Wednesday, August 22, 2012

Astrocytes Control the Generation of New Neurons from Neural Stem Cells

Source: University of Gothenburg
Date: 22 August 2012

Summary:

Researchers from the Laboratory of astrocyte biology and CNS regeneration headed by Prof. Milos Pekny at the University of Gothenburg just published a research article in a journal Stem Cells on the molecular mechanism that controls generation of new neurons in the brain. Astrocytes are cells that have many functions in the central nervous system, such as the control of neuronal synapses, blood flow, or the brain's response to neurotrauma or stroke.

Reduces brain tissue damage
Prof. Pekny's laboratory together with collaborators have earlier demonstrated that astrocytes reduce the brain tissue damage after stroke and that the integration of transplanted neural stem cells can be largely improved by modulating the activity of astrocytes.

Generation of new neurons
In their current study, the Sahlgrenska Academy researchers show how astrocytes control the generation of new neurons in the brain. An important contribution to this project came from Åbo Academy, one of Sahlgrenska's traditional collaborative partners.