Thursday, October 04, 2007

Human Embryonic Stem Cells Remain Embryonic Because Of Epigenetic Factors

Source: Agency for Science, Technology and Research
Date: October 4, 2007

Summary:

A human embryonic stem cell is reined in – prevented from giving up its unique characteristics of self-renewal and pluripotency – by the presence of a protein modification that stifles any genes that would prematurely instruct the cell to develop into heart or other specialized tissue. But, thanks to the simultaneous presence of different protein modifications, stem cells are primed and poised, ready to develop into specialized body tissue, Singapore scientists reported in last month’s issue of the journal Cell Stem Cell.