Source: Samuel Lunenfield Research Institute of Mount Sinai Hospital
Date: July 2, 2010
Summary:
Mount Sinai Hospital researchers including Drs. Andras Nagy and Jeff Wrana have discovered new insights into the genesis of stem cells, which will improve the efficiency of stem cell creation for use in tissue regeneration and in the development of new drugs. The study was published today in the leading biomedical journal Cell Stem Cell.
The goal of the study was to explore the process of changing fully mature cells of the body (known as somatic cells) into a pluripotent state (i.e., cells that can develop into most other cell types), and understand the molecular and genetic changes that occur during the cells’ reprogramming. Understanding this process will help researchers identify limitations in making induced pluripotent stem (iPS) cells, which are a source of great hope for use in regenerative medicine, as well as in the development of new drugs to prevent and treat various diseases.
