Wednesday, October 27, 2010

Too Much SP2 Protein Turns Stem Cells Into “Evil Twin” Tumor-forming Cancer Cells

Source: North Carolina State University
Date: October 27, 2010

Summary:

Researchers at North Carolina State University have found that the overproduction of a key protein in stem cells causes those stem cells to form cancerous tumors. Their work may lead to new treatments for a variety of cancers. The team of researchers looked at the protein SP2, which regulates the activity of other genes. They knew that elevated amounts of SP2 had been observed in human prostate-cancer patients, and that these levels only increased as the tumors became more dangerous. They then showed that precisely the same thing occurs in mouse skin tumors. The researchers’ results are published in the Nov. 3 edition of the journal Cancer Research.