Tuesday, December 15, 2009

How Do Salamanders Grow a New Leg? Protein Mechanisms Behind Limb Regeneration

Source: Indiana University School of Medicine
Date:December 15, 2009

Summary:

The most comprehensive study to date of the proteins in a species of salamander that can regrow appendages may provide important clues to how similar regeneration could be induced in humans. Researchers at the School of Science at Indiana University-Purdue University Indianapolis and colleagues investigated over three hundred proteins in the amputated limbs of axolotls, a type of salamander that has the unique natural ability to regenerate appendages from any level of amputation, with the hope that this knowledge will contribute to a better understanding of the mechanisms that allow limbs to regenerate. Findings were published online in the journal Biomedical Central Biology on November 30 (BMC Biology 7:83, 2009).