Source: Burnham Institute for Medical Research
Date: june 30, 2008
Summary:
In a breakthrough scientific study published today in the Proceedings of the National Academy of Sciences, scientists at the Burnham Institute for Medical Research have shown that neural stem cell development may be linked to Autism. The study demonstrated that mice lacking the myocyte enhancer factor 2C (MEF2C) protein in neural stem cells had smaller brains, fewer nerve cells and showed behaviors similar to those seen in humans with a form of autism known as Rett Syndrome. This work represents the first direct link between a developmental disorder of neural stem cells and the subsequent onset of autism.
Monday, June 30, 2008
Study identifies toxic key to Alzheimer’s disease memory loss
Source: University College Dublin
Date: June 30, 2008
Summary:
Using new scientific techniques, scientists have unlocked the cascade of molecular events that lead to Alzheimer’s disease. The scientific findings published in the latest edition of Nature Medicine suggest a potential new target for the development of drug therapies to fight the irreversible and degenerative disease. The team of Irish and international researchers have identified that the accumulation of a particular protein (called amyloid ß-protein - Aß) in the brain initiates Alzheimer’s disease and that it directly alters the structure and function of brain cells. The findings place a significant emphasis on the development of new therapeutic strategies targeted at the reduction of the formation of Aß as opposed to the reduction of the plaque burden associated with the disease.
Date: June 30, 2008
Summary:
Using new scientific techniques, scientists have unlocked the cascade of molecular events that lead to Alzheimer’s disease. The scientific findings published in the latest edition of Nature Medicine suggest a potential new target for the development of drug therapies to fight the irreversible and degenerative disease. The team of Irish and international researchers have identified that the accumulation of a particular protein (called amyloid ß-protein - Aß) in the brain initiates Alzheimer’s disease and that it directly alters the structure and function of brain cells. The findings place a significant emphasis on the development of new therapeutic strategies targeted at the reduction of the formation of Aß as opposed to the reduction of the plaque burden associated with the disease.
Thursday, June 26, 2008
Scientists discover how an injured embryo can regenerate itself: Keep its organs in relative proportion
Source: Weizmann Institute of Science
Date: June 26, 2008
Summary:
Scientists have developed a mathematical model to describe interactions that occur within genetic networks of an embryo, answering the age-old question of how half embryos are able to maintain their tissues and organs in the correct proportions despite being smaller than a normal sized embryo. Understanding the processes that govern embryonic cell development, may lead, in the future, to scientists being able to repair injured tissues.
Date: June 26, 2008
Summary:
Scientists have developed a mathematical model to describe interactions that occur within genetic networks of an embryo, answering the age-old question of how half embryos are able to maintain their tissues and organs in the correct proportions despite being smaller than a normal sized embryo. Understanding the processes that govern embryonic cell development, may lead, in the future, to scientists being able to repair injured tissues.
Ronin an alternate control for embryonic stem cells
Source: Baylor College of Medicine
Date: June 26, 2008
Summary:
Like the masterless samurai for whom it is named, the protein Ronin chooses an independent path, maintaining embryonic stem cells in their undifferentiated state and playing essential roles in genesis of embryos and their development, said Baylor College of Medicine researchers who reported on this novel cellular regulator in the current issue of the journal Cell.
Date: June 26, 2008
Summary:
Like the masterless samurai for whom it is named, the protein Ronin chooses an independent path, maintaining embryonic stem cells in their undifferentiated state and playing essential roles in genesis of embryos and their development, said Baylor College of Medicine researchers who reported on this novel cellular regulator in the current issue of the journal Cell.
Wednesday, June 25, 2008
Repairing damage to brain may be nearer: Study gets stem cells to function in mice
Source: San Diego Union-Tribune
Date: June 25, 2008
Summary:
The San Diego Union-Tribune reports researchers at the Burnham Institute for Medical Research successfully turned embryonic stem cells into nerve cells in mice:
"A team of San Diego scientists has moved embryonic stem cell research a step closer to helping repair the brains of stroke victims and people with diseases such as Parkinson's and Alzheimer's. The team, led by the Burnham Institute's Stuart Lipton, figured out how to coax the embryonic stem cells of mice to become nerve cells that, when transplanted into a mouse brain damaged by stroke, link themselves to the existing network of neurons."
Date: June 25, 2008
Summary:
The San Diego Union-Tribune reports researchers at the Burnham Institute for Medical Research successfully turned embryonic stem cells into nerve cells in mice:
"A team of San Diego scientists has moved embryonic stem cell research a step closer to helping repair the brains of stroke victims and people with diseases such as Parkinson's and Alzheimer's. The team, led by the Burnham Institute's Stuart Lipton, figured out how to coax the embryonic stem cells of mice to become nerve cells that, when transplanted into a mouse brain damaged by stroke, link themselves to the existing network of neurons."
Nerve Cells Derived From Stem Cells And Transplanted Into Mice May Lead To Improved Brain Treatments
Source: Burnham Institute for Medical Research
Date: June 25, 2008
Summary:
Scientists at the Burnham Institute for Medical Research have, for the first time, genetically programmed embryonic stem (ES) cells to become nerve cells when transplanted into the brain, according to a study published today in The Journal of Neuroscience. The research, an important step toward developing new treatments for stroke, Alzheimer's, Parkinson's and other neurological conditions showed that mice afflicted by stroke showed tangible therapeutic improvement following transplantation of these cells. None of the mice formed tumors, which had been a major setback in prior attempts at stem cell transplantation.
Date: June 25, 2008
Summary:
Scientists at the Burnham Institute for Medical Research have, for the first time, genetically programmed embryonic stem (ES) cells to become nerve cells when transplanted into the brain, according to a study published today in The Journal of Neuroscience. The research, an important step toward developing new treatments for stroke, Alzheimer's, Parkinson's and other neurological conditions showed that mice afflicted by stroke showed tangible therapeutic improvement following transplantation of these cells. None of the mice formed tumors, which had been a major setback in prior attempts at stem cell transplantation.
