Source: Imperial College London
Date: 3 July 2012
Summary:
Stem cells found in amniotic fluid can be transformed into a more versatile state similar to embryonic stem cells, according to a study published July 3 in the journal Molecular Therapy. Scientists from Imperial College London and the UCL Institute of Child Health succeeded in reprogramming amniotic fluid cells without having to introduce extra genes. The findings raise the possibility that stem cells derived from donated amniotic fluid could be stored in banks and used for therapies and in research, providing a viable alternative to the limited embryonic stem cells currently available.
Showing posts with label reproductive biology. Show all posts
Showing posts with label reproductive biology. Show all posts
Tuesday, July 03, 2012
Thursday, March 01, 2012
Cell and Signaling Pathway That Regulates the Placental Blood Stem Cell Niche Identified
Source: University of California - Los Angeles
Date: March 1, 2012
Summary:
UCLA stem-cell researchers have identified a certain type of cell and a signaling pathway in the placental niche that play a key role in stopping blood stem cells from differentiating into mature blood cells in the placenta. Preventing this premature differentiation is critical to ensuring a proper blood supply for an individual's lifetime.
The placental niche is considered a stem cell "safe zone," which supports the creation and expansion of blood stem cells without promoting their differentiation into mature cells. This allows for the establishment of a pool of precursor cells that will later provide blood cells for fetal and post-natal life, said the study's senior author, Dr. Hanna Mikkola, an associate professor of molecular cell and developmental biology at UCLA and a researcher at UCLA's Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research.
Mikkola and her team found that PDGF-B signaling in specialized cells in the placenta called trophoblasts — which facilitate embryo implantation and exchanges of nutrients between the mother and fetus — is vital to maintaining the unique micro-environment needed for the blood precursor cells. When PDGF-B signaling is halted, these blood precursors differentiate too early, creating red blood cells in the placenta, Mikkola said.
The study, done in mouse models, appears March 1 in the peer-reviewed journal Developmental Cell.
Date: March 1, 2012
Summary:
UCLA stem-cell researchers have identified a certain type of cell and a signaling pathway in the placental niche that play a key role in stopping blood stem cells from differentiating into mature blood cells in the placenta. Preventing this premature differentiation is critical to ensuring a proper blood supply for an individual's lifetime.
The placental niche is considered a stem cell "safe zone," which supports the creation and expansion of blood stem cells without promoting their differentiation into mature cells. This allows for the establishment of a pool of precursor cells that will later provide blood cells for fetal and post-natal life, said the study's senior author, Dr. Hanna Mikkola, an associate professor of molecular cell and developmental biology at UCLA and a researcher at UCLA's Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research.
Mikkola and her team found that PDGF-B signaling in specialized cells in the placenta called trophoblasts — which facilitate embryo implantation and exchanges of nutrients between the mother and fetus — is vital to maintaining the unique micro-environment needed for the blood precursor cells. When PDGF-B signaling is halted, these blood precursors differentiate too early, creating red blood cells in the placenta, Mikkola said.
The study, done in mouse models, appears March 1 in the peer-reviewed journal Developmental Cell.
Thursday, September 22, 2011
Important Step in Sperm Reprogramming Identified
Source: University of North Carolina School of Medicine
Date: September 22, 2011
Summary:
A study from the University of North Carolina at Chapel Hill School of Medicine has illuminated a key step of demethylation, giving stem cell researchers critical information as they try to reprogram adult cells to mimic the curative and self-renewing properties of stem cells. Previous research had shown that the methyl tags on sperm DNA are converted to their chemical cousin, hydroxymethyl, before disappearing completely. The current finding, published online in the Sept. 22, 2011, issue of Science (ScienceExpress), suggests that the disappearance of these chemical tags in the later steps of demethylation is not an active process catalyzed by an enzyme but is rather a passive process.
