Source: Cell Press
Posted: July 10, 2006
Summary:
Researchers have discovered new evidence that surprisingly simple genetic abnormalities in the machinery of critical neuronal growth-regulating molecules can kill neurons in Down's syndrome, Alzheimer's disease, and other neurodegenerative disorders. The researchers said their basic findings could aid progress toward treatment for the cognitive deficits in these disorders. The study revealed that an increase in the expression of a gene for amyloid precursor protein (APP) disrupts transport of the neurotrophin "nerve growth factor" (NGF). APP is also a central molecule in the pathology of Alzheimer's disease.
Commentary: Maybe this finding will lead to treatmets that will decrease cognitive deficits in neurodegenerative disorders and improve overall cognitive fuction in humans.
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