Sunday, June 22, 2008
New Source Of Heart Stem Cells Discovered
Source: Children's Hospital Boston
Date: June 22, 2008
Summary:
Researchers at Children's Hospital Boston are continuing to document the heart's earliest origins. Now, they have pinpointed a new, previously unrecognized group of stem cells that give rise to cardiomyocytes, or heart muscle cells. These stem cells, located in the surface of the heart, or epicardium, advance the hope of being able to regenerate injured heart tissue. This finding, published online by the journal Nature on June 22, comes on the heels of parallel cardiac stem cell discoveries in 2006, at both Children's and Massachusetts General Hospital. Then, the Children's team found that a specific stem cell or progenitor, marked by expression of a gene called Nkx2-5, forms many components of the heart: heart muscle cells, vascular smooth muscle cells, and the endothelial cells lining blood vessels in the heart's left-sided chambers. The team at MGH found a related progenitor, marked by expression of the Isl1 gene, that produces these same cell-types in the right-sided heart chambers. Now, researchers at Children's have shown that heart muscle cells can also be derived from a third type of cardiac progenitor, located within the epicardium and identifiable through its expression of a gene called Wt1.
Date: June 22, 2008
Summary:
Researchers at Children's Hospital Boston are continuing to document the heart's earliest origins. Now, they have pinpointed a new, previously unrecognized group of stem cells that give rise to cardiomyocytes, or heart muscle cells. These stem cells, located in the surface of the heart, or epicardium, advance the hope of being able to regenerate injured heart tissue. This finding, published online by the journal Nature on June 22, comes on the heels of parallel cardiac stem cell discoveries in 2006, at both Children's and Massachusetts General Hospital. Then, the Children's team found that a specific stem cell or progenitor, marked by expression of a gene called Nkx2-5, forms many components of the heart: heart muscle cells, vascular smooth muscle cells, and the endothelial cells lining blood vessels in the heart's left-sided chambers. The team at MGH found a related progenitor, marked by expression of the Isl1 gene, that produces these same cell-types in the right-sided heart chambers. Now, researchers at Children's have shown that heart muscle cells can also be derived from a third type of cardiac progenitor, located within the epicardium and identifiable through its expression of a gene called Wt1.
Wednesday, June 18, 2008
Scientists use 'biological alchemy' to convert one cell type into another
Source: Daily Telegraph - UK
Posted: 18 June 2008 6:01pm BST
Summary:
Scientists converted specialist "pancreatic exocrine cells" that secrete digestive enzymes, into beta cells, which make the hormone insulin to control blood sugar levels. This was achieved by locating genes that control how the genetic code is interpreted by cells to turn them into brain, bone, heart and other human cell types. The scientists discovered nine so called transcription factor genes were important for beta cell production. Using a standard method of genetic modification where a virus is used to introduced a gene, they injected the viruses into the pancreases of lab mice and found that some of the pancreatic exocrine cells turned into fully functional beta cells and produced insulin.
Posted: 18 June 2008 6:01pm BST
Summary:
Scientists converted specialist "pancreatic exocrine cells" that secrete digestive enzymes, into beta cells, which make the hormone insulin to control blood sugar levels. This was achieved by locating genes that control how the genetic code is interpreted by cells to turn them into brain, bone, heart and other human cell types. The scientists discovered nine so called transcription factor genes were important for beta cell production. Using a standard method of genetic modification where a virus is used to introduced a gene, they injected the viruses into the pancreases of lab mice and found that some of the pancreatic exocrine cells turned into fully functional beta cells and produced insulin.
Patient's own infection-fighting T cells put late-stage melanoma into long-term remission — without chemotherapy or radiation
Source: Fred Hutchinson Cancer Research Center
Date: June 18, 2008
Summary:
Researchers describe the first successful use of a human patient's cloned infection-fighting T cells as the sole therapy to put an advanced solid-tumor cancer into long-term remission. A team led by Cassian Yee, M.D., an associate member of the Clinical Research Division at Fred Hutchinson Cancer Research Center, reports these findings in the June 19 issue of the New England Journal of Medicine.
Date: June 18, 2008
Summary:
Researchers describe the first successful use of a human patient's cloned infection-fighting T cells as the sole therapy to put an advanced solid-tumor cancer into long-term remission. A team led by Cassian Yee, M.D., an associate member of the Clinical Research Division at Fred Hutchinson Cancer Research Center, reports these findings in the June 19 issue of the New England Journal of Medicine.
Tuesday, June 17, 2008
Stem Cells Might Treat Tough Fractures
Source: HealthDay News
Date: June 17, 2008
Summary:
HealthDay News reports on a study by researchers at the University of North Carolina at Chapel Hill using adult stem cells to improve healing of bone fractures:
"The UNC team used adult stem cells to heal fractures of the tibia (the long bone of the leg) in mice. The bone marrow-derived stem cells were engineered to express insulin-like growth factor 1 (IGF-1), which help bones grow in strength and size. The transplanted stem cells migrated to the site of the fracture and improved healing by increasing the bone and cartilage that bridged the break."
The story continues to describe the procedure implemented in and results obtained from the study:
"The UNC team used adult stem cells to heal fractures of the tibia (the long bone of the leg) in mice. The bone marrow-derived stem cells were engineered to express insulin-like growth factor 1 (IGF-1), which help bones grow in strength and size. The transplanted stem cells migrated to the site of the fracture and improved healing by increasing the bone and cartilage that bridged the break. The bone at the fracture site of the mice that received stem cell transplants was three time stronger than healed fractures in untreated mice, the team reported."
Date: June 17, 2008
Summary:
HealthDay News reports on a study by researchers at the University of North Carolina at Chapel Hill using adult stem cells to improve healing of bone fractures:
"The UNC team used adult stem cells to heal fractures of the tibia (the long bone of the leg) in mice. The bone marrow-derived stem cells were engineered to express insulin-like growth factor 1 (IGF-1), which help bones grow in strength and size. The transplanted stem cells migrated to the site of the fracture and improved healing by increasing the bone and cartilage that bridged the break."
The story continues to describe the procedure implemented in and results obtained from the study:
"The UNC team used adult stem cells to heal fractures of the tibia (the long bone of the leg) in mice. The bone marrow-derived stem cells were engineered to express insulin-like growth factor 1 (IGF-1), which help bones grow in strength and size. The transplanted stem cells migrated to the site of the fracture and improved healing by increasing the bone and cartilage that bridged the break. The bone at the fracture site of the mice that received stem cell transplants was three time stronger than healed fractures in untreated mice, the team reported."
Stem cells may help heal broken bones
Source: Raleigh News & Observer
Published: June 17, 2008 12:30 AM Modified: June 17, 2008 05:23 AM
Summary:
The Raleigh News & Observer reports researchers at the University of North Carolina at Chapel Hill have made progress in using adult bone marrow stem cells to heal broken bones and bone fractures:
"Medical researchers at UNC-Chapel Hill announced Monday that they have made strides in the technology to rebuild damaged bone tissue using stem cells. The research team, led by Dr. Anna Spagnoli, an associate professor of pediatrics at UNC-CH, derived the stem cells from bone marrow samples to locate and repair broken bones in mice. Now the work is poised to move to humans."
