Source: Washington University School of Medicine
Date: September 11, 2006
Summary:
Researchers at Washington University School of Medicine in St. Louis demonstrated that a drug called AMD3100 can mobilize angiogenic cells from bone marrow of human patients in a matter of hours instead of days, as was the case with a related agent called G-CSF. The researchers showed that AMD3100 caused a 10- to 20-fold increase in certain angiogenic cells in the blood within four hours in human subjects, suggesting the drug could be a more effective treatment for heart attack or stroke. The researchers are planning a clinical trial to test G-CSF in patients with peripheral vascular disease to find out if the drug will lead to long-lasting improvement in blood flow, heal ulcers, relieve pain and prevent amputations.
Commentary: Hopefully this new drug will be sucessful in clinical trials and improve the quality of live for patients with cardiac, neurological and circulatory conditions.
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