Date: September 22, 2011
Summary:
A study from the University of North Carolina at Chapel Hill School of Medicine has illuminated a key step of demethylation, giving stem cell researchers critical information as they try to reprogram adult cells to mimic the curative and self-renewing properties of stem cells. Previous research had shown that the methyl tags on sperm DNA are converted to their chemical cousin, hydroxymethyl, before disappearing completely. The current finding, published online in the Sept. 22, 2011, issue of Science (ScienceExpress), suggests that the disappearance of these chemical tags in the later steps of demethylation is not an active process catalyzed by an enzyme but is rather a passive process.
Wednesday, September 14, 2011
Researchers Use Uterine Stem Cells to Treat Diabetes
Source: Yale University
Date: September 14, 2011
Summary:
New Haven, Conn. — Controlling diabetes may someday involve mining stem cells from the lining of the uterus, Yale School of Medicine researchers report in a new study published in the journal Molecular Therapy. The team treated diabetes in mice by converting cells from the uterine lining into insulin-producing cells. The endometrium or uterine lining, is a source of adult stem cells. These cells generate uterine tissue each month as part of the menstrual cycle. Like other stem cells, however, they can divide to form other kinds of cells. The Yale team's findings suggest that endometrial stem cells could be used to develop insulin-producing islet cells, which are found in the pancreas. These islet cells could then be used to advance the study of islet cell transplantation to treat people with diabetes.
Date: September 14, 2011
Summary:
New Haven, Conn. — Controlling diabetes may someday involve mining stem cells from the lining of the uterus, Yale School of Medicine researchers report in a new study published in the journal Molecular Therapy. The team treated diabetes in mice by converting cells from the uterine lining into insulin-producing cells. The endometrium or uterine lining, is a source of adult stem cells. These cells generate uterine tissue each month as part of the menstrual cycle. Like other stem cells, however, they can divide to form other kinds of cells. The Yale team's findings suggest that endometrial stem cells could be used to develop insulin-producing islet cells, which are found in the pancreas. These islet cells could then be used to advance the study of islet cell transplantation to treat people with diabetes.
Tuesday, February 01, 2011
Transplanted human placenta-derived stem cells show therapeutic potential in stroke models
Source: University of South Florida (USF Health)
Date: February 1, 2011
Summary:
Human amniotic epithelial cells, stem cells derived from human placenta left over from live births and generally discarded, proliferated and differentiated when they interacted with one kind of melatonin receptor, MT1. This potentially therapeutic response occurred when the stem cells were transplanted into laboratory test tube and animal models of stroke. The same cells did not perform similarly when interacting with melatonin receptor MT2.
Researchers from the University of South Florida's Department of Neurosurgery and Brain Repair, and co-researchers in Brescia, Italy, concluded that the placenta-derived stem cells and their interaction with MT1 promoted functional recovery in the laboratory mice with modeled stroke. Their study is published in the current issue of the Journal of Pineal Research.
Date: February 1, 2011
Summary:
Human amniotic epithelial cells, stem cells derived from human placenta left over from live births and generally discarded, proliferated and differentiated when they interacted with one kind of melatonin receptor, MT1. This potentially therapeutic response occurred when the stem cells were transplanted into laboratory test tube and animal models of stroke. The same cells did not perform similarly when interacting with melatonin receptor MT2.
Researchers from the University of South Florida's Department of Neurosurgery and Brain Repair, and co-researchers in Brescia, Italy, concluded that the placenta-derived stem cells and their interaction with MT1 promoted functional recovery in the laboratory mice with modeled stroke. Their study is published in the current issue of the Journal of Pineal Research.
Sunday, December 12, 2010
Researchers Turn Human Testes Cells Into Insulin-Producing Islet Cells
Source: Georgetown University Medical Center
Date: December 12, 2010
Summary;
Men with type 1 diabetes may be able to grow their own insulin-producing cells from their testicular tissue, say Georgetown University Medical Center (GUMC) researchers. Their laboratory and animal study is a proof of principle that human spermatogonial stem cells (SSCs) extracted from testicular tissue can morph into insulin-secreting beta islet cells normally found in the pancreas. And the researchers say they accomplished this feat without use of any of the extra genes now employed in most labs to turn adult stem cells into a tissue of choice.
