Source: University of Illinois at Chicago
Posted: July 12, 2006
Summary:
University of Illinois at Chicago College of Medicine researchers have published a study that describes a way to possibly pre-empt the onset of comlications that may result in transplant patients with conditions such as graft rejection or graft-versus-host disease.
In laboratory and animal models, the researchers demonstrated that alloreactive T cells change the fate of blood stem cells and may themselves stimulate a strong immune response.
Discoverinng how stem cells change in may enable testing of immunosuppressive drugs and different T cell subsets, potentially preventing or reducing graft-versus-host disease or rejection.
The researchers believe that by blocking some molecules, the complications could be reversed, potentially leading to improved outcomes for transplant patients.
Commentary: Maybe this research will lead to new methods of preventing immune rejection in stem cell transplantation for all types of human stem cells and enable a greater number of human diseases and conditions to be successfully treated using stem cells.
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