Source: Washington University School of Medicine
Date: June 28, 2010
Summary:
In a step toward curing diabetes in humans, scientists at Washington University School of Medicine in St. Louis have alleviated the disease in rats using transplants from both embryonic and adult pigs. The rats adopted the pig transplants as their own and produced enough insulin to control their blood sugar – all without the need for anti-rejection drugs. The researchers report their findings online in the American Journal of Pathology.
Using a two-step approach, the researchers first transplanted a cluster of embryonic pig pancreatic cells into diabetic rats. These cells grow to become the pancreas, which houses the islet cells that produce insulin. The embryonic cells primed the rats’ immune system to accept a second implant of islets from adult pigs several weeks later.
The new research – the first long-term, successful cross-species transplant of pig islets without immune suppression – raises the prospect that it may one day be possible to cure diabetes in humans using a similar strategy. Pig cells could overcome the shortage of human islets available from deceased donors and the need for transplant patients to take anti-rejection drugs for life.