Date: December 12, 2010
Summary;
Men with type 1 diabetes may be able to grow their own insulin-producing cells from their testicular tissue, say Georgetown University Medical Center (GUMC) researchers. Their laboratory and animal study is a proof of principle that human spermatogonial stem cells (SSCs) extracted from testicular tissue can morph into insulin-secreting beta islet cells normally found in the pancreas. And the researchers say they accomplished this feat without use of any of the extra genes now employed in most labs to turn adult stem cells into a tissue of choice.
Friday, November 19, 2010
Reprogrammed amniotic fluid cells can generate all types of body cells
Source: Max-Planck-Gesellschaft
Date: November 19, 2010
Summary:
High hopes rest on stem cells: one day, they may be used to treat many diseases. To date, embryos are the main source of these cells, but this raises ethical problems. Scientists at the Max Planck Institute for Molecular Genetics in Berlin have now managed to convert amniotic fluid cells into pluripotent stem cells. These amniotic fluid-derived iPS cells are hardly distinguishable from embryonic stem cells - however, they "remember" where they came from. (PLoS One, October 29, 2010)
Date: November 19, 2010
Summary:
High hopes rest on stem cells: one day, they may be used to treat many diseases. To date, embryos are the main source of these cells, but this raises ethical problems. Scientists at the Max Planck Institute for Molecular Genetics in Berlin have now managed to convert amniotic fluid cells into pluripotent stem cells. These amniotic fluid-derived iPS cells are hardly distinguishable from embryonic stem cells - however, they "remember" where they came from. (PLoS One, October 29, 2010)
Friday, June 25, 2010
Mechanism that may trigger degenerative disease identified
Source: Penn State University
Date: June 25, 2010
Summary:
A mechanism that regulates stem-cell differentiation in mice testes suggests a similar process that may trigger degenerative disease in humans, according to researchers at Penn State University. Research involved manipulating a protein called STAT3 that signals stem cells to decide whether to differentiate into a specialized type of cell or self-renew and remain stem cells. By manipulating STAT3, researchers identified a key regulator of spermatogonial stem cell self-renewal. Every time a stem cell divides, it produces two new cells. The findings were published in the June online issue of Biology of Reproduction.
Date: June 25, 2010
Summary:
A mechanism that regulates stem-cell differentiation in mice testes suggests a similar process that may trigger degenerative disease in humans, according to researchers at Penn State University. Research involved manipulating a protein called STAT3 that signals stem cells to decide whether to differentiate into a specialized type of cell or self-renew and remain stem cells. By manipulating STAT3, researchers identified a key regulator of spermatogonial stem cell self-renewal. Every time a stem cell divides, it produces two new cells. The findings were published in the June online issue of Biology of Reproduction.
Thursday, April 22, 2010
Scientists Create Stem Cells from Eggs of Aging Mice
Source: New York University Langone Medical Center
Date: April 22, 2010
Summary:
Researchers at NYU Langone Medical Center have created stem cells from the eggs of aging mice that could be used for reproductive purposes and regenerative medicine. The study, published in April issue of the journal Aging Cell, found that even though the eggs from older females were slightly less efficient at making stem cells than those from younger females, the capacity to create stem cells was sustained.
Date: April 22, 2010
Summary:
Researchers at NYU Langone Medical Center have created stem cells from the eggs of aging mice that could be used for reproductive purposes and regenerative medicine. The study, published in April issue of the journal Aging Cell, found that even though the eggs from older females were slightly less efficient at making stem cells than those from younger females, the capacity to create stem cells was sustained.
Monday, March 15, 2010
Amniotic Fluid Cells More Efficiently Reprogrammed to Pluripotency Than Adult Cells
Source: Mount Sinai School of Medicine
Date: March 15, 2010
Summary:
In a breakthrough that may help fill a critical need in stem cell research and patient care, researchers at Mount Sinai School of Medicine have demonstrated that skin cells found in human amniotic fluid can be efficiently "reprogrammed" to pluripotency, where they have characteristics similar to human embryonic stem cells that can develop into almost any type of cell in the human body. The study is online now and will appear in print in the next issue of the journal Cellular Reprogramming, to be published next month.
