.
Posted: November 8, 2006
Summary:
British researchers restored sight to blind mice by implanting immature "precursor" cells into their eyes. The cells then developed into fully functioning, cells specialized to sense or receive light called photoreceptors. The researchers are calling the study a "stunning" breakthrough that could lead to the same result in humans.
Blind mice could help humans regain sight
Source: The Times
Posted: November 08, 2006
Summary:
British scientists have enabled blind mice to see, successfully transplanted retinal cells into mice that were blind as a result of a genetic defect, the effects of which are very similar to the human disease retinitis pigmentosa. The treated mice regained some vision, and scientists showed that the transplanted cells integrated into the retina and formed new photoreceptors, the cells that are sensitive to light. The finding could lead to treatments for millions of people who lose their sight.
Posted: November 08, 2006
Summary:
British scientists have enabled blind mice to see, successfully transplanted retinal cells into mice that were blind as a result of a genetic defect, the effects of which are very similar to the human disease retinitis pigmentosa. The treated mice regained some vision, and scientists showed that the transplanted cells integrated into the retina and formed new photoreceptors, the cells that are sensitive to light. The finding could lead to treatments for millions of people who lose their sight.
Transplanted photoreceptor precursor cells restore visual function in mice with retinal degeneration: U-M & London team says technique has implication
Source: University of Michigan Health System
Date: November 8, 2006
Summary:
Scientists have successfully transplanted light-sensing cells called photoreceptors directly into the eyes of mice and restored their visual function. The achievement is based on a new technology in which the cells are introduced at a particular stage in their development. The team of scientists found that transplanted photoreceptor precursor cells survived and became integrated into the mouse retina--and that the technique succeeded because the cells were isolated when they had reached a certain level of maturity. The technology represents a breakthrough in transplantation-based therapies for neuro-degenerative diseases. It suggests that scientists may need to introduce changes in stem cells in order for them to become highly specialized neurons.
Commentary: Maybe this finding will provide scientists with a basis to eventually develop specialize neurons to treat eye diseases and disorders as well as other neurological disorders and conditions.
Date: November 8, 2006
Summary:
Scientists have successfully transplanted light-sensing cells called photoreceptors directly into the eyes of mice and restored their visual function. The achievement is based on a new technology in which the cells are introduced at a particular stage in their development. The team of scientists found that transplanted photoreceptor precursor cells survived and became integrated into the mouse retina--and that the technique succeeded because the cells were isolated when they had reached a certain level of maturity. The technology represents a breakthrough in transplantation-based therapies for neuro-degenerative diseases. It suggests that scientists may need to introduce changes in stem cells in order for them to become highly specialized neurons.
Commentary: Maybe this finding will provide scientists with a basis to eventually develop specialize neurons to treat eye diseases and disorders as well as other neurological disorders and conditions.
Retinal Transplant Restores Vision in Mice: Transplanting stem cells into retinas replaces light-sensitive photoreceptors that have been lost to eye d
Source: MIT Technology Review
Posted: November 08, 2006
Summary:
British scientists have successfully transplanted the first retinal cells into the eyes of mice, marking the first time that vision has been restored by transplanting light-sensitive photoreceptor cells. Previous efforts to do this have failed. According to the experiment's lead scientist, using stem cells that had stopped dividing and were beginning to actually turn into photoreceptors just before transplanting them into the host enabled the transplant to succeed. Other scientists are heralding the the experiment a signifcant advance toward eventually treating humans with visual diseases and impairments. However, some scientists caution that photoreceptor cells must be replaced in order to potentially treat people with these conditions.
Commentary: This advance could enable to further experiments transplanting light-sensitive photoreceptor cells in larger animals, which could eventually lead to experiments in humans.
Posted: November 08, 2006
Summary:
British scientists have successfully transplanted the first retinal cells into the eyes of mice, marking the first time that vision has been restored by transplanting light-sensitive photoreceptor cells. Previous efforts to do this have failed. According to the experiment's lead scientist, using stem cells that had stopped dividing and were beginning to actually turn into photoreceptors just before transplanting them into the host enabled the transplant to succeed. Other scientists are heralding the the experiment a signifcant advance toward eventually treating humans with visual diseases and impairments. However, some scientists caution that photoreceptor cells must be replaced in order to potentially treat people with these conditions.
Commentary: This advance could enable to further experiments transplanting light-sensitive photoreceptor cells in larger animals, which could eventually lead to experiments in humans.
Blindness cure breakthrough
Source: Press Association
Posted: November 8, 2006
Summary:
Scientists are contemplating the real possibility of curing blindness after demonstrating that destroyed retinas can be rebuilt. In a breakthrough described by one expert as "stunning", British researchers restored sight to blind mice. Although much more work needs to be done, they believe the same goal could one day be achieved in human patients.
Commentary: It will be important for these results to be safely and effectively replicated and in a large and diverse patient population monitored over a long period of time.
Posted: November 8, 2006
Summary:
Scientists are contemplating the real possibility of curing blindness after demonstrating that destroyed retinas can be rebuilt. In a breakthrough described by one expert as "stunning", British researchers restored sight to blind mice. Although much more work needs to be done, they believe the same goal could one day be achieved in human patients.