Published: June 17, 2008 12:30 AM Modified: June 17, 2008 05:23 AM
Summary:
The Raleigh News & Observer reports researchers at the University of North Carolina at Chapel Hill have made progress in using adult bone marrow stem cells to heal broken bones and bone fractures:
"Medical researchers at UNC-Chapel Hill announced Monday that they have made strides in the technology to rebuild damaged bone tissue using stem cells. The research team, led by Dr. Anna Spagnoli, an associate professor of pediatrics at UNC-CH, derived the stem cells from bone marrow samples to locate and repair broken bones in mice. Now the work is poised to move to humans."
Stem Cells to Fight Muscle Aging
Source: Ivanhoe Newswire
Date: June 17, 2008
Summary:
Ivanhoe Newswire reports on a study in which adult stem cells were shown to stop the effects of aging, including muscle degeneration, in neuromuscular and neurodegenerative diseases:
"A recent study on mice shows stem cells may be able to stop the effects of aging on muscles, which could prevent conditions like muscle atrophy and Parkinson’s disease. Adult stem cells in muscles have a receptor called Notch that, when activated, tells them to grow and divide. As the body ages, this receptor’s activity is inhibited by the activity of another receptor for the protein TGF-beta. These two pathways -- one an aging pathway, one a youthful pathway -- compete for control of stem cell growth and division."
Date: June 17, 2008
Summary:
Ivanhoe Newswire reports on a study in which adult stem cells were shown to stop the effects of aging, including muscle degeneration, in neuromuscular and neurodegenerative diseases:
"A recent study on mice shows stem cells may be able to stop the effects of aging on muscles, which could prevent conditions like muscle atrophy and Parkinson’s disease. Adult stem cells in muscles have a receptor called Notch that, when activated, tells them to grow and divide. As the body ages, this receptor’s activity is inhibited by the activity of another receptor for the protein TGF-beta. These two pathways -- one an aging pathway, one a youthful pathway -- compete for control of stem cell growth and division."
Researchers find key developmental pathway activates lung stem cells
Source: University of Pennsylvania
Date: June 17, 2008
Summary:
Researchers from the University of Pennsylvania School of Medicine found that the activation of a molecular pathway important in stem cell and developmental biology leads to an increase in lung stem cells. Harnessing this knowledge could help develop therapies for lung-tissue repair after injury or disease. The investigators published their findings online last week in advance of print publication in Nature Genetics.
Date: June 17, 2008
Summary:
Researchers from the University of Pennsylvania School of Medicine found that the activation of a molecular pathway important in stem cell and developmental biology leads to an increase in lung stem cells. Harnessing this knowledge could help develop therapies for lung-tissue repair after injury or disease. The investigators published their findings online last week in advance of print publication in Nature Genetics.
Monday, June 16, 2008
Lou Gehrig's protein found throughout brain, suggesting effects beyond motor neurons
Source: University of Pennsylvania
Date: June 16, 2008
Summary:
Two years ago researchers at the University of Pennsylvania School of Medicine discovered that misfolded proteins called TDP-43 accumulated in the motor areas of the brains of patients with amyotropic lateral sclerosis (ALS), or Lou Gehrig's disease. Now, the same group has shown that TDP-43 accumulates throughout the brain, suggesting ALS has broader neurological effects than previously appreciated and treatments need to take into account more than motor neuron areas. Their article appeared in last month's issue of the Archives of Neurology.
Date: June 16, 2008
Summary:
Two years ago researchers at the University of Pennsylvania School of Medicine discovered that misfolded proteins called TDP-43 accumulated in the motor areas of the brains of patients with amyotropic lateral sclerosis (ALS), or Lou Gehrig's disease. Now, the same group has shown that TDP-43 accumulates throughout the brain, suggesting ALS has broader neurological effects than previously appreciated and treatments need to take into account more than motor neuron areas. Their article appeared in last month's issue of the Archives of Neurology.
Adult Stem Cells Aid Fracture Healing; Study Lays Groundwork for Potential Treatments
Source: University of North Carolina at Chapel Hill School of Medicine
Date: June 16, 2008
Summary:
In an approach that could become a new treatment for the 10 to 20 percent of people whose broken bones fail to heal, researchers at the University of North Carolina at Chapel Hill have shown that transplantation of adult stem cells can improve healing of fractures. Researchers have used adult stem cells in a few cases to improve fracture healing, but further studies were needed to show that this method was truly effective and safe before it can be pursued as a new treatment. Now scientists at UNC have provided the scientific foundation for future clinical trials of this approach by demonstrating in animal models that these cells can be used to repair broken bones.
Date: June 16, 2008
Summary:
In an approach that could become a new treatment for the 10 to 20 percent of people whose broken bones fail to heal, researchers at the University of North Carolina at Chapel Hill have shown that transplantation of adult stem cells can improve healing of fractures. Researchers have used adult stem cells in a few cases to improve fracture healing, but further studies were needed to show that this method was truly effective and safe before it can be pursued as a new treatment. Now scientists at UNC have provided the scientific foundation for future clinical trials of this approach by demonstrating in animal models that these cells can be used to repair broken bones.
Old muscle gets new pep in UC Berkeley stem cell study
Source: University of California - Berkeley
Date: June 16, 2008
Summary:
Old muscle got a shot of youthful vigor in a stem cell experiment by bioengineers at the University of California, Berkeley, setting the path for research on new treatments for age-related degenerative conditions such as muscle atrophy or Alzheimer's and Parkinson's diseases. In a new study published June 15 in an advanced online issue of the journal Nature, researchers identified two key regulatory pathways that control how well adult stem cells repair and replace damaged tissue. They then tweaked how those stem cells reacted to those biochemical signals to revive the ability of muscle tissue in old mice to repair itself nearly as well as the muscle in the mice's much younger counterparts.
Date: June 16, 2008
Summary:
Old muscle got a shot of youthful vigor in a stem cell experiment by bioengineers at the University of California, Berkeley, setting the path for research on new treatments for age-related degenerative conditions such as muscle atrophy or Alzheimer's and Parkinson's diseases. In a new study published June 15 in an advanced online issue of the journal Nature, researchers identified two key regulatory pathways that control how well adult stem cells repair and replace damaged tissue. They then tweaked how those stem cells reacted to those biochemical signals to revive the ability of muscle tissue in old mice to repair itself nearly as well as the muscle in the mice's much younger counterparts.