The Mount Sinai researchers found that when compared to cultured adult skin cells, the amniotic fluid skin cells formed stem cell colonies in about half the time and yielded nearly a 200 percent increase in number. Reprogramming fetal skin cells also cuts significantly the cost of generating patient-specific induced pluripotent stem cells when compared to reprogramming other cell types.
Date: March 15, 2010
Summary:
In a breakthrough that may help fill a critical need in stem cell research and patient care, researchers at Mount Sinai School of Medicine have demonstrated that skin cells found in human amniotic fluid can be efficiently "reprogrammed" to pluripotency, where they have characteristics similar to human embryonic stem cells that can develop into almost any type of cell in the human body. The study is online now and will appear in print in the next issue of the journal Cellular Reprogramming, to be published next month.
The Mount Sinai researchers found that when compared to cultured adult skin cells, the amniotic fluid skin cells formed stem cell colonies in about half the time and yielded nearly a 200 percent increase in number. Reprogramming fetal skin cells also cuts significantly the cost of generating patient-specific induced pluripotent stem cells when compared to reprogramming other cell types.
Monday, November 23, 2009
New research shows versatility of amniotic fluid stem cells
Source: Wake Forest University Baptist Medical Center
Date: November 23, 2009
Summary:
WINSTON-SALEM, N.C. – For the first time, scientists have demonstrated that stem cells found in amniotic fluid meet an important test of potential to become specialized cell types, which suggests they may be useful for treating a wider array of diseases and conditions than scientists originally thought. Reporting in Oncogene, a publication of Nature Publishing Group, the research teams of Anthony Atala, M.D., director of the Wake Forest Institute for Regenerative Medicine, and Markus Hengstschläger, Ph.D., from the Medical University of Vienna, have shown that these amnion stem cells can form three-dimensional aggregates of cells known as embryoid bodies (EBs). It is believed that cells at this stage of development can be directed to become virtually any cell in the human body.
Date: November 23, 2009
Summary:
WINSTON-SALEM, N.C. – For the first time, scientists have demonstrated that stem cells found in amniotic fluid meet an important test of potential to become specialized cell types, which suggests they may be useful for treating a wider array of diseases and conditions than scientists originally thought. Reporting in Oncogene, a publication of Nature Publishing Group, the research teams of Anthony Atala, M.D., director of the Wake Forest Institute for Regenerative Medicine, and Markus Hengstschläger, Ph.D., from the Medical University of Vienna, have shown that these amnion stem cells can form three-dimensional aggregates of cells known as embryoid bodies (EBs). It is believed that cells at this stage of development can be directed to become virtually any cell in the human body.
Wednesday, October 28, 2009
Stem Cells Changed Into Precursors For Sperm, Eggs
Source: Stanford University School of Medicine
Date: October 28, 2009
Summary:
Human embryonic stem cells derived from excess IVF embryos may help scientists unlock the mysteries of infertility for other couples struggling to conceive, according to new research from the Stanford University School of Medicine. Researchers at the school have devised a way to efficiently coax the cells to become human germ cells -- the precursors of egg and sperm cells -- in the laboratory. Unlike previous research, which yielded primarily immature germ cells, the cells in this most-recent study functioned well enough to generate sperm cells.
Here is a link to a news story associated with this news release from the San Jose Mercury News.
Date: October 28, 2009
Summary:
Human embryonic stem cells derived from excess IVF embryos may help scientists unlock the mysteries of infertility for other couples struggling to conceive, according to new research from the Stanford University School of Medicine. Researchers at the school have devised a way to efficiently coax the cells to become human germ cells -- the precursors of egg and sperm cells -- in the laboratory. Unlike previous research, which yielded primarily immature germ cells, the cells in this most-recent study functioned well enough to generate sperm cells.