Commentary: It will be important for these results to be safely and effectively replicated and in a large and diverse patient population monitored over a long period of time.
Blind mice see again after cell transplants: Research could lead to new treatments of human eye diseases
Source: Reuters
Posted: 6:51 a.m. AKT Nov 8, 2006
Summary:
British and American scientists have restored vision in blind mice by transplanting light-sensitive cells into their eyes in a breakthrough that could lead to new treatments of human eye diseases. But instead of using stem cells, which could form into any cell type, the scientists transplanted cells that had reached a later stage of development towards becoming photoreceptor cells.
Posted: 6:51 a.m. AKT Nov 8, 2006
Summary:
British and American scientists have restored vision in blind mice by transplanting light-sensitive cells into their eyes in a breakthrough that could lead to new treatments of human eye diseases. But instead of using stem cells, which could form into any cell type, the scientists transplanted cells that had reached a later stage of development towards becoming photoreceptor cells.
Retinal transplants may help restore sight
Source: United Press International
Date: November 8, 2006
Summary:
British scientists have discovered non-dividing retinal cells implanted into adult mouse retina can generate new photoreceptors. The results, say the researchers, suggest precursor cells grown from human adult or embryonic stem cells might also serve to restore sight, and challenge the assumption that stem cells offer the best prospect for tissue repair.
Commentary: Maybe this finding will eventually lead to stem cell treatments for eye diseases and disorders in humans that avoid the ethical controversy that has been associated with embryonic stem cells.
Date: November 8, 2006
Summary:
British scientists have discovered non-dividing retinal cells implanted into adult mouse retina can generate new photoreceptors. The results, say the researchers, suggest precursor cells grown from human adult or embryonic stem cells might also serve to restore sight, and challenge the assumption that stem cells offer the best prospect for tissue repair.
Commentary: Maybe this finding will eventually lead to stem cell treatments for eye diseases and disorders in humans that avoid the ethical controversy that has been associated with embryonic stem cells.
Insulin Stem Cells Hold Hope for Diabetes Treatment: In study with mice, they also repaired damage to kidneys
Source: HealthDay News
Date: November 7, 2006
Summary:
Stem cells might one day pack a one-two punch when it comes to treating people with diabetes. In a new study conducted with diabetic mice, human stem cells not only repaired insulin-producing cells in the rodents, they also fixed cells in damaged kidneys.
Date: November 7, 2006
Summary:
Stem cells might one day pack a one-two punch when it comes to treating people with diabetes. In a new study conducted with diabetic mice, human stem cells not only repaired insulin-producing cells in the rodents, they also fixed cells in damaged kidneys.
Stem cells help mice make insulin
Source: Bloomberg News
Posted: November 7, 2006
Summary:
Stem cells from adult human bone helped mice with diabetes make insulin, suggesting new treatments for the disease.
Commentary: It will be important to make sure these results can be successfully replicated in humans with diabetes and that the patients be monitored over a prolonged period of time in order to ensure that any treatments are both safe and effective.
Posted: November 7, 2006
Summary:
Stem cells from adult human bone helped mice with diabetes make insulin, suggesting new treatments for the disease.
Commentary: It will be important to make sure these results can be successfully replicated in humans with diabetes and that the patients be monitored over a prolonged period of time in order to ensure that any treatments are both safe and effective.
Adult Stem Cells May Treat Diabetes: In Lab Tests, Human Adult Stem Cells Increased Insulin in Mice With High Blood Sugar
Source: WebMD Medical News
Posted: November 8, 2006
Summary;
Studies on diabetic mice revealed that adult stem cells from human bone marrow may help treat type 2 diabetes. The researchers studied male mice with high blood sugar like that in type 2 diabetes. Half the mice received two injections of adult stem cells taken from human bone marrow. With their defective immune systems, the mice didn't reject the human cells.
For comparison, the other mice didn't get any injections. Over the next month or so, mice treated with stem cells made more insulin, a hormone that controls blood sugar. Stem cells turned up in the mice's pancreas, which makes insulin. The stem-cell treated mice also had less kidney damage than mice in the comparison group, the study shows. Diabetes can also cause kidney damage. Stem cells showed up in the mice's kidneys as well; the injected cells may have helped repair damage, the researchers say. From these results, researchers believe that stem cells could increase insulin production and repair or regenerate damaged or destroyed tissue in people with diabetes.
Commentary: If this fiding can be successfully replicated in a large and heterogenous patient population, it could lead to an effective treatment for adult-onset-or type 2-diabetes.
Posted: November 8, 2006
Summary;
Studies on diabetic mice revealed that adult stem cells from human bone marrow may help treat type 2 diabetes. The researchers studied male mice with high blood sugar like that in type 2 diabetes. Half the mice received two injections of adult stem cells taken from human bone marrow. With their defective immune systems, the mice didn't reject the human cells.
