Low Oxygen Preserves Usefulness of Stem Cells

Source: Yale University
Posted: October 18, 2006

Summary;

Low levels of oxygen, or hypoxia, may help preserve the unique undifferentiated nature of stem or progenitor cells, according to a report by Yale School of Medicine researchers in the Journal of Biological Chemistry.

Stem cell therapy is a possible future approach for the treatment of cancer and other genetic diseases. However, it is difficult to maintain the biological functions of stem cells and progenitor cells in culture. Both stem cells and progenitor cells can give rise to mature functional cell types. Progenitor cells, also called precursor cells, are derived from stem cells, but can only produce a more limited number of mature cell types.

Zhong Yun, the senior author of the study said the research could facilitate the use of these cells in future stem cell therapies by leading to improved conservation methods.

“Once we know how the microenvironment regulates the functions of stem and progenitor cells, we can potentially protect them from premature differentiation or find ways to mobilize these cells for tissue repair and/or regeneration,” he said.

Commentary: Maybe this finding wll hasten researchers' ability to create specific cell types to treat diseases and injuries.