Research illuminates how stem cells may work
Source: San Francisco Chronicle
Date: June 16, 2008
Summary:
The San Francisco Chronicle reports researchers at the University of California, Berkeley have gained new insight into how stem cells might function:
"UC Berkeley scientists are a step closer to understanding how a series of molecular switches can turn on or off the regenerative power of stem cells that normally build new muscle tissue after it has been damaged. The research, conducted on laboratory mice, is years away from practical therapies for human beings. Nevertheless, this latest work, published online Sunday by the journal Nature, provides insight into how scientists are dissecting, step-by-step, the processes that govern how stem cells work. A goal of such research is to find ways to intervene and control these molecular switches - to improve healing and perhaps slow the effects of aging."
Date: June 16, 2008
Summary:
The San Francisco Chronicle reports researchers at the University of California, Berkeley have gained new insight into how stem cells might function:
"UC Berkeley scientists are a step closer to understanding how a series of molecular switches can turn on or off the regenerative power of stem cells that normally build new muscle tissue after it has been damaged. The research, conducted on laboratory mice, is years away from practical therapies for human beings. Nevertheless, this latest work, published online Sunday by the journal Nature, provides insight into how scientists are dissecting, step-by-step, the processes that govern how stem cells work. A goal of such research is to find ways to intervene and control these molecular switches - to improve healing and perhaps slow the effects of aging."
Ability to track stem cells in tumors could advance cancer treatments
Source: Society of Nuclear Medicine
Date: June 16, 2008
Summary:
NEW ORLEANS, La.—Using noninvasive molecular imaging technology, a method has been developed to track the location and activity of mesenchymal stem cells (MSCs) in the tumors of living organisms, according to researchers at SNM's 55th Annual Meeting. This ability could lead to major advances in the use of stem cell therapies to treat cancer.
Date: June 16, 2008
Summary:
NEW ORLEANS, La.—Using noninvasive molecular imaging technology, a method has been developed to track the location and activity of mesenchymal stem cells (MSCs) in the tumors of living organisms, according to researchers at SNM's 55th Annual Meeting. This ability could lead to major advances in the use of stem cell therapies to treat cancer.
Stem cell researchers give old muscle new pep
Source: University of California - Berkeley
Date: June 16, 2008
Summary;
Old muscle got a shot of youthful vigor in a stem cell experiment by bioengineers at the University of California, Berkeley, setting the path for research on new treatments for age-related degenerative conditions such as muscle atrophy or Alzheimer's and Parkinson's diseases. In a new study to be published June 15 in an advanced online issue of the journal Nature, researchers identified two key regulatory pathways that control how well adult stem cells repair and replace damaged tissue. They then tweaked how those stem cells reacted to those biochemical signals to revive the ability of muscle tissue in old mice to repair itself nearly as well as the muscle in the mice's much younger counterparts.
Date: June 16, 2008
Summary;
Old muscle got a shot of youthful vigor in a stem cell experiment by bioengineers at the University of California, Berkeley, setting the path for research on new treatments for age-related degenerative conditions such as muscle atrophy or Alzheimer's and Parkinson's diseases. In a new study to be published June 15 in an advanced online issue of the journal Nature, researchers identified two key regulatory pathways that control how well adult stem cells repair and replace damaged tissue. They then tweaked how those stem cells reacted to those biochemical signals to revive the ability of muscle tissue in old mice to repair itself nearly as well as the muscle in the mice's much younger counterparts.
Sunday, June 15, 2008
Researchers create molecule that nudges nerve stem cells to mature
Source: UT Southwestern Medical Center
Date: June 15, 2008
Summary:
Inspired by a chance discovery during another experiment, researchers at UT Southwestern Medical Center have created a small molecule that stimulates nerve stem cells to begin maturing into nerve cells in culture. This finding might someday allow a person's own nerve stem cells to be grown outside the body, stimulated into maturity, and then re-implanted as working nerve cells to treat various diseases, the researchers said.
Date: June 15, 2008
Summary:
Inspired by a chance discovery during another experiment, researchers at UT Southwestern Medical Center have created a small molecule that stimulates nerve stem cells to begin maturing into nerve cells in culture. This finding might someday allow a person's own nerve stem cells to be grown outside the body, stimulated into maturity, and then re-implanted as working nerve cells to treat various diseases, the researchers said.
Saturday, June 14, 2008
Stem cell method improved
Source: Milwaukee Journal Sentinel
Date: June 14, 2008
Summary:
The Milwaukee Journal Sentinel reports researchers have found a method to improve reprogramming adult stem cells into an emnbryonic stem cell-like state:
"One of the two stem cell scientists who achieved a major breakthrough last November by reprogramming human skin cells back to an embryonic state has found a way to boost the efficiency of the procedure, though he told more than 2,000 fellow researchers that challenges remain. Shinya Yamanaka of Kyoto University and the Gladstone Institute of Cardiovascular Disease — who pioneered the reprogramming method in mice in 2006, then shared the breakthrough in human cells with James Thomson at the University of Wisconsin-Madison — said that he had achieved better results by combining his method with Thomson’s."
Date: June 14, 2008
Summary:
The Milwaukee Journal Sentinel reports researchers have found a method to improve reprogramming adult stem cells into an emnbryonic stem cell-like state:
"One of the two stem cell scientists who achieved a major breakthrough last November by reprogramming human skin cells back to an embryonic state has found a way to boost the efficiency of the procedure, though he told more than 2,000 fellow researchers that challenges remain. Shinya Yamanaka of Kyoto University and the Gladstone Institute of Cardiovascular Disease — who pioneered the reprogramming method in mice in 2006, then shared the breakthrough in human cells with James Thomson at the University of Wisconsin-Madison — said that he had achieved better results by combining his method with Thomson’s."
Friday, June 13, 2008
Wealth of genomic hotspots discovered in embryonic stem cells
Source: Agency for Science, Technology and Research (A*STAR)
Date: June 13, 2008
Summary:
In a paper published in Cell on June 13, 2008, Singapore scientists at the Genome Institute of Singapore (GIS) and the National University of Singapore (NUS) unveil an atlas that showing the location of "genomic hotspots" of essential protein "switches" (transcription factors) that are critical for maintaining the embryonic stem (ES) cell state. Using advanced high throughput sequencing technology, the scientists discovered over 3,000 hotspots. These findings could improve understanding of the unique properties of stem cells that enable them to maintain their intriguing ability to grow and differentiate to virtually any cell type.