Here is a link to a news story associated with this news release from the San Jose Mercury News.
Tuesday, July 28, 2009
Male Germ Cells Can Be Directly Converted Into Other Cell Types
Source: University of Illinois at Urbana-Champaign
Date: July 28, 2009
Summary:
CHAMPAIGN, lll. – Researchers at the University of Illinois at Urbana-Champaign have found a way to directly convert spermatogonial stem cells, the precursors of sperm cells, into tissues of the prostate, skin and uterus. Their approach, described this month in the journal Stem Cells, may prove to be an effective alternative to the medical use of embryonic stem cells. The new method, co-developed by postdoctoral researcher Liz Simon takes advantage of the unusual interaction of two tissue types: the epithelium and the mesenchyme.
The hunt for alternatives to embryonic stem cells has led to some promising yet problematic approaches, some of which involve spermatagonial stem cells (SSCs). Researchers recently observed, for example, that SSCs grown in the laboratory will eventually give rise to a few cells that look and act like embryonic stem cells. This process can take months, however, and only a small percentage of the SSCs are converted into “embryonic stem-like” cells.
Date: July 28, 2009
Summary:
CHAMPAIGN, lll. – Researchers at the University of Illinois at Urbana-Champaign have found a way to directly convert spermatogonial stem cells, the precursors of sperm cells, into tissues of the prostate, skin and uterus. Their approach, described this month in the journal Stem Cells, may prove to be an effective alternative to the medical use of embryonic stem cells. The new method, co-developed by postdoctoral researcher Liz Simon takes advantage of the unusual interaction of two tissue types: the epithelium and the mesenchyme.
The hunt for alternatives to embryonic stem cells has led to some promising yet problematic approaches, some of which involve spermatagonial stem cells (SSCs). Researchers recently observed, for example, that SSCs grown in the laboratory will eventually give rise to a few cells that look and act like embryonic stem cells. This process can take months, however, and only a small percentage of the SSCs are converted into “embryonic stem-like” cells.
Saturday, July 18, 2009
Placentas found to be rich in stem cells
Source: San Francisco Chronicle
Date: July 18, 2009
Summary:
The San Francisco Chronicle reports researchers have discovered that placentas contain stem cells that can treat blood diseases:
"Bay Area researchers have found that human placentas - typically tossed as medical waste after birth - are full of the kind of stem cells that can treat leukemia and dozens of other diseases of the blood. Placental stem cells, much like the cells retrieved from umbilical cord blood, do not have the broad potential of embryonic stem cells that can turn into nearly any kind of tissue or organ in the body. But they can replace some cells and help rebuild entire systems damaged by disease."
Date: July 18, 2009
Summary:
The San Francisco Chronicle reports researchers have discovered that placentas contain stem cells that can treat blood diseases:
"Bay Area researchers have found that human placentas - typically tossed as medical waste after birth - are full of the kind of stem cells that can treat leukemia and dozens of other diseases of the blood. Placental stem cells, much like the cells retrieved from umbilical cord blood, do not have the broad potential of embryonic stem cells that can turn into nearly any kind of tissue or organ in the body. But they can replace some cells and help rebuild entire systems damaged by disease."
Friday, June 19, 2009
Discarded Fallopian Tubes Could Be Rich Source Of Stem Cells, Study
Source: Medical News Today
Article Date: 19 June 2009 - 10:00 PDT
Summary:
Medical News Today reports researchers have found that stem cells from fallopian tubes may be potential sources of mesenchymal (blood and bone marrow) stem cells:
"Fallopian tubes normally discarded after hysterectomies and other procedures could become rich potential sources for mesenchymal stem cells which like other types of stem cell can be coaxed to develop into a variety of cell types, according to a new study by researchers in Brazil. Researchers from the University of São Paulo's Human Genome Research Centre, which is directed by Dr Mayana Zatz conducted the study in collaboration with medical doctors from the University's reproductive surgery department. The results are published as an online paper in BioMed Central's open access Journal of Translational Medicine."
