Source: Cell Press
Date: May 31, 2007
Summary:
Cell Press reports on a new discovery of stem cells that promote muscle growth:
"A new report confirms the existence of some apparently uncommitted stem cells amongst cells responsible for generating the bulging biceps of body builders and the rippling abs of fitness buffs. The findings could lead to new muscle-regenerating therapies--including cell transplantation regimens and stem cell-replenishing drugs--for people with various muscle-wasting diseases, including muscular dystrophies. Ultimately, such treatments might also help keep people strong as they age, according to the researchers."
Thursday, May 31, 2007
Stem cells help paralyzed rats walk
Source: United Press International
Posted: May 31, 2007 5:34 PM EDT
Summary:
Human stem cell transplants appear to help paralyzed rats regain their mobility, U.S. doctors said this week. Scientists at the University of California, San Diego, reporting in the online journal Neuroscience, suggested that the animal experiments might some day help humans overcome paralysis.
Posted: May 31, 2007 5:34 PM EDT
Summary:
Human stem cell transplants appear to help paralyzed rats regain their mobility, U.S. doctors said this week. Scientists at the University of California, San Diego, reporting in the online journal Neuroscience, suggested that the animal experiments might some day help humans overcome paralysis.
Newfound Muscle Stem Cells May Lead to Regenerative Therapies
Source: Scientific American
Date: May 31, 2007
Summary:
Scientific American reports on the discovery of a new type of satellite stem cell that could eventually be turned into a muscle cell and be used to treat muscle and other neurodegenerative diseases:
"Canadian researchers have identified a previously unknown type of stem cell in muscles that may one day be targeted to treat muscular dystrophy, a debilitating degenerative disease that affects some 250,000 Americans."
Date: May 31, 2007
Summary:
Scientific American reports on the discovery of a new type of satellite stem cell that could eventually be turned into a muscle cell and be used to treat muscle and other neurodegenerative diseases:
"Canadian researchers have identified a previously unknown type of stem cell in muscles that may one day be targeted to treat muscular dystrophy, a debilitating degenerative disease that affects some 250,000 Americans."
COMMON CANCER GENE SENDS DEATH ORDER TO TINY KILLER
Source: Johns Hopkins Medical Institutions
Date: May 31, 2007
Summary:
Scientists at Johns Hopkins have discovered one way the p53 gene does what it's known for—stopping the colon cancer cells. Their report will be published in the June 8 issue of Molecular Cell.
Date: May 31, 2007
Summary:
Scientists at Johns Hopkins have discovered one way the p53 gene does what it's known for—stopping the colon cancer cells. Their report will be published in the June 8 issue of Molecular Cell.
Human stem cell treatment restores motor function in paralyzed rats
Source: University of California - San Diego
Date: May 31, 2007
Summary:
Rats paralyzed due to loss of blood flow to the spine returned to near normal ambulatory function six weeks after receiving grafts of human spinal stem cells (hSSCs), researchers from the University of California, San Diego (UCSD) School of Medicine report. The study, led by Martin Marsala, M.D., UC San Diego professor of anesthesiology, is published in the June 29, 2007 issue of the journal Neuroscience, which is now online.
Date: May 31, 2007
Summary:
Rats paralyzed due to loss of blood flow to the spine returned to near normal ambulatory function six weeks after receiving grafts of human spinal stem cells (hSSCs), researchers from the University of California, San Diego (UCSD) School of Medicine report. The study, led by Martin Marsala, M.D., UC San Diego professor of anesthesiology, is published in the June 29, 2007 issue of the journal Neuroscience, which is now online.
Wednesday, May 30, 2007
Italian doctor builds new, more natural vagina
Source: Reuters
Posted: May 30, 2007 2:03PM EDT
Summary:
An Italian doctor has reconstructed vaginas for two women born with a rare congenital deformation, using their own cells to build vaginal tissue in the lab for the first time.
Posted: May 30, 2007 2:03PM EDT
Summary:
An Italian doctor has reconstructed vaginas for two women born with a rare congenital deformation, using their own cells to build vaginal tissue in the lab for the first time.
Neuralstem's cells reverse paralysis
Source: United Press International
Posted: May 30, 2007 11:10 AM EDT
Summary:
U.S. firm Neuralstem said Wednesday its human spinal stem cells reversed paralysis in a rat model of a spinal disorder.
Posted: May 30, 2007 11:10 AM EDT
Summary:
U.S. firm Neuralstem said Wednesday its human spinal stem cells reversed paralysis in a rat model of a spinal disorder.
Neuralstem reports spinal cord damage results
Source: Washington Business Journal
Posted: May 30, 2007 8:44 AM EDT
Summary:
Neuralstem, Inc. announced that stem cells given to rats with spinal cord injuries restored mobility. In a study published in the online journal Neuroscience, The company reported that three rats paralyzed by a specific spinal cord injury returned to near normal ambulatory function six weeks after having stems cells grafted to their spinal cords. Three others showed significant improvement after two months.
Posted: May 30, 2007 8:44 AM EDT
Summary:
Neuralstem, Inc. announced that stem cells given to rats with spinal cord injuries restored mobility. In a study published in the online journal Neuroscience, The company reported that three rats paralyzed by a specific spinal cord injury returned to near normal ambulatory function six weeks after having stems cells grafted to their spinal cords. Three others showed significant improvement after two months.
Neuralstem's Cells Restore Motor Function in Spinal Ischemia-Paralyzed Rats
Source: Neuralstem, Inc.
Date: May 30, 2007
Summary:
Neuralstem, Inc. reported results of a study conducted at the University of California at San Diego in which rats with spinal cord injuries regained function after receiving embryonic stem cells:
"Three rats paralyzed due to spinal ischemia returned to near normal ambulatory function six weeks after having received
human spinal stem cells (hSSCs) developed by Neuralstem, Inc. researchers reported online in the journal Neuroscience. Three other rats, while not able to stand up two months after treatment, showed significant improvement in the mobility of all three lower extremity joints and increased muscle tone. In all the grafted animals, the majority of transplanted hSSCs cells survived and became mature neurons."
Date: May 30, 2007
Summary:
Neuralstem, Inc. reported results of a study conducted at the University of California at San Diego in which rats with spinal cord injuries regained function after receiving embryonic stem cells:
"Three rats paralyzed due to spinal ischemia returned to near normal ambulatory function six weeks after having received
human spinal stem cells (hSSCs) developed by Neuralstem, Inc. researchers reported online in the journal Neuroscience. Three other rats, while not able to stand up two months after treatment, showed significant improvement in the mobility of all three lower extremity joints and increased muscle tone. In all the grafted animals, the majority of transplanted hSSCs cells survived and became mature neurons."
Tuesday, May 29, 2007
Do these world-first images hold key to cancer cure?
Source: Scotsman - Edinburgh, Scotland, UK
Date: 29 May 2007
Summary:
The Scotsman reports on a new breakthrough in imaging techniques that may lead to the early detection of cancer and other diseases:
"A BREAKTHROUGH in imaging techniques could enable scientists to watch the moment that cancer first strikes, holding out the prospect of radical new treatments. In a world first, researchers at Dundee University managed to film healthy, live cells within an embryo dividing and redividing after developing a new way of using a powerful microscope."
Date: 29 May 2007
Summary:
The Scotsman reports on a new breakthrough in imaging techniques that may lead to the early detection of cancer and other diseases:
"A BREAKTHROUGH in imaging techniques could enable scientists to watch the moment that cancer first strikes, holding out the prospect of radical new treatments. In a world first, researchers at Dundee University managed to film healthy, live cells within an embryo dividing and redividing after developing a new way of using a powerful microscope."
New beta cells without stem cells?
Source: Scientist - UK
Published 29th May 2007 02:58 PM GMT
Summary:
Scientist reports on a new finding that adult stem cells may be able to treat diabetes:
"Adult non-progenitor cells maintain the population of insulin-secreting beta cells, according to two papers published this month. The findings, produced by two independent groups led by Doug Melton at Harvard University and Jake Kushner at the University of Pennsylvania School of Medicine, contradict a popular hypothesis that beta cell regeneration relies on specialized progenitor cells."
Published 29th May 2007 02:58 PM GMT
Summary:
Scientist reports on a new finding that adult stem cells may be able to treat diabetes:
"Adult non-progenitor cells maintain the population of insulin-secreting beta cells, according to two papers published this month. The findings, produced by two independent groups led by Doug Melton at Harvard University and Jake Kushner at the University of Pennsylvania School of Medicine, contradict a popular hypothesis that beta cell regeneration relies on specialized progenitor cells."
Monday, May 28, 2007
Kobe Team Succeeds In Mass Cultivation Of Stem Cells
Source: The Daily Yomiuri
Updated: 2007-05-28 15:55:19 MYT
Summary:
The Daily Yomiuri reports that a research team in Kobe, Japan has created an efficient method to mass produce human embryonic stem cells:
"A research team from the Kobe-based Center for Developmental Biology, affiliated with the Institute of Physical and Chemical Science (Riken) has succeeded in an efficient, mass cultivation of human embryonic stem cells, a Web version of the scientific journal, Nature Biotechnology, announced Sunday. The research team, headed by Yoshiki Sasai and others, also successfully developed the increased embryonic stem cells into brain cells. Experts believe that the new finding will contribute to the actual use of human stem cells for the treatment of strokes and incurable diseases related to the nervous system."
