Drug Dials Down The Energy Within Cells, Researchers Find

Source: University of Michigan
Posted: July 5, 2006

Summary:

University of Michigan researchers have discovered that Bz-423, a drug effective at treating animal models of human autoimmune disorders and other diseases, works by dialing down the activity of a key enzyme involved in energy production. The drug lowers enzyme activity to a level that maintains normal function while simultaneously allowing for initiation of a process that selectively kills or disables disease-causing cells. Unlike conventional drugs for these conditions, which can’t discriminate between healthy and disease-causing cells, Bz-423 is highly selective, homing in on disease-causing cells. The researchers believe the findings may have applications not only for lupus, arthritis and psoriasis, but also for other conditions.

Commentary: Hopefully this drug will be effective in treating autoimmune diseases in a diverse patient population.