Source: University of Michigan
Date: October 13, 2008
Summary:
Four genes previously implicated in the control of cancer have been shown by University of Michigan scientists to play key roles in the aging process and stem-cell regulation. It’s a case of genetic multiple personalities: Four genes that suppress tumor formation also regulate the ability of adult stem cells to replace worn-out tissues, as well as the shut-down of stem cells during aging. The genes switch on and off in a coordinated fashion as cells age to reduce the risk of cancer. In the process, they also shut down stem-cell function in aging tissues, reducing their capacity to regenerate. The findings, reported in the Oct. 17 edition of the journal Cell, clarify and highlight the links between cancer, aging and stem-cell function by revealing some of their shared genetic pathways.