Updated: 2007-05-28 15:55:19 MYT
Summary:
The Daily Yomiuri reports that a research team in Kobe, Japan has created an efficient method to mass produce human embryonic stem cells:
"A research team from the Kobe-based Center for Developmental Biology, affiliated with the Institute of Physical and Chemical Science (Riken) has succeeded in an efficient, mass cultivation of human embryonic stem cells, a Web version of the scientific journal, Nature Biotechnology, announced Sunday. The research team, headed by Yoshiki Sasai and others, also successfully developed the increased embryonic stem cells into brain cells. Experts believe that the new finding will contribute to the actual use of human stem cells for the treatment of strokes and incurable diseases related to the nervous system."
Sunday, May 27, 2007
Human stem cell breakthrough brings hope for diabetes cure
Source: Sydney Morning Herald - Sydney, Australia
Date: May 27, 2007
Summary:
The Sydney Morning Herald reports on a new experiment in which embryonic stem cells were transformed into insulin-producing cells, paving the way for potential new treatments for diabetes:
"HUMAN embryonic stem cells can be transformed into pancreatic cells that produce insulin, offering the potential to cure diabetes, researchers say. The finding, published in the journal Stem Cells, has been hailed as a significant step forward in the quest to improve the lives of millions of the world's insulin-dependent diabetics, especially children."
Date: May 27, 2007
Summary:
The Sydney Morning Herald reports on a new experiment in which embryonic stem cells were transformed into insulin-producing cells, paving the way for potential new treatments for diabetes:
"HUMAN embryonic stem cells can be transformed into pancreatic cells that produce insulin, offering the potential to cure diabetes, researchers say. The finding, published in the journal Stem Cells, has been hailed as a significant step forward in the quest to improve the lives of millions of the world's insulin-dependent diabetics, especially children."
Friday, May 25, 2007
Researchers engineer stem cells to make insulin
Source: Reuters
Posted: May 25, 2007 1:40 p.m. PT
Summary:
Reuters reports on a new stem cell research study in which stem cells taken from umbilical cords were made to produce insulin to potentially treat diabetes:
"Stem cells taken from the umbilical cords of newborns can be engineered to produce insulin and may someday be used to treat diabetes, U.S. and British researchers reported. They said they were able to first grow large numbers of the stem cells and then direct them to resemble the insulin-producing cells of the pancreas that are damaged in diabetes."
Posted: May 25, 2007 1:40 p.m. PT
Summary:
Reuters reports on a new stem cell research study in which stem cells taken from umbilical cords were made to produce insulin to potentially treat diabetes:
"Stem cells taken from the umbilical cords of newborns can be engineered to produce insulin and may someday be used to treat diabetes, U.S. and British researchers reported. They said they were able to first grow large numbers of the stem cells and then direct them to resemble the insulin-producing cells of the pancreas that are damaged in diabetes."
Adult stem cells from human cord umbilical cord blood successfully engineered to make insulin
Source: University of Texas Medical Branch at Galveston
Date: May 25, 2007
Summary:
In a fundamental discovery that someday may help cure type 1 diabetes by allowing people to grow their own insulin-producing cells for a damaged or defective pancreas, medical researchers have reported that they have engineered adult stem cells derived from human umbilical cord blood to produce insulin.
Date: May 25, 2007
Summary:
In a fundamental discovery that someday may help cure type 1 diabetes by allowing people to grow their own insulin-producing cells for a damaged or defective pancreas, medical researchers have reported that they have engineered adult stem cells derived from human umbilical cord blood to produce insulin.
Thursday, May 24, 2007
Researchers probe bones' tiny building blocks
Source: Massachusetts Institute of Technology
Date: May 24, 2007
Summary:
In work that could lead to more effective diagnoses and treatments of bone diseases using only a pinhead-sized sample of a patient's bone, MIT researchers report a first-of-its-kind analysis of bone's mechanical properties.
Date: May 24, 2007
Summary:
In work that could lead to more effective diagnoses and treatments of bone diseases using only a pinhead-sized sample of a patient's bone, MIT researchers report a first-of-its-kind analysis of bone's mechanical properties.
Magnets may make the brain grow stronger
Source: New Scientist
Date: 24 May 2007
Summary:
Researchers at at the City University of New York have discovered that stimulating the brains of mice with a magnetic coil, a procedure known as Transcranial magnetic stimulation (TMS), appears to promote the growth of new neurons in areas associated with learning and memory. If the effect is confirmed in humans, it might open up new ways of treating age-related memory decline and diseases like Alzheimer's.
Date: 24 May 2007
Summary:
Researchers at at the City University of New York have discovered that stimulating the brains of mice with a magnetic coil, a procedure known as Transcranial magnetic stimulation (TMS), appears to promote the growth of new neurons in areas associated with learning and memory. If the effect is confirmed in humans, it might open up new ways of treating age-related memory decline and diseases like Alzheimer's.
Magnetic field found to stimulate brain cells
Source: Guardian Unlimited - UK
Date: May 24, 2007
Summary:
The Guardian reports on new research using a magnetic field to stimulate the brain to grow new nerve cells, a finding that could lead to new treatments for neurodegenerative diseases:
"A magnetic field can stimulate the brain and promote the growth of new nerve cells, scientists have found, raising the possibility of treating conditions linked to neuron death such as Alzheimer's disease, and perhaps one day of enhancing humans' memory capacity."
Date: May 24, 2007
Summary:
The Guardian reports on new research using a magnetic field to stimulate the brain to grow new nerve cells, a finding that could lead to new treatments for neurodegenerative diseases:
"A magnetic field can stimulate the brain and promote the growth of new nerve cells, scientists have found, raising the possibility of treating conditions linked to neuron death such as Alzheimer's disease, and perhaps one day of enhancing humans' memory capacity."
Wednesday, May 23, 2007
New Neurons in Old Brains Exhibit Babylike Plasticity
Source: Scientific American
Date: May 23, 2007
Summary:
Scientific American reports on new observations about the capabilities and functions of new nerve cells in adult brains:
"Researchers have identified a "critical period" during which new nerve cells in adult brains have the same capacity to learn as those in developing brains. The finding in mice, reported in this week's Neuron, provides the promise of therapies that may one day limit or perhaps even reverse the damage of neurodegenerative diseases such as multiple sclerosis and Parkinson's."
Date: May 23, 2007
Summary:
Scientific American reports on new observations about the capabilities and functions of new nerve cells in adult brains:
"Researchers have identified a "critical period" during which new nerve cells in adult brains have the same capacity to learn as those in developing brains. The finding in mice, reported in this week's Neuron, provides the promise of therapies that may one day limit or perhaps even reverse the damage of neurodegenerative diseases such as multiple sclerosis and Parkinson's."
Adult Brain Cells Rediscover Their Inner Child
Source: Johns Hopkins Medical Institutions
Date: May 23, 2007
Summary:
You may not be able to relive your youth, but part of your brain can. Johns Hopkins researchers have found that newly made nerves in an adult brain's learning center experience a one-month period when they are just as active as the nerves in a developing child. The study, appearing this week in Neuron, suggests that new adult nerves have a deeper role than simply replacing dead ones.
Date: May 23, 2007
Summary:
You may not be able to relive your youth, but part of your brain can. Johns Hopkins researchers have found that newly made nerves in an adult brain's learning center experience a one-month period when they are just as active as the nerves in a developing child. The study, appearing this week in Neuron, suggests that new adult nerves have a deeper role than simply replacing dead ones.
Stem Cells May Look Malignant, Not Act It
Source: University of Florida
Date: May 23, 2007
Summary:
Call it the cellular equivalent of big glasses, a funny nose and a fake mustache. Bone marrow stem cells attracted to the site of a cancerous growth frequently take on the outward appearance of the malignant cells around them, University of Florida researchers report in a paper to be published in the August issue of Stem Cells.
But whether that enables them to fuel cancer’s ability to develop and then spread, as some scientists suspect, is not entirely clear. The findings, available early in this month’s online edition of the journal, actually contest the increasingly popular theory that bone marrow stem cells seed cancer. Instead, these cells might simply look like cancer, not act like it.
Date: May 23, 2007
Summary:
Call it the cellular equivalent of big glasses, a funny nose and a fake mustache. Bone marrow stem cells attracted to the site of a cancerous growth frequently take on the outward appearance of the malignant cells around them, University of Florida researchers report in a paper to be published in the August issue of Stem Cells.
But whether that enables them to fuel cancer’s ability to develop and then spread, as some scientists suspect, is not entirely clear. The findings, available early in this month’s online edition of the journal, actually contest the increasingly popular theory that bone marrow stem cells seed cancer. Instead, these cells might simply look like cancer, not act like it.
Developments In Tissue Engineering Offer New Sources For Stem Cell Treatments
Source: American Urological Association
Posted: 23 May 2007 - 14:00 PDT
Summary:
Tissue engineering and regenerative medicine offer future patients greater options for treatment and cure of a wide array of urologic conditions, and controversies surrounding the sources of stem cells as well as their use have fueled increased research. Developers from around the world are researching new sources and applications of stem cells.