Date: June 13, 2008
Summary:
In a paper published in Cell on June 13, 2008, Singapore scientists at the Genome Institute of Singapore (GIS) and the National University of Singapore (NUS) unveil an atlas that showing the location of "genomic hotspots" of essential protein "switches" (transcription factors) that are critical for maintaining the embryonic stem (ES) cell state. Using advanced high throughput sequencing technology, the scientists discovered over 3,000 hotspots. These findings could improve understanding of the unique properties of stem cells that enable them to maintain their intriguing ability to grow and differentiate to virtually any cell type.
Thursday, June 12, 2008
Geron's Embryonic Stem Cell Therapy for Heart Failure Evades Direct Attack by Immune System
Source: Geron Corporation
Date: June 12, 2008
Summary:
In an official company news release, Geron Corporation, a biotechnology company in the field of stem cell research, reported its embryonic stem cell therapy to treat heart failure evaded attack by the immune system:
"Geron Corporation announced the presentation of research studies indicating that GRNCM1, the company's human embryonic stem cell (hESC)–based therapeutic for the treatment of heart failure, evades direct attack by the human immune system in vitro. The data presented at the International Society for Stem Cell Research (ISSCR) Annual Meeting indicate that, unlike whole organ transplants, cell therapies derived from hESCs may provoke only minimal immune reactions suggesting that rejection may be controlled or prevented by short courses of low–dose immunosuppressive drugs. The work also suggests that patient–specific hESC lines may not be needed to prevent immune rejection."
Date: June 12, 2008
Summary:
In an official company news release, Geron Corporation, a biotechnology company in the field of stem cell research, reported its embryonic stem cell therapy to treat heart failure evaded attack by the immune system:
"Geron Corporation announced the presentation of research studies indicating that GRNCM1, the company's human embryonic stem cell (hESC)–based therapeutic for the treatment of heart failure, evades direct attack by the human immune system in vitro. The data presented at the International Society for Stem Cell Research (ISSCR) Annual Meeting indicate that, unlike whole organ transplants, cell therapies derived from hESCs may provoke only minimal immune reactions suggesting that rejection may be controlled or prevented by short courses of low–dose immunosuppressive drugs. The work also suggests that patient–specific hESC lines may not be needed to prevent immune rejection."
Monday, June 09, 2008
A tiny key to lock blood cells' fate
Source: Broad Institute
Date: June 9, 2008
Summary:
Scientists have wondered for decades how two very different types of blood cells —platelets and red blood cells — arise from the exact same precursor cell. In work described in the June issue of Developmental Cell, a team of Boston area researchers has unearthed a tiny and unexpected answer: a small snippet of nucleic acid called microRNA-150. This new methodology, called plate-based capture, allows researchers to analyze microRNAs by capturing and immobilizing them in a small plastic dish. Lu and his colleagues used this technique to monitor how microRNA levels change as MEPs mature. They observed the most dramatic change in the levels of miR-150, a surprising result because miR-150 was previously thought to be unique to immune cells. Nevertheless, the researchers’ data pointed to an important role for miR-150 in this stage of blood cell development.
Date: June 9, 2008
Summary:
Scientists have wondered for decades how two very different types of blood cells —platelets and red blood cells — arise from the exact same precursor cell. In work described in the June issue of Developmental Cell, a team of Boston area researchers has unearthed a tiny and unexpected answer: a small snippet of nucleic acid called microRNA-150. This new methodology, called plate-based capture, allows researchers to analyze microRNAs by capturing and immobilizing them in a small plastic dish. Lu and his colleagues used this technique to monitor how microRNA levels change as MEPs mature. They observed the most dramatic change in the levels of miR-150, a surprising result because miR-150 was previously thought to be unique to immune cells. Nevertheless, the researchers’ data pointed to an important role for miR-150 in this stage of blood cell development.
Stem cell discovery sheds light on placenta development
Source: University of Florida
Date: June 9, 2008
Summary:
Researchers studying embryonic stem cells have explored the first fork in the developmental road, getting a new look at what happens when fertilized eggs differentiate to build either an embryo or a placenta. By manipulating a specific gene in a mouse blastocyst — the structure that develops from a fertilized egg but is not yet an actual embryo — scientists with the University of Florida's McKnight Brain Institute and the Harvard Stem Cell Institute caused cells destined to build an embryo to instead change direction and build the cell mass that leads to the placenta.
Date: June 9, 2008
Summary:
Researchers studying embryonic stem cells have explored the first fork in the developmental road, getting a new look at what happens when fertilized eggs differentiate to build either an embryo or a placenta. By manipulating a specific gene in a mouse blastocyst — the structure that develops from a fertilized egg but is not yet an actual embryo — scientists with the University of Florida's McKnight Brain Institute and the Harvard Stem Cell Institute caused cells destined to build an embryo to instead change direction and build the cell mass that leads to the placenta.
Human cells used to cure brain disease in mice
Source: Nature
Published online 4 June 2008 | Nature | doi:10.1038/news.2008.875
Corrected online: 9 June 2008
Summary:
Nature reports injections of human brain cells have treated abnormal brain development in mice with fatal brain disorders:
"Human brain cells have been used to correct abnormal brain development in mice with fatal brain disorders, offering hope for treating a range of neurological disorders including some deadly childhood genetic diseases. Those behind the new treatment hope that human clinical trials could be just a few years away. The treatment uses human glial progenitor cells — cells that can differentiate into the glial cells that, among other things, make up myelin. Myelin, a protein that insulates the long 'arms' of nerve cells, called axons, helps the conduction of neural signals throughout the nervous system."
Published online 4 June 2008 | Nature | doi:10.1038/news.2008.875
Corrected online: 9 June 2008
Summary:
Nature reports injections of human brain cells have treated abnormal brain development in mice with fatal brain disorders:
"Human brain cells have been used to correct abnormal brain development in mice with fatal brain disorders, offering hope for treating a range of neurological disorders including some deadly childhood genetic diseases. Those behind the new treatment hope that human clinical trials could be just a few years away. The treatment uses human glial progenitor cells — cells that can differentiate into the glial cells that, among other things, make up myelin. Myelin, a protein that insulates the long 'arms' of nerve cells, called axons, helps the conduction of neural signals throughout the nervous system."
Sunday, June 08, 2008
Caution On Stem Cell Therapy: Single Organs May Contain Several Types Of Adult Stem Cells
Source: University of Utah Health Sciences
Date: June 9, 2008
Summary:
A single organ may contain more than one type of adult stem cell -- a discovery that complicates prospects for using the versatile cells to replace damaged tissue as a treatment for disease, according to a new study from the laboratory of geneticist Mario Capecchi, the University of Utah's Nobel Laureate.