Article Date: 19 June 2009 - 10:00 PDT
Summary:
Medical News Today reports researchers have found that stem cells from fallopian tubes may be potential sources of mesenchymal (blood and bone marrow) stem cells:
"Fallopian tubes normally discarded after hysterectomies and other procedures could become rich potential sources for mesenchymal stem cells which like other types of stem cell can be coaxed to develop into a variety of cell types, according to a new study by researchers in Brazil. Researchers from the University of São Paulo's Human Genome Research Centre, which is directed by Dr Mayana Zatz conducted the study in collaboration with medical doctors from the University's reproductive surgery department. The results are published as an online paper in BioMed Central's open access Journal of Translational Medicine."
Sunday, March 22, 2009
Human adult testes cells can become embryonic-like
Source: Georgetown University Medical Center
Date: March 22, 2009
Summary:
Using what they say is a relatively simple method, scientists at Georgetown University Medical Center have extracted stem/progenitor cells from testes and have converted them back into pluripotent embryonic-like stem cells. Researchers say that the naďve cells are now potentially capable of morphing into any cell type that a body needs, from brain neurons to pancreatic tissue. And because they produced these stem cells without the use of additional genes, the technology should be safe for human use, the researchers say in a paper published online in the journal Stem Cells and Development.
Date: March 22, 2009
Summary:
Using what they say is a relatively simple method, scientists at Georgetown University Medical Center have extracted stem/progenitor cells from testes and have converted them back into pluripotent embryonic-like stem cells. Researchers say that the naďve cells are now potentially capable of morphing into any cell type that a body needs, from brain neurons to pancreatic tissue. And because they produced these stem cells without the use of additional genes, the technology should be safe for human use, the researchers say in a paper published online in the journal Stem Cells and Development.
Monday, January 05, 2009
Testes Stem Cell Can Change Into Other Body Tissues, Study Shows
Source: Source: Stanford University Medical Center
Date: January 5, 2009
Summary:
Scientists at the Stanford University School of Medicine and at UC-San Francisco have succeeded in isolating stem cells from human testes. The cells bear a striking resemblance to embryonic stem cells — they can differentiate into each of the three main types of tissues of the body — but the researchers caution against viewing them as one and the same.
According to the study, the testes stem cells have different patterns of gene expression and regulation and they do not proliferate and differentiate as aggressively as human embryonic stem cells. The findings, published in the January issue of the journal Stem Cells, are in contrast to those reported in a recent Nature paper, which concluded that the cells were, in fact, as pluripotent as embryonic stem cells. Pluripotent cells can become any cell in the body and form tumors called teratomas when transplanted into mice.
Date: January 5, 2009
Summary:
Scientists at the Stanford University School of Medicine and at UC-San Francisco have succeeded in isolating stem cells from human testes. The cells bear a striking resemblance to embryonic stem cells — they can differentiate into each of the three main types of tissues of the body — but the researchers caution against viewing them as one and the same.
According to the study, the testes stem cells have different patterns of gene expression and regulation and they do not proliferate and differentiate as aggressively as human embryonic stem cells. The findings, published in the January issue of the journal Stem Cells, are in contrast to those reported in a recent Nature paper, which concluded that the cells were, in fact, as pluripotent as embryonic stem cells. Pluripotent cells can become any cell in the body and form tumors called teratomas when transplanted into mice.
Thursday, September 04, 2008
Scientists reveal changes to embryonic stem cells caused by Down syndrome
Source: Queen Mary, University of London
Date: 4 September 2008
Summary:
Scientists investigating the mechanisms of Down Syndrome (DS) have revealed the earliest developmental changes in embryonic stem cells caused by an extra copy of human chromosome 21 – the aberrant inheritance of which results in the condition. Their study is published online today (Thursday 4 September) in the American Journal of Human Genetics.