Posted: 23 May 2007 - 14:00 PDT
Summary:
Tissue engineering and regenerative medicine offer future patients greater options for treatment and cure of a wide array of urologic conditions, and controversies surrounding the sources of stem cells as well as their use have fueled increased research. Developers from around the world are researching new sources and applications of stem cells.
Tuesday, May 22, 2007
Immune Antibodies Penetrate Neurons to Clear Alzheimer's-Linked Amyloid
Source: Weill Cornell Medical College
Date: May 22, 2007
Summary:
Researchers at Weill Cornell Medical College have gotten much closer to understanding how immune-based therapies can treat Alzheimer's disease — by studying how antibodies go inside brain cells to reduce levels of Alzheimer's-linked amyloid peptides that form plaques between neurons.
Date: May 22, 2007
Summary:
Researchers at Weill Cornell Medical College have gotten much closer to understanding how immune-based therapies can treat Alzheimer's disease — by studying how antibodies go inside brain cells to reduce levels of Alzheimer's-linked amyloid peptides that form plaques between neurons.
Stem cells provide clues to cancer spread
Source: University of Manchester
Date: 22 May 2007
Summary:
Scientists at the University of Manchester have made an important discovery in understanding how cancers spread in what could lead to new ways of beating the disease. The study used embryonic stem (ES) cells to investigate how some tumours are able to migrate to other parts of the body, which makes the treatment of cancer much more difficult. The scientists discovered that ES cells lose the proteins that cells use to bind to each other and have other protein alterations that are characteristic of spreading cancer cells. The scientists believe the finding could provide new insights into how cancer spreads, and lead to new strategies to stop it from spreading.
Date: 22 May 2007
Summary:
Scientists at the University of Manchester have made an important discovery in understanding how cancers spread in what could lead to new ways of beating the disease. The study used embryonic stem (ES) cells to investigate how some tumours are able to migrate to other parts of the body, which makes the treatment of cancer much more difficult. The scientists discovered that ES cells lose the proteins that cells use to bind to each other and have other protein alterations that are characteristic of spreading cancer cells. The scientists believe the finding could provide new insights into how cancer spreads, and lead to new strategies to stop it from spreading.
Monday, May 21, 2007
Stem cell research throws lifeline to heart patients
Source: Australian Broadcasting Corporation
Posted: May 22, 2007. 9:00am (AEST)
Summary:
The Australian Broadcasting Corporation reports on new research using Adult bone marrow stem cells to treat heart disease:
"Scientists say stem cells could be used to make heart muscle from a person's own tissue. Stem cells have been discovered within the heart and scientists say they might be able to use hormones to stimulate them to produce new heart tissue."
Posted: May 22, 2007. 9:00am (AEST)
Summary:
The Australian Broadcasting Corporation reports on new research using Adult bone marrow stem cells to treat heart disease:
"Scientists say stem cells could be used to make heart muscle from a person's own tissue. Stem cells have been discovered within the heart and scientists say they might be able to use hormones to stimulate them to produce new heart tissue."
Stem Cells May Help Treat Incontinence
Source: WebMD
Date: May 21, 2007
Summary:
For the more than 13 million women in the U.S. who suffer from stress urinary incontinence, stem cells derived from their own muscle cells may improve the condition, a study shows. At the same meeting, other researchers reported their efforts in obtaining stem cells from the body's fat tissue, from urine, and from human cord blood to treat urinary problems.
Date: May 21, 2007
Summary:
For the more than 13 million women in the U.S. who suffer from stress urinary incontinence, stem cells derived from their own muscle cells may improve the condition, a study shows. At the same meeting, other researchers reported their efforts in obtaining stem cells from the body's fat tissue, from urine, and from human cord blood to treat urinary problems.
Cleveland BioLabs Protectan CBLB612 Produces Breakthrough in Bone Marrow Stem Cell Transplant Study
Source: Cleveland BioLabs, Inc.
Date: May 21, 2007
Summary:
Cleveland BioLabs, Inc. today announced the results of a study of the efficacy of Protectan CBLB612, in an animal bone marrow stem cell transplantation model. Blood from healthy mice treated by Protectan CBLB612 was transplanted into mice that received a lethal dose of radiation that killed hematopoietic (bone marrow/blood production) stem cells. A small amount of blood from the CBLB612 treated mice successfully rescued the mice with radiation-induced bone marrow stem cell deficiency. 100% of the deficient mice transplanted with blood from CBLB612 treated mice survived past the 60-day mark, while 85% of the untreated deficient mice died within the first three weeks of the experiment.
Date: May 21, 2007
Summary:
Cleveland BioLabs, Inc. today announced the results of a study of the efficacy of Protectan CBLB612, in an animal bone marrow stem cell transplantation model. Blood from healthy mice treated by Protectan CBLB612 was transplanted into mice that received a lethal dose of radiation that killed hematopoietic (bone marrow/blood production) stem cells. A small amount of blood from the CBLB612 treated mice successfully rescued the mice with radiation-induced bone marrow stem cell deficiency. 100% of the deficient mice transplanted with blood from CBLB612 treated mice survived past the 60-day mark, while 85% of the untreated deficient mice died within the first three weeks of the experiment.
Mice and men make livers differently
Source: Massachusetts Institute of Technology
Date: May 21, 2007
Summary:
Scientists often study mice as a model for human biology and disease, because their basic biological processes are assumed to be essentially the same as those of humans. But now, a team of MIT researchers has uncovered a surprising difference. In a study of gene regulation in mouse and human liver cells, they found that master regulatory proteins function in very different ways in mice and humans.
Date: May 21, 2007
Summary:
Scientists often study mice as a model for human biology and disease, because their basic biological processes are assumed to be essentially the same as those of humans. But now, a team of MIT researchers has uncovered a surprising difference. In a study of gene regulation in mouse and human liver cells, they found that master regulatory proteins function in very different ways in mice and humans.
Researchers awaken vision cells in blind mice
Source: University of Florida
Date: May 21, 2007
Summary:
University of Florida researchers used gene therapy to restore sight in mice with a form of hereditary blindness, a finding that has bearing on many of the most common blinding diseases.
Date: May 21, 2007
Summary:
University of Florida researchers used gene therapy to restore sight in mice with a form of hereditary blindness, a finding that has bearing on many of the most common blinding diseases.
Parkinson's protein protects neurons from stress induced cell death
Source: GSF - National Research Center for Environment and Health
Date: May 21, 2007
Summary:
Parkinson’s disease, also known as shaking palsy, is one of the most frequent diseases of the nervous system. Cell death of neurons in specific regions of the midbrain is leading to the onset of the disease. However, the the causes for this extensive cell death are unknown. Especially in cases of early manifestation of the disease mutations in the so-called parkin gene are of great significance. German scientists have now been able to reveal a novel function for the Parkin protein. The scientists could show that Parkin prevents the induction of neuronal cell death. As reported in the Journal of Neuroscience, the protein activates a survival mechanism which had been known for its prominent role in immune response.
Date: May 21, 2007
Summary:
Parkinson’s disease, also known as shaking palsy, is one of the most frequent diseases of the nervous system. Cell death of neurons in specific regions of the midbrain is leading to the onset of the disease. However, the the causes for this extensive cell death are unknown. Especially in cases of early manifestation of the disease mutations in the so-called parkin gene are of great significance. German scientists have now been able to reveal a novel function for the Parkin protein. The scientists could show that Parkin prevents the induction of neuronal cell death. As reported in the Journal of Neuroscience, the protein activates a survival mechanism which had been known for its prominent role in immune response.
Nanomedicine opens the way for nerve cell regeneration
Source: Elsevier Health Sciences
Date: May 21, 2007
Summary:
The ability to regenerate nerve cells in the body could reduce the effects of trauma and disease in a dramatic way. In two presentations at the NSTI Nanotech 2007 Conference, researchers describe the use of nanotechnology to enhance the regeneration of nerve cells. In the first method, developed at the University of Miami, researchers show how magnetic nanoparticles (MNPs) may be used to create mechanical tension that stimulates the growth and elongation of axons of the central nervous system neurons. The second method from the University of California, Berkeley uses aligned nanofibers containing one or more growth factors to provide a bioactive matrix where nerve cells can regrow.
Date: May 21, 2007
Summary:
The ability to regenerate nerve cells in the body could reduce the effects of trauma and disease in a dramatic way. In two presentations at the NSTI Nanotech 2007 Conference, researchers describe the use of nanotechnology to enhance the regeneration of nerve cells. In the first method, developed at the University of Miami, researchers show how magnetic nanoparticles (MNPs) may be used to create mechanical tension that stimulates the growth and elongation of axons of the central nervous system neurons. The second method from the University of California, Berkeley uses aligned nanofibers containing one or more growth factors to provide a bioactive matrix where nerve cells can regrow.
Researchers Growing Bone in a Lab
Source: Florida State University
Date: May 21, 2007
Summary:
A Florida State University researcher is looking to develop new technologies that could replace bone mass lost to the disease, as well as treat traumatic bone injuries such as those suffered in automobile accidents or combat and generate bone cells in a laboratory that then could be transplanted into human patients. The research involves growing human mesenchymal, or adult, stem cells in a laboratory using a device he has patented known as a perfusion bioreactor. By subjecting the stem cells to very specific conditions that mimic those they would encounter in the human body, he seeks to determine what type of cell they turn into - in this case, bone. The bone cells then would be combined with a biomaterial to create tissue similar in structure and density to that of actual bone.
Date: May 21, 2007
Summary:
A Florida State University researcher is looking to develop new technologies that could replace bone mass lost to the disease, as well as treat traumatic bone injuries such as those suffered in automobile accidents or combat and generate bone cells in a laboratory that then could be transplanted into human patients. The research involves growing human mesenchymal, or adult, stem cells in a laboratory using a device he has patented known as a perfusion bioreactor. By subjecting the stem cells to very specific conditions that mimic those they would encounter in the human body, he seeks to determine what type of cell they turn into - in this case, bone. The bone cells then would be combined with a biomaterial to create tissue similar in structure and density to that of actual bone.
Muscle Stem Cells Effectively Treat Urinary Incontinence Long Term
Source: University of Pittsburgh Schools of the Health Sciences
Date: May 21, 2007
Summary:
Women with stress urinary incontinence (SUI) treated using muscle-derived stem cell injections to strengthen their sphincter muscles experience long-term improvements in their condition, according to a study led by researchers at the University of Pittsburgh School of Medicine and Sunnybrook Health Sciences Centre in Toronto.
Date: May 21, 2007
Summary:
Women with stress urinary incontinence (SUI) treated using muscle-derived stem cell injections to strengthen their sphincter muscles experience long-term improvements in their condition, according to a study led by researchers at the University of Pittsburgh School of Medicine and Sunnybrook Health Sciences Centre in Toronto.
Friday, May 18, 2007
Discovery Of The Cellular Origin Of Ewing's Sarcoma
Source: Curie Institute
Date: May 18, 2007
Summary:
Inserm researchers at the Institut Curie have identified the cells that cause Ewing's sarcoma. They are cells of the mesenchyme, the connective tissue that supports other tissues. The Institut Curie is the reference center in France for Ewing's sarcoma, a bone tumor of children, adolescents, and young adults. The researchers have also succeeded "to make" the tumor cells to become virtually normal mesenchymal cells again. These results, published in Cancer Cell on 7 May 2007, open up new therapeutic possibilities for blocking the development of Ewing's sarcoma in young patients.
Date: May 18, 2007
Summary:
Inserm researchers at the Institut Curie have identified the cells that cause Ewing's sarcoma. They are cells of the mesenchyme, the connective tissue that supports other tissues. The Institut Curie is the reference center in France for Ewing's sarcoma, a bone tumor of children, adolescents, and young adults. The researchers have also succeeded "to make" the tumor cells to become virtually normal mesenchymal cells again. These results, published in Cancer Cell on 7 May 2007, open up new therapeutic possibilities for blocking the development of Ewing's sarcoma in young patients.
Thursday, May 17, 2007
Studies Hint at a Way to Regrow Lost Hair
Source: National Public Radio (NPR) - All Things Considered
Date: May 17, 2007
Summary:
NPR covers the new finding reported in the journal Nature using Adult skin stem cells to re-grow hair:
"Researchers have found a way to encourage new hair growth in mice, and they're hoping something similar can be done with humans." An NPR streaming radio broadcast accompanies this story.
Date: May 17, 2007
Summary:
NPR covers the new finding reported in the journal Nature using Adult skin stem cells to re-grow hair:
"Researchers have found a way to encourage new hair growth in mice, and they're hoping something similar can be done with humans." An NPR streaming radio broadcast accompanies this story.
New Hope For Baldness Treatment: Hair Follicles Created For First Time In Mouse Study
Source: University of Pennsylvania School of Medicine
Date: May 17, 2007
Summary:
Researchers at the University of Pennsylvania School of Medicine have found that hair follicles in adult mice regenerate by re-awakening genes once active only in developing embryos. These findings provide unequivocal evidence for the first time that, like other animals such as newts and salamanders, mammals have the power to regenerate. A better understanding of this process could lead to novel treatments for hair loss, other skin and hair disorders, and wounds.
Date: May 17, 2007
Summary:
Researchers at the University of Pennsylvania School of Medicine have found that hair follicles in adult mice regenerate by re-awakening genes once active only in developing embryos. These findings provide unequivocal evidence for the first time that, like other animals such as newts and salamanders, mammals have the power to regenerate. A better understanding of this process could lead to novel treatments for hair loss, other skin and hair disorders, and wounds.
Geron says embryonic stem cells produce insulin
Source: Reuters
Posted: May 17, 2007 1:16PM EDT
Summary:
Geron Corporation reported it successfully turned human embryonic stem cells into the pancreatic cells that produce insulin, an advancement that may lead to a treatment for diabetes. The company collaborated with Canadian researchers who have specialized in a transplant technique called the Edmonton Protocol, which as been shown to restore insulin-producing cells in patients with type-1 diabetes. Researchers believe the finding, published in the journal Stem Cells, might provide evidence of one of the most sought-after functions of embryonic stem cells -- treating diabetes.
Posted: May 17, 2007 1:16PM EDT
Summary:
Geron Corporation reported it successfully turned human embryonic stem cells into the pancreatic cells that produce insulin, an advancement that may lead to a treatment for diabetes. The company collaborated with Canadian researchers who have specialized in a transplant technique called the Edmonton Protocol, which as been shown to restore insulin-producing cells in patients with type-1 diabetes. Researchers believe the finding, published in the journal Stem Cells, might provide evidence of one of the most sought-after functions of embryonic stem cells -- treating diabetes.
How Insulin-producing Cells Develop -- New Finding Could Help Fight Against Diabetes
Source: Imperial College London
Date: May 17, 2007
Summary:
A key aspect of how embryos create the cells which secrete insulin is revealed in a new study published tomorrow (18 May) in the Journal of Biological Chemistry. The researchers hope that their findings will enable the development of new therapies for diabetes, a condition caused by insufficient levels of insulin.
Date: May 17, 2007
Summary:
A key aspect of how embryos create the cells which secrete insulin is revealed in a new study published tomorrow (18 May) in the Journal of Biological Chemistry. The researchers hope that their findings will enable the development of new therapies for diabetes, a condition caused by insufficient levels of insulin.
Geron Scientists and Collaborators Differentiate Human Embryonic Stem Cells Into Insulin-Producing Islet-Like Clusters
Source: Geron Corporation
Posted: May 17, 2007 07:30 AM EDT
Summary:
In an official press release, Geron Corporation announced that its scientists and collaborators at the University of Alberta have differentiated human embryonic stem cells (hESCs) into islet-like clusters (ILCs) that secrete insulin in response to elevated glucose levels. The studies demonstrate the feasibility of producing therapeutic cell types from hESCs for the treatment of diabetes.
Posted: May 17, 2007 07:30 AM EDT
Summary:
In an official press release, Geron Corporation announced that its scientists and collaborators at the University of Alberta have differentiated human embryonic stem cells (hESCs) into islet-like clusters (ILCs) that secrete insulin in response to elevated glucose levels. The studies demonstrate the feasibility of producing therapeutic cell types from hESCs for the treatment of diabetes.
Scientists Make Skin Grow New Hair Follicles By Itself
Source: Medical News Today
Article Date: 17 May 2007 - 0:00 PDT
Summary:
Medical News Today reports on a new study in which researchers used adult skin stem cells to grow new hair follicles:
"US scientists have found a way to make the skin of laboratory mice gives rise to new fully working hair follicles complete with new hair by using a protein that stimulates follicle generating genes in skin cells when skin is wounded." The scientists discovered that the cells of the epidermis take on the properties of stem cells and generate new hair follicles that are capable of growing new shafts of hair. So far the results have only been achieved in mice, but the hope is the same is true of human skin and that the discovery may one day lead to treatments for baldness and abnormal hair growth. The study is published in the journal Nature.
Article Date: 17 May 2007 - 0:00 PDT
Summary:
Medical News Today reports on a new study in which researchers used adult skin stem cells to grow new hair follicles:
"US scientists have found a way to make the skin of laboratory mice gives rise to new fully working hair follicles complete with new hair by using a protein that stimulates follicle generating genes in skin cells when skin is wounded." The scientists discovered that the cells of the epidermis take on the properties of stem cells and generate new hair follicles that are capable of growing new shafts of hair. So far the results have only been achieved in mice, but the hope is the same is true of human skin and that the discovery may one day lead to treatments for baldness and abnormal hair growth. The study is published in the journal Nature.
Wednesday, May 16, 2007
Baldness breakthrough: Stem cells coaxed into growing hair
Source: Daily Mail
Date: 17 May 2007
Summary:
Scientists have coaxed stem cells into growing hair for the first time. Writing in the journal Nature, the scientists described how they had shown that adult mammals are able to grow new hair follicles. The breakthrough could also lead to new treatments for other conditions, such as alopecia, in which hair is lost in patches. Within a decade, advances in stem cell science could help them to regrow their own hair where it has been lost.
Date: 17 May 2007
Summary:
Scientists have coaxed stem cells into growing hair for the first time. Writing in the journal Nature, the scientists described how they had shown that adult mammals are able to grow new hair follicles. The breakthrough could also lead to new treatments for other conditions, such as alopecia, in which hair is lost in patches. Within a decade, advances in stem cell science could help them to regrow their own hair where it has been lost.