Date: June 9, 2008
Summary:
A single organ may contain more than one type of adult stem cell -- a discovery that complicates prospects for using the versatile cells to replace damaged tissue as a treatment for disease, according to a new study from the laboratory of geneticist Mario Capecchi, the University of Utah's Nobel Laureate.
Friday, June 06, 2008
Brain Stem Cells Can Be Awakened, Say Scientists
Source: Schepens Eye Research Institute
Date: June 6, 2008
Summary:
Scientists at Schepens Eye Research Institute have identified specific molecules in the brain that are responsible for awakening and putting to sleep brain stem cells, which, when activated, can transform into neurons (nerve cells) and repair damaged brain tissue. Their findings were recently published online in the Proceedings of the National Academy of Science (PNAS).
Date: June 6, 2008
Summary:
Scientists at Schepens Eye Research Institute have identified specific molecules in the brain that are responsible for awakening and putting to sleep brain stem cells, which, when activated, can transform into neurons (nerve cells) and repair damaged brain tissue. Their findings were recently published online in the Proceedings of the National Academy of Science (PNAS).
Adult stem cell findings offer new hope for Parkinson's cure
Source: Griffith University / Research Australia
Date: June 6, 2008
Summary:
Research released today provides evidence that a cure for Parkinson's disease could lie just inside the nose of patients themselves. The Griffith University study published today in the journal Stem Cells found that adult stem cells harvested from the noses of Parkinson's patients gave rise to dopamine-producing brain cells when transplanted into the brain of a rat.
Date: June 6, 2008
Summary:
Research released today provides evidence that a cure for Parkinson's disease could lie just inside the nose of patients themselves. The Griffith University study published today in the journal Stem Cells found that adult stem cells harvested from the noses of Parkinson's patients gave rise to dopamine-producing brain cells when transplanted into the brain of a rat.
Thursday, June 05, 2008
Human Stem Cells Cure Fatal Myelin Deficiency In Mice And Could One Day Help Children
Source: Medical News Today
Article Date: 5 June 2008 - 12:00 PDT
Summary
Medical News Today reports researchers have used human adult neural stem cell to grow myelin in mice:
"Scientists in the US have used human cells that behave like stem cells to help "shiverer" mice grow myelin around their nerve fibres and thereby avoid an inevitable early death and poor quality of life; the researchers hope their finding will one day lead to treatments for similar neurological conditions in humans, and children especially."
Article Date: 5 June 2008 - 12:00 PDT
Summary
Medical News Today reports researchers have used human adult neural stem cell to grow myelin in mice:
"Scientists in the US have used human cells that behave like stem cells to help "shiverer" mice grow myelin around their nerve fibres and thereby avoid an inevitable early death and poor quality of life; the researchers hope their finding will one day lead to treatments for similar neurological conditions in humans, and children especially."
Brain Stem Cells Reverse Myelin Deficiency in Mice
Source: HealthDay News
Date: June 5, 2008
Summary:
HealthDay News reports researchers treated a congenital brain disorder in mice with neural stem cells:
"Researchers report they have used neural stem cells to correct a congenital brain disorder in mice. Dr. Steven Goldman, of the University of Rochester Medical Center in New York, and his colleagues used a type of neural stem cell called "glial progenitor cells" (GPCs), derived from human fetuses, to correct both behavioral and physiological abnormalities in a mouse model of a myelin-deficiency disorder."
Date: June 5, 2008
Summary:
HealthDay News reports researchers treated a congenital brain disorder in mice with neural stem cells:
"Researchers report they have used neural stem cells to correct a congenital brain disorder in mice. Dr. Steven Goldman, of the University of Rochester Medical Center in New York, and his colleagues used a type of neural stem cell called "glial progenitor cells" (GPCs), derived from human fetuses, to correct both behavioral and physiological abnormalities in a mouse model of a myelin-deficiency disorder."
New technology enhances therapeutic potential of cord blood stem cells
Source: Rush University Medical Center
Date: June 5, 2008
Summary:
A CD26 Inhibitor increases the efficiency and responsiveness of umbilical cord blood for bone marrow transplants and may improve care for blood cancer patients according to research from Rush University Medical Center being presented at the 6th Annual International Umbilical Cord Blood Transplantation Symposium, June 6-7 in Los Angeles. Kent W. Christopherson II, PhD, assistant professor of medicine and researcher in the Sections of Hematology and Stem Cell Transplantation at Rush, is researching a CD26 Inhibitor, a small molecule enzyme inhibitor that enhances directional homing of stem cells to the bone marrow by increasing the responsiveness of donor stem cells to a natural homing signal. Homing is the process by which the donor stem cells find their way to the bone marrow. It is the first and essential step in stem cell transplantation.
Date: June 5, 2008
Summary:
A CD26 Inhibitor increases the efficiency and responsiveness of umbilical cord blood for bone marrow transplants and may improve care for blood cancer patients according to research from Rush University Medical Center being presented at the 6th Annual International Umbilical Cord Blood Transplantation Symposium, June 6-7 in Los Angeles. Kent W. Christopherson II, PhD, assistant professor of medicine and researcher in the Sections of Hematology and Stem Cell Transplantation at Rush, is researching a CD26 Inhibitor, a small molecule enzyme inhibitor that enhances directional homing of stem cells to the bone marrow by increasing the responsiveness of donor stem cells to a natural homing signal. Homing is the process by which the donor stem cells find their way to the bone marrow. It is the first and essential step in stem cell transplantation.
Wednesday, June 04, 2008
Human stem cells help brain-impaired mice
Source: Reuters
Posted: June 4, 2008 5:46 PM ET
Summary:
Reuters reports researchers treated mice with brain injuries using human neural stem cells:
"Injecting human stem cells into the brains of mice helped them recover almost fully from a neurological condition similar to a group of childhood diseases in people, researchers said on Wednesday. Some, but not all, of the mice in the study made major improvements after a one-time injection of stem cells, leading the scientists to express hope that the same approach might be tried in children within just a couple of years. The treatment, in essence, fixed defective wiring throughout the brain and spinal cord, the researchers said."
Posted: June 4, 2008 5:46 PM ET
Summary:
Reuters reports researchers treated mice with brain injuries using human neural stem cells:
"Injecting human stem cells into the brains of mice helped them recover almost fully from a neurological condition similar to a group of childhood diseases in people, researchers said on Wednesday. Some, but not all, of the mice in the study made major improvements after a one-time injection of stem cells, leading the scientists to express hope that the same approach might be tried in children within just a couple of years. The treatment, in essence, fixed defective wiring throughout the brain and spinal cord, the researchers said."