Lead by Dean Nizetic, Professor of Cellular and Molecular Biology at Barts and The London School of Medicine and Dentistry, the team utilised embryonic stem cells from a previously genetically engineered species of mice carrying a copy of human chromosome 21. They discovered that extra chromosome 21 - a genetic state known as trisomy 21 - disturbs a key regulating gene called NRSF or REST, which in turn disturbs the cascade of other genes that control normal development at the embryonic stem cell stage. Furthermore, they identified one gene (DYRK1A) on human chromosome 21, whose overdose in trisomy (DS), is responsible for the observed effects.
Date: 4 September 2008
Summary:
Scientists investigating the mechanisms of Down Syndrome (DS) have revealed the earliest developmental changes in embryonic stem cells caused by an extra copy of human chromosome 21 – the aberrant inheritance of which results in the condition. Their study is published online today (Thursday 4 September) in the American Journal of Human Genetics.
Lead by Dean Nizetic, Professor of Cellular and Molecular Biology at Barts and The London School of Medicine and Dentistry, the team utilised embryonic stem cells from a previously genetically engineered species of mice carrying a copy of human chromosome 21. They discovered that extra chromosome 21 - a genetic state known as trisomy 21 - disturbs a key regulating gene called NRSF or REST, which in turn disturbs the cascade of other genes that control normal development at the embryonic stem cell stage. Furthermore, they identified one gene (DYRK1A) on human chromosome 21, whose overdose in trisomy (DS), is responsible for the observed effects.
Monday, July 21, 2008
Stem Cell Chicken and Egg Debate Moves to Unlikely Arena: The Testes
Source: Salk Institute
Date: July 21, 2008
Summary:
Logic says it has to be the niche. As air and water preceded life, so the niche, that hospitable environment that shelters adult stem cells in many tissues and provides factors necessary to keep them young and vital, must have emerged before its stem cell dependents. A team of scientists at the Salk Institute for Biological Studies led by Leanne Jones, Ph.D., assistant professor in the Laboratory of Genetics, now suggests that this is not always the case. They report in the July 20 advance online edition of the journal Nature that the cells that comprise a specialized niche in the testis of fruit flies actually emerge from adult stem cells, a finding with implications for regenerative medicine, aging research, and cancer therapeutics.
Date: July 21, 2008
Summary:
Logic says it has to be the niche. As air and water preceded life, so the niche, that hospitable environment that shelters adult stem cells in many tissues and provides factors necessary to keep them young and vital, must have emerged before its stem cell dependents. A team of scientists at the Salk Institute for Biological Studies led by Leanne Jones, Ph.D., assistant professor in the Laboratory of Genetics, now suggests that this is not always the case. They report in the July 20 advance online edition of the journal Nature that the cells that comprise a specialized niche in the testis of fruit flies actually emerge from adult stem cells, a finding with implications for regenerative medicine, aging research, and cancer therapeutics.
Wednesday, July 09, 2008
New Technique Harvests Stem Cells at Earlier Stage
Source: HealthDay News
Date: July 9, 2008
Summary:
HealthDay News reports scientists have found a way to obtain embryonic stem cells in blastomere stage of embryonic development without destroying the embryo, a finding that could end the ethical controversy surrounding the field of embryonic stem cell research:
"Scientists say they have finally succeeded in developing human embryonic stem cells earlier in the development stage of a blastomere, or a 4-cell stage embryo, so the whole embryo is not destroyed. The development, expected to be presented Wednesday at the European Society of Human Reproduction & Embryology annual conference in Barcelona, may make stem cell research easier to conduct by not raising as many ethical concerns, the researchers added."
Date: July 9, 2008
Summary:
HealthDay News reports scientists have found a way to obtain embryonic stem cells in blastomere stage of embryonic development without destroying the embryo, a finding that could end the ethical controversy surrounding the field of embryonic stem cell research:
"Scientists say they have finally succeeded in developing human embryonic stem cells earlier in the development stage of a blastomere, or a 4-cell stage embryo, so the whole embryo is not destroyed. The development, expected to be presented Wednesday at the European Society of Human Reproduction & Embryology annual conference in Barcelona, may make stem cell research easier to conduct by not raising as many ethical concerns, the researchers added."
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