Sunday, August 06, 2006

Neural stem cells derived from human embryonic stem cells carry abnormal gene expression

Source: University of California - Los Angeles
Posted: August 6, 2006

Summary:

Neural stem cells grown from one of the federally approved human embryonic stem cell lines proved to be inferior to neural stem cells derived from fetal tissue donated for research, a UCLA study has found.

Researchers from the Institute for Stem Cell Biology and Medicine at UCLA coaxed cells from the federally approved line to differentiate into neural stem cells, a process that might one day be used to grow replacement cells to treat such debilitating diseases as Parkinson's and Alzheimer's. However, the neural stem cells expressed a lower level of a metabolic gene called CPT 1A, a condition that causes hypoglycemia in humans.

Commentary: Hopefully this finding will enable scientists to use neural cells to treat diseases that are safe and free of harmful side effects.

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