Human Stem Cell Transplant Helps Brain-Impaired Mice
Source: HealthDay News
Date: June 4, 2008
Summary:
HealthDay News reports human neural stem cell transplants improved functioning in mice with multiple sclerosis:
"Mice with a congenital brain disorder improved after receiving human neural stem cell transplants, a U.S. study finds. The mice lacked myelin, a substance that plays a critical role in the transmission of electrical signals between nerve cells. When myelin is missing or damaged, electrical signals aren't properly transmitted. These "shiverer" mice typically die within months of birth."
The study compared previous research using cell transplants to restore destroyed myelin with results found in the current study:
"Previous research has examined the use of cell transplantation for restoring absent or lost myelin to diseased nerve fibers. But, until now, no transplantation of human neural stem cells or of their derivatives (glial progenitor cells) had been successful in test animals. In this new study, researchers from the University of Rochester Medical Center and a number of other universities (Cornell, UCLA and Baylor) created a new method for harvesting and purification of human fetal glial progenitor cells. They also developed a new cell delivery strategy that uses multiple injection sites to encourage widespread and dense take-up of the transplanted cells through the central nervous system. When the researchers used these new approaches, the transplanted cells took hold throughout the brain and spinal cord, and the mice showed robust, efficient and functional myelination. Some of the mice showed neurological improvement and a fraction of them were save by the procedure."
Date: June 4, 2008
Summary:
HealthDay News reports human neural stem cell transplants improved functioning in mice with multiple sclerosis:
"Mice with a congenital brain disorder improved after receiving human neural stem cell transplants, a U.S. study finds. The mice lacked myelin, a substance that plays a critical role in the transmission of electrical signals between nerve cells. When myelin is missing or damaged, electrical signals aren't properly transmitted. These "shiverer" mice typically die within months of birth."
The study compared previous research using cell transplants to restore destroyed myelin with results found in the current study:
"Previous research has examined the use of cell transplantation for restoring absent or lost myelin to diseased nerve fibers. But, until now, no transplantation of human neural stem cells or of their derivatives (glial progenitor cells) had been successful in test animals. In this new study, researchers from the University of Rochester Medical Center and a number of other universities (Cornell, UCLA and Baylor) created a new method for harvesting and purification of human fetal glial progenitor cells. They also developed a new cell delivery strategy that uses multiple injection sites to encourage widespread and dense take-up of the transplanted cells through the central nervous system. When the researchers used these new approaches, the transplanted cells took hold throughout the brain and spinal cord, and the mice showed robust, efficient and functional myelination. Some of the mice showed neurological improvement and a fraction of them were save by the procedure."
Researchers Discover Synthetic Chemicals that Create Pluripotent Stem Cells from Adult Cells
Source: The Scripps Research Institute
Date: June 4, 2008
Summary:
LA JOLLA, CA, June 4, 2008—Scientists at The Scripps Research Institute report that they have significantly improved upon a revolutionary technique that uses genes to turn skin cells from an adult back into pluripotent stem cells. In the June 5, 2008 issue of the journal Cell Stem Cell, investigators describe for the first time how they identified and used small, drug-like chemicals to help coax mouse brain cells back into pluripotent stem cells in a way that reduced some of the major drawbacks of the technique developed two years ago by Japanese researcher Shinya Yamanaka to produce pluripotent stem cells, once derived only from embryos, from adult cells. The new findings provide a safer, more efficient method to reprogram cells, paving the way for clinical testing of reprogrammed stem cells.
Date: June 4, 2008
Summary:
LA JOLLA, CA, June 4, 2008—Scientists at The Scripps Research Institute report that they have significantly improved upon a revolutionary technique that uses genes to turn skin cells from an adult back into pluripotent stem cells. In the June 5, 2008 issue of the journal Cell Stem Cell, investigators describe for the first time how they identified and used small, drug-like chemicals to help coax mouse brain cells back into pluripotent stem cells in a way that reduced some of the major drawbacks of the technique developed two years ago by Japanese researcher Shinya Yamanaka to produce pluripotent stem cells, once derived only from embryos, from adult cells. The new findings provide a safer, more efficient method to reprogram cells, paving the way for clinical testing of reprogrammed stem cells.
Neurologically Impaired Mice Improve After Receiving Human Stem Cells
Source: Cell Press / Cell Stem Cell
Date: June 4, 2008
Summary:
Scientists report a dramatic success in what may be the first documented rescue of a congenital brain disorder by transplantation of human neural stem cells. The research, published by Cell Press in the June issue of the journal Cell Stem Cell, may lead the way to new strategies for treating certain hereditary and perinatal neurological disorders.
The researchers found that the new transplant procedure resulted in infiltration of human glial progenitor cells throughout the brain and spinal cord. The engrafted mice exhibited robust, efficient and functional myelination. Most notably, many of the mice displayed progressive, neurological improvement and a fraction of the mice were actually rescued by the procedure. "The neurological recovery and survival of the mice receiving transplants was in sharp contrast to the fate of their untreated controls, which uniformly died by five months," explains Dr. Goldman. Upon histological examination well over a year after the procedure, the white matter of the surviving mice had been essentially re-myelinated by human cells.
Date: June 4, 2008
Summary:
Scientists report a dramatic success in what may be the first documented rescue of a congenital brain disorder by transplantation of human neural stem cells. The research, published by Cell Press in the June issue of the journal Cell Stem Cell, may lead the way to new strategies for treating certain hereditary and perinatal neurological disorders.
The researchers found that the new transplant procedure resulted in infiltration of human glial progenitor cells throughout the brain and spinal cord. The engrafted mice exhibited robust, efficient and functional myelination. Most notably, many of the mice displayed progressive, neurological improvement and a fraction of the mice were actually rescued by the procedure. "The neurological recovery and survival of the mice receiving transplants was in sharp contrast to the fate of their untreated controls, which uniformly died by five months," explains Dr. Goldman. Upon histological examination well over a year after the procedure, the white matter of the surviving mice had been essentially re-myelinated by human cells.
Human Stem Cells Show Promise Against Fatal Children's Diseases
Source: University of Rochester Medical Center
Date: June 4, 2008
Summary:
Scientists have used human stem cells to dramatically improve the condition of mice with a neurological condition similar to a set of diseases in children that are invariably fatal, according to an article in the June issue of the journal Cell Stem Cell. With a one-time injection of stem cells just after birth, scientists were able to repair defective wiring throughout the brain and spinal cord – the entire central nervous system – of mutant “shiverer mice,” so called because of the way they shake and wobble. The work marks an important step toward the day when stem cells become an option for the treatment of neurological diseases in people.
Neuroscientists at the University of Rochester Medical Center injected a type of fetal human stem cell known as glial stem cells into newborn mice born with a condition that normally claims their lives within about 20 weeks of birth, after a lifetime of seizures and other serious consequences. While most of the 26 mice that received transplanted glial stem cells still died, a group of six lived far beyond their usual lifespan, and four appeared to be completely cured – a first for shiverer mice. The scientists plan to gather more evidence before trying the approach in sick children.
Date: June 4, 2008
Summary:
Scientists have used human stem cells to dramatically improve the condition of mice with a neurological condition similar to a set of diseases in children that are invariably fatal, according to an article in the June issue of the journal Cell Stem Cell. With a one-time injection of stem cells just after birth, scientists were able to repair defective wiring throughout the brain and spinal cord – the entire central nervous system – of mutant “shiverer mice,” so called because of the way they shake and wobble. The work marks an important step toward the day when stem cells become an option for the treatment of neurological diseases in people.
Neuroscientists at the University of Rochester Medical Center injected a type of fetal human stem cell known as glial stem cells into newborn mice born with a condition that normally claims their lives within about 20 weeks of birth, after a lifetime of seizures and other serious consequences. While most of the 26 mice that received transplanted glial stem cells still died, a group of six lived far beyond their usual lifespan, and four appeared to be completely cured – a first for shiverer mice. The scientists plan to gather more evidence before trying the approach in sick children.
Enzyme plays key role in cell fate
Source: Baylor College of Medicine
Date: June 4, 2008
Summary:
The road to death or differentiation follows a similar course in embryonic stem cells, said researchers at Baylor College of Medicine in Houston in a report that appears online today in the journal Cell Stem Cell. Dr. Thomas Zwaka, assistant professor in the Stem Cells and Regenerative Medicine Center (STaR) at BCM, and his colleagues at BCM found an “overlap between the pathways that drive cell death and cell differentiation” in a group of enzymes called caspases.
Date: June 4, 2008
Summary:
The road to death or differentiation follows a similar course in embryonic stem cells, said researchers at Baylor College of Medicine in Houston in a report that appears online today in the journal Cell Stem Cell. Dr. Thomas Zwaka, assistant professor in the Stem Cells and Regenerative Medicine Center (STaR) at BCM, and his colleagues at BCM found an “overlap between the pathways that drive cell death and cell differentiation” in a group of enzymes called caspases.
Tuesday, June 03, 2008
Finding clues for nerve cell repair
Source: Montreal Neurological Institute and Hospital
Date: June 3, 2008
Summary:
A new study at the Montreal Neurological Institute at McGill University identifies a key mechanism for the normal development of motor nerve cells (motor neurons) - cells that control muscles. This finding is crucial to understanding and treating a range of conditions involving nerve cell loss or damage, from spinal cord injury to neurodegenerative diseases such as ALS, also known as Lou Gehrig's disease. The study, published recently in the Proceedings of the National Academy of Sciences, provides invaluable insight into these vital processes by understanding the mechanisms involved in normal development of selected types of spinal cord motor nerve cells.
Date: June 3, 2008
Summary:
A new study at the Montreal Neurological Institute at McGill University identifies a key mechanism for the normal development of motor nerve cells (motor neurons) - cells that control muscles. This finding is crucial to understanding and treating a range of conditions involving nerve cell loss or damage, from spinal cord injury to neurodegenerative diseases such as ALS, also known as Lou Gehrig's disease. The study, published recently in the Proceedings of the National Academy of Sciences, provides invaluable insight into these vital processes by understanding the mechanisms involved in normal development of selected types of spinal cord motor nerve cells.
Damaged brains helped by stem cell therapy
Source: United Press International
Posted: June 3, 2008 at 2:10 PM EDT
Summary:
United Press International reports researchers have discovered how neural stem cells might be able to repair damaged brains:
U.S. medical scientists say they have found a way in which neuronal stem cells in the adult brain might be used in treating brain injuries. According to some experts, newly born adult neuronal brain stem cells could help repair brain injuries, but first a way must be found to regulate the manner in which they are created -- a process known as neurogenesis.
The study also found that hypothermia can control the growth of new nerve cells:
"According to the study, neurogenesis can be regulated through induced hypothermia. In rat subjects, a mild decrease in body temperature was found to substantially decrease the proliferation of newly-born neurons, the researchers said."
Posted: June 3, 2008 at 2:10 PM EDT
Summary:
United Press International reports researchers have discovered how neural stem cells might be able to repair damaged brains:
U.S. medical scientists say they have found a way in which neuronal stem cells in the adult brain might be used in treating brain injuries. According to some experts, newly born adult neuronal brain stem cells could help repair brain injuries, but first a way must be found to regulate the manner in which they are created -- a process known as neurogenesis.
The study also found that hypothermia can control the growth of new nerve cells:
"According to the study, neurogenesis can be regulated through induced hypothermia. In rat subjects, a mild decrease in body temperature was found to substantially decrease the proliferation of newly-born neurons, the researchers said."
Stem Cells Correct Defect in Child’s Fatal Skin Disease
Source: Columbia University Medical Center
Date: June 3, 2008
Summary;
Researchers and clinicians have paved the way toward a cure for a young boy's genetic and fatal skin disease, recessive dystrophic epidermolysis bullosa (RDEB), by using a cord blood and bone marrow transplant.
Date: June 3, 2008
Summary;
Researchers and clinicians have paved the way toward a cure for a young boy's genetic and fatal skin disease, recessive dystrophic epidermolysis bullosa (RDEB), by using a cord blood and bone marrow transplant.
Researchers identify gene that regulates glucose levels
Source: University of Southern California
Date: June 3, 2008
Summary:
In an effort to understand how genes work, a collaborative study which includes the University of Southern California (USC) has identified a gene that regulates glucose levels. The results, which will be published in the July issue of the Journal of Clinical Investigation and is currently available online, may provide further understanding of the underlying causes of diabetes.
Date: June 3, 2008
Summary:
In an effort to understand how genes work, a collaborative study which includes the University of Southern California (USC) has identified a gene that regulates glucose levels. The results, which will be published in the July issue of the Journal of Clinical Investigation and is currently available online, may provide further understanding of the underlying causes of diabetes.
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