For comparison, the other mice didn't get any injections. Over the next month or so, mice treated with stem cells made more insulin, a hormone that controls blood sugar. Stem cells turned up in the mice's pancreas, which makes insulin. The stem-cell treated mice also had less kidney damage than mice in the comparison group, the study shows. Diabetes can also cause kidney damage. Stem cells showed up in the mice's kidneys as well; the injected cells may have helped repair damage, the researchers say. From these results, researchers believe that stem cells could increase insulin production and repair or regenerate damaged or destroyed tissue in people with diabetes.
Commentary: If this fiding can be successfully replicated in a large and heterogenous patient population, it could lead to an effective treatment for adult-onset-or type 2-diabetes.
Blind Mice See Again After Retinal Stem Cell Transplant
Source: Medical News Today
Posted: November 8, 2006 - 11:00am (PST)
Summary:
British scientists reported that blind mice regained their vision by observing that their pupils contracted when exposed to light after undergoing retinal stem cell transplants. The researchers believe this study could eventually lead to sight restoration for humans blinded by diabetes or age-related macular degeneration.
Posted: November 8, 2006 - 11:00am (PST)
Summary:
British scientists reported that blind mice regained their vision by observing that their pupils contracted when exposed to light after undergoing retinal stem cell transplants. The researchers believe this study could eventually lead to sight restoration for humans blinded by diabetes or age-related macular degeneration.
Researchers Map Protein Network that Regulates "Stemness"
Source: Howard Hughes Medical Institute
Date: November 8, 2006
Summary:
Howard Hughes Medical Institute (HHMI) researchers have developed a map that charts the largely unexplored proteins that regulate a stem cell's ability to differentiate into multiple types of mature cells. Researchers believe that Understanding this protein network in greater detail could help stem cell biologists to coax mature cells to revert to an embryonic state. Reprogramming adult cells in this way could provide an alternative source of stem cells to use in regenerating tissues damaged by disease or trauma, instead of using embryonic cells.
Date: November 8, 2006
Summary:
Howard Hughes Medical Institute (HHMI) researchers have developed a map that charts the largely unexplored proteins that regulate a stem cell's ability to differentiate into multiple types of mature cells. Researchers believe that Understanding this protein network in greater detail could help stem cell biologists to coax mature cells to revert to an embryonic state. Reprogramming adult cells in this way could provide an alternative source of stem cells to use in regenerating tissues damaged by disease or trauma, instead of using embryonic cells.
Retina Stem Cells May Restore Sight: Stem Cells Harvested in Later Stage of Development Restored Vision in Mice
Source: WebMD
Posted: November 8, 2006
Summary:
In a new study, retina stem cells harvested at a particular stage of development successfully restored visual function in mice affected by a common cause of blindness also found in humans, known as photoreceptor loss.
Posted: November 8, 2006
Summary:
In a new study, retina stem cells harvested at a particular stage of development successfully restored visual function in mice affected by a common cause of blindness also found in humans, known as photoreceptor loss.
Cell transplant may restore lost sight
Source: NewScientist.com news service
Posted: 08 November 2006
Summary:
British researchers have restored sight in blind mice by transplanting precursor retinal cells into their damaged eyes. When transplanted into the eyes of blind mice, the retinal precursor cells differentiated into rod cells and grew to make the short neural connections required to restore sight. The new procedure could eventually lead to a cure for age-related macular degeneration or blindness due to diabetes.
Commentary: Hopefully this research will be successfully replicated in humans and eventually lead to effective treatment for blindness and eye diseases.
Posted: 08 November 2006
Summary:
British researchers have restored sight in blind mice by transplanting precursor retinal cells into their damaged eyes. When transplanted into the eyes of blind mice, the retinal precursor cells differentiated into rod cells and grew to make the short neural connections required to restore sight. The new procedure could eventually lead to a cure for age-related macular degeneration or blindness due to diabetes.
Commentary: Hopefully this research will be successfully replicated in humans and eventually lead to effective treatment for blindness and eye diseases.
Vaccination with embryonic stem cells prevents lung cancer in mice
Source: European Organisation for Research and Treatment of Cancer
Date: November 8, 2006
Summary:
Researchers have discovered that vaccinating mice with embryonic stem cells prevented lung cancer in those animals that had had cancer cells transplanted into them after the vaccination or that had been exposed to cancer-causing chemicals. The findings suggest that it could be possible to develop embryonic stem cell vaccines that prevent cancers in humans, such as hereditary breast and colon cancer and lung cancer caused by smoking or other environmental factors.
Commentary: Maybe further studies in larger animals will enable human studies using embryonic stem cells. However, it will be important for any results in humans to be replicated in a large and heterogenous patient population to ensure that treatments are both safe and effective.
Date: November 8, 2006
Summary:
Researchers have discovered that vaccinating mice with embryonic stem cells prevented lung cancer in those animals that had had cancer cells transplanted into them after the vaccination or that had been exposed to cancer-causing chemicals. The findings suggest that it could be possible to develop embryonic stem cell vaccines that prevent cancers in humans, such as hereditary breast and colon cancer and lung cancer caused by smoking or other environmental factors.
Commentary: Maybe further studies in larger animals will enable human studies using embryonic stem cells. However, it will be important for any results in humans to be replicated in a large and heterogenous patient population to ensure that treatments are both safe and effective.
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