Friday, January 07, 2011

Researchers pinpoint origin of deadly brain tumor

Source: University of Rochester Medical Center
Date: January 7, 2011

Summary:

Scientists at University of Rochester Medical Center have identified the type of cell that is at the origin of brain tumors known as oligodendrogliomas, which are a type of glioma – a category that defines the most common type of malignant brain tumor. In a paper published in the December 2010 issue of the journal Cancer Cell, investigators found that the tumor originates in and spreads through cells known as glial progenitor cells – cells that are often referred to as "daughter" cells of stem cells. The work comes at a time when many researchers are actively investigating the role that stem cells which have gone awry play in causing cancer. For scientists trying to create new ways to treat brain tumors, knowing whether stem cells or progenitor cells are part of the process is crucial.

In a paper published in the December 2010 issue of the journal Cancer Cell, investigators found that the tumor originates in and spreads through cells known as glial progenitor cells – cells that are often referred to as "daughter" cells of stem cells. The work comes at a time when many researchers are actively investigating the role that stem cells which have gone awry play in causing cancer. For scientists trying to create new ways to treat brain tumors, knowing whether stem cells or progenitor cells are part of the process is crucial.