Experiment offers hope of remedy for baldness
Source: Reuters
Posted: May 16, 2007 3:24PM EDT
Summary:
Mice with deep skin wounds can grow new hair, a finding that offers hope for a baldness remedy for humans scientists said. The mice regenerated hair at the site of the wound via molecular processes similar to those used in embryonic development, according to the research, published in the journal Nature. The findings show mammals possess greater regenerative abilities than commonly believed. While some amphibians can regenerate limbs and some reptiles can regenerate tails, regeneration in mammals is far more limited.
Posted: May 16, 2007 3:24PM EDT
Summary:
Mice with deep skin wounds can grow new hair, a finding that offers hope for a baldness remedy for humans scientists said. The mice regenerated hair at the site of the wound via molecular processes similar to those used in embryonic development, according to the research, published in the journal Nature. The findings show mammals possess greater regenerative abilities than commonly believed. While some amphibians can regenerate limbs and some reptiles can regenerate tails, regeneration in mammals is far more limited.
Pediatric cancer stem cell identified: understanding the origin of ERMS
Source: Cold Spring Harbor Laboratory
Date: May 16, 2007
Summary:
As published in the June 1 issue of Genes & Development, Dr. Leonard Zon (Children’s Hospital Boston) and colleagues have identified the cancer stem cell for rhabdomyosarcoma, the most common soft-tissue sarcoma of childhood.
Date: May 16, 2007
Summary:
As published in the June 1 issue of Genes & Development, Dr. Leonard Zon (Children’s Hospital Boston) and colleagues have identified the cancer stem cell for rhabdomyosarcoma, the most common soft-tissue sarcoma of childhood.
Implanting Dopamine Generators In Brain Cells Obtains Improvement In Parkinson's In Monkeys
Source: Basque Research
Date: May 16, 2007
Summary:
Implanting dopamine generators (dopaminergics) in brain cells has produced improvement in the symptoms in Parkinson’s, according to the results of tests carried out with monkeys by the Navarra University Hospital, led by Dr MarÃa Rosario Luquin Piudo, neurologist at the Hospital and at the other Navarra University-based medical centre, CIMA (the Research Centre for Applied Medicine).
Date: May 16, 2007
Summary:
Implanting dopamine generators (dopaminergics) in brain cells has produced improvement in the symptoms in Parkinson’s, according to the results of tests carried out with monkeys by the Navarra University Hospital, led by Dr MarÃa Rosario Luquin Piudo, neurologist at the Hospital and at the other Navarra University-based medical centre, CIMA (the Research Centre for Applied Medicine).
Gene find triggers baldness hope
Source: BBC News
Posted: 16 May 2007, 17:01 GMT 18:01 UK
Summary:
BBC News reports on the discovery of a gene that, in combination with stem cells, could lead to new treatments for baldness and healing of wounds:
"Hair loss in humans might be reversible, suggest scientists who have helped create new hair cells on the skin of mice. It was thought hair follicles, once damaged, could never be replaced. But a University of Pennsylvania team, writing in the journal Nature, says hair growth can actually be encouraged using a single gene. A UK expert said the study could prove more important in aiding development of better wound-healing techniques."
Posted: 16 May 2007, 17:01 GMT 18:01 UK
Summary:
BBC News reports on the discovery of a gene that, in combination with stem cells, could lead to new treatments for baldness and healing of wounds:
"Hair loss in humans might be reversible, suggest scientists who have helped create new hair cells on the skin of mice. It was thought hair follicles, once damaged, could never be replaced. But a University of Pennsylvania team, writing in the journal Nature, says hair growth can actually be encouraged using a single gene. A UK expert said the study could prove more important in aiding development of better wound-healing techniques."
Patient-specific stem cell lines sought
Source: United Press International
Date: May 16, 2007
Summary:
U.S. scientists have launched a project to develop stem cell lines that genetically match human patients. University of California-Irvine neurobiologist Hans Keirstead and his team are using a nuclear transfer technique to pursue the goal that will allow scientists to better study conditions ranging from diabetes to Parkinson's disease and provide the basis for potential patient-specific stem cell treatments.
Date: May 16, 2007
Summary:
U.S. scientists have launched a project to develop stem cell lines that genetically match human patients. University of California-Irvine neurobiologist Hans Keirstead and his team are using a nuclear transfer technique to pursue the goal that will allow scientists to better study conditions ranging from diabetes to Parkinson's disease and provide the basis for potential patient-specific stem cell treatments.
Skin's own cells could beat baldness
Source: Nature
Date: 16 May 2007
Summary:
The journal Nature reports on a new study which has revealed that adult skin stem cells may be able to grow hair:
"Skin may have the capacity to regenerate lost hair follicles from within, according to a new discovery that could yield better treatments for baldness or abnormal hair growth. Researchers have found that, when skin is wounded, skin cells can assume the properties of stem cells that generate hair follicles and growing new hair."
Date: 16 May 2007
Summary:
The journal Nature reports on a new study which has revealed that adult skin stem cells may be able to grow hair:
"Skin may have the capacity to regenerate lost hair follicles from within, according to a new discovery that could yield better treatments for baldness or abnormal hair growth. Researchers have found that, when skin is wounded, skin cells can assume the properties of stem cells that generate hair follicles and growing new hair."
Tuesday, May 15, 2007
Stemming the Tide
Source: University of Southern California
Date: May 15, 2007
Summary:
Songtao Shi, a researcher at USC's Center for Craniofacial Molecular Biology, and colleagues at dental school's in Korea and China have discovered that mesenchymal stem cells (MSCs) are capable of regenerating facial bone and skin tissue in mouse and swine models. The work published in the April 2007 issue of the journal Stem Cells points to a future in which MSCs become a plastic surgeon's weapon of choice for everything from repairing severe facial disfigurement to removing wrinkles.
Date: May 15, 2007
Summary:
Songtao Shi, a researcher at USC's Center for Craniofacial Molecular Biology, and colleagues at dental school's in Korea and China have discovered that mesenchymal stem cells (MSCs) are capable of regenerating facial bone and skin tissue in mouse and swine models. The work published in the April 2007 issue of the journal Stem Cells points to a future in which MSCs become a plastic surgeon's weapon of choice for everything from repairing severe facial disfigurement to removing wrinkles.
UCI to attempt therapeutic cloning
Source: Orange County Register
Date: May 15, 2007
Summary:
Researchers at UC Irvine are attempting to develop treatments using embryonic stem cells from people who suffer such afflictions as spinal cord injuries and Parkinson's disease. This has led some researchers to believe it may be possible to create patient-specific treatments that match their specific genetic make-up, since the cells would likely be accepted by the donor's immune system. The technique has never been achieved in humans.
Date: May 15, 2007
Summary:
Researchers at UC Irvine are attempting to develop treatments using embryonic stem cells from people who suffer such afflictions as spinal cord injuries and Parkinson's disease. This has led some researchers to believe it may be possible to create patient-specific treatments that match their specific genetic make-up, since the cells would likely be accepted by the donor's immune system. The technique has never been achieved in humans.
QBI neuroscientists edge closer to decoding brain repair
Source: University of Queensland
Date: May 15, 2007
Summary:
Neuroscientists at UQ's Queensland Brain Institute (QBI) have revealed two major discoveries, edging them closer to harnessing the brain's inherent powers of self-repair and regeneration. In one study, findings announced in the Journal of Neuroscience, QBI neuroscientists have identified the stem cell population responsible for production of neurons, and the mechanism which drives this process. In a second study, a team of QBI neuroscientists found a way to identify neurons at the intermediate stage of development, when the cells are in the process of changing from stem cells to mature nerve cells.
Date: May 15, 2007
Summary:
Neuroscientists at UQ's Queensland Brain Institute (QBI) have revealed two major discoveries, edging them closer to harnessing the brain's inherent powers of self-repair and regeneration. In one study, findings announced in the Journal of Neuroscience, QBI neuroscientists have identified the stem cell population responsible for production of neurons, and the mechanism which drives this process. In a second study, a team of QBI neuroscientists found a way to identify neurons at the intermediate stage of development, when the cells are in the process of changing from stem cells to mature nerve cells.
Monday, May 14, 2007
UCI launches effort to develop patient-specific stem cell lines
Source: University of California - Irvine
Date: May 14, 2007
Summary:
UC Irvine neurobiologist Hans Keirstead and his research team today launched a project to develop stem cell lines that genetically match human patients. These lines would allow scientists to better study conditions ranging from diabetes to Parkinson’s disease, and they would provide the basis for potential patient-specific stem cell treatments. Keirstead will use a technique called somatic cell nuclear transfer (SCNT) in which a patient’s DNA is transplanted into a donated unfertilized egg cell in order to generate stem cell lines with the same genetic makeup of the patient.
Date: May 14, 2007
Summary:
UC Irvine neurobiologist Hans Keirstead and his research team today launched a project to develop stem cell lines that genetically match human patients. These lines would allow scientists to better study conditions ranging from diabetes to Parkinson’s disease, and they would provide the basis for potential patient-specific stem cell treatments. Keirstead will use a technique called somatic cell nuclear transfer (SCNT) in which a patient’s DNA is transplanted into a donated unfertilized egg cell in order to generate stem cell lines with the same genetic makeup of the patient.
Thursday, May 10, 2007
Breakdown of Myelin Implicated in Alzheimer’s, UCLA Research Shows
Source: University of California - Los Angeles
Date: May 10, 2007
Summary:
In a report in the April issue of the journal Alzheimer's & Dementia, UCLA researchers suggest that it is the breakdown of this late-stage myelin, the fatty sheath that coats the axons of the nerves, allowing for efficient conduction of nerve impulses, that promotes the buildup of toxic amyloid-beta fibrils that eventually deposit in the brain and become the plaques which have long been associated with Alzheimer's disease.
Date: May 10, 2007
Summary:
In a report in the April issue of the journal Alzheimer's & Dementia, UCLA researchers suggest that it is the breakdown of this late-stage myelin, the fatty sheath that coats the axons of the nerves, allowing for efficient conduction of nerve impulses, that promotes the buildup of toxic amyloid-beta fibrils that eventually deposit in the brain and become the plaques which have long been associated with Alzheimer's disease.
Bone Marrow Stem Cells May Cure Eye Disease
Source: University of Cincinnati
Date: May 10, 2007
Summary:
Adult bone marrow stem cells may help cure certain genetic eye diseases, according to University of Cincinnati (UC) researchers. Scientists have completed a study using mice which showed that bone marrow stem cells can switch roles and produce keratocan, a natural protein involved in the growth of the cornea—the transparent, outer layer of the eyeball. This ability of marrow cells to “differentiate” into keratocan-producing cells might provide a means for treating abnormal corneal cell growth in people.
Date: May 10, 2007
Summary:
Adult bone marrow stem cells may help cure certain genetic eye diseases, according to University of Cincinnati (UC) researchers. Scientists have completed a study using mice which showed that bone marrow stem cells can switch roles and produce keratocan, a natural protein involved in the growth of the cornea—the transparent, outer layer of the eyeball. This ability of marrow cells to “differentiate” into keratocan-producing cells might provide a means for treating abnormal corneal cell growth in people.
Wednesday, May 09, 2007
Scientists discover genetic 'shut down' trigger in healthy immune cells
Source: University of Pittsburgh Schools of the Health Sciences
Date: May 9, 2007
Summary:
A fundamental genetic mechanism that shuts down an important gene in healthy immune system cells has been discovered that could one day lead to new therapies against infections, leukemia and other cancers. Results of a University of Pittsburgh School of Medicine study on the mechanism, called a somatic stop-codon mutation, are being reported today in the online journal PLoS ONE, published by the Public Library of Science.
Date: May 9, 2007
Summary:
A fundamental genetic mechanism that shuts down an important gene in healthy immune system cells has been discovered that could one day lead to new therapies against infections, leukemia and other cancers. Results of a University of Pittsburgh School of Medicine study on the mechanism, called a somatic stop-codon mutation, are being reported today in the online journal PLoS ONE, published by the Public Library of Science.
Analysis: Stem cells closer to trials
Source: United Press International
Posted: May 9, 2007 at 8:31 PM ET
Summary:
Two biotechnology companies recently reported they are close to entering clinical trials with embryonic cells. Geron plans to use cells derived from embryonic stem cells for treating spinal injuries. Advanced Cell Technology announced it has developed a technique to generate a type of progenitor cell that could move into the clinic in 2008 for treating a variety of ills.
Posted: May 9, 2007 at 8:31 PM ET
Summary:
Two biotechnology companies recently reported they are close to entering clinical trials with embryonic cells. Geron plans to use cells derived from embryonic stem cells for treating spinal injuries. Advanced Cell Technology announced it has developed a technique to generate a type of progenitor cell that could move into the clinic in 2008 for treating a variety of ills.
Embryonic stem cells trial on track to start
Source: Financial Times
Date: May 9, 2007
Summary:
The first clinical trial of embryonic stem cells is on track to start early next year on patients with spinal cord injury. Geron, the California-based biotechnology company, will carry out the study on accident victims in six trauma centres across the US.
Date: May 9, 2007
Summary:
The first clinical trial of embryonic stem cells is on track to start early next year on patients with spinal cord injury. Geron, the California-based biotechnology company, will carry out the study on accident victims in six trauma centres across the US.
Tissue engineered scaffolding allows reproduction of cartilage tissue
Source: Blackwell Publishing Ltd.
Date: May 9, 2007
Summary:
A new study examines the use of tissue-engineered scaffolding made of cartilage cells, which have a limited ability to heal naturally, to replace defective cartilage tissue. Cartilage cells are extracted and seeded to the scaffold which is implanted into the body, where new cartilage tissue is grown along the structure. The study appears in the journal Artificial Organs.
Date: May 9, 2007
Summary:
A new study examines the use of tissue-engineered scaffolding made of cartilage cells, which have a limited ability to heal naturally, to replace defective cartilage tissue. Cartilage cells are extracted and seeded to the scaffold which is implanted into the body, where new cartilage tissue is grown along the structure. The study appears in the journal Artificial Organs.
Tuesday, May 08, 2007
New Stem Cell Method Promises To Repair Severe Blood Vessel Damage
Source: Medical News Today
Article Date: May 8, 2007 - 5:00 PDT
Summary:
Scientists have found a new way to produce precursor cells that can repair severely damaged blood vessels in mice and other laboratory animals from human embryonic stem cells. They believe this method could eventually lead to the repair extensive blood vessel damage in humans,. The finding is being hailed as a breakthrough. The research is published in the journal Nature Methods.
Article Date: May 8, 2007 - 5:00 PDT
Summary:
Scientists have found a new way to produce precursor cells that can repair severely damaged blood vessels in mice and other laboratory animals from human embryonic stem cells. They believe this method could eventually lead to the repair extensive blood vessel damage in humans,. The finding is being hailed as a breakthrough. The research is published in the journal Nature Methods.
Stem cells yield fixes for vascular injuries
Source: Milwaukee Journal Sentinel
Date: May 8, 2007
Summary:
A team of scientists from Advanced Cell Technology, Memorial Sloan-Kettering Cancer Center in New York and the University of Florida in Gainesville, has shown that early blood and immune cells from human embryonic stem cells can effectively target and fix vascular injuries in a mouse's body. The scientists are planning to bring these cells, called hemangioblasts, into the clinic in the next few years.
Date: May 8, 2007
Summary:
A team of scientists from Advanced Cell Technology, Memorial Sloan-Kettering Cancer Center in New York and the University of Florida in Gainesville, has shown that early blood and immune cells from human embryonic stem cells can effectively target and fix vascular injuries in a mouse's body. The scientists are planning to bring these cells, called hemangioblasts, into the clinic in the next few years.
US firm applies to test 'incredible' stem cell technique on humans
Source: Guardian Unlimited - UK
Date: May 8, 2007
Summary:
Advanced Cell Technology (ACT), a biotechnology company in the field of stem cell research, has applied for permission from US authorities to begin trials on humans of a new stem cell technique that it says holds out the promise of rapid healing of damaged eyes, lungs, hearts and arteries. The company announced it had devised a simple method for taking stem cells from human embryos and turning them into the precursor cells of blood vessels. Injected into mice and rats, the researchers found that the cells migrated to damaged parts of the body and helped to repair them.
Date: May 8, 2007
Summary:
Advanced Cell Technology (ACT), a biotechnology company in the field of stem cell research, has applied for permission from US authorities to begin trials on humans of a new stem cell technique that it says holds out the promise of rapid healing of damaged eyes, lungs, hearts and arteries. The company announced it had devised a simple method for taking stem cells from human embryos and turning them into the precursor cells of blood vessels. Injected into mice and rats, the researchers found that the cells migrated to damaged parts of the body and helped to repair them.
Stem cells used to repair others: Worcester research aimed at diabetes
Source: Bloomberg News
Date: May 8, 2007
Summary:
Bloomberg News reports on a new experiment by Advanced Cell Technology in which embryonic stem cells were turned into a type of cell to treat eye disorders and create new blood vessels:
"Advanced Cell Technology Inc. said it has turned embryonic stem cells into a type of repair cell that helped treat damaged eyes and generated new blood vessels in the limbs and hearts of animals in a study. The repair cell, called a hemangioblast, can become either a blood-building cell or one that can form the lining of blood vessels, depending on which chemicals are used to coax the cell into changing, a study says. The repair cells can be produced in large quantities and under tightly controlled and replicable conditions, the Alameda, Calif.-based company said."
Date: May 8, 2007
Summary:
Bloomberg News reports on a new experiment by Advanced Cell Technology in which embryonic stem cells were turned into a type of cell to treat eye disorders and create new blood vessels:
"Advanced Cell Technology Inc. said it has turned embryonic stem cells into a type of repair cell that helped treat damaged eyes and generated new blood vessels in the limbs and hearts of animals in a study. The repair cell, called a hemangioblast, can become either a blood-building cell or one that can form the lining of blood vessels, depending on which chemicals are used to coax the cell into changing, a study says. The repair cells can be produced in large quantities and under tightly controlled and replicable conditions, the Alameda, Calif.-based company said."
Stem Cells Repair Blood Vessels
Source: MIT Technology Review
Date: May 08, 2007
Summary:
MIT Technology Review covers an advance in stem cell research in which embryonic stem cells have been turned into blood vessels:
"An efficient new method to generate what appears to be a novel type of stem cell could be a boon to diseases linked to lack of blood flow. Scientists in Massachusetts and Florida have developed a way to coax embryonic stem cells into a more adult form of stem cell that has the potential to form blood vessels. The new type of cells helped repair tissue in animals that had had heart attacks or eye damage due to diabetes."
Date: May 08, 2007
Summary:
MIT Technology Review covers an advance in stem cell research in which embryonic stem cells have been turned into blood vessels:
"An efficient new method to generate what appears to be a novel type of stem cell could be a boon to diseases linked to lack of blood flow. Scientists in Massachusetts and Florida have developed a way to coax embryonic stem cells into a more adult form of stem cell that has the potential to form blood vessels. The new type of cells helped repair tissue in animals that had had heart attacks or eye damage due to diabetes."
Stem cells 'can mend an ailing heart'
Source: Daily Telegraph - UK
Date: May 8, 2007
Summary:
The Daily Telegraph reports on new research which has revealed the capabilities of embryonic stem cells to turn into blood vessels, called hemangioblasts, to potentially treat cardiac conditions and circulatory disorders:
"One day soon it should be possible to inject cells that can grow into new blood vessels to nourish an ailing heart, or help restore circulation in a leg that would otherwise have to be amputated. These are some of the possibilities raised by the discovery and isolation of a special class of stem cells from human embryos, called hemangioblast cells, which can repair blood vessels, according to tests on animals published today."
Date: May 8, 2007
Summary:
The Daily Telegraph reports on new research which has revealed the capabilities of embryonic stem cells to turn into blood vessels, called hemangioblasts, to potentially treat cardiac conditions and circulatory disorders:
"One day soon it should be possible to inject cells that can grow into new blood vessels to nourish an ailing heart, or help restore circulation in a leg that would otherwise have to be amputated. These are some of the possibilities raised by the discovery and isolation of a special class of stem cells from human embryos, called hemangioblast cells, which can repair blood vessels, according to tests on animals published today."
Monday, May 07, 2007
Adult stem cells don't help make insulin
Source: United Press International
Date: May 7, 2007
Summary:
Unlike most body tissues that are renewed from adult stem cells, insulin-producing beta cells renew themselves, U.S. researchers have found.
Date: May 7, 2007
Summary:
Unlike most body tissues that are renewed from adult stem cells, insulin-producing beta cells renew themselves, U.S. researchers have found.
New Recipe for Powerful Stem Cells Promises Greater Insight
Source: Scientific American
Date: May 7, 2007
Summary:
Scientific American reports on a new study by Advanced Cell Technology in which human embryonic stem cells were transformed into blood vessels:
"Advanced Cell Technology, Inc. announced it has grown large numbers of a rare type of human embryonic stem cell that can transform into blood and blood vessels. When injected into mice, the cells congregated around damaged blood vessels in the eye, heart and limbs, where they seemed to help rebuild injured tissue. The company says it plans to request approval by the end of next year to conduct human trials of the cells, called hemangioblasts. If the cells replace blood vessels in people, they might lead to new treatments for diseases that result from a lack of blood to some part of the body, including heart attack, stroke and the complications of diabetes."
Date: May 7, 2007
Summary:
Scientific American reports on a new study by Advanced Cell Technology in which human embryonic stem cells were transformed into blood vessels:
"Advanced Cell Technology, Inc. announced it has grown large numbers of a rare type of human embryonic stem cell that can transform into blood and blood vessels. When injected into mice, the cells congregated around damaged blood vessels in the eye, heart and limbs, where they seemed to help rebuild injured tissue. The company says it plans to request approval by the end of next year to conduct human trials of the cells, called hemangioblasts. If the cells replace blood vessels in people, they might lead to new treatments for diseases that result from a lack of blood to some part of the body, including heart attack, stroke and the complications of diabetes."
Alameda biotech firm regrows blood vessels in rodent
Source: San Jose Mercury News
Posted: May 7, 2007 01:35:42 PM PDT
Summary:
The San Jose Mercury News reports on an advancement in growing blood vessels from human embryonic stem cells:
"Scientists at Advanced Cell Technology in Alameda claim to have rapidly regrown rodent blood vessels from human embryonic stem cells using a technique they hope one day may treat people suffering from heart attacks, diabetes and other ailments. The key to the discovery is a type of cell with highly regenerative capabilities - called a hemangioblast - which the researchers created in vast numbers from the stem cells, according to a study they published today in the journal Nature Methods."
Posted: May 7, 2007 01:35:42 PM PDT
Summary:
The San Jose Mercury News reports on an advancement in growing blood vessels from human embryonic stem cells:
"Scientists at Advanced Cell Technology in Alameda claim to have rapidly regrown rodent blood vessels from human embryonic stem cells using a technique they hope one day may treat people suffering from heart attacks, diabetes and other ailments. The key to the discovery is a type of cell with highly regenerative capabilities - called a hemangioblast - which the researchers created in vast numbers from the stem cells, according to a study they published today in the journal Nature Methods."
Embryonic stem cells can repair eyes, company says
Source: Reuters
Posted: May 7, 2007 1:11PM EDT
Summary:
Reuters reports on a new procedure developed by Advanced Cell Technology using embryonic stem cells that may potentially be able to treat eye disorders:
"Stem cells made from human embryos can home in on damaged eyes, hearts and arteries of mice and rats, and appear to start repairs, a U.S. company said. Massachusetts-based Advanced Cell Technology said it had devised a straightforward way to make blood vessel precursor cells out of the stem cells and plans to test them in humans."
Posted: May 7, 2007 1:11PM EDT
Summary:
Reuters reports on a new procedure developed by Advanced Cell Technology using embryonic stem cells that may potentially be able to treat eye disorders:
"Stem cells made from human embryos can home in on damaged eyes, hearts and arteries of mice and rats, and appear to start repairs, a U.S. company said. Massachusetts-based Advanced Cell Technology said it had devised a straightforward way to make blood vessel precursor cells out of the stem cells and plans to test them in humans."
Embryonic stem cells yield advance for blood cells, vascular damage
Source: Agence France Presse (AFP)
Date: May 7, 2007
Summary:
Researchers in the United States say they have been able to coax embryonic stemcells into yielding a plentiful supply of versatile cells that can repair damage to blood vessels.
Date: May 7, 2007
Summary:
Researchers in the United States say they have been able to coax embryonic stemcells into yielding a plentiful supply of versatile cells that can repair damage to blood vessels.
Precursor Cells Generated From Human Embryonic Stem Cells Show Ability to Repair Vascular Damage in Animals
Source: Advanced Cell Technology, Inc.
Date: May 7, 2007
Summary:
Advanced Cell Technology, Inc. reported for the first time that hemangioblast (blood) precursor cells derived from human embryonic stem (hES) cells can be used to achieve vascular repair. The research, which appears today online (ahead of print) in the journal Nature Methods, by Advanced Cell Technology (ACT) and its collaborators, describes an efficient method for generating large numbers of bipotential progenitors—known as hemangioblasts—from hES cells that are capable of differentiating into blood vessels, as well as into all blood and immune cell lineages.
Date: May 7, 2007
Summary:
Advanced Cell Technology, Inc. reported for the first time that hemangioblast (blood) precursor cells derived from human embryonic stem (hES) cells can be used to achieve vascular repair. The research, which appears today online (ahead of print) in the journal Nature Methods, by Advanced Cell Technology (ACT) and its collaborators, describes an efficient method for generating large numbers of bipotential progenitors—known as hemangioblasts—from hES cells that are capable of differentiating into blood vessels, as well as into all blood and immune cell lineages.
The Stem Cells That Weren't There -- Surprising Finding May Lead To New Diabetes Treatments
Source: Children's Hospital of Philadelphia
Date: May 7, 2007
Summary:
Diabetes researchers, investigating how the body supplies itself with insulin, discovered to their surprise that adult stem cells, which they expected to play a crucial role in the process, were nowhere to be found. Many researchers had proposed that adult stem cells develop into insulin-producing cells, called beta cells, in the pancreas.
Date: May 7, 2007
Summary:
Diabetes researchers, investigating how the body supplies itself with insulin, discovered to their surprise that adult stem cells, which they expected to play a crucial role in the process, were nowhere to be found. Many researchers had proposed that adult stem cells develop into insulin-producing cells, called beta cells, in the pancreas.
Cryo-Cell Isolates Maternal Stem Cell With New Therapeutic Potential for Advancing Women's Healthcare
Source: Cryo-Cell International Inc.
Date: May 7, 2007
Summary:
In a news release, Cryo-Cell International Inc. announced the isolation of a new type of adult stem cell:
"Researchers at Cryo-Cell International Inc. have isolated a new type of adult stem cell with potential for treating a broad range of diseases in the future. The stem cell, called a maternal placental stem cell (MPSC), is taken from the discarded placental tissue immediately after childbirth."
The release also mentions potential applications of maternal placental stem cells (MPSC's) in regenerative medicine:
"Maternal stem cells have not to date been used in human therapies however, researchers believe that these cells may serve as an alternative to embryonic stem cells in the development of human cellular therapies and for use in regenerative medicine associated with the donor (mother)."
Date: May 7, 2007
Summary:
In a news release, Cryo-Cell International Inc. announced the isolation of a new type of adult stem cell:
"Researchers at Cryo-Cell International Inc. have isolated a new type of adult stem cell with potential for treating a broad range of diseases in the future. The stem cell, called a maternal placental stem cell (MPSC), is taken from the discarded placental tissue immediately after childbirth."
The release also mentions potential applications of maternal placental stem cells (MPSC's) in regenerative medicine:
"Maternal stem cells have not to date been used in human therapies however, researchers believe that these cells may serve as an alternative to embryonic stem cells in the development of human cellular therapies and for use in regenerative medicine associated with the donor (mother)."
Saturday, May 05, 2007
Surgeons Hail Bone Stem Cell Breakthrough
Source: Sky News - Isleworth,UK
Posted: May 05, 2007 10:23 AM GMT
Summary:
Sky News reports on a breakthrough using bone marrow stem cells to heal broken bones:
"Surgeons are using bone marrow stem cells to fix broken bones that won't mend on their own. Surgeons collect the stem cells in a sample of bone marrow, usually from the patient's pelvis. They are purified and then multiplied in a sterile laboratory. Three weeks later surgeons expose the broken bone and place the cells around the fracture."
Posted: May 05, 2007 10:23 AM GMT
Summary:
Sky News reports on a breakthrough using bone marrow stem cells to heal broken bones:
"Surgeons are using bone marrow stem cells to fix broken bones that won't mend on their own. Surgeons collect the stem cells in a sample of bone marrow, usually from the patient's pelvis. They are purified and then multiplied in a sterile laboratory. Three weeks later surgeons expose the broken bone and place the cells around the fracture."
Friday, May 04, 2007
New technique dissects stem cells’ picky likes, dislikes
Source: University of Wisconsin-Madison
Date: May 4, 2007
Summary:
Whether their goal is to create therapies or simply investigate how organisms develop, stem cell researchers face what is perhaps one of biological science's toughest assignments: keeping their tiny research subjects under control. in a study published in the May 11 online edition of ACS Chemical Biology, University of Wisconsin-Madison researchers describe a system that can quickly and systemically screen hundreds of individual molecules for their ability to influence stem cell fates.
Date: May 4, 2007
Summary:
Whether their goal is to create therapies or simply investigate how organisms develop, stem cell researchers face what is perhaps one of biological science's toughest assignments: keeping their tiny research subjects under control. in a study published in the May 11 online edition of ACS Chemical Biology, University of Wisconsin-Madison researchers describe a system that can quickly and systemically screen hundreds of individual molecules for their ability to influence stem cell fates.
Thursday, May 03, 2007
National Center For Regenerative Medicine Researchers Find Innovative Methods For Treating Heart Attacks
Source: Medical News Today
Date: May 3, 2007 - 14:00 PDT
Summary:
Medical News Today reports on new methods to treat heart attack patients:
"Researchers from the National Center for Regenerative Medicine (NCRM) have identified two innovative and distinctly different methods to help treat patients recovering from a heart attack. The first study showed that cell-based gene therapy to regenerate damaged cardiac muscle tissue and improve mechanical cardiac function was feasible using skeletal muscle stem cells modified to express a stem cell honing signal. The second study showed that bone marrow stem cells could emerge as a valuable treatment for repairing damaged hearts by regenerating damaged heart muscle and maintaining the electrical conduction across the heart. The researchers believe that combining cell and gene therapy can enhance the effects of cell transplantation and optimize regeneration of tissue in the heart."
Date: May 3, 2007 - 14:00 PDT
Summary:
Medical News Today reports on new methods to treat heart attack patients:
"Researchers from the National Center for Regenerative Medicine (NCRM) have identified two innovative and distinctly different methods to help treat patients recovering from a heart attack. The first study showed that cell-based gene therapy to regenerate damaged cardiac muscle tissue and improve mechanical cardiac function was feasible using skeletal muscle stem cells modified to express a stem cell honing signal. The second study showed that bone marrow stem cells could emerge as a valuable treatment for repairing damaged hearts by regenerating damaged heart muscle and maintaining the electrical conduction across the heart. The researchers believe that combining cell and gene therapy can enhance the effects of cell transplantation and optimize regeneration of tissue in the heart."
Researchers work out the mechanics of asymmetric cell division
Source: European Molecular Biology Laboratory
Date: May 3, 2007
Summary:
When a cell divides, normally the result is two identical daughter cells. In some cases however, cell division leads to two cells with different properties. This is called asymmetric cell division and plays an important role in embryonic development and the self-renewal of stem cells.
Date: May 3, 2007
Summary:
When a cell divides, normally the result is two identical daughter cells. In some cases however, cell division leads to two cells with different properties. This is called asymmetric cell division and plays an important role in embryonic development and the self-renewal of stem cells.
Master Regulatory Gene Of Epithelial Stem Cells Identified
Source: Harvard Medical School
Date: May 3, 2007
Summary:
The skin's ability to replace the tissue it sloughs off is controlled by a variety of genes. A new study from Harvard Medical School published in the May 4 issue of Cell, however, identifies a "master regulator" of this regeneration process not only for skin, but for many epithelial tissues including breast, prostate, and urogenital tract.
Date: May 3, 2007
Summary:
The skin's ability to replace the tissue it sloughs off is controlled by a variety of genes. A new study from Harvard Medical School published in the May 4 issue of Cell, however, identifies a "master regulator" of this regeneration process not only for skin, but for many epithelial tissues including breast, prostate, and urogenital tract.
Mice experiments offer possible Alzheimer's treatment: study
Source: Agence France Presse (AFP)
Posted: May 3, 2007 2:07 PM ET
Summary:
Experiments to reduce a key brain protein in mice could lead to possible treatments for Alzheimer's disease, US researchers reported in the journal Science.
Posted: May 3, 2007 2:07 PM ET
Summary:
Experiments to reduce a key brain protein in mice could lead to possible treatments for Alzheimer's disease, US researchers reported in the journal Science.
Wednesday, May 02, 2007
FDA Clearance Received for Heart Attack Stem Cell Clinical Trial
Source: Mesoblast Limited
Date: May 2, 2007
Summary:
Australia's adult stem cell company, Mesoblast Limited today announced that the United States Food and Drug Administration (US FDA) has cleared the Investigational New Drug Submission (IND) of its US-based sister company, Angioblast Systems Inc., to commence a Phase 2 clinical trial of its allogeneic, or 'off-the-shelf', adult stem cells for patients with heart attacks.
Date: May 2, 2007
Summary:
Australia's adult stem cell company, Mesoblast Limited today announced that the United States Food and Drug Administration (US FDA) has cleared the Investigational New Drug Submission (IND) of its US-based sister company, Angioblast Systems Inc., to commence a Phase 2 clinical trial of its allogeneic, or 'off-the-shelf', adult stem cells for patients with heart attacks.
Tuesday, May 01, 2007
Unstable Leukemia Stem Cells May Predispose Patients To Drug Resistance
Source: Journal of the National Cancer Institute
Date: May 1, 2007
Summary:
Scientists believe the rapid mutation of a gene in chronic myeloid leukemia stem cells may help explain why patients are predisposed to resistance to drugs like imatinib that target that gene, according to a study in the May 2 Journal of the National Cancer Institute. The original news release can be foundhere .
Date: May 1, 2007
Summary:
Scientists believe the rapid mutation of a gene in chronic myeloid leukemia stem cells may help explain why patients are predisposed to resistance to drugs like imatinib that target that gene, according to a study in the May 2 Journal of the National Cancer Institute. The original news release can be found
WHEN stem cells TURN BAD: Researchers turn their microscopes on a new target in the fight against cancer
Source: The Columbus Dispatch
Date: May 1, 2007
Summary:
Stem cells often are heralded as having infinite curative possibilities. But a growing field of research suggests that some stem cells turn bad. And when they do, they can be hard to kill. Normal stem cells divide into one identical stem cell and a second that is an organ or tissue cell, say for the blood, skin or kidney. Cancer stem cells work the same way as normal stem cells, but with a deadly twist. When a cancer stem cell divides, one becomes an identical cancer stem cell, while the other becomes a tumor cell.
Date: May 1, 2007
Summary:
Stem cells often are heralded as having infinite curative possibilities. But a growing field of research suggests that some stem cells turn bad. And when they do, they can be hard to kill. Normal stem cells divide into one identical stem cell and a second that is an organ or tissue cell, say for the blood, skin or kidney. Cancer stem cells work the same way as normal stem cells, but with a deadly twist. When a cancer stem cell divides, one becomes an identical cancer stem cell, while the other becomes a tumor cell.
Paralyzed Mice Walk Again: Scientists Use Nanotechnology to Mend Broken Spinal Cords
Source: ABC News
Date: May 1, 2007
Summary:
Scientists are using nanotechnology to mend the broken spinal cords of mice. The results of their research could signal the end to diseases in humans, like Parkinson's and Alzheimer's, and enable paralyzed people to walk again, ushering in a new era of medicine -- regenerative medicine.
Date: May 1, 2007
Summary:
Scientists are using nanotechnology to mend the broken spinal cords of mice. The results of their research could signal the end to diseases in humans, like Parkinson's and Alzheimer's, and enable paralyzed people to walk again, ushering in a new era of medicine -- regenerative